ライフサイエンスコーパス: self-administration

1 rats and monkeys, but did not affect cocaine self-administration.

2 and medication event-monitoring devices for self-administration.

3 ale and female rats with a history of heroin self-administration.

4 e stroke-induced increase in operant alcohol self-administration.

5 riatum dopamine activity and blunted cocaine self-administration.

6 ferentiation and maturation following heroin self-administration.

7 ring early extinction training after cocaine self-administration.

8 -response curve after acquisition of cocaine self-administration.

9 punishment-induced suppression of aggression self-administration.

10 ced dopamine responses and increases alcohol self-administration.

11 receptors was sufficient to augment cocaine self-administration.

12 y-like behavior, fear conditioning, and drug self-administration.

13 ased after 7 days of withdrawal from cocaine self-administration.

14 ll of reward and extinction memories of food self-administration.

15 social defeat stress escalates later cocaine self-administration.

16 d persisted even following prolonged cocaine self-administration.

17 ce-like phenotypes such as escalated alcohol self-administration.

18 ated neuropathology with and without cocaine self-administration.

19 is observed after adolescent-onset nicotine self-administration.

20 the changes in nicotine doses available for self-administration.

21 g under a progressive-ratio schedule of drug self-administration.

22 and accelerates extinction following cocaine self-administration.

23 cipitation following abstinence from cocaine self-administration.

24 had no effect on drug taking during cocaine self-administration.

25 nk between stress history and escalated drug self-administration.

26 muli after prolonged abstinence from cocaine self-administration.

27 response and prevented the increased alcohol self-administration.

28 lowed either short or long access to cocaine self-administration.

29 males before and after 12 months of alcohol self-administration.

30 also occurs after adolescent-onset nicotine self-administration.

31 drug taking and drug seeking during cocaine self-administration.

32 nderpin the increased acquisition of cocaine self-administration.

33 ss also augmented the acquisition of cocaine self-administration.

34 tress potentiated the acquisition of cocaine self-administration.

35 punishment-induced suppression of aggression self-administration.

36 elated behaviors following prolonged cocaine self-administration.

37 longer apparent following prolonged cocaine self-administration.

38 graphy before and after 16 months of cocaine self-administration.

39 ntly increased after 6- and 12-month ethanol self-administration.

40 ts extinguished from cocaine but not sucrose self-administration.

41 doses (.3-3 mg/kg) that did not affect food self-administration.

42 egulates the initiation of voluntary alcohol self-administration.

43 nd was not seen during extinction of sucrose self-administration.

44 n difficult to demonstrate following cocaine self-administration.

45 ine conditioned place preference and cocaine self-administration.

46 es; and (4) had no effect on cocaine or food self-administration.

47 structural plasticity in mPFC after cocaine self-administration.

48 ar plasticity in the brain following cocaine self-administration.

49 ould facilitate extinction following cocaine self-administration.

50 st), or vehicle for an additional 3 weeks of self-administration.

51 ng- (12 h; LgA) access to intravenous heroin self-administration.

52 ine and the effects of some drugs on cocaine self-administration.

53 neurons that were active during operant food self-administration.

54 r, as did withdrawal from ShA or LgA cocaine self-administration.

55 e found that PE led to increased amphetamine self-administration.

56 in vivo expedited the acquisition of cocaine self-administration.

57 ergent effects on brain function and cocaine self-administration.

58 lated in the NAcsh of rats following cocaine self-administration.

59 dopamine activity and lower cocaine operant self-administration.

60 mine in the nucleus accumbens nor maintained self-administration.

61 educes AMPH-self administration but not food self-administration.

62 hA) or long (6 hours; LgA) access to cocaine self-administration.

63 ing the acquisition or maintenance of heroin self-administration.

