ライフサイエンスコーパス: selectivity

1 ear tonotopic position (i.e. sound frequency selectivity).

2 catalytic centers, hence their activity and selectivity.

3 distinct conformations underlying functional selectivity.

4 membranes with high water flux and enhanced selectivity.

5 t properties without adversely affecting the selectivity.

6 edesign of channelrhodopsins for altered ion selectivity.

7 H2O is a crucial parameter in the control of selectivity.

8 ovide the BCN precursor with 79:21 syn/ anti selectivity.

9 es an electrophile yielding Aldol-Tishchenko selectivity.

10 highly substituted pyrrolizidines with endo selectivity.

11 silylidene led to a slight increase in alpha-selectivity.

12 used to predict reversible covalent binding selectivity.

13 (specifically monoenes) with high yield and selectivity.

14 inity nitrate transport activity and nitrate selectivity.

15 50s in the low nanomolar range and excellent selectivity.

16 fine-grain pattern of object, body, and face selectivity.

17 ostatic interactions as the common driver of selectivity.

18 t are important for ligand functionality and selectivity.

19 re correlated with the thermodynamic binding selectivity.

20 KD of 120nM and also retains excellent state selectivity.

21 changing its preferred direction or level of selectivity.

22 en the two eye inputs required for disparity selectivity.

23 utput may be one means to achieve phenotypic selectivity.

24 accurate substrate recognition and catalytic selectivity.

25 llent yield and good to excellent equatorial selectivity.

26 hases by increasing rates, stability, and/or selectivity.

27 mapped molecular determinants governing this selectivity.

28 tematic variation of the catalyst to enhance selectivity.

29 o reflects fine-grained patterns of neuronal selectivity.

30 ls but cannot account for its unique subtype selectivity.

31 enges in terms of chemo-, regio- and enantio-selectivity.

32 between NIMS surface morphology and analyte selectivity.

33 eters such as excitation threshold and fiber selectivity.

34 synergistic effects while still maintaining selectivity.

35 tion capacities and different CO2 versus CH4 selectivities.

36 tituted beta-lactams in excellent yields and selectivities.

37 nors, which thereby affect the fragmentation selectivities.

38 d by a cycloaddition reaction displayed high selectivity (223- to 467-fold) toward MC4R over MC3R and

39 te to high yields (67-79 %) with excellent Z-selectivity (95-99 %).

40 grees C and 0.15 bar), extraordinary CO2 /N2 selectivities (98-205 at 25 degrees C), and excellent ac

41 In order to achieve high selectivity, a combination of Pt/Al2O3 and ZnO have been

42 anomolar affinity and excellent KOP receptor selectivity acting as full or partial agonists, and one

43 the structural dynamics underlying substrate selectivity among eukaryotic kinases.

44 The unique features of CNNB in terms of NA-selectivity among multi-competitive components, long-ter

45 characteristic hallmarks such as high Ca(2+) selectivity, an increase in current density when switchi

46 that form stronger Lewis acids give greater selectivities and rates for the desired epoxidation path

47 tance, there is a lack of knowledge on their selectivity and activity mechanisms.

48 imerization of ethylene has a combination of selectivity and activity that surpasses that of commerci

49 TT1 tumor-penetrating peptide improves tumor selectivity and antitumor efficacy of IP pro-apoptotic N

50 , the receptors feature high sensitivity and selectivity and are water-soluble, and their (19)F-NMR a

51 The principles, sensitivity, selectivity and challenges of electrochemical biosensors

52 Owing to the high selectivity and cost-effective binding capacity of affin

53 ts GTP binding ability with a high degree of selectivity and efficiency (kinact/KI > 10(5) M(-1) min(

54 The technique provides high spatial selectivity and enables room-temperature lasing in prote

55 ought to develop a predictive model for site selectivity and extend this aryl functionalization chemi

56 This efficient reaction features high selectivity and good functional-group tolerance.

57 First, we find a high degree of mixed selectivity and heterogeneity in superficial entorhinal

58 and properties such as low detection limit, selectivity and miniaturized size enables potential appl

59 1-AR affinity >500-fold beta1-AR vs beta2-AR selectivity and no agonism.

