ライフサイエンスコーパス: selenomethionine

1 sothiourea, and the peroxynitrite scavenger, selenomethionine.

2 onine and substituting leucine residues with selenomethionine.

3 , and Met261 were only partially replaced by selenomethionine.

4 at is associated with impaired metabolism of selenomethionine.

5 bserved, indicating the previous presence of selenomethionine.

6 ially incorporated into organic Se mainly as selenomethionine.

7 ied from the sam1(-) sam2(-) strain grown in selenomethionine.

8 conducted a randomized, controlled trial of selenomethionine 200 microg daily and/or celecoxib 200 m

9 elenium as selenate (200 or 400 mug/d) or as selenomethionine (200 mug/d) for 4 wk.

10 bioaccessible selenium was mainly present as selenomethionine, a good bioavailable source of selenium

11 e accumulated in an algal-wetland system are selenomethionine, a precursor of volatile Se formation,

12 Toxicity of selenomethionine, an organic derivative of selenium wide

13 avelength anomalous diffraction phasing with selenomethionine analogs that retain the biophysical cha

14 ubstituting the nine methionines in hTF with selenomethionine and 2) the structure of glycosylated ap

15 d in Linxian, China to assess the effects of selenomethionine and celecoxib on the natural history of

16 y growth-arrested, toxic amino acids such as selenomethionine and fluorophenylalanine were efficientl

17 wo fractions were identified specifically as selenomethionine and selenocystamine, estimated to be pr

18 ated by devising a simple synthesis for Fmoc-selenomethionine and substituting leucine residues with

19 enium and tellurium analogues, Se-adenosyl-L-selenomethionine and Te-adenosyl-L-telluromethionine (Se

20 Oral selenium (200 microg/d from L-selenomethionine) and matched vitamin E placebo, vitamin

21 plements of selenium (200 mug per day from L-selenomethionine) and vitamin E (400 IU per day of all r

22 eased production of protein during growth in selenomethionine, and efficient replacement of methionin

23 ength anomalous diffraction (MAD) phasing on selenomethionine, and refined to an R(cryst) = 0.24 and

24 rate the free amino acids selenocysteine and selenomethionine, and these are incorporated nonspecific

25 waterborne dissolved selenite and to dietary selenomethionine as selenized algae.

26 g using selenium substitution in the form of selenomethionine as the anomalous scatterer.

27 urrogate, ProSeAM (propargylic Se-adenosyl-l-selenomethionine), as a reporter of methyltransferases.

28 , and efficient replacement of methionine by selenomethionine, based on quantitative mass spectrometr

29 f the species produced by the plant, such as selenomethionine, can be identified at ppb levels by RP-

30 ely to show an improvement when treated with selenomethionine compared with placebo (P = 0.02).

31 sequencing and mass spectrometry analysis of selenomethionine-containing peptides suggests that Met30

32 e the structures of the native protein and a selenomethionine-containing variant, solved to 2.8 A.

33 sed to different concentrations of dietary l-selenomethionine (control, 2.3, 9.7, 32.5, or 57.7 mug S

34 Cytotoxicity of selenomethionine decreased when the extracellular concen

35 length anomalous diffraction experiment on a selenomethionine derivative of the truncated MAO-N-D5 en

36 -wavelength anomalous dispersion (SAD) using selenomethionine-derivative protein.

37 ctional difference between the wild-type and selenomethionine derivatives.

38 d esophageal squamous dysplasia at baseline, selenomethionine did have a protective effect.

39 ethionine residues in the native enzyme with selenomethionine does not affect the structure of the Ni

40 ltiwavelength anomalous dispersion data from selenomethionine-enriched protein and refined to an R fa

41 elenomethionine indicating that selenide and selenomethionine exert their toxicity via distinct mecha

42 In unplanned stratified analyses, selenomethionine favorably affected a change in dysplasi

43 ever, extensive replacement of methionine by selenomethionine for anomalous dispersion phasing has pr

44 placement using a uranium derivative and the selenomethionine form of the enzyme (SeMAT).

45 oprotein pool, shown by others to be largely selenomethionine in albumin, declined.

46 beled tyrosine was also co-incorporated with selenomethionine in order to confirm these assignments.

47 readily incorporated forms of selenium (ie, selenomethionine) in HIV-infected breastfeeding women.

48 creased accumulation of organoselenium (e.g. selenomethionine) in selenate-treated roots.

49 forms that probably differ in the degree of selenomethionine incorporation and the extent of selenom

50 two regions near 1,284 and 900 cm(-1) due to selenomethionine incorporation.