64 naive animals and after a history of cocaine self-administration (1.5 mg/kg/infusion, fixed-ratio 1,

65 , but not MAO-B, increases low-dose nicotine self-administration, (3) partial MAO-A inhibition, to th

66 % received further medical prescriptions for self-administration: 67% corticosteroids, 83% antihistam

67 ethamphetamine or saline (control condition) self-administration (9 h/d, 10 d).

68 G/G male mice escalated the amount of heroin self-administration across 10 extended-access sessions m

69 that BDNF was no longer able to gate alcohol self-administration after a history of repeated cycles o

70 from aspirin warrants public education about self-administration after possible TIA.

71 Cocaine self-administration also increased TrkB signaling in the

72 These findings suggest that cocaine self-administration alters the ability for dopamine sign

73 and MTEP dose-dependently decreased cocaine self-administration and attenuated the discriminative st

74 (FosGFP(+)) that were activated during food self-administration and compared these with alterations

75 eadout of acetylated lysines, reduced heroin self-administration and cue-induced drug-seeking behavio

76 Alcohol self-administration and cue-induced reinstatement behavi

77 e nucleus accumbens (NAc) over the course of self-administration and determine the roles of alpha1- a

78 exposure that resulted in escalated alcohol self-administration and elevated physiological withdrawa

79 a behavioral economics approach with cocaine self-administration and ex vivo voltammetric recording o

80 Cocaine or saline self-administration and extinction were paired with GFAP

81 t alone reinstates cocaine seeking following self-administration and extinction, but each treatment p

82 Following cocaine self-administration and extinction, female rats were ova

83 st in a hyporeactive state following cocaine self-administration and extinction.

84 ly reduced in the NAc core following cocaine self-administration and extinction.

85 Using cocaine self-administration and fast-scan cyclic voltammetry in

86 Herein we used animal models of self-administration and in vivo microdialysis to study t

87 rlying PE-induced enhancement in amphetamine self-administration and increased addiction risk in indi

88 experienced extended access methamphetamine self-administration and individual differences in drug t

89 oinjections prevented acquisition of cocaine self-administration and laser preference, whereas CeA in

90 KOR antagonism on escalated operant alcohol self-administration and physiological withdrawal symptom

91 s HS, accelerated the acquisition of cocaine self-administration and promoted persistent responding d

92 maintenance on naltrexone decreased cannabis self-administration and ratings of 'good effect' in nont

93 rat alcohol exposure procedures and cocaine self-administration and reinstatement (relapse) procedur

94 ays, would reduce cocaine seeking in the rat self-administration and reinstatement model of addiction

95 r injection) effects on intravenous nicotine self-administration and reinstatement of nicotine seekin

96 fect on cue-induced reinstatement or sucrose self-administration and reinstatement.

97 were injected intracranially to reduce drug self-administration and reinstatement.

98 dings in rodent and primate models that drug self-administration and relapse are reduced by systemic

99 g levels of alcohol had no effect on cocaine self-administration and relapse to cocaine seeking.

100 instated cocaine seeking in a mouse model of self-administration and relapse, and found that either i

101 g Prosapip1 in mechanisms underlying alcohol self-administration and reward.

102 nsmission in different brain regions in drug self-administration and rodent models of relapse.

103 aving occurs after adolescent-onset nicotine self-administration and that neuronal ensembles in centr

104 lso observed after adolescent-onset nicotine self-administration and that neuronal ensembles in the c

105 p between plasma aldosterone levels, ethanol self-administration and the expression of CYP11B2 and MR

106 der in another social group affected cocaine self-administration and these effects were dependent on

107 entricular corticosterone attenuated cocaine self-administration and this effect was blocked in anima

108 te smokers, also increases low-dose nicotine self-administration, and (4) TCP decreases the threshold

109 hibited cocaine-enhanced locomotion, cocaine self-administration, and cocaine-induced reinstatement o

110 y changed long after withdrawal from cocaine self-administration, and demonstrate that sleep interven

111 s after repeated cocaine exposure, including self-administration, and in the NAc of cocaine-addicted

112 ant increases in alcohol preference, operant self-administration, and relapse.