60 s study thus offers predictions on how mixed selectivity and other properties evolve with training.

61 tion, which play a key role in defining both selectivity and permeation.

62 tions led to inhibitors with increased PACE4 selectivity and potent antiproliferative effects.

63 nables ligand evolution to address issues of selectivity and reactivity.

64 We aimed to improve human nNOS potency and selectivity and reduce off-target binding by (a) truncat

65 Likewise, this probe evidenced high selectivity and sensitivity and fast recognition for CN(

66 been shown to be a promising agent with high selectivity and sensitivity in imaging bacterial infecti

67 be performed in a short time, achieving high selectivity and sensitivity levels.

68 The sensor showed high selectivity and sensitivity towards NSE, produced a line

69 non-activated clones, so to characterize the selectivity and specificity of the system.

70 The method presented very high selectivity and specificity, excellent linearity (R(2)>0

71 llenge due to the low activity, poor product selectivity and stability of electrocatalysts.

72 cal areas where neurons are heterogeneous in selectivity and temporal responses, and are not function

73 ies is a powerful tool to leverage diffusion selectivities, and has opened the door to many challengi

74 end the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRI

75 ation (IMS) improved the molecular coverage, selectivity, and identification of the detected biomolec

76 f metal and oxide at the interface in tuning selectivity, and identify the key descriptors to control

77 ptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the cluster of di

78 trast sensitivity (C-50 values), directional selectivity, and optimal stimulus velocity.

79 lar mechanisms underpinning histone binding, selectivity, and regulation of these highly dynamic prot

80 irect inhibitors that offer better efficacy, selectivity, and safety could be discovered by exploitin

81 ity (the detection limit was 1.2ng/ml), good selectivity, and wide linear range of 5-200ng/ml.

82 est that the tuning parameters for direction selectivity are specified independently of an animal's s

83 pes are not directionally selective and that selectivity arises in the T4 dendrites.

84 ion mechanism including kinetics and product selectivity as a function of pH and applied potential fo

85 Here, we found that the selectivity at each membrane face is pH-dependent and th

86 mpounds shed light on the role of functional selectivity at the 5-HT2C receptor with respect to antip

87 Functional selectivity at the micro opioid receptor (microR), a pro

88 the new catalyst is capable of precise site-selectivity at the most accessible tertiary C-H bonds.

89 O1 --> O2 transition and how ChR2 modulates selectivity between states is currently unresolved.

90 Experimental realization of peak selectivity between targets under the selected optimal w

91 erlie the differences in function and ligand selectivity between these receptors, here we report crys

92 unzipping, allowing determination of ligand selectivity both for small drugs and large proteins with

93 fic stimulus features, and they derive their selectivity both from excitatory and inhibitory synaptic

94 We impose spin-selectivity by coating the anode with chiral organic sem

95 tative screen to assess peptide activity and selectivity by precisely controlling exposure to vesicle

96 eering to achieve more control over the mode selectivity by suppressing the mode that has the highest

97 ul changes in dynamically controlled product selectivity can be achieved with few weak noncovalent in

98 ts may also be present such that appreciable selectivity can be achieved, providing an uncommon level

99 ith complementary substrate scope as well as selectivity can be identified.

100 states, for instance, heightened attentional selectivity, can become directly associated with, and su

101 The notion that neurons with higher selectivity carry more information about external sensor

102 lized ligand as responsible for the dramatic selectivity changes.

103 ds (with Cu(II) as the limiting reagent) and selectivity combined with turnover numbers >800.

104 to this conformation can explain the strong selectivity compared to homologous aminopeptidases ERAP1

105 The increase in SKA-121's KCa3.1 selectivity compared with its parent, SKA-31, seems to b

106 In this implementation, the slice selectivity depends on the conductivity of the material,

107 Ps@MOF composites not only exhibit effective selectivity derived from MOF cavities, but also enhanced

108 gies with the experiments to give reactivity-selectivity descriptors.

