ライフサイエンスコーパス: self-association

1 rations studied with no evidence of catalyst self-association.

2 o 152) to identify determinants required for self-association.

3 to ensure aqueous solubility and discourage self-association.

4 KD approximately 0.26 muM and is capable of self-association.

5 rovide a lead to develop inhibitors of Abeta self-association.

6 ate subdomain of HSA domain 3 inhibits Abeta self-association.

7 hown to serve as a potent inhibitor of Abeta self-association.

8 a helix within the SAM domain contributed to self-association.

9 ins to solvent and may serve as hotspots for self-association.

10 interaction and, surprisingly, promote Upf1 self-association.

11 s for effects on Abeta(1-42) aggregation and self-association.

12 ations that make TRBP more like PACT enhance self-association.

13 published results and perhaps due to type-N self-association.

14 ion of a conserved leucine residue abolishes self-association.

15 n with RTA, in the latter case by preventing self-association.

16 p120 of HIV-1, dimerize, and undergo further self-association.

17 vide additional support for actin-induced Vt self-association.

18 ence and structural determinants of antibody self-association.

19 PRY) domain is not required for higher order self-association.

20 USP19 itself, which is facilitated by USP19 self-association.

21 ut did not affect SMN axonal localization or self-association.

22 regions 183-205 and 232-251 are involved in self-association.

23 erent degrees of target-binding affinity and self-association.

24 rh), such as capsid binding and higher-order self-association.

25 dies aimed at dissecting the determinants of self-association.

26 d the M1 protein potently and weakened M1-M1 self-association.

27 4 tails recapitulate most of the inter-array self-association.

28 ut chemical cross-linking, demonstrated RGS7 self-association.

29 ilized wild type HNP1 and to undergo further self-association.

30 efficient transport by repressing premature self-association.

31 ogen bonds according to reliable patterns of self-association.

32 with the Dicer-binding region implicated in self-association.

33 de the hindrance that His-36 puts on KIR2DL1 self-association.

34 rrays to undergo salt-induced compaction and self-association.

35 ia electrostatic surface anchoring and chain self-association.

36 utations on these residues disrupt AIM2(PYD) self-association.

37 ional role in destructosome assembly through self-association.

38 probably required for efficient higher order self-association; 4) the Linker 2 region contributes to

39 developmental signals that otherwise promote self-association [9, 12].

40 with histone-modifying, histone-binding, and self-association activities.

41 ervation consistent with a model wherein Rev self-association acts to transiently mask the NES peptid

42 arameter than the chemical shift for probing self-association, aggregation and inter-molecular intera

43 p between conformational changes and protein self-association/aggregation remains elusive due to the

44 led-coil structural feature involved in HOP2 self-association, allow us to explain important aspects

45 Moreover, we find that YY1 self-association also occurs in vivo using bimolecular f

46 of the second ExsA monomer in the absence of self-association also required the presence of a high-af

47 ast, deletion of the H5 alpha helix impaired self-association and anti-CD3 induced AP1/NFAT transcrip

48 Arsenite stress stimulates LRRK2 self-association and association with protein phosphatas

49 s C-terminal OB-fold domain (OB4) to mediate self-association and binding to Cdc13A.

50 y, the distinctive Ag43a L shape facilitates self-association and cell aggregation.

51 tations in the truncated region also abolish self-association and cell-death signaling.

52 utant, we found that PINK1 stimulated Parkin self-association and complex formation upstream of mitoc

53 (I17A) decreased the binding affinity of SLN self-association and converted higher order oligomers in

54 We have defined the domain involved in self-association and demonstrate that it is critical for

55 ization loss mutant of RNF144A still retains self-association and E3 ligase activity, which can be bl

56 Self-association and electron microscopy studies reveale

57 ing the molecular mechanisms involved in the self-association and fibrillization of monomeric soluble

58 picomolar affinity, but undergoes reversible self-association and has a poor pharmacokinetic profile

59 owing for the study of high-affinity protein self-association and hetero-association.

