ライフサイエンスコーパス: selectivity filter

1 ces pharmacophore-like features that act as "selectivity filters".

2 cal marker of conformational dynamics at the selectivity filter.

3 the channel structure and its bearing on the selectivity filter.

4 ideas about the location and function of the selectivity filter.

5 NaK2K outside the immediate vicinity of the selectivity filter.

6 llular entryway, the gate must be within the selectivity filter.

7 sequences unrelated to any other known ionic selectivity filter.

8 y encoded at Y671, a residue proximal to the selectivity filter.

9 including the conducting conformation of the selectivity filter.

10 rus is a proton channel that uses His37 as a selectivity filter.

11 water in the central cavity adjacent to the selectivity filter.

12 lity of Ca(2+) to a site at the entry to the selectivity filter.

13 m a conformational change near the channel's selectivity filter.

14 presence of four glutamate residues in their selectivity filter.

15 llowed by ion expulsion at the extracellular selectivity filter.

16 mity to Lys-1237 of the domain III pore-loop selectivity filter.

17 R has four aspartate residues in its GGGIGDE selectivity filter.

18 x transmembrane helices, a pore helix, and a selectivity filter.

19 n previously to increase the diameter of the selectivity filter.

20 of the pore and an inactivation gate at the selectivity filter.

21 n by buried water molecules bound behind the selectivity filter.

22 the fact that both ions can bind within the selectivity filter.

23 e chains lining the extracellular end of the selectivity filter.

24 as a wide extracellular 'mouth' with a short selectivity filter.

25 cts directly with conducting ions inside the selectivity filter.

26 s define an extracellular ion pathway to the selectivity filter.

27 site thus serve as characteristic substrate selectivity filter.

28 composition and solvent accessibility of the selectivity filter.

29 ontains a urea conduction pore with a narrow selectivity filter.

30 tivity through conformational changes at the selectivity filter.

31 residues on its extracellular side forms the selectivity filter.

32 er of anionic and cationic groups within the selectivity filter.

33 We also show that E71A has a disordered selectivity filter.

34 prevented by mutations in the extracellular selectivity filter.

35 ity of H(V)1 requires an acidic group at the selectivity filter.

36 feature of these channels' versatile charge-selectivity filter.

37 coupling between the activation gate and the selectivity filter.

38 annel and may represent a weak intracellular selectivity filter.

39 ing midway, the length of TM2 that serves as selectivity filter.

40 te is followed by C-type inactivation at the selectivity filter.

41 s the level of inactivation occurring at the selectivity filter.

42 ions central to stabilizing the K(+) channel selectivity filter.

43 significantly reduced throughout the entire selectivity filter.

44 helix S6 at an alanine hinge just below the selectivity filter.

45 inner pore region nearest the bottom of the selectivity filter.

46 lly be occupied by K(+) before it enters the selectivity filter.

47 t barttin binding sites, dimer interface and selectivity filter.

48 ct interdomain interface movement behind the selectivity filter.

49 the C-type inactivation gate at or near the selectivity filter.

50 into the high electric field of an inactive selectivity filter.

51 ponds to a "constricted" conformation of the selectivity filter.

52 dynamics of the alpha-helical region of the selectivity filter.

53 +) by a ring of aspartate side chains in the selectivity filter.

54 of the channel act as a pH sensor and proton selectivity filter.

55 ar entrance and a second constriction at the selectivity filter.

56 fic heavy ((13)C(18)O) isotope labels in the selectivity filter.

57 mutagenesis, these rings appear to form the selectivity filter.

58 diameter of 1.8 nm and located the channel's selectivity filter.

59 ibutable to simply a modification of the CCR selectivity filter.

60 racellular and intracellular entrance of the selectivity filter.

61 ular side of the membrane and another in the selectivity filter.

62 s) showed radical differences in their anion selectivity filters.

63 onovalent Na(+) with H3O(+) in various model selectivity filters.

