ライフサイエンスコーパス: selector

1 sarily weaker than strong agonists (negative selectors).

2 ing more strongly associated with the chiral selector.

3 hat is, to use it as both solvent and chiral selector.

4 yte in the gas phase to the dissolved chiral selector.

5 s using only beta-cyclodextrin as the chiral selector.

6 pite the high retentitivity of the quinidine selector.

7 that this component is most likely a chiral selector.

8 tions as a multiplexer with arabinose as the selector.

9 ted with distinct structural features of the selector.

10 alytes with the cationic headgroup of chiral selectors.

11 tures, were investigated as potential chiral selectors.

12 Without a negative selector, 19-fold affinity improvement (clone Q, where Q

13 nable acousto-optical filter as a wavelength selector, a novel approach to a broadband stimulated Ram

14 Transcription factors called terminal selectors activate identity-specific effector genes duri

15 Taken together, terminal selectors activate identity-specific genes and make non-

16 n via protonation and the rest of the chiral selector, affords selector-analyte complexes in the elec

17 We also demonstrate that using a threshold selector algorithm for probability adjustment leads to m

18 ty values that are produced by the threshold selector algorithm impact the protein inference stage pe

19 of a cost matrix and a probability threshold selector algorithm to the learning task further improves

20 h have rather limited capabilities as chiral selectors, aliphatic- and aromatic-functionalized CF6s p

21 and the rest of the chiral selector, affords selector-analyte complexes in the electrospray ionizatio

22 The relationship between the ratio of the selector-analyte complexes in the electrospray ionizatio

23 L-His was used as a chiral ligand-exchange selector and copper (II) as a central ion.

24 in neurons that lack their resident terminal selector and genetic epistasis studies with H3K9 methylt

25 the proper combination of highly cooperative selector and pre-pattern factors present in the cell.

26 The obligate integration of selector and signaling protein inputs on cis-regulatory

27 graphy using beta-cyclodextrin as the chiral selector and sodium taurocholate as the micelle-forming

28 0 built-in algorithms of feature extractors, selectors and classifiers in BIOCAT.

29 study whereby the characterization of chiral selectors and identification of optimal separation condi

30 of serving simultaneously as solvent, chiral selector, and fluorescent reporter in chiral analytical

31 characteristics which are highly suitable to selector application for x-point memory arrays.

32 olipids, suggesting that different molecular selectors are at play in these organisms but serve a com

33 to achieve separation of enantiomers, chiral selectors are designed to display differential affinity

34 enantiomers, thereby eliminating the chiral selector as a source of physical contamination of the en

35 m/z 1991.9 peak was isolated by a timed ion selector as the precursor ion for further MS analysis.

36 mentum separator, rather than a droplet size selector, as it removes droplets having larger sizes or

37 with sulfated beta-CD (S-beta-CD) as chiral selector at low pH and reverse polarity.

38 Attachment of a chiral selector based on L-valine-3,5-dimethylanilide through a

39 isia, mutational analysis was performed with selector-based, high-throughput sequencing.

40 iomers using 15% beta-cyclodextrin, a chiral selector, but not with alpha- or gamma-cyclodextrins.

41 n which a partial resolution with one chiral selector can be brought to baseline with one of the othe

42 ations can be done in two ways: (1) a chiral selector can be dissolved in an achiral ionic liquid, or

43 tion of a novel morphogenetic regulator to a selector cascade causes cellular instability, resulting

44 oviral cDNA expression libraries, transduced selector cells expressing single cDNAs were stimulated w

45 With GM2 as a negative selector, clone Y (where Y is the symbol for tyrosine) w

46 An unusual class of chiral selectors, cyclofructans, is introduced for the first ti

47 Furthermore, efficiency of the negative selector depends on its cross-reactive affinity with the

48 ites of CNTs or graphite with small molecule selectors--designed to interact with specific classes of

49 ificantly increases the efficiency of chiral selector determination by eliminating the need for multi

50 iral phosphorus compound, was achieved using selectors developed from a small peptide library.

51 otential applications as a highly non-linear selector element in emerging nonvolatile memory (NVM) an

52 een these methods were observed at the stage selector element, -50 region, of gamma-globin promoter.

53 e CACCC and TATA elements, but not the stage selector element, inhibit inappropriate embryonic/fetal

54 rol region and of the TATA, CACCC, and stage selector elements of the gamma-globin promoter, in compe

55 fficients (catalyst precursors) as prebiotic selectors emerges.