109 eads to azetidine products in good yield and selectivity (ee >96 %).

110 euromagnetic recordings to examine how color selectivity emerges in the human brain.

111 experience determines when broad orientation selectivity emerges in visual cortical PV interneurons.

112 Rate data attribute the high selectivity exclusively to monosolvated-dimer-based tran

113 inetic properties (slow development of KOP-r selectivity, extremely long duration of action) that lim

114 a kinetic resolution with an extremely high selectivity factor (E > 500), showing that the classical

115 extended linear range, high sensitivity and selectivity, fast response time and low oxygen-, tempera

116 n and mutual inhibition, which have distinct selectivity (feature vs. eye of origin) and dynamics (re

117 that directly or indirectly gate the channel selectivity filter (SF).

118 the potassium affinity at the extracellular selectivity filter by more than three orders of magnitud

119 st RNA targets, and that disruptions of this selectivity filter give rise to autoimmune diseases.

120 n nonconductive and conductive states of the selectivity filter in which to test competitive binding

121 tetrameric K(+) channels and lacks the TVGYG selectivity filter motif found in these channels.

122 in barttin-binding sites, dimer interface or selectivity filter often have severe functional conseque

123 rplay between the intracellular gate and the selectivity filter underlies the structural basis for ga

124 pling resulted in consistently high anomeric selectivities for both anomers with mono- and oligosacch

125 New materials with high selectivities for CO2 adsorption, large CO2 removal capa

126 reocenter can be isolated in high yields and selectivities for further derivatization.

127 The aryl/methyl fragmentation selectivities for phenyltrimethylstannane and (4-methylp

128 The cholinergic anthelmintics had different selectivities for these receptors.

129 basic scaffold could enhance the potency and selectivity for ALDH1A1 or ALDH2 and generate chemical p

130 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis.

131 utcomes, collagen has limited conformational selectivity for binding A1.

132 antially increased current density, improved selectivity for carbon monoxide, and enhanced durability

133 (ionophore I) were found to exhibit the best selectivity for chloride over major lipophilic anions su

134 opment of new fluorescence sensors with high selectivity for chloride.

135 iconductor surface is key in controlling the selectivity for CO2 reduction over H2 evolution in aqueo

136 Recently, D4 ligands with improved selectivity for D4 against not only D1-3,5 but also othe

137 e rate of mitophagy as well as decreases the selectivity for DeltaOTC during mitophagy.

138 s proven challenging to achieve high binding selectivity for different isoforms of this protein famil

139 n residue side chains vs backbone as well as selectivity for different residue types to map integrati

140 e roundworm, Ascaris suum, that demonstrates selectivity for forming products with an alpha-methyl br

141 30.4% of the transcriptome but showed little selectivity for gene upregulation or silenced genes.

142 The proposed ECL aptasensor showed high selectivity for Hg(2+) determination compared to other e

143 atin by its potency, cellular mechanism, and selectivity for MMR-deficient cells.

144 ERG affinity led to greater than a 3000-fold selectivity for PDE1B over hERG.

145 phopeptide enrichment provided more than 90% selectivity for phosphopeptides.

146 T2 inhibitor with good potency and excellent selectivity for SIRT2.

147 -Lys-Thr-Cys]-d-Tyr-NH2), an antagonist with selectivity for sstr subtype 2, showed the best overall

148 The sensor also exhibited excellent selectivity for SY over its structural analogs, good sta

149 cy to the phenoxy analogues and demonstrated selectivity for the liver enzyme hCE1.

150 s a high-affinity interaction with exquisite selectivity for this sequence.

151 lability, stability in a broad pH range, and selectivity for toxic metals.

152 te proof-reading by eliminating or enhancing selectivity for viral RNA, with major implications for a

153 that the ketoreductase is the key driver for selectivity, forming predominantly alpha-branched produc

154 amorphosis of FPPase to CPPase, with product selectivity gradually switching from FPP to GPP, until r

155 Disparity selectivity has already reached a matured level before t

156 Cp(X)) ligand structure on reaction rate and selectivity has been viewed as a black box, and a truly

157 ts mechanism of action and the basis for its selectivity have so far been unknown.