64 delineating an ion-occupied ready to conduct selectivity filter, a confined aqueous cavity, and a clo

65 (+) ions permeate in single file through the selectivity filter, a narrow pore lined by backbone carb

66 they may be activated by a change within the selectivity filter, a narrow region at the extracellular

67 ion I4897T results in destabilization of the selectivity filter, a possible cause of the CCD-specific

68 ed hypothesis that multiple K(+) ions in the selectivity filter act to mutually destabilize binding.

69 In the crystal structure, the selectivity filter adopts a novel conformation with Ca(2

70 tinuous alpha helix in which the Gly-Ala-Ser selectivity filter adopts an extended, belt-like conform

71 The channel selectivity filter adopts similar conformations in both

72 ner transmembrane helix (98-103), and in the selectivity filter, all of which resemble changes seen u

73 location of Ser507 in the pore-loop near the selectivity filter and Ala532 in an adjacent position in

74 0.2 mus, with multiple cations occupying the selectivity filter and cytosolic vestibule, but not the

75 ore, optimizing K(+) ion coordination in the selectivity filter and increasing current amplitudes.

76 structural and dynamic coupling between the selectivity filter and intracellular constriction point

77 ve focused on ion occupancy of the channel's selectivity filter and its ability to alter gating, with

78 was enough to modify the conformation of the selectivity filter and its conduction properties.

79 conformational landscape of the K(+) channel selectivity filter and its dependence on the state of th

80 dynamics and conformational stability of the selectivity filter and might serve as a general modulato

81 ion permeation pathway is constricted at the selectivity filter and near the cytoplasmic end of S6, s

82 ylogeny we infer ancestral states of the ion selectivity filter and show that this state has been ret

83 h the innermost acidic residue (D523) of the selectivity filter and subsequent long-term channel inac

84 one or two hydrated Ca(2+) ions bound in the selectivity filter and supports a 'knock-off' mechanism

85 structural and dynamic coupling between the selectivity filter and the channel scaffold, which has s

86 This region likely contains the H(+) selectivity filter and the conduction pore.

87 eletions in an ancestral channel between the selectivity filter and the outer carboxylates allowed bu

88 us crystallographic views, we found that the selectivity filter and turret region, coupled to the sur

89 (i) as a channel blocker at the base of the selectivity filter, and (ii) as a modulator to restrict

90 t the extracellular surface, T189 in the ion selectivity filter, and all phenylalanine residues.

91 n gate to "remember" the conformation of the selectivity filter, and hence KcsA requires a different

92 he detailed architecture of the K(+) channel selectivity filter, and not only its equilibrium ion pre

93 t with directly neighboring K(+) ions in the selectivity filter, and our model offers an intuitive ex

94 In this study, how the structure of the selectivity filter, and the free-energy profile of perme

95 s S5 and S6, the turret, the pore helix, the selectivity filter, and the loop preceding S6, with a te

96 re, we show that AQP2 has an unconventional "selectivity filter." AQP2-specific gene knockout generat

97 Immediately intracellular to the selectivity filter are an intramembrane loop and an argi

98 that buried water molecules bound behind the selectivity filter are at the origin of the slowness of

99 Thus, aromatic residues in the OSM-9 selectivity filter are critical for pain behaviour and i

100 ng the presence of a cysteine residue in the selectivity filter as predicted by our structure model.

101 the outer pore, including the pore helix and selectivity filter, as well as pronounced dilation of a

102 wild-type Na(V)Ab models, reshaping the ion selectivity filter at the extracellular end of the pore,

103 membrane loop is found immediately after the selectivity filter at the intracellular side of the prot

104 t the nonmetal-ligating Lys in the DKEA/DEKA selectivity filter attenuates metal-protein interactions

105 uctures provide an unprecedented view of the selectivity filter backbone in its collapsed deep C-type

106 rbon nanotubes have been designed to include selectivity filters based on combinations of anionic and

107 the potassium affinity at the extracellular selectivity filter by more than three orders of magnitud

108 other potassium channels, K2P channels use a selectivity filter 'C-type' gate as the principal gating

109 (+) channel, KcsA, highlight the role of the selectivity filter carbonyls from the GYG signature sequ

110 Unlike C-type inactivation, a consequence of selectivity filter closure, in many K(+) channels, the r

111 ough the pore is restricted by a hydrophobic selectivity filter comprising disordered phenylalanine-g

