ライフサイエンスコーパス: selective toxicity

1 e a new group of anticancer drugs with tumor selective toxicity.

2 evaluated in cell culture to delineate their selective toxicity.

3 ine atovaquone-binding affinity, and thereby selective toxicity.

4 ent a new class of anticancer agents showing selective toxicity against cancer cells.

5 ions include: (a) tirapazamine having a high selective toxicity against hypoxic cells; (b) the nature

6 inhibitors (BXI-61 and BXI-72) that exhibit selective toxicity against lung cancer cells compared wi

7 t disulfiram (DSF) is shown to have a highly selective toxicity against melanoma in culture, inducing

8 humans, inhibitors that target DapE may have selective toxicity against only bacteria.

9 inhibitor does not consistently produce the selective toxicity and pathological hallmarks characteri

10 ecificity for insect nicotinic receptors and selective toxicity as insecticides.

11 cations for insecticide cross-resistance and selective toxicity between insects and mammals.

12 ical screen and discovered compounds showing selective toxicity for breast CSCs.

13 Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHCs

14 The complex displays selective toxicity for HMLER breast cancer cells enriche

15 n-binding drug combretastatin A-4 exhibits a selective toxicity for proliferating endothelial cells i

16 ative, the antimalaria drug quinacrine, have selective toxicity for tumor cells and can simultaneousl

17 o spinal mitochondria as the basis for their selective toxicity in ALS.

18 has focused on genomic expression related to selective toxicity in chiral pesticide, nor on epigeneti

19 ition of KSR1 or EPHB4 effectors may lead to selective toxicity in colorectal tumors.

20 e (GSH) depletion induces ROS production and selective toxicity in HL60 cells that overexpress Bcl-2

21 This type of selective toxicity might be potentially important in the

22 ytotoxic drug cargo, exhibited M2 macrophage-selective toxicity not observed in monovalent M2pep trea

23 d patterns of Htt proteolysis leading to the selective toxicity observed in HD striatum.

24 Although the selective toxicity of 5,7-dihydroxytryptamine (5,7-DHT)

25 The cell-selective toxicity of Abeta resembles the selective dama

26 important implications for understanding the selective toxicity of anti-cancer drugs in tumor cells.

27 nderstanding of the structural basis for the selective toxicity of atovaquone could help in designing

28 il, a P-gp inhibitor, partially reversed the selective toxicity of both 1 and 10.

29 The selective toxicity of chemicals to lung tissues is predo

30 The exact mechanisms for the selective toxicity of chemotherapeutic drugs against tum

31 The selective toxicity of DEP for DA neurons was demonstrate

32 To investigate the selective toxicity of emodepside, we performed transgeni

33 We describe a novel strategy to increase the selective toxicity of genotoxic compounds.

34 Mechanistic studies indicated that the selective toxicity of miR-17 approximately 92 polycistro

35 ition alone is not sufficient to explain the selective toxicity of MPP(+) to dopaminergic neurons.

36 , 88-amino acid protein that may mediate the selective toxicity of organotins.

37 abotropic glutamate receptors attenuates the selective toxicity of rotenone on DA neurons by activati

38 nase kinases (MKK) significantly reduced the selective toxicity of rotenone or colchicine.

39 Here we show a completely new mechanism of selective toxicity of superparamagnetic nanoparticles (S

40 ysis of Msh2+/+ and Msh2-/- cells shows that selective toxicity of the halogenated nucleotide analogu

41 Several models could explain the selective toxicity of the mustard-phenylindole compounds

42 gases and is responsible for determining the selective toxicity of these compounds in mammals.

43 Specifically, selective toxicity of tiopronin toward MDR cells is achi

44 The selective toxicity of WL-276 against drug-resistant PC-3

45 ity of rotenone plays a critical role in its selective toxicity on DA neurons.

46 ity of rotenone plays a critical role in its selective toxicity on tyrosine hydroxylase-positive (TH+

47 2; however, the mechanism(s) for cancer cell-selective toxicity remain unknown.

48 experiments indicate hydrogel surfaces show selective toxicity to bacterial versus mammalian cells.

49 M2pep]4-Biotin and [M2pep]2-[KLA]2 exhibited selective toxicity to both M2-like TAMs and malignant ce

50 ygen species drive pharmacologic ascorbate's selective toxicity to cancer cells in vitro, in mice, an

51 rough to using genes to mediate powerful and selective toxicity to cancer cells.

52 Mutant alpha-synuclein also causes selective toxicity to catecholaminergic neurons in prima

53 Hence, we hypothesized that HNO can exert selective toxicity to cells subjected to acidosis.

54 otenone, another complex I inhibitor, causes selective toxicity to dopamine neurons, and Ndufs4 inact

55 n of BPNT-1 in the nervous system, can cause selective toxicity to specific neurons, resulting in cor

56 poxic cytotoxic agent tirapazamine exhibited selective toxicity to the primitive stem cell subset.

57 al injection of 6-hydroxydopamine results in selective toxicity to these neurons.

58 clinical trials demonstrate the feasibility, selective toxicity, tolerability, and potential efficacy

59 l cell-based Gli1-mediated transcription and selective toxicity toward cancer cells.

60 offer a promising therapeutic strategy with selective toxicity toward malignant but not normal cells

61 These compounds show a selective toxicity toward MOLT-4 compared to HeLa cells

62 The molecule's selective toxicity toward the beetle's fungal antagonist

63 allowed facile screening for compounds with selective toxicity toward the mutant Ras genotype.

64 or related compounds, might exhibit greater selective toxicity toward tumor cells that overexpress t

65 anti-cancer drugs due to their demonstrated selective toxicity towards cancer cells relative to norm

66 Genotype-selective toxicity was first determined through short-te