51 pe growth rate properties in the presence of selenomethionine indicating that selenide and selenometh

52 We show that selenium in the form of selenomethionine induces a DNA repair response in normal

53 provided by selenium after incorporation of selenomethionine instead of natural methionine by geneti

54 We report a general method to incorporate selenomethionine into proteins expressed in yeast based

55 rally, combining cell-free incorporations of selenomethionine into proteins with FTIR difference spec

56 ifference spectra recorded for unlabeled and selenomethionine-labeled cell-free expressed BR closely

57 ngth anomalous diffraction technique using a selenomethionine-labeled crystal containing 88 selenium

58 e of glypican-1 was solved using crystals of selenomethionine-labeled glypican-1 core protein lacking

59 Selenomethionine-labeled RF1 crystallized in space group

60 X-ray absorption spectroscopy approach using selenomethionine labeling to distinguish the metal sites

61 exposures; larvae predominantly accumulated selenomethionine-like species regardless of uptake route

62 ithin the eye lens of the intact larva was a selenomethionine-like species.

63 cture of hiNadR complexed with NAD using the selenomethionine MAD phasing method.

64 terococcus faecalis (MVAS) was determined by selenomethionine MAD phasing to 2.4 A and the enzyme com

65 protein, C.AhdI, to 1.69 A resolution using selenomethionine MAD.

66 Selenomethionine markers clearly indicate an antiparalle

67 deficiency is associated with impairment of selenomethionine metabolism.

68 ommon dietary selenium compounds - selenite, selenomethionine, methylselenocysteine and selenocystine

69 eceive a daily supplement of 100 mug Se as l-selenomethionine (n = 129) or placebo (n = 126) for 12 w

70 After a 10-month intervention, neither selenomethionine nor celecoxib inhibited esophageal squa

71 By comparing the sensitivity to selenomethionine of mutants impaired in the sulfur amino

72 ious stages of catalysis, in the presence of selenomethionine or Se-adenosyl-L-selenomethionine, reve

73 f massive annual algal blooms showed that no selenomethionine or selenomethionine oxide was present.

74 tation were given daily selenium (200 mug as selenomethionine) or placebo as supplements from recruit

75 treated with DHEA, DFMO, tocopherol acetate, selenomethionine, or 9-cis-retinoic acid, although the e

76 nomethionine incorporation and the extent of selenomethionine oxidation.

77 al blooms showed that no selenomethionine or selenomethionine oxide was present.

78 Production and emission of selenomethionine, selenomethionine oxide, and other discrete organic selen

79 own to produce and release selenomethionine, selenomethionine oxide, and several other organic seleni

80 ia progression (14% vs 19%) compared with no selenomethionine (P = .08).

81 s of LAM and shows selenium in Se-adenosyl-L-selenomethionine poised to ligate the unique iron in the

82 y compare the effect on protein stability of selenomethionine relative to methionine.

83 spectroscopy of multiple selenocysteine and selenomethionine residues in the sulfhydryl oxidase augm

84 The SeMAT data (9 selenomethionine residues out of 383 amino acid residues

85 insic binuclear zinc centre and incorporated selenomethionine residues.

86 Overall, selenomethionine resulted in a trend toward increased dy

87 the entire digestion, whereas incubation of selenomethionine resulted in the chemical and microbial

88 resence of selenomethionine or Se-adenosyl-L-selenomethionine, reveals that the cofactor is cleaved o

89 for methionine and grown in the presence of selenomethionine (Se(Met)), the single methionine of the

90 and linear relationship between total Se or selenomethionine (Se-Met) accumulation in grain and Se d

91 ascaris acus or not, were exposed to dietary selenomethionine (Se-Met) at an environmentally relevant

92 d a XAD(R) resin was employed as sorbent for selenomethionine (Se-Met), selenomethylselenocysteine (S

93 he positions of Met95 have been confirmed by selenomethionine ((Se)Met) MAD.

94 is of two analogues of AdoMet, Se-adenosyl-L-selenomethionine (SeAdoMet) and Te-adenosyl-L-telluromet

95 e kinetics with the SAM analog Se-adenosyl-l-selenomethionine (SeAM) as a cofactor surrogate.

96 0, 100, or 200 microg Se ( approximately 60% selenomethionine), selenium-enriched onion meals ( appro

97 w molecular weight organoselenium compounds (selenomethionine, selenoethionine, trimethylselenonium i

98 Production and emission of selenomethionine, selenomethionine oxide, and other disc

99 o selenate were shown to produce and release selenomethionine, selenomethionine oxide, and several ot

100 Here, we use selenomethionine (SeM) active site labels in a series of

101 In earlier work we showed that selenomethionine (SeM) substitution of the coordinated M

102 methionine (DFM), trifluoromethionine (TFM), selenomethionine (SeM), and norleucine (Nle) using expre

103 ostructural amino acids norleucine (Nle) and selenomethionine (SeM).

104 ne (SeC), Se-methylselenocysteine (SeMC) and selenomethionine (SeM).