112 ransition from the inactivated nonconductive selectivity filter conformation toward the conductive co

113 l and crystallographic analyses of a calcium selectivity filter constructed in the homotetrameric bac

114 The tightly packed selectivity filter contains multiple ion-binding sites,

115 brane helix 1) and the pore helix behind the selectivity filter contributes to K(+) channel inactivat

116 nd strong evidence that the channel's proton selectivity filter controls blocker binding cooperativit

117 The binding of Ca(2+) ion in the selectivity filter controls the widening of the pore as

118 ion that the constricted conformation of the selectivity filter corresponds to the functional C-type

119 We further suggest that stability of the selectivity filter critically depends on the interaction

120 mpetition between Mg(2+) and Ca(2+) in model selectivity filters depends on the degree of metal hydra

121 cturally different from KcsA because the NaK selectivity filter does not collapse under low-cation co

122 blocking the constricted conformation of the selectivity filter does not prevent inactivation, which

123 At the selectivity filter entry, Site 1 is formed by four carbo

124 This channel's selectivity filter exhibits an EEEE ring sequence, chara

125 Their selectivity filter exhibits four binding sites with appr

126 of alternating sites within the KcsA channel selectivity filter exists, which are thermodynamically s

127 at the site interacts with K(+) ions in the selectivity filter, facilitating a conformational change

128 lso demonstrate that the Arg-147 is a strong selectivity filter for carboxylate-containing substrates

129 the very segment that may also serve as the selectivity filter for CFTR.

130 activation/deactivation and the other at the selectivity filter for slow C-type inactivation/recovery

131 f the NPC may explain how NPC functions as a selectivity filter for transport of large molecules and

132 bacterium Tsukamurella paurometabola with a selectivity filter formed by an uncommon proline-rich se

133 HCN channels contain a K(+) channel selectivity filter-forming sequence from which the amino

134 n extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) io

135 with the 'TXVGYG' signature sequence of the selectivity filter found in K(+) channels.

136 odifications are not believed to prevent the selectivity filter from adopting the constricted conform

137 Mutation of the Na(V)Sp1p selectivity filter from LESWSM to LDDWSD, a change simil

138 endence of pH gating, thereby uncoupling the selectivity filter gate from the cytoplasmic-side bundle

139 y E132, R128, and F127 stabilize the Kir1.1b selectivity filter gate in an open conformation, allowin

140 obe the structural changes that occur during selectivity filter gating in Kv11.1 channels, at near at

141 er and might serve as a general modulator of selectivity filter gating in other members of the K(+) c

142 ak mode' and provide direct evidence for K2P selectivity filter gating.

143 mic role as a bidirectional interface during selectivity filter gating.

144 tead they play a crucial dynamic role during selectivity filter gating.

145 st RNA targets, and that disruptions of this selectivity filter give rise to autoimmune diseases.

146 ction-catalyzing conformations of the AChR's selectivity-filter glutamates.

147 lecular dynamics simulations showed that the selectivity filter has two urea binding sites separated

148 ivation is modulated by ion binding near the selectivity filter; however, the molecular forces that i

149 s negatively charged residues at or near the selectivity filter in a conformation that facilitates Ca

150 s with an open intracellular gate revealed a selectivity filter in a constricted conformation similar

151 electivity filter interactions that lock the selectivity filter in a nonconductive conformation.

152 uctures of KcsA's mutants that stabilize the selectivity filter in its conductive (E71A, at 2.25 A) a

153 The selectivity filter in potassium channels, a main compone

154 112 in the transmembrane VSD to form the ion selectivity filter in the channel's open conformation.