113 ding responses to cocaine, including cocaine self-administration, and resilience to chronic social de

114 c neuroadaptations that characterize cocaine self-administration are induced by acute stress.

115 hol and determined the effects of AZD8529 on self-administration, as well as stress-induced and cue-i

116 the recommended adrenaline auto-injector for self-administration at discharge.

117 In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not a

118 AZD8529 marginally decreased alcohol self-administration at doses that neither affected 0.2%

119 After extinction of self-administration behavior, the presentation of the av

120 underlying individual differences in cocaine self-administration behaviors are not fully understood.

121 After withdrawal from cocaine self-administration, BRG1 expression and complex formati

122 nt of rats with 6 mg/kg 6c s.c. reduces AMPH-self administration but not food self-administration.

123 stinct pathways after acquisition of ethanol self-administration but before extinction and reinstatem

124 the control, significantly decreased cocaine self-administration by 67% relative to baseline at great

125 alidated a novel preclinical model of opioid self-administration by inhalation that does not require

126 rlies the behavioral potentiation of cocaine self-administration by sigma1R agonists in animal models

127 old-chain independence and the potential for self-administration can expand influenza vaccination cov

128 etreatment with CTDP-32476 inhibited cocaine self-administration, cocaine-associated cue-induced rela

129 B receptors differentially modulates cocaine self-administration, depending on the brain regions invo

130 Following cocaine self-administration, dopamine release, maximal rate of u

131 ood-drug choice procedure in which a cocaine self-administration dose-effect curve was determined dai

132 (PPAR-alpha) receptors; (2) shifted nicotine self-administration dose-response functions in a manner

133 f the stimulus that drives escalated alcohol self-administration during acute withdrawal and protract

134 ism in the CeA ameliorated escalated alcohol self-administration during both acute withdrawal and pro

135 nt paper, we used a model of methamphetamine self-administration during which we used footshocks to d

136 Cocaine self-administration elevated BNST PACAP, and BNST PACAP

137 increasing sleep fragmentation after cocaine self-administration expedited the development of incubat

138 n the NAc is altered in animals with cocaine self-administration experience or if these animals learn

139 During a progressive-ratio alcohol self-administration experiment, participants could press

140 lcohol pre-exposure had no effect on cocaine self-administration, extinction responding, and reinstat

141 Rats underwent cocaine self-administration, followed by extinction training.

142 hich demonstrate sex differences in nicotine self-administration for doses that are near to the reinf

143 wly incident drug users and with tracking of self-administration frequencies and DD clinical features

144 These results dissociate escalated alcohol self-administration from physiological withdrawal sympto

145 ally, our previous results show that cocaine self-administration generates AMPA receptor (AMPAR)-sile

146 ion group, 74.0% (CI, 68.9% to 78.6%) in the self-administration group, and 76.4% (CI, 71.3% to 80.8%

147 We examined the impact that prior cocaine self-administration had on firing in dorsal lateral stri

148 Loss of TrkB function after cocaine self-administration, however, leaves spine density intac

149 ore effective in suppressing operant alcohol self-administration in 118GG mice.

150 ch social defeat prevented escalated cocaine self-administration in a 24 h "binge." VTA CRF continues

151 at pDNA-IL-10 treatment reduces remifentanil self-administration in a drug-concentration-dependent ma

152 brain and subsequently increase cannabinoid self-administration in adulthood-suggest a mechanism by

153 binoid drugs to produce hedonia and maintain self-administration in both human and animal subjects.

154 e GluA1 increases induced by chronic cocaine self-administration in male rats.

155 ol dependence and a meta-analysis of alcohol self-administration in mice.

156 leep parameters disrupted by methamphetamine self-administration in non-human primates.