105 Selenomethionine (SeMet) and selenomethylcysteine (SeMeS

106 ay dietary exposure to food augmented with l-selenomethionine (SeMet) at measured concentrations of 0

107 rty of methylselenol, which is released from selenomethionine (SeMET) by cancer cells with the adenov

108 We show that selenium in the form of selenomethionine (SeMet) can activate the p53 tumor supp

109 xposure to hypersaline conditions and 50 muM selenomethionine (SeMet) decreased embryo hatch and depl

110 Selenomethionine (SeMet) is a potentially toxic amino ac

111 identification showed selenocystathionine-to-selenomethionine (SeMet) ratios of 75:25, 71:29, and 32:

112 te by ATP sulfurylase, and (b) conversion of selenomethionine (SeMet) to DMSe.

113 cystine (SeCys; detected as [SeCys]2 dimer), selenomethionine (SeMet), and methyl-selenocysteine (MeS

114 ioaccessibility of Se, and its organic forms selenomethionine (SeMet), and selenocysteine (SeCys2) wa

115 afish (Danio rerio) after exposure to excess selenomethionine (SeMet, the dominant chemical species o

116 utant (used to obtain experimental phases by selenomethionine single-wavelength anomalous diffraction

117 The structure was solved by selenomethionine single-wavelength anomalous dispersion

118 (gi 4981173) at 2.65 Angstrom resolution by selenomethionine single-wavelength anomalous dispersion

119 bstitution of these methionine residues with selenomethionine slightly stabilizes the protein.

120 saminate methyl-L-selenocysteine (MSC) and L-selenomethionine (SM) to beta-methylselenopyruvate (MSP)

121 Moreover, selenomethionine (SM), a prostate cancer treatment adjuv

122 ic and organic Hg (HgCl2 and MeHgCl) and Se (selenomethionine, sodium selenite, and sodium selenate)

123 system containing an amino acid mixture with selenomethionine substituted for methionine.

124 aracteristics, the crystal structures of the selenomethionine substituted StnA (SeMet-StnA) and the c

125 d expressed at high levels as the native and selenomethionine-substituted (SeMet) proteins.

126 ength anomalous diffraction techniques and a selenomethionine-substituted analogue of the enzyme.

127 We have solved the crystal structure of selenomethionine-substituted CheY** in the presence of i

128 velength anomalous dispersion methods on a L-selenomethionine-substituted complex of LAM with [4Fe-4S

129 elength anomalous diffraction phasing from a selenomethionine-substituted crystal at 3.0 A resolution

130 gth anomalous diffraction (MAD) phasing of a selenomethionine-substituted derivative to define a new

131 This model was further confirmed using selenomethionine-substituted DGCR8 and mercury titration

132 with data obtained from the E. coli Ni-GlxI selenomethionine-substituted enzyme.

133 The native and the selenomethionine-substituted forms of the phenylalanine-

134 th x-ray data collected from crystals of the selenomethionine-substituted L99A/M102L mutant of T4 lys

135 The crystal structure of selenomethionine-substituted malate synthase G, an 81 kD

136 NMT from Thalictrum flavum was solved using selenomethionine-substituted protein (dmin = 2.8 A).

137 Using selenomethionine-substituted protein and multiple anomal

138 The structure was determined using selenomethionine-substituted protein and multiwavelength

139 Crystals of the selenomethionine-substituted protein have space group P2

140 The selenomethionine-substituted protein was induced in the

141 nomalous diffraction, using a crystal of the selenomethionine-substituted protein.

142 The activity was not increased more by selenomethionine supplementation than by the placebo in

143 by selenite uptake and by the conversion of selenomethionine to dimethylselenide.

144 enosylmethionine is blocked, exhibit reduced selenomethionine toxicity compared with wild-type yeast,

145 Involvement of superoxide radicals in selenomethionine toxicity in vivo is suggested by the hy

146 Instead, we found that selenomethionine toxicity is mediated by the trans-sulfu

147 ced repair complex formation was observed in selenomethionine-treated cells.

148 namic range allows quantitative detection of selenomethionine, trimethylselenonium ion, methylselenog

149 This is, however, increasingly offset in the selenomethionine variants, ultimately resulting in a dif

150 Results were compared by agent group (selenomethionine vs placebo; celecoxib vs placebo).

151 Selenomethionine was efficiently incorporated into this

152 Selenomethionine was incorporated into BR using a cell-f

153 lenocysteine, but not the non-thiol-reactive selenomethionine, was shown to induce Top2alpha cleavage

154 ies, including a cyclic oxidation product of selenomethionine, were observed, indicating the previous

155 d plants accumulated organic Se, most likely selenomethionine, whereas selenate-supplied plants accum

156 Selenomethionine, which is the principal dietary form of

157 Oral selenium (200 mug/d from L-selenomethionine) with matched vitamin E placebo, vitami