155 n nonconductive and conductive states of the selectivity filter in which to test competitive binding

156 experimental data and help to elucidate the selectivity filters in the Mg(2+)-selective TRPM6 and Co

157 ly induces an asymmetric conformation of the selectivity filter, in which partially dehydrated Ca(2+)

158 hus, unlike ion channels that have a single "selectivity filter," in bestrophin, distinct regions of

159 Recent studies suggest that beyond the selectivity filter, inactivation involves widespread rea

160 ral elements supporting the integrity of the selectivity filter; instead they play a crucial dynamic

161 nd I312R KCNQ3 channels is due to pore helix-selectivity filter interactions that lock the selectivit

162 nimal sodium channels and has a putative ion selectivity filter intermediate between calcium and sodi

163 gh this modification is believed to lock the selectivity filter into its conductive conformation, whe

164 The structure also reveals the selectivity filter ion entry site, termed the "outer ion

165 odel in which the loss of K(+) ions from the selectivity filter is a major factor in promoting inacti

166 for Mg(2+) over Ca(2+) in the Mg(2+) channel selectivity filter is a pore that is sufficiently large

167 The selectivity filter is an essential functional element of

168 In potassium channels, the selectivity filter is critical for both endowing an exqu

169 o channels with an inactivated or conductive selectivity filter is different from K(+) ion binding to

170 A mutant in which a hydrogen-bond behind the selectivity filter is disrupted, also displays decreased

171 The ion channel selectivity filter is formed by the extended portions of

172 whether the constricted conformation of the selectivity filter is in fact the C-type inactivated sta

173 he structure appears to be dewetted when the selectivity filter is in the conductive state.

174 We infer that the charge selectivity filter is in the cytoplasmic half of the cha

175 cient for Na(+) selectivity and why the DKEA selectivity filter is less Na(+)-selective than the DEKA

176 The selectivity filter is lined by the carboxylate side chai

177 We report that the human PKD2-L1 selectivity filter is partially selective to calcium ion

178 a voltage stimulus, whereas the gate at the selectivity filter is responsible for C-type inactivatio

179 The NavAb selectivity filter is short, approximately 4.6 A wide, a

180 long molecular dynamics simulations, how the selectivity filter is sterically locked in the inactive

181 onal coupling between the inner gate and the selectivity filter is widespread in ion channels.

182 with the anionic (carboxylate) groups of the selectivity filter lead to (partial) replacement of solv

183 tion of the voltage sensor S4 helix, an open selectivity filter leading to an open activation gate at

184 dified semisynthetic KcsA channels along the selectivity filter led to the conclusion that the constr

185 Within the selectivity filter, M(601)-F(609), Y604G strongly reduce

186 t (N628P and S629A), pore helix (F638A), and selectivity filter (M644A) domains.

187 ants, located in the pore turret (G618W) and selectivity filter (M644I), resulted in significantly re

188 at this single amino acid replacement in the selectivity filter made DMI1 solo sufficient for symbios

189 Such activation of the selectivity filter may be a universal gating mechanism w

190 A glutamine in the selectivity filter may be an important determinant of mo

191 A subtle structural feature of the hERG selectivity filter might correlate with its fast inactiv

192 tetrameric K(+) channels and lacks the TVGYG selectivity filter motif found in these channels.

193 In an E178D selectivity filter mutant constructed to have altered io

194 tracellular pore constriction and within the selectivity filter near the extracellular side but the s

195 A distinct conformational change in the selectivity filter near the extracellular side has been

196 Crystal structures of E71A reveal that the selectivity filter no longer assumes the "collapsed," pr

197 ficity can be explained by the conserved ion selectivity filter observed in the channel's crystal str

198 sible influx and efflux of Na(+) through the selectivity filter occurred spontaneously during simulat

199 During C-type inactivation, the selectivity filter of a K(+) channel changes conformatio

200 nd temporal distribution of water behind the selectivity filter of a membrane-embedded K(+) channel i

201 the detailed locations of sodium ions in the selectivity filter of a sodium channel.

202 osing and desensitization gate, and that the selectivity filter of ASIC1 is a transient structure tha

203 sis Methods for multiple ions traversing the selectivity filter of bacterial Na(v)Ab channel.

204 hly conserved aromatic residue near the pore selectivity filter of claudins contributes to cation sel

205 aspartate 112 as a crucial component of the selectivity filter of H(V)1.