56 A motorized filter cube selector facilitated imaging every 5 seconds at 1 of 3 d

57 During eye development, the selector factors of the Eyeless/Pax6 or Retinal Determin

58 in AWC(ON), thus acting as a transcriptional selector for a randomly specified neuronal identity.

59 Thus, UNC-3 is a terminal selector for cholinergic motor neuron differentiation wh

60 while the overlapping svb function is a key selector for epidermal structures under the control of w

61 was found to be a broadly applicable chiral selector for micellar electrokinetic chromatography.

62 nteraction set, we find that the best single selector for negative interactions is a lack of co-funct

63 l IL serving both as solvent and as a chiral selector for the determination of enantiomeric purity.

64 contains a PDZ domain and serves as a cargo selector for the retromer complex.

65 loride (DTC), has been evaluated as a chiral selector for the separation of optical isomers of organi

66 re library components for their potential as selectors for chiral chromatography is described.

67 6 L-amino acid anilides, which are potential selectors for chiral HPLC, was synthesized in solution a

68 oyl)leucine were prepared and used as chiral selectors for enantiomer discrimination in single-stage

69 e misfolded proteins via action as substrate selectors for quality control (QC) machines that fold or

70 Selection of chiral selectors for the resolution of racemic N-(1-naphthyl)le

71 eoselective antibodies as tailor-made chiral selectors for the separation of enantiomers in HPLC unde

72 The best selector from the library was identified by a deconvolut

73 ion, six CSPs were prepared using individual selectors from the library, and screening results indica

74 ar dynamics simulations to show that peptide selector function correlates with protein plasticity, an

75 single point mutation, which altered in vivo selector function in a predictable way.

76 Skn-1 proteins, and suggest that the pharynx selector function of CncB is highly conserved on some br

77 llosterically, resulting in enhanced peptide selector function.

78 Using the less efficient negative selector GD3, a clone mixture (Q, V, and Y, where V is t

79 V axis, along with apterous (ap) as a dorsal selector gene [5], mediating cell interactions by regula

80 Here, we report that Fezf2 is a selector gene able to regulate the expression of gene se

81 ntral appendage that forms in the absence of selector gene activity is leglike but consists of only t

82 like appendages could have developed without selector gene activity.

83 The selector gene apterous (ap) is expressed in dorsal cells

84 on, it is clear that key functions of the ap selector gene are mediated by only a small number of dow

85 Expression of the mec-3/unc-86 selector gene complex induces the differentiation of the

86 e cis-regulatory logic on which the terminal selector gene concept is based may contribute to the evo

87 The Drosophila selector gene cut is a hierarchal regulator of external

88 The neural selector gene cut, a homeobox transcription factor, is r

89 sociated with otd repression of the homeotic selector gene Deformed (Dfd).

90 stral regulatory hierarchy in development of selector gene differentiation of serial elements.

91 rmation in the abdomen by repressing the leg selector gene Distalless, whereas Antennapedia (Antp), a

92 ompartment, distinguished by activity of the selector gene engrailed (en) in P but not A compartment

93 Ubx, in combination with the posterior selector gene engrailed (en), represses dally expression

94 men and wing P compartment cells express the selector gene engrailed and secrete Hedgehog protein whi

95 vels of Taranis, expression of the posterior selector gene engrailed is silenced through an autoregul

96 have assumed that the presence or absence of selector gene expression autonomously drives the express

97 process, which requires tight regulation of selector gene expression to specify individual organ typ

98 us far described, we argue that fkh is not a selector gene for salivary gland development and that th

99 Dar1 likely functions as a terminal selector gene for the basic layout of neuron morphology

100 t non-VMH identity, suggesting that Rax is a selector gene for VMH cellular fates.

101 d tubulogenesis in the ASP and that homeotic selector gene function is necessary for the temporal and

102 t of ectopic expression of HoxB4, a homeotic selector gene implicated in self-renewal of definitive H

103 subtype-specific genes identifies Tlx3 as a selector gene in ES cells undergoing neural differentiat

104 that the activity of a neuron type-specific selector gene is modulated by a variety of distinct mean

105 Polycomb group gene depends on the homeotic selector gene locus as well as on spatial and temporal c

106 The context-dependent function of Tlx3 as a selector gene may be used to establish a novel strategy

107 nhanced variability in the expression of the selector gene mec-3, which is needed, together with unc-

108 show that ray identities are patterned by a selector gene mechanism in a manner similar to other ser

109 lished later by the expression of the dorsal selector gene pannier (pnr).

110 o foregut (pharynx) cells in response to the selector gene PHA-4/FoxA.