60 binds disordered proteins and promotes their self-association and higher order assembly.

61 anism by which MLL-AF6, through constitutive self-association and in cooperation with DOT-1L, activat

62 ins two distinct binding sites important for self-association and interaction with NLRP3 and the modu

63 chain length at position 233 in HrpS affects self-association and interaction with the HrpR and demon

64 eraction overlap with those required for ASC self-association and interaction with the PYDs of inflam

65 -36 side chain prevents constitutive KIR2DL1 self-association and ITIM phosphorylation.

66 patches may form the hot spots in AIM2(PYD) self-association and may represent a common mode of PYD/

67 G-like sequence is an important site for AP7 self-association and mineral nucleation, and this repres

68 testing of the biological role of arrestin-1 self-association and pave the way to elucidation of full

69 R2DL1-H36A) resulted in constitutive KIR2DL1 self-association and phosphorylation, as well as recruit

70 Type-C self-association and precipitation occurred even with a

71 trinsic disorder of the Abeta peptide drives self-association and progressive reordering of the confo

72 lation of apoptosis and inflammation through self-association and protein-protein interactions mediat

73 ires specific cleavage between F1 and F2 for self-association and rearrangement into stable postfusio

74 insight into the competition between solvent self-association and solvent-solute interactions in thes

75 lecular complex formation prevents IAPP from self-association and subsequent aggregation, reducing T2

76 secondary signal relies on EGF-induced EGFR self-association and switches suppressive recycling to d

77 s that the TM domain is required for RNF144A self-association and that the self-association may be pa

78 ion, we have characterized ASC and NLRP3 PYD self-association and their intermolecular interaction by

79 albumin (HSA) is a potent inhibitor of Abeta self-association and this novel, to our knowledge, funct

80 derstand the fundamentals of their molecular self-association and to unveil their application spectru

81 Interestingly, RNF144A-G252D still preserves self-association and ubiquitin ligase activity but loses

82 es membrane localization but is defective in self-association and ubiquitin ligase activity.

83 yopathy patients, led to a loss of Dsg2 tail self-association and underwent rapid endocytosis in card

84 t on avidity, demanding appropriate receptor self-association and/or HA multimerization.

85 omputational modeling of their dimerization (self-association) and heteroassociation supports the exp

86 carboxyl terminus (CT) in actin binding, Vt self-association, and actin bundling, we employed smalle

87 C at the interface), transient multicellular self-association, and dynamical escape from the interfac

88 astin has a decreased propensity for initial self-association, and it cross-links aberrantly into den

89 FSHR self-association appears to be required for receptor cou

90 ENTH domain membrane binding and ENTH domain self-association are also discussed.

91 Although measurements of antibody self-association are critical for understanding this com

92 usion, both proper membrane localization and self-association are important for RNF144A function.

93 t critical protein-protein interfaces in BAK self-association are limited to the alpha2-5 homodimeriz

94 ErbB2 oncogene, and find that insertion and self-association are strongly coupled in receptor homodi

95 insights into the ABCA1 reaction and suggest self-association as a functional feature of apoA-I.

96 09 SERT mutants to form a disulfide bond and self-association as evidenced by immunoprecipitation ass

97 e consistent with a monomer-dimer reversible self-association at pH 2.5, 3.5, 6.5, and 7.5.

98 ility when compared with magainin 2, resists self-association at the membrane surface and penetrates

99 d acceptor solutes must compete with solvent self-association, because the amide H-bond donor site is

100 protein concentrations (<40 mug/mL) display self-association behavior (as measured by the interparti

101 he antibodies display a complex pH-dependent self-association behavior that is strongly influenced by

102 S) moieties has been demonstrated to exhibit self-association behavior to give various distinguishabl

103 viously proposed for the inhibition of Abeta self-association by another plasma and cerebrospinal flu

104 n modulating its conformational dynamics and self-association by disrupting the disulfide bridge (Cys