157 R-MOD alone neither sustained self-administration in P-rats previously self-administer

158 f a HCRT-R2 antagonist, NBI-80713, on heroin self-administration in rats allowed short- (1 h; ShA) or

159 Treatment with Ro 61-8048 decreased nicotine self-administration in rats and monkeys, but did not aff

160 d reinstatement of cocaine seeking following self-administration in rats and that this potentiation a

161 tle choice chronic ethanol intake or operant self-administration in rats before or after dependence.

162 that preclude BDNF's ability to gate alcohol self-administration in rats by the recruitment of the lo

163 Here we determined that cocaine self-administration in rats produced tolerance to the do

164 aphe 5-HT1A autoreceptors attenuates cocaine self-administration in rats with 6 h extended access, bu

165 gnificantly increased breakpoint for cocaine self-administration in rats, but decreased it in mice.

166 ine potentiated the dose response of cocaine self-administration in rats, consistent with the effects

167 Consistent with our findings following self-administration in rats, pretreatment of male C57/BL

168 Using cocaine self-administration in rats, we link tolerance to cocain

169 of cre from NAc efferents decreased cocaine self-administration in rats.

170 nificantly reduced cocaine, but not sucrose, self-administration in rats.

171 ChRs) that was reported to decrease nicotine self-administration in rats.

172 ing and after stress influence later cocaine self-administration in rats.In vivo microdialysis of CRF

173 is assessed after cessation of operant drug self-administration in rodents and monkeys.

174 motivation for cocaine, heroin, and alcohol self-administration in the absence of N/OFQ function.

175 Both drugs attenuated alcohol self-administration in Wt rats but not in NOP (-/-) rats

176 In experiment 1, cocaine self-administration increased BNST PACAP transcript leve

177 ain slice preparation, we found that operant self-administration increased excitability of FosGFP(+)

178 Cocaine self-administration increased TrkB signaling and activat

179 rdm2 knockdown resulted in increased alcohol self-administration, increased aversion-resistant alcoho

180 Cocaine self-administration increases expression of GluA1 subuni

181 e role of NMDArs in either process following self-administration is unclear.

182 cocaine potency, demonstrating that cocaine self-administration leaves the dopamine transporter in a

183 Chronic cocaine self-administration led to a significant (25.8 +/- 7.8%)

184 -transgenic rats, we found that operant food self-administration led to increased intrinsic excitabil

185 renocortical activity resulting from cocaine self-administration may contribute to regressive prefron

186 ical activity resulting from chronic cocaine self-administration may contribute to regressive prefron

187 MSNs did not change any parameter of cocaine self-administration measured.

188 otubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place pref

189 emonstrate that the operant sufentanil vapor self-administration model has both face and construct va

190 ine intake in the socially acquired nicotine self-administration model is controlled by genetic facto

191 the consequences on cocaine seeking in a rat self-administration model of relapse.

192 A rat heroin self-administration model was used to obtain translation

193 ions and relapse-like behaviors in a cocaine self-administration model.

194 hetamine (METH) intake in an extended-access self-administration model.

195 Drug self-administration models of addiction typically requir

196 t doses that neither affected 0.2% saccharin self-administration nor locomotor activity.

197 al specificity of AZD8529 was assessed using self-administration of 0.2% saccharin and locomotor acti

198 baclofen has been shown to suppress operant self-administration of alcohol in animals and alcohol us

199 ADX71441 dose-dependently decreased alcohol self-administration of both dependent and non-dependent

200 ojection underwent complex adaptations after self-administration of cocaine (0.75 mg/kg/infusion; 2 h

201 We previously found that self-administration of cocaine increases AMPA glutamate

202 own about its role in memory retrieval after self-administration of cocaine, an operant paradigm, or

203 termittent cocaine injections or intravenous self-administration of cocaine, followed by cue-induced

204 her handling nor pDNA-IL-10 treatment alters self-administration of food or sucrose rewards.

205 Number of deaths from self-administration of lethal medication versus number o

206 seeking exploratory behavior and facilitates self-administration of natural reward.