158 n for its high catalytic activity and target selectivity; however, the biggest barrier for its introd

159 ), as well as high levels of sensitivity and selectivity (i.e., resisting interference from external

160 Preparatively useful and complementary site selectivities in the addition of secondary and tertiary

161 nd branched isomers to be prepared with high selectivity in an efficient manner.

162 s at the single-molecule level with enhanced selectivity in biological fluids has been in part a driv

163 and torsional effects as tools to implement selectivity in C-H oxidation reactions are briefly discu

164 e response to pH and salt concentration, and selectivity in cargo transport can be simultaneously ach

165 ntify residues that contribute to gating and selectivity in discrete open states.

166 the complex sheds light on the mechanism of selectivity in extracellular recognition of GPCRs by mon

167 n and disruption of granules, as well as RNA selectivity in granule composition are regulated by dist

168 The selectivity in its peripheral inhibitory action may part

169 nt elucidates the structural basis for Na(+) selectivity in mammalian TPCs.

170 and successful strategies for enhancing the selectivity in photocatalysis are abridged to reinvigora

171 te the proper mature expression of direction selectivity in primary visual cortex.

172 ibutes to the emergence of broad orientation selectivity in PV interneurons.

173 wo FMOs to chlorination versus hydroxylation selectivity in SyrB2 is related to a reaction mechanism

174 Interpreting the size-selectivity in terms of smooth cylindrical pores using t

175 mug mL(-1); T, C = 1.0 mug mL(-1)), and high selectivity in the presence of common interfering factor

176 DOT-PdBPI-co-HKCN)/GOx electrode showed good selectivity in the presence of ethanol and phenol.

177 simple acoustical cues as a basis for voice selectivity in the TVAs.

178 chitectures of glycans can influence binding selectivity in unanticipated manners.

179 p450 enzymes exhibit C-H oxidation site-selectivity, in which the enzyme scaffold causes a speci

180 Examples demonstrating such selectivity include reactions with: phenolics, through d

181 reat opportunities to control reactivity and selectivity (including enantioselectivity) in Pd-catalyz

182 elopment based on activity (EC50 = 0.21 muM, selectivity index (SI) 40) and scaffold.

183 The capability to increase sorption selectivities is a powerful tool to leverage diffusion s

184 Computationally, the prediction of binding selectivity is a challenge, and generally applicable met

185 Binding selectivity is a requirement for the development of a sa

186 ictated by their metabolic demands; cellular selectivity is based on demand.

187 Complete branched selectivity is even achieved for ethyl methacrylate, whi

188 , the interplay of factors regulating target selectivity is not well understood and often overlooked

189 This selectivity is primarily mediated by the interaction bet

190 The neural circuit mechanism underlying this selectivity is still unclear, but some studies have prop

191 cate that the key determining factor for the selectivity is the presence or absence of a cation-n int

192 of RB function; however, the basis for this selectivity is unknown.

193 mic-scale descriptions of the SrtC substrate selectivity mechanisms and extend the emerging model of

194 eloped and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokineti

195 High-selectivity neurons respond to a narrow range of sensory

196 The selectivities of high-resolution MS (HRMS) alone or in c

197 signing catalysts that achieve the rates and selectivities of natural enzymes is a long-standing goal

198 (-1) between D2 and H2 results in D2-over-H2 selectivity of 11 at 100 K, to the best of our knowledge

199 We investigated the reactivity and selectivity of 2-azidofucosyl (FucN3) donors, valuable s

200 ntified governing mechanism of the substrate selectivity of a particular phosphatase was previously u

201 l to predict improved efficiency and product selectivity of any molecular PCET catalyst, based on its

202 biquitin signals in control of amplitude and selectivity of autophagy pathways as well as their impac

203 nge from 1pg/ml to 10ng/ml; in addition, the selectivity of biosensor was evaluated.

204 control the activity and, in particular, the selectivity of catalysts.