105 Both types of self-association can result in precipitates, as measured

106 This reagent left the intrinsic self-association capacity of the spectrin dimers unaffec

107 f the C-terminal tail does not attenuate the self-association characteristic of HMO1 but alters the s

108 Self-association, coimmunoprecipitation with HopBA1, and

109 2-mers also form duplexes, but the observed self-association constants are strongly affected by fold

110 ociate both in vitro and in planta, and this self-association correlates with their cell death signal

111 The mutations included a Nab3 self-association defect, a Nab3-Nrd1 heterodimerization

112 s L137, C139, L140, K141, and L148 exhibited self-association defects and were required for maximal a

113 e SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse d

114 Although caspase-8 self-association depends on p62/SQSTM1, its self-process

115 Mechanistically, self-association directly promotes transcriptional repre

116 The self-association/dissociation of Grb2 represents a switc

117 Interestingly, this Atg1 self-association does not require Atg17, suggesting that

118 e show that a novel N-terminal coil, the APC self-association domain (ASAD), found in vertebrate and

119 nduced LCR-promoter looping by tethering the self-association domain (SA) of Ldb1 to the beta-globin

120 Remarkably, targeting Ldb1 or only its self-association domain to the beta-globin promoter subs

121 Ss even in the presence of intact C-terminus self-association domain.

122 lactosamine-containing glycan induced type-C self-association, even if the latter gave precipitates w

123 hat specificity determinants of higher order self-association exist.

124 n required for both cell death signaling and self-association extends to amino acid 142, thus includi

125 a TEL dimer as a model polymer, we show that self-association facilitates cooperative binding to DNA.

126 s were found to display remarkably different self-association features and optical properties, which

127 iciently high lipid/protein ratios minimized self-association for both proteins.

128 role for the SAM domain in mediating SLP-76 self-association for T-cell function.

129 Here we document self-association (homotypic interaction) of the NP of th

130 tion rates of amyloid beta peptide (Abeta40) self-association, implicated in Alzheimer's disease.

131 tion suggests that the transporter undergoes self-association in a concentration-dependent manner.

132 characterizing such concentration-dependent self-association in a high-throughput manner.

133 We now show that Hed1 undergoes self-association in a Rad51-dependent manner and binds s

134 terface involved in the tubulin longitudinal self-association in a way that inhibits nucleotide excha

135 erty of DeltaW-apoA-I to analyze the role of self-association in determining the structure and lipid-

136 Although foldamer self-association in nonpolar chloroform increased with l

137 e and properties of the macrocycles, such as self-association in solution and optical and electrochem

138 his is the first demonstration of a specific self-association in solution for the Fis1 cytoplasmic do

139 ant for good ionophoric activity than strong self-association in the bilayer.

140 , because both CMV and HSV gH/gL demonstrate self-association in the FRET system.

141 at the major transition pathway is first via self-association in the semiopen/open enzyme states, fol

142 We evaluated possible self-association in this inverted tandem conjugate via a

143 tercellular interactions and is capable of a self-association in trans.

144 Linker 2 region contributes to higher order self-association, independently of effects of Linker 2 c

145 with TRAF6, was unable to cause either TRAF6 self-association, induce the TRAF6-TAK1 association, or

146 ble competition between Gal3-Gal80 and Gal80 self-association interactions.

147 lysis, the sigma(54) binding loop 1, and the self-association interface.

148 pAA afforded peptide 7HSAP1, which undergoes self-association into a nanotube via noncovalent interac

149 ng a point mutation that blocks SAM-mediated self-association into the yan genomic locus and compared

150 Self-association is a common phenomenon in biology and o

151 Uncontrolled self-association is a major challenge in the exploitatio

152 ssociation, suggesting that constitutive MLL self-association is a more common pathogenic mechanism f

153 VWF self-association is accelerated by shear stress.

154 Self-association is an inherent property of the lipid-fr

155 A key endogenous inhibitor of Abeta self-association is human serum albumin (HSA), which bin

156 Understanding the nature and mechanisms of self-association is important for modulating these syste

157 Therefore, ExsA self-association is indispensable and provides an attrac

158 iate into Fn14 dimers, and we show that Fn14 self-association is mediated by an 18-aa region within t

159 uated in this work, suggesting that antibody self-association is more specific than previously realiz

160 Based on these data, ExsA self-association is necessary to overcome inhibition by

161 as wide opening of the flaps in concert with self-association is not observed.