207 bserved strong motivation to acquire operant self-administration of opportunities to aggress and rela

208 e drug seeking and taking, using intravenous self-administration of oxycodone, fentanyl, and buprenor

209 NTS GLP-1R knockdown significantly increased self-administration of palatable food under both fixed a

210 al plasma N-glycome and the association with self-administration of postoperative morphine in two coh

211 hat neonatal handling attenuates intravenous self-administration of the opioid remifentanil in a drug

212 e compared the potential for compulsive-like self-administration of these prescription opioids and he

213 the effects of extinction from daily cocaine self-administration on astrocyte characteristics includi

214 (NAc), few studies have explored effects of self-administration on the structure and physiology of a

215 red effects of cocaine, morphine, and heroin self-administration on two forms of extinction learning:

216 se, continuous amphetamine treatment, during self-administration or abstinence, completely reversed c

217 found no sex differences in methamphetamine self-administration or in the strong preference for the

218 We also found no sex differences in heroin self-administration or the strong preference for the pal

219 ocaine seeking after withdrawal from cocaine self-administration, our present study reveals that afte

220 (PP) individuals based on their patterns of self-administration over 7 weeks.

221 t nicotine dependent rats increased nicotine self-administration over time as compared to non-depende

222 caine and palatable food pellets in a choice self-administration paradigm to identify 'addicted' coca

223 We used conditioned place preference and self-administration paradigms to examine reward-related

224 tle free-choice drinking and operant alcohol self-administration paradigms.

225 in the VTA limited to the 3 weeks of cocaine self-administration prevents the subsequent increase in

226 ocaine self-administration procedure [puzzle self-administration procedure (PSAP)] that required rats

227 addicts, we first developed a novel cocaine self-administration procedure [puzzle self-administratio

228 alcohol using a two-bottle choice or operant self-administration procedure.

229 nist, remifentanil, tested under intravenous self-administration procedures, as well as the subjectiv

230 n and palatable food was enhanced in operant self-administration procedures.

231 In addition, although cocaine self-administration produced opposite effects on TrkB si

232 is needed for DHE delivery enabling painless self-administration, quick onset of action, and high bio

233 Nicotine self-administration rate was negatively correlated with

234 In a substitution test, cocaine self-administration rats displayed a progressive reducti

235 Subsequently, methamphetamine self-administration rats were punished by mild electric

236 that after prolonged withdrawal from cocaine self-administration, rats exhibited persistent reduction

237 After cocaine self-administration, rats exhibited stronger biases towa

238 After cocaine self-administration, rats underwent modified extinction

239 y under ShA conditions and, like ShA cocaine self-administration, reduced corticotropin-releasing fac

240 y under LgA conditions and, like LgA cocaine self-administration, reduced CRF immunodensity in the ce

241 PS activity after an extended-access cocaine self-administration regimen that leads to withdrawal-dep

242 onkeys, focusing on whether they reduce drug self-administration, reinstatement of drug seeking, and

243 We used a rodent self-administration/reinstatement model of relapse to sh

244 Here, we used a modified self-administration/reinstatement procedure combined wit

245 We found that meth self-administration resulted in an inability to induce p

246 In addition, this manipulation during drug self-administration resulted in slower rates of extincti

247 d-type TrkB expression after chronic cocaine self-administration reverses the sustained increase in d

248 he NAc shell (NAcSh) would attenuate cocaine self-administration (SA) and cocaine-seeking behavior.

249 separation, increases adult methamphetamine self-administration (SA) in male rats as compared with h

250 enal toxicity induced by 2 weeks of ketamine self-administration (SA) in rodents.

251 However, these self-administration (SA) models do not include adverse c

252 control over drug seeking in several cocaine self-administration (SA) paradigms in rats.