205 The surface selectivity of CFH, a soluble protein containing 20 comp

206 The high selectivity of Cl(-) anions can be attributed to the hig

207 The unique high selectivity of copper in the electrochemical reduction o

208 Cross reactivity analysis showed the selectivity of detecting cTnT and cTnI in human serum wi

209 The selectivity of each separation was quantified by calcula

210 unding FG sequences impact the structure and selectivity of FG-based gels.

211 volved in it are of minor consequence to the selectivity of forward over backward steps and instead s

212 ibition, providing an opportunity to improve selectivity of future clinical drug candidates.

213 his structural insight suggests that subunit selectivity of glutamate-site antagonists can be mediate

214 have been used extensively to understand the selectivity of GPCR signaling pathways.

215 a critical role in determining the frequency selectivity of hearing.

216 tTPC1) and compared its selectivity with the selectivity of human TPC2 (HsTPC2).

217 a global level, we found that the frequency selectivity of individual thalamocortical axons is surpr

218 The exquisite isoform selectivity of lynx1 interactions provides new insights

219 proach to tune electrocatalytic activity and selectivity of metal catalysts for CO2RR by creating opt

220 perform quantitative assessment of the tumor selectivity of nanomedicine-based systems.

221 smitters like acetylcholine demonstrated the selectivity of our detection method for transmitters wit

222 the overall strategies which can improve the selectivity of photocatalysis encompassing a wide variet

223 re, the authors exploit the element and site selectivity of soft X-ray absorption to sensitively foll

224 Selectivity of the (bio)sensors in power generation mode

225 nt gases reveals the highest sensitivity and selectivity of the array AgNRs toward H2S.

226 The simplicity and exquisite site-selectivity of the aza-Michael ligation described herein

227 The selectivity of the biosensor was tested by using normal

228 for understanding the factors governing the selectivity of the cooperatively catalyzed reactions.

229 The selectivity of the cyclization of (omega-haloalkyl)alkyl

230 identified as responsible for the change in selectivity of the heterogenized Mn catalyst.

231 de a structural basis for the conformational selectivity of the interaction.

232 The extraordinary selectivity of the MSL complex for the X chromosome has

233 More rigid piperidines provided the highest selectivity of the reaction.

234 nistic experiments suggest that the rate and selectivity of the reduction is closely dependent on the

235 disarming groups further decreased the alpha-selectivity of the studied donors, whereas substitution

236 We thus show that the cation selectivity of the Tim23 channel is a key feature for su

237 by a lack of knowledge on the reactivity and selectivity of their constituent building blocks.

238 Factors affecting the sensitivity and selectivity of this assay were investigated, including i

239 ormed systematic characterization of the ion selectivity of TPC1 from Arabidopsis thaliana (AtTPC1) a

240 The distinctive selectivity offered by these gold clusters originates fr

241 We elucidate the complex dependence of selectivity on a framework's intrinsic flexibility where

242 IC-functionalized sensing have focused on IC selectivity or sensitivity or development of suitable me

243 1 had no effect on Kv1.1 (KCNA1) gating, ion selectivity, or pharmacology.

244 ng compound, trans-(+)-1d, showed remarkable selectivity over a panel of more than 15 receptors as we

245 tor antagonist 7 indicates high affinity and selectivity over a panel of receptors including 5-HT2B s

246 ibitors of CDPK1 with the goal of increasing selectivity over host enzymes, improving antiparasite po

247 -HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11beta-hydroxysteroid dehydrogena

248 ibition of NaV1.7 and exhibit high levels of selectivity over other sodium channel isoforms.

249 s and this approach allows for unprecedented selectivity over the metal and chalcogen ions present wi

250 The mode of interaction can allow TrkA selectivity over TrkB and TrkC or promiscuous, pan-Trk i

251 hthalimides with CumO(*), the reactivity and selectivity patterns parallel those observed in the oxid

252 degrader, BETd-246, which exhibits superior selectivity, potency, and antitumor activity.

253 tudy uncovered differences in the fatty acid selectivity profiles of cellular zDHHC enzymes and mappe

254 of tyrosine kinase inhibitors with different selectivity profiles.