162 ther, these results establish that rhodopsin self-association is not required to enable arrestin bind

163 1 x 10(4) s(-1), suggesting that N-terminal self-association is not the rate-limiting step in the pr

164 liest events in amyloid beta-protein (Abeta) self-association is nucleation of Abeta monomer folding

165 When all three light chains are bound, IC self-association is shifted to another region.

166 iners exhibit good water solubility and weak self-association (Ks </= 624 M(-1)).

167 nserved GRASP domain of GRASP65 disrupts its self-association, leading to a loss of Golgi membrane te

168 sults suggest that an A52 dimer causes TRAF6 self-association, leading to TAK1 recruitment and p38 ac

169 Dynamic, higher-order protein self-association may be a general mechanism to concentra

170 hat cis intramolecular interaction and trans self-association may be general mechanisms for regulatio

171 s had DeltaA1-488 bound, suggesting that VWF self-association may be necessary for cell activation.

172 ed for RNF144A self-association and that the self-association may be partially mediated through a cla

173 , previous observations of higher-order MinE self-association may explain this inhibition.

174 achieve multivalency through this multisite self-association mechanism facilitated by fuzzy interact

175 y structural asymmetry and that this unusual self-association mechanism is conserved from flies to hu

176 r data reveal an unexpected diversity in the self-association mechanism of TRIMs that might be crucia

177 s increased measurably the extent of FH19-20 self-association, nor did these mutations significantly

178 Self-association occurred independent of ubiquitination

179 Hill-Scatchard model whereby the Abeta(1-40) self-association occurs cooperatively and generates Abet

180 We observed that VWF self-association occurs during adsorption of VWF onto su

181 wo-hybrid experiments demonstrate that CtBP1 self-association occurs within the nucleus, and depends

182 rations but below the concentration at which self-association occurs) at different water pH (pH 0.3 t

183 steric zippers, reveal a variety of modes of self-association of Abeta.

184 The result is that self-association of alcohols does not compete with solva

185 Self-association of amyloid beta (Abeta) peptides is a h

186 We propose a model of how self-association of apoA-IV can result in spherical lipo

187 solvophobic and van der Waals forces in the self-association of apolar chains.

188 at paraspeckles may potentially form through self-association of DBHS dimers into higher-order struct

189 ogical systems and nanoscale assemblies, the self-association of DNA is typically studied and applied

190 ate and invertebrate APCs, directly mediates self-association of Drosophila APC2 and plays an essenti

191 ar interaction between these two domains and self-association of each of these domains.

192 gh the extent and functional significance of self-association of full-length Yan remain unclear.

193 ASF also induced weaker type-C self-association of galectin-3 lacking its N-terminal do

194 the complex assembles and prevents possible self-association of harmonin-a.

195 We identified key residues required for the self-association of HrpR (D32, E202 and K235) with HrpS

196 We have investigated the weak self-association of human growth hormone (hGH, KD = 0.90

197 Here, we captured the critical self-association of immature HIV-1 protease to its exten

198 omers in individual VWF multimers and on the self-association of individual VWF multimers into larger

199 d that ITIM phosphorylation is controlled by self-association of KIR and that His-36 serves as a gate

200 y, these higher-order assemblies involve the self-association of LANA into supermolecular spirals.

