ライフサイエンスコーパス: selenoprotein P

1 t dependent on cis-acting elements unique to selenoprotein P.

2 was fully dependent on the supplies of Se by selenoprotein P.

3 a constituent of the heparin-binding site of selenoprotein P.

4 cted 57-kDa size of full-length glycosylated selenoprotein P.

5 e protein forms from immunoaffinity-purified selenoprotein P.

6 Selenoprotein P, a glycoprotein that contains 10 selenoc

7 associated signal transducer-2 (Trop-2), and Selenoprotein-P, a gene that binds selenium and prevents

8 Nevertheless, selenoprotein P and several other selenoproteins are kno

9 Full-length selenoprotein P and three smaller isoforms that have ide

10 Four isoforms of selenoprotein P are present in rat plasma.

11 Selenoprotein P binds to endothelial cells in the rat, a

12 It was distinguished from selenoprotein P by N-glycosidase assay and by the period

13 , and seventh selenocysteines in full-length selenoprotein P can alternatively serve to terminate tra

14 To optimize the plasma selenoprotein P concentration in this study, 50 microg S

15 one peroxidase activity was optimized before selenoprotein P concentration was optimized, indicating

16 roxidase activity and in plasma selenium and selenoprotein P concentrations were measured.

17 tive real-time reverse transcription-PCR for Selenoprotein-P demonstrated a similar down-regulation o

18 (a) of which is 7.0, explains the release of selenoprotein P from heparin binding as pH rises above 7

19 peculative and much work on the mechanism of selenoprotein P function lies ahead.

20 single UGA codon and a single SECIS element, selenoprotein P genes encode multiple UGAs and two SECIS

21 have identified evolutionary adaptations in selenoprotein P genes that contribute to the efficiency

22 The function of selenoprotein P has remained elusive, in part due to the

23 first time the expression of recombinant rat selenoprotein P in a transiently transfected human epith

24 Measurement of selenoprotein P in human plasma has shown that it is dep

25 property would lead to increased binding of selenoprotein P in tissue regions that have low pH.

26 st, the efficiency of Sec incorporation into selenoprotein P in vitro is approximately 40%, suggestin

27 oteins, glutathione peroxidase (GSHPx-3) and selenoprotein P, in the plasma of patients with cirrhosi

28 Selenoprotein P increased significantly in all selenium

29 Selenoprotein P is a plasma protein that has oxidant def

30 Plasma selenoprotein P is a useful biomarker of status in popul

31 Selenoprotein P is an abundant extracellular glycoprotei

32 Selenoprotein P is an abundant extracellular glycoprotei

33 Rat selenoprotein P is an extracellular glycoprotein of 366

34 Thus, full-length selenoprotein P is both N- and O-glycosylated.

35 s were reduced by about 75%, suggesting that selenoprotein P is primarily exported from the liver.

36 ration was optimized, indicating that plasma selenoprotein P is the better index of human selenium nu

37 Selenoprotein P is unique in that its mRNA encodes 10-12

38 These findings demonstrate that selenoprotein P isoforms of differing peptide lengths ar

39 Selenoprotein P knockout mice have very low selenium con

40 Plasma selenoprotein P levels were reduced by about 75%, sugges

41 the possibility that the second UGA codon in selenoprotein P mRNA can have alternative functions: cod

42 Third, the two SECIS elements in selenoprotein P mRNA function with differing efficiencie

43 been identified in rat plasma, but only one selenoprotein P mRNA has been characterized.

44 Gla protein, apolipoprotein D precursor, and selenoprotein P precursor).

45 Selenoprotein P (Se-P) contains most of the selenium in

46 Selenoprotein P (Sel P) is a selenium-rich glycoprotein

47 nd two SECIS elements make the mRNA encoding selenoprotein P (Sel P) unique.

48 iosynthesis of the selenium (Se) transporter selenoprotein P (SELENOP) is particularly sensitive to a

49 A coding for the selenium transport protein, selenoprotein P (SELENOP), which in vertebrates may cont

50 GPx-2), thioredoxin reductase-1 (TrxR-1) and selenoprotein P (SeP) mRNA expression and GPx-1 enzyme a

51 ckdowns of the SEPP1 gene, which encodes the selenoprotein P (SeP) protein, have been shown to increa

52 ed into at least 25 selenoproteins including selenoprotein P (SePP), which transports Se within the b

53 Selenoprotein P (Sepp1) and its receptor, apolipoprotein

54 in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop se

55 The liver synthesizes selenium-rich selenoprotein P (SEPP1) and secretes it into the plasma

56 Selenoprotein P (Sepp1) contains most of the selenium in

57 Selenoprotein P (Sepp1) has two domains with respect to

58 type II diabetes risk, and plasma levels of selenoprotein P (SEPP1) have been positively correlated

59 ciency by curtailing excretion and secreting selenoprotein P (Sepp1) into the plasma at the expense o

60 Selenoprotein P (Sepp1) is a plasma and extracellular pr

61 Selenoprotein P (Sepp1) is an important protein involved

62 Among selenoproteins, selenoprotein P (Sepp1) is particularly distinctive due

63 The selenium-rich plasma protein selenoprotein P (Sepp1) is required for maintenance of t

64 Selenoprotein P (Sepp1) is taken up by receptor-mediated

65 oprotein S (SelS) production and circulating selenoprotein P (Sepp1) levels are significantly diminis

66 quantification of selenium (Se) included in selenoprotein P (SEPP1), an important biomarker for huma

67 sported from the liver to target tissues via selenoprotein P (SEPP1).

68 logous to regions of deduced sequence of the selenoprotein-P (SPP) family in bovine, rat, and human.

69 Several forms of selenoprotein P that share the same N-terminal sequence

70 , and recognizing the important functions of selenoprotein P, these results provide important evidenc

71 Selenoprotein P turns over rapidly in rat plasma with th

72 Immunoaffinity-purified selenoprotein P was digested with proteases, and the res

73 Selenoprotein P was purified from rat plasma, and the fo

74 and known to be correlated with circulating selenoprotein P, was the biomarker chosen.

75 Based on the histidine-rich nature of selenoprotein P, we have purified the recombinant and en

76 n of lung glutathione peroxidase-1 and liver selenoprotein P were increased in OVA-challenged mice co

77 Selenoprotein P, which originates largely in the liver,

78 The shortest isoform of selenoprotein P, which terminates at residue 244, was an

79 This predicts that full-length selenoprotein P will contain 10 selenocysteine residues.