255 oncerted action of DNA polymerase nucleotide selectivity, proofreading activity, and DNA mismatch rep

256 nt pairing is critical for optimal yield and selectivity; proper choice of nonpolar solvent provided

257 This highly unusual selectivity relies on a phospholane-phosphite ligand pro

258 This spatial pattern selectivity requires touch-dependent dopamine signaling,

259 nd cheaper biodevices, while improving their selectivity, sensitivity and stability.

260 Without exception, SMIT1 altered KCNQ ion selectivity, sensitivity to extracellular K(+), and phar

261 The assay was validated in terms of selectivity, sensitivity, accuracy/precision, carry-over

262 talyst immobilization efficiency and product selectivity shows that anchoring the molecular catalyst

263 r experience in the development of direction selectivity.SIGNIFICANCE STATEMENT The proper developmen

264 A selectivity study also showed that the CIP could discrim

265 n plasma (Ki = 1.63 +/- 0.18 nM, >27000-fold selectivity, t1/2(plasma) =16 +/- 4 h).

266 Selectivity test demonstrates that the nanobiosensor cou

267 wing to the proximity-induced reactivity and selectivity that is enabled by coordinating functional g

268 The Rh catalysis provides ortho:meta:para selectivity that is opposite to traditional acid-based c

269 These mutations alter channel selectivity to allow abnormal Na+ conductance, resulting

270 Selected polyphenols exhibited binding selectivity to different cellulose-based composites and

271 ds to minutes), specificity to a target, and selectivity to function in complex media.

272 The probe shows high selectivity to HNO over other reactive oxygen/nitrogen a

273 These findings demonstrate the emergence of selectivity to natural images in V3.

274 tion (LOQ) of 2.03x10(-13)M is deduced, with selectivity to single-RNA-base mismatched sequences.

275 Both fast uptake kinetics and great sorption selectivity toward PFOS are observed.

276 ed to design polymer electrodes with kinetic selectivity toward redox active species and help guide s

277 The nanoparticle ensemble exhibited selectivity towards Arg by showing distinguishable colou

278 ment of a small molecule with around 75-fold selectivity towards KDM2A/7A versus other KDMs, as well

279 uptake carrier exhibits a very high level of selectivity towards small substrates including the natur

280 a change in cortical state that leaves their selectivity unchanged but strengthens their responses.

281 which undergo [2,3]-rearrangements with high selectivities (up to >95:5 r.r., up to >95:5 d.r., and u

282 clic carbene (NHC) precursors with excellent selectivity (up to 95%) and good yields.

283 rectly predict the direction of the trend in selectivity versus alkene size but overpredict its magni

284 6133, 61) exhibited an IC50 value of 233 nM, selectivity versus other P2Y receptor subtypes, and is t

285 nhanced signal-to-noise, and even heightened selectivity via functionalization with an embedded recep

286 The exceptional size-selectivity was also evident through contrast studies.

287 ithin this temperature range, the separation selectivity was carbohydrate structure dependent.

288 le of detecting HA with high sensitivity and selectivity was developed.

289 that explain the high levels of potency and selectivity we have measured.

290 Sensitivity and selectivity were determined for each of the developed as

291 gen and carbon monoxide partial pressures on selectivity were measured.

292 use of photoredox catalysis as a platform to selectivity wherein the discrepancy in oxidation potenti

293 ages based on these complex forms of feature selectivity while allowing for multiple scales of positi

294 f this morphological variability on MF input selectivity will be attenuated by high levels of CGC inh

295 ibitor combines high inhibitory affinity and selectivity with a good stability in plasma (Ki = 1.63 +

296 Assessment of method selectivity with a suite of model compounds has shown th

297 hnique could also be used to provide spatial selectivity with arbitrary B 1 field distributions in no

298 size but overpredict its magnitude, and the selectivity with large alkenes remains unpredictable wit

299 abidopsis thaliana (AtTPC1) and compared its selectivity with the selectivity of human TPC2 (HsTPC2).

300 promise for improving catalyst activity and selectivity, yet little is known about the dynamic compo