206 o a Na(+)-selective channel by mimicking the selectivity filter of HsTPC2 and identified key residues

207 The selectivity filter of K(+) channels is conserved through

208 FABC complex with a potassium ion within the selectivity filter of KdpA and a water molecule at a can

209 of the critical serine by an alanine in the selectivity filter of Lj-POLLUX conferred a symbiotic pe

210 llular K+ ions can block the entrance to the selectivity filter of Na(v)Ab in the presence of applied

211 We analyse the putative selectivity filter of OSM-9, a TRPV channel, in osmotic

212 The multi-ion selectivity filter of our CaVAb model establishes a stru

213 barriers preclude Na(+) ions to permeate the selectivity filter of prokaryotic Na(+)-channels when on

214 The selectivity filter of SLAC/SLAH anion channels is determ

215 gests that Cd(2)(+) can permeate through the selectivity filter of the channel into the cytosol.

216 To examine permeation of Na(+) through the selectivity filter of the channel, we performed large-sc

217 rged residues on the vestibular wall and the selectivity filter of the channel.

218 the ion conduction pathway and serve as the selectivity filter of the channel.

219 spects of CRAC channels and suggest that the selectivity filter of the CRAC channel is a dynamic stru

220 lly determined electron density found in the selectivity filter of the crystal structure.

221 binding site in the constricted state of the selectivity filter of the KcsA channel when the intracel

222 4, but also creates a functional link to the selectivity filter of the neighboring subunit.

223 The gate and ion-selectivity filter of the P2X7R could be colocalized at

224 recurrent somatic mutations in and near the selectivity filter of the potassium (K(+)) channel KCNJ5

225 hway for Na(+) ion translocation through the selectivity filter of the recently determined crystal st

226 f MitTx action, defines the structure of the selectivity filter of voltage-independent, sodium-select

227 the Glu from domain II/III in the EEEE/DEEA selectivity filters of Ca(2+)-selective channels to Lys

228 sis was used to introduce d-Alanine into the selectivity filters of the KcsA channel and the voltage-

229 in barttin-binding sites, dimer interface or selectivity filter often have severe functional conseque

230 surface charges stabilize external K in the selectivity filter or at the S(0)-K binding site just ou

231 of the pore on the intracellular side of the selectivity filter, physically blocking the ion-conducti

232 In K(+) channels, the selectivity filter, pore helix, and outer vestibule play

233 mutations identified all altered the channel selectivity filter, producing increased Na(+) conductanc

234 Gly 443 residues of the selectivity filter provide a ring of three carbonyl oxyg

235 ning residues, including those that form the selectivity filter, providing a structural framework for

236 n question whether gating transitions in the selectivity filter region are also actuated by voltage s

237 a sodium channel, gating transitions in the selectivity filter region are also coupled to the moveme

238 sensor is coupled to the conformation of the selectivity filter region of the sodium channel.

239 In addition to ionic discrimination, the selectivity filter regulates the flow of ions across the

240 ons over other cations in the channel's His4 selectivity filter remain elusive.

241 d and are associated with side chains of the selectivity filter residues, rather than polypeptide bac

242 and IV, three positions downstream from the selectivity-filter residues.

243 d rival cations such as Na(+) depends on the selectivity filter's (1) histidine protonation state, (2

244 ammonium at the most cytoplasmic site in the selectivity filter (S4) suggests that such a site, when

245 annels, but instead possess unique pore-loop selectivity filter sequences unrelated to any other know

246 evious studies suggested that the pore helix/selectivity filter serves as the activation gate in Slo2

247 o-Ala (NPA) region and the aromatic/arginine selectivity filter (SF) domain.

248 equires an aspartate near an arginine in the selectivity filter (SF), a narrow region that dictates p

249 athway, three relatively narrow regions (the selectivity filter (SF), the inner helix bundle crossing

250 ode involves a change in conformation at the selectivity filter (SF), which impedes ion flow at this

251 that directly or indirectly gate the channel selectivity filter (SF).

252 ignature motif and the aromatic and arginine selectivity filter (SF).