253 short access) or 6 hours (long access [LgA]) self-administration (SA) sessions until LgA rats display

254 tations in reward circuits following cocaine self-administration (SA) underlie reinstatement of drug-

255 ve ingredient in marijuana, as assessed with self-administration (SA), has only been established in N

256 lop a rodent model of adolescent cannabinoid self-administration (SA), using the synthetic cannabinoi

257 Cocaine self-administration selectively and persistently up-regu

258 discrete motivational states during a single self-administration session.

259 0, 2, 4, or 6 mug) prior to operant alcohol self-administration sessions and physiological withdrawa

260 le food was then restricted to daily operant self-administration sessions using fixed ratio 1, 3, and

261 ltered cocaine intake during extended access self-administration sessions was observed in rats expose

262 ale and female rats with a history of heroin self-administration showed incubation of heroin craving

263 e have previously shown that methamphetamine self-administration significantly disrupts activity-base

264 tant NMDA receptor (NMDAR) activation during self-administration, similar to cocaine-induced long-ter

265 These results suggest that cocaine self-administration strengthens action-outcome encoding

266 Cannabis self-administration, subjective effects, and cannabis ra

267 tinic receptors (nAChRs) can reduce nicotine self-administration, suggesting that a positive alloster

268 Furthermore, after cocaine self-administration, synaptic plasticity was selectively

269 king D2 autoreceptors acquire a cued-operant self-administration task for cocaine faster than litterm

270 orcing effect of cocaine in an operant-based self-administration task.

271 for and intake of cocaine in an intravenous self-administration test.

272 roin (20 mug/infusion) and ethanol (10% v/v) self-administration, they showed significantly lower dru

273 ses of relapse after extinction from cocaine self-administration to assess how cocaine use affects t-

274 r) or long access (LgA) (6 hours) to cocaine self-administration to model moderate versus compulsive-

275 abstinence from intravenous methamphetamine self-administration, to demonstrate that the activation

276 given for five consecutive days during which self-administration took place in the morning.

277 nsic excitability after 10 d of operant food self-administration training (1 h/d).

278 Rats underwent 12 days of cocaine self-administration training during which time active le

279 A transmission and on rat intravenous heroin self-administration under fixed ratio (FR) and progressi

280 he groups of rats for acquisition of cocaine self-administration using ascending cocaine doses (0.125

281 of once-weekly isoniazid and rifapentine by self-administration versus direct observation.

282 stress to augment the acquisition of cocaine self-administration was abolished.

283 URB694 self-administration was blocked by pretreatment with an

284 data showed that acquisition of WIN55,212-2 self-administration was enhanced in THC-exposed rats rel

285 Conversely, saccharin self-administration was not affected by NOP deletion, ex

286 ttenuation of either cocaine or remifentanil self-administration was obtained at the highest doses of

287 using a rat model of compulsive-like cocaine self-administration, we found that inhibition of dorsal

288 Specifically, 1d after cocaine self-administration, we observed increased levels of AMP

289 ce preference (CPP) and saccharin (0.2% w/v) self-administration were also investigated.

290 lso significantly faster to initiate alcohol self-administration when they received ghrelin, compared

291 gonism, rather than agonism, blocks nicotine self-administration, which strongly suggests a critical

292 in D1-MSNs blocks drug seeking after cocaine self-administration, while enhancing the fission promoti

293 Amphetamine self-administration, whole-cell recordings, and electron

294 played a progressive reduction in CTDP-32476 self-administration with an extinction pattern of drug-t

295 iazid and rifapentine by direct observation, self-administration with monthly monitoring, or self-adm

296 f-administration with monthly monitoring, or self-administration with weekly text message reminders a

297 group, and 76.4% (CI, 71.3% to 80.8%) in the self-administration-with-reminders group.

298 DAGL inhibition reduces nicotine self-administration without disrupting operant respondin

299 T) blocks amphetamine-induced locomotion and self-administration without impacting cocaine-induced be

300 of the drug-reinforced action during cocaine self-administration, without affecting cue-induced reins