111 the T-box gene TBX-38 and express the organ selector gene PHA-4/FoxA.

112 t known for its fundamental role as a dorsal selector gene required for patterning and growth of the

113 This confirms the role of Hoxa2 as a selector gene specifying second arch fate.

114 One selector gene that promotes the identities of a subset o

115 A-interference, a functional analysis of the selector gene tiptop and the Hox gene Antennapedia in On

116 We propose that Tbx1 acts in the manner of a selector gene to control neural and sensory organ fate s

117 Here we show that in Drosophila the Hox selector gene Ultrabithorax (Ubx) modulates morphogen si

118 g primordium is defined by expression of the selector gene vestigial (vg) in a discrete subpopulation

119 g primordium is specified by activity of the selector gene vestigial (vg).

120 Within this outgrowth, the wing selector gene vg is activated in some cells, changing th

121 spatially restricted expression of labial, a selector gene with a role in cell type specification in

122 f cJun that regulates tlx3, a glutamate/GABA selector gene, accounting for calcium-spike BDNF-depende

123 artment by induction of apterous, the dorsal selector gene, and consequently also controls wing devel

124 these data indicate that hth is an antennal selector gene, and that Antp promotes leg development by

125 expression of a sensory neuron-type-specific selector gene, che-1, which encodes a zinc-finger transc

126 Head specification by the head-selector gene, orthodenticle (otx), is highly conserved

127 homothorax, a previously identified antennal selector gene, to induce antennal differentiation.

128 and that there is no master, salivary gland selector gene.

129 otypes are consistent with Lmx1a's role as a selector gene.

130 ar identity through direct repression of Hox selector genes and effector genes.

131 y differences in cell affinity controlled by selector genes and intercellular signals.

132 Members of one subclass, Pax6, function as selector genes and play key roles in the retinal develop

133 nts, we studied the function of the homeotic selector genes APETALA3 (AP3) and PISTILLATA (PI), which

134 In insects, selector genes are thought to modify the development of

135 t sites "terminal selector motifs." Terminal selector genes assign individual neuronal identities by

136 body parts differ in size, the ways in which selector genes create size differences are unknown.

137 epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) a

138 ventral appendages that depend on different selector genes for their unique identities.

139 Selector genes generate these differences by altering th

140 es for Lhx2 that acts as one of the terminal selector genes in controlling principal properties of ne

141 The dispersal of selector genes in the genomes of arthropods in conjuncti

142 tested by examination of the distribution of selector genes in the genomes of arthropods.

143 Selector genes modify developmental pathways to sculpt a

144 vide a potentially general mechanism for how selector genes modify organ sizes.

145 ies that there is a common ground state that selector genes modify to generate these different append

146 s cells with higher levels of Dally and that selector genes modulate organ development by regulating

147 ins and restriction to the dorsal eye by the selector genes of the Iroquois complex (Iro-C).

148 The homeotic selector genes of the red flour beetle, Tribolium castan

149 nvolved in repressing expression of homeotic selector genes outside of their appropriate anterior/pos

150 Here, we demonstrate that homeotic selector genes provide positional information that deter

151 sequenced the region containing the homeotic selector genes required for proper development of the he

152 propriate expression of several head capsule selector genes such as cut, Lim1 and wingless.

153 veloping systems, in some cases by acting as selector genes that define compartment identity.

154 ans and appendages are regulated by specific selector genes that encode transcription factors that re

155 y organogenesis, which requires the input of selector genes that specify the identity of various morp

156 l seeing animals is controlled by a group of selector genes that together forms the retinal determina

157 in maintaining active expression of homeotic selector genes within their appropriate anterior/posteri

158 I propose to term these TFs "terminal selector genes" and their cognate cis-regulatory target

159 te homologs of the Drosophila HOM-C homeotic selector genes, are expressed in rhombomere-restricted p

160 to repress the transcription of non-retinal selector genes, thereby allowing induction of the retina

161 al class of transcription factors encoded by selector genes.

162 sayed with regard to the floral homeotic ABC selector genes.

163 to maintain active transcription of homeotic selector genes.

164 maintain the expression pattern of homeotic selector genes.

165 red to repress the expression of non-retinal selector genes.

166 the correct segmental expression of homeotic selector genes.

167 ing that the zebrafish Hox PG2 genes act as "selector genes."

168 ecific identities through the expression of 'selector' genes [1,2,4].