253 that the number of ion binding sites in the selectivity filter shifts the equilibrium distribution o

254 ium (DMA(+)), the side chain of Glu66 in the selectivity filter shows multiple conformations and the

255 e role of a hydrogen bond network behind the selectivity filter, side-chain conformational dynamics,

256 A selectivity filter, similar in architecture to those of

257 transient period of ion conduction until the selectivity filter spontaneously undergoes a conformatio

258 hout producing discernable alteration of the selectivity filter structure and is oriented to project

259 ues in both pore domains contributing to the selectivity filter (T118 and L228).

260 from a ring of aspartate side chains in the selectivity filter that binds Ca(2+) tightly.

261 he invariant ring of charged residues in the selectivity filter that governs calcium selectivity in c

262 and involves a conformational change in the selectivity filter that is mediated by cooperative subun

263 ated with structural changes around the K(+)-selectivity filter that may have implications for mechan

264 Overall, the data point to a dynamic selectivity filter that may serve as a gate for permeati

265 d Na(+) channels, which is controlled by the selectivity filter (the narrowest region of an open pore

266 Their selectivity filters (the narrowest part of the open pore

267 while helping Na(+) ions diffuse within the selectivity filter, the conformational flexibility of E1

268 nic nonannular lipids close to the channel's selectivity filter, the influence of nonannular lipid bi

269 e of the K(+) binding sites in the channel's selectivity filter, the S4 site, also binds Ba(2+) ions,

270 t of the high structural conservation of the selectivity filter, the size and chemical environment di

271 csA channel removes steric restraints at the selectivity filter, thus resulting in structural fluctua

272 substitutions in the protein backbone of the selectivity filter to alter ion binding at specific site

273 the stimulus closes the gate and allows the selectivity filter to interconvert back to its conductiv

274 cal similarity of the x-ray structure of the selectivity filter to other K(+) channels, the structure

275 e center of the membrane that might act as a selectivity filter to prevent permeation of anions throu

276 This splicing event establishes a selectivity filter to restrict the ligand binding specif

277 complex hydrogen-bond network that link the selectivity filter to the surrounding pore helices diffe

278 +, three Na+ ions move favorably through the selectivity filter together as a unit in a loose "knock-

279 ammalian voltage-gated calcium channel (CaV) selectivity filters, together with functional studies, s

280 are primarily occupied by K(+) ions in their selectivity filters under physiological conditions, demo

281 Thus, upon prolonged stimulation, the TRPM2 selectivity filter undergoes a conformational change rem

282 rplay between the intracellular gate and the selectivity filter underlies the structural basis for ga

283 "Collapse" of the selectivity filter upon K(+) removal did not alter pf an

284 elix is positioned above the entrance to the selectivity-filter vestibule.

285 volve multiple conformational changes at the selectivity filter, we propose that the BK channel's nor

286 n which chemical synthesis is limited to the selectivity filter whereas the rest of the protein is ob

287 w end of the funnel serves as a broad cation selectivity filter, whereas an arginine/lysine ring that

288 inine and lysine residues can wedge into the selectivity filter, whereas the side chains of other bas

289 external or internal pH, and mutation of the selectivity filter (which we identify as Asp(51)) result

290 channels distinguish K(+) from Na(+) in the selectivity filter, which consists of four ion-binding s

291 cific ion-mediated structural changes in the selectivity filter, which influences the permeability pr

292 protein and reveals the organization of the selectivity filter, which is composed of the signature m

293 tricted region of its open pore known as the selectivity filter, which is lined by four absolutely co

294 lular gate causes a structural change in the selectivity filter, which leads to a change in the ion o

295 e revealed a constricted conformation of the selectivity filter, which was proposed to represent the

296 wing water to penetrate the space behind the selectivity filter while simultaneously reducing the loc

297 vation by means of a local disruption in the selectivity filter, while severing the Tyr445-Thr439 H-b

298 olvated monovalent ions permeate through the selectivity filter with comparable energetic barriers vi

299 a(2+)-dependent gating in MthK occurs at the selectivity filter with coupled movement of the intracel

300 stituting the first conserved glycine in the selectivity filter with the unnatural amino acid d-Alani

301 ree energy for replacing Ca(2+) inside model selectivity filters with Na(+), we find that the nonmeta