201 tural model for EGFR multimerization through self-association of ligand-bound dimers, in which the ma

202 ctures formed by reversible Mg(2+)-dependent self-association of linear 12-mer nucleosomal arrays usi

203 We hypothesized that impairing self-association of M1 through a small molecule 'wedge',

204 trometry we map the residues responsible for self-association of MEDI1912 and show that disruption of

205 embrane penetration of H(0) is important for self-association of membrane-bound dAmp-BAR and EndoA1-B

206 ify the amino acids responsible for aberrant self-association of monoclonal antibodies and the design

207 Self-association of MutL is quite sensitive to solution

208 and pressures up to 1 kbar are reached, the self-association of Na25'-GMP is most favoured.

209 compared with the calculated DeltaG for the self-association of NHERF1.

210 Nucleotide binding stimulates self-association of NrdR, with tri- and diphosphates sti

211 The self-association of prion protein (PrP) is a critical st

212 Self-association of proteins is important in a variety o

213 of such behavior is the role it plays in the self-association of proteins to form organized aggregate

214 mediates methyl-beta-cyclodextrin-sensitive self-association of purified gB.

215 druplex ligands were designed to exploit the self-association of quartets, being themselves synthetic

216 The self-association of R10 is stronger at lower ionic stren

217 but has been suggested to be responsible for self-association of SHARPIN, presumably via a coiled-coi

218 ts indicate that SMN tetramers are formed by self-association of stable, non-dissociating dimers.

219 o and is a major signal for cross-beta-sheet self-association of the 49-mer Phe521Leufs peptide ident

220 e novel findings suggest that ligand-induced self-association of the betaGRP-beta-1,3-glucan complex

221 the formation of chiral helical polymers by self-association of the BTA monomers through noncovalent

222 As a test case, we have probed the self-association of the chemotaxis kinase CheA, which fo

223 These results lead us to the conclusion that self-association of the G domains cannot be responsible

224 l line of experiments to detect and map weak self-association of the G domains, we analyzed NMR chemi

225 bridge at the SAM polymer interface, reduces self-association of the isolated SAM domain as well as h

226 These data suggest that self-association of the minimal CC domain is necessary f

227 ce of a significant increase in folding upon self-association of the monomers into oligomers, indicat

228 Here we find that self-association of the Nek9-CTD is needed for Nek7 acti

229 entrifugation showed concentration-dependent self-association of the peptide into a hexamer.

230 rin complex show that ligand binding induces self-association of the protein-carbohydrate complex int

231 nal properties of KIR2DL4 may be mediated by self-association of the receptor.

232 Here we demonstrate that self-association of the serine-aspartate repeat protein

233 The process involves the pH-triggered self-association of the spidroin N-terminal domain (NTD)

234 in domain severely reduced the efficiency of self-association of the VCC monomer with the beta-barrel

235 The self-association of these proteins in the presence of Zn

236 Non-orthologous ancillary factors and self-association of TP0326 via its beta-barrel may both

237 lts are in line with the solution studies of self-association of ureas.

238 Here, we show that self-association of Xenopus laevis Mcm10 is mediated by

239 heap and safe components that are capable of self-association, often through hydrogen bond interactio

240 D complex and provide first-time evidence of self-association on its luminal side.

241 cipients), post-translational modifications, self-association, or ligand binding.

242 mental validation in order to illustrate the self-association outcomes predicted by the three metrics

243 eosinophils and clarify how its polymorphic self-association pathways regulate toxicity intra- and e

244 sed to demonstrate that while extensive urea self-association persists in the flexible semiopen compl

245 echanistic aspects that underpin intertwined self-association processes in proteins.

246 We attribute differences in the self-association properties of Loqs, TRBP and PACT to di

247 We have investigated the self-association properties of MutL and its binding to D

248 y inactive, degradation product with altered self-association properties.

249 e two alpha-catenin variants differ in their self-association properties: at physiological temperatur

250 The self-association property of Nab3 adds to the previously

251 RNP formation predicts a self-association property of NPs.

252 Rca self-association regulates the CO(2) fixing activity of

253 ing, and computational modeling to study the self-association-related multivalency of galectin-3 at t

254 polymorphic properties, the details of their self-association remain elusive.