169 hought that the posterior expression of the 'selector' genes engrailed and invected control the subdi

170 A small number of major regulatory (selector) genes have been identified in animals that con

171 tivated by two visual-specific transcription selectors, Glass and Sine Oculis, that bind to an enhanc

172 The trifunctional selector has three important properties: it noncovalentl

173 The selector homeoprotein Even skipped (Eve) plays a very sp

174 Our results raise the possibility that each selector homeoprotein may directly regulate the expressi

175 The selector homeoproteins are a highly conserved group of t

176 controlled by Eve and probably by the other selector homeoproteins as well.

177 Previously, the Drosophila selector homeoproteins Eve and Ftz were shown to bind wi

178 Suspecting that the selector homeoproteins may affect many more genes than p

179 ctly or indirectly controlled by most or all selector homeoproteins.

180 rtholog mef2cb, or that it is related to the selector (homeotic) gene function of mef2ca.

181 homeodomain proteins encoded by the homeotic selector (Hox) gene complexes and increase their DNA-bin

182 Homeotic selector (Hox) proteins often bind DNA cooperatively wit

183 pairs was obtained with addition of a chiral selector (i.e., beta-cyclodextrin) in the running buffer

184 w the choice of data set size, regressor and selector impact the design.

185 The use of a guanosine gel as a chiral selector in capillary electrophoresis is introduced.

186 A, and teicoplanin can all be used as chiral selectors in capillary electrophoresis (CE).

187 n, transcription factors operate as terminal selectors in distinct combinations in different neuron t

188 memristor that negates the need for external selectors in large arrays.

189 miconductor technology, and require external selectors in order for large memristor arrays to functio

190 s therefore proof the role of the 'substrate selector' in plant PPOs.

191 en separated using these ionic liquid chiral selectors include alcohols, diols, sulfoxides, epoxides,

192 e isoform selectivity found on quinine-based selectors is explained by van't Hoff plots, revealing a

193 t moieties of the original cinchonan-derived selector, it was shown that intercalation by the quinoli

194 ontaining a subset of the amino acid anilide selector library was screened for enantioselectivity.

195 Terminal selectors mediate this restriction at least partially by

196 t property-most often, affinity for a target selector molecule.

197 ognate cis-regulatory target sites "terminal selector motifs." Terminal selector genes assign individ

198 Derivatives of the chiral selector N-(3,5-dinitrobenzoyl)leucine were prepared and

199 fic effector genes, indicating that terminal selectors not only activate effector gene batteries but

200 Activated sludge was sampled from an anoxic selector of a municipal wastewater treatment plant (WWTP

201 cally expressed C. elegans CHE-1, a terminal selector of ASE sensory neuron identity.

202 ecificity by modeling the neuron as a biased selector of hair-cell polarity and find evidence for bia

203 etabolites concentrations) probably acted as selector of metabolic pathways, favoring H(2)-producing

204 zing the activity of broadly acting terminal selectors of neuron identity in a subtype-specific fashi

205 contrast, removal of the respective terminal selectors of other sensory, inter-, or motor neuron type

206 mplementation of a high mass quadrupole mass selector on the recently introduced Orbitrap Exactive EM

207 onsists of 81 peptide-based potential chiral selectors on polymeric synthesis resins.

208 r needed to immobilize the identified chiral selectors onto silica gel proved important in the chiral

209 enantiomers in solution without using chiral selectors or circularly polarized light.

210 nder nonoptimum concentrations of the chiral selector, other experimental parameters such as ionic st

211 he obligate integration of inputs of a field-selector (Otx2) and localized signaling (Notch) within t

212 t the environment not only acts as an active selector over the genotypes, but also enhances the capac

213 Selector probes enable the amplification of many selecte

214 ne that automates the procedure of designing selector probes for exon resequencing applications.

215 SCALLOPED, the DNA binding component of the selector protein complex for the Drosophila wing field,

216 The Scalloped selector protein controls wing development in Drosophila

217 The modification of selector protein DNA-binding specificity by co-factors a

218 gulated by multiple signaling pathways and a selector protein during Drosophila wing development.

219 controlling wing development, including the selector protein Engrailed.

220 site for the fetal/erythroid-specific stage selector protein in the gamma-promoter abolished the add

221 The Abdominal-B selector protein induces organogenesis of the posterior

222 Similarly, insertion of the stage selector protein site into the beta-promoter boosted enh

223 that TnsC interacts directly with the target selector protein TnsD.

224 element, we demonstrate that Apterous (Ap, a selector protein), and the Notch and Wingless (Wg) signa

225 sequence-specific DNA binding of the target selector protein, TnsD.

226 combinatorial peptide library using mu4 as a selector protein.

227 ors) and several binding sites for the stage selector protein.