255 Disruption of self-association resulted in decreased binding to T3SS p

256 chanism of fibronectin (FN) assembly and the self-association sites are still unclear and contradicto

257 g of a spectrin peptide directed against the self-association sites.

258 ine, and myo-inositol have a tendency toward self-association; sorbitol and most other nonrenal osmol

259 Physiologic mechanisms may alter the native self-association state and contribute to apoA-I dysfunct

260 hat both the amphiphilic environment and the self-association state of CcO affect its kinetic stabili

261 all, this work suggests a model whereby this self-association stimulates the autophosphorylation of A

262 e the inter-relationship of foldamer length, self-association strength, and ionophoric ability, which

263 her, the AF6 RA1 domain efficiently mediated self-association, suggesting that constitutive MLL self-

264 first time, we have found a fully reversible self-association (tetramerisation) within this family of

265 ns or oxidation, produce an altered state of self-association that may contribute to apoA-I dysfuncti

266 icA levels, we identified a Mg(2+)-dependent self-association that occludes the ompA-recognition regi

267 uires elucidation of the structural basis of self-association, the conformational heterogeneity of di

268 is finding indicated that, in the absence of self-association, the NTD prevents binding by a second m

269 er transferrin is also able to inhibit Abeta self-association through direct binding of Abeta.

270 omer in solution but may form a homodimer by self-association through its carbohydrate recognition do

271 We show that self-association to a catalytically viable state require

272 We named this type-C self-association to distinguish it from the previously p

273 the hypothesis that LC8 binding promotes IC self-association to form a coiled-coil or other intercha

274 anges in conformation that facilitates their self-association to form pores in the mitochondrial oute

275 tetranucleosomal arrays exhibit cooperative self-association to form species composed of many copies

276 ifferent chains binding its own N termini by self-association to the active site, but a complete stru

277 y affected its cellular functions, including self-association, Tyr(925) phosphorylation, paxillin bin

278 nimal model that von Willebrand factor (VWF) self-association under shear stress can be modulated by

279 h NLRP3, rationalizing the model whereby ASC self-association upon recruitment to NLRP3 promotes clus

280 m thermodynamics and kinetics of folding and self-association using dynamic light scattering, stopped

281 heteroassociation, as well as a weaker Nank self-association, using sedimentation velocity analytica

282 idine-4-ylethynyl)benzene, which can undergo self-association via hydrogen bonding (H-bonding) to for

283 Self-association via the coiled-coil has been suggested

284 LCMV NP self-association was dependent on the presence of single

285 ntacts.The dynamic strength of the homomeric self-association was measured as a function of calcium i

286 nd a chemical modification that prevents HD5 self-association was strongly attenuating.

287 Homologous association (self-association) was more efficient than the heterologo

288 the structural determinants of higher order self-association, we studied TRIM mutants and chimeras.

289 FRET results for SLN self-association were supported by the effects of SLN ex

290 tial N-terminal threading can play a role in self-association, whereas wide opening of the flaps in c

291 sis, we propose a molecular model for e-gp41 self-association, which can guide the production of solu

292 idered both affinity for BZLF1 and undesired self-association, which can weaken the effectiveness of

293 ontributes to the efficiency of higher order self-association, which enhances the binding of TRIM5alp

294 coding for a hydrophobic motif that promotes self-association with CD1d.

295 indicate that ELP[V5G3A2-150] undergoes weak self-association with increasing temperature, and above

296 e absence of H1-4 sufficed to support SLP-76 self-association with smaller microclusters that neverth

297 tides to systematically explore biomolecular self-association with the ESI-mass spectrometry (MS) tit

298 ds of point mutations on helix insertion and self-association within the bacterial inner membrane.

299 e results suggest that interference with VWF self-association would be a new approach to treating thr

300 t the inter-protein interaction modulated by self-association yields functional changes observable fr