228 as a novel role as a positive actin-binding "selector" protein that promotes the access of other prot

229 Combinatorial regulation by selector proteins and signal transducers is likely to be

230 tions between extradenticle and the homeotic selector proteins and that extradenticle is not simply a

231 tegration of multiple signaling pathways and selector proteins can be achieved during wing developmen

232 tory DNA may be a general mechanism by which selector proteins control extensive genetic regulatory n

233 nderstood how the target selectivity of most selector proteins is determined in vivo.

234 The DNA-binding domains of selector proteins often exhibit relatively low DNA-bindi

235 tive expression of various homeodomain (HOX) selector proteins, which mediate the activation of disti

236 ting the DNA-binding specificity of homeotic selector proteins.

237 rimental proof of the role of the 'substrate selector' residue in plant polyphenol oxidases.

238 hensive with advanced features like sequence selector, search set builder, enzyme chooser, access to

239 s, including optical filtering, polarization selectors, sensing, lasers, modulators and nonlinear opt

240 utually exclusive nature of the docking site:selector sequence interactions suggests that the formati

241 Strikingly, each selector sequence is complementary to a portion of the d

242 n downstream of constitutive exon 5, and the selector sequences, which are located upstream of each e

243 a mem-ristor and a trilayer crested barrier selector, showing repeatable nonlinear current-voltage s

244 columns packed with highly efficient chiral selectors (sub-2 mum fully porous and 2.7 mum fused-core

245 e contamination, a negatively charged chiral selector, sulfated beta-cyclodextrin (sulfated beta-CD),

246 phila TCF (dTCF) and the Vestigial/Scalloped selector system and that temporal control is provided by

247 We developed the Tree-Based Alignment Selector (T-BAS) toolkit to allow evolutionary placement

248 tion of chiral analyte molecules with chiral selectors that could potentially be applied to the study

249 We find that selectors that use information about the prediction unce

250 software system GEMS (Gene Expression Model Selector) that automates high-quality model construction

251 based on oligonucleotide constructs, called selectors, that guide the circularization of specific DN

252 sing an anti-D-amino acid antibody as chiral selector, the L-enantiomers eluted with the void volume,

253 ause of the synthetic nature of these chiral selectors, the configuration of the stereogenic center c

254 ption factor ttx-3, which acts as a terminal selector to drive the terminal differentiation program o

255 n modification acts downstream of a terminal selector to restrict plasticity.

256 pared by covalent attachment of the Whelk-O1 selector to spherical, high-surface-area 1.7-mum porous

257 to prevent misincorporation and as positive selectors to enhance correct incorporation.

258 3, and N(6) of purine dNTPs both as negative selectors to prevent misincorporation and as positive se

259 A terminal selector transcription factor, CHE-1, is required for th

260 ne gene and ectopic expression of a terminal selector transcription factor.

261 Crosses between the puDeltatk selector transgenic line and existing cre lines will fac

262 ed by the specific combination of a terminal selector type of transcription factors that also specify

263 c regulatory signature and cognate, terminal selector-type transcription factors that define the enti

264 collaboration with non-sex-specific terminal selector-type transcription factors, whereas the sex spe

265 The conserved COE-type terminal selector UNC-3 not only controls the expression of trait

266 that are directly activated by the terminal selector UNC-3.

267 mpounds was achieved using DTC as the chiral selector under optimized background electrolytic conditi

268 ndividual components of the materials; and a selector uses these predictions and their uncertainties

269 s further deconvoluted until the single best selector was found.

270 ta-cyclodextrin, a negatively charged chiral selector, was used for the enantiomeric separation of ra

271 The chiral selectors were designed to remove the ionization site fr

272 bonding groups and d-carbohydrates as chiral selectors were developed to achieve control over the chi

273 Four chiral selectors were examined under various conditions to expl

274 Cyclodextrins as common chiral selectors were used as model complexation agents.

275 her proteins, including a putative substrate selector, which associate with the enzyme in yeast and m

276 are accomplished by the addition of a chiral selector, which causes the different enantiomers of an a

277 olution of the two pseudoenantiomeric chiral selectors, which differ in absolute stereochemistry and

278 plexes of cinchona alkaloid carbamate chiral selectors with N-dinitrobenzoylleucine enantiomers and a

279 It is also demonstrated that selectors with separation factors as low as 1.4 could be

280 type of velocity-insensitive adiabatic spin selector, with potential application in devices such as

281 sited TaN1+x /Ta2 O5 /TaN1+x crested barrier selector yields a large nonlinearity (>10(4) ), high end