ライフサイエンスコーパス: self-avoidance

1 impairs dendritic arborization and dendrite self-avoidance.

2 important for neuronal self-recognition and self-avoidance.

3 evolution of a common molecular strategy for self-avoidance.

4 pulsion between processes, thereby promoting self-avoidance.

5 functions in an analogous fashion to promote self-avoidance.

6 rodevelopmental processes, including neurite self-avoidance.

7 drite and dendrite-substrate interactions in self-avoidance.

8 evere axonal arborization defect and loss of self-avoidance.

9 s) generate a repulsive signal that leads to self-avoidance.

10 ary isoforms within the same neuron restored self-avoidance.

11 icating a role for substrate interactions in self-avoidance.

12 cdhg proteins with a single isoform restores self-avoidance.

13 e same cell provides the molecular basis for self-avoidance.

14 distinguish between self and non-self during self-avoidance.

15 ity provides the molecular basis for neurite self-avoidance.

16 ies in Dscam(-/-) mice, suggesting a role in self-avoidance.

17 crine cell bodies, also indicating a role in self-avoidance.

18 ants was sufficient to significantly restore self-avoidance.

19 ontact with one another, a behavior known as self-avoidance.

20 in self-recognition and repulsion leading to self-avoidance [3-11].

21 overlap is prevented by a contact-dependent self-avoidance, a mechanism that is also employed by sen

22 Self-avoidance, a process preventing interactions of axo

23 n usually develop nonoverlapping patterns by self-avoidance, a process requiring contact-dependent re

24 ring homotypic neurons, indicating a role in self-avoidance among cells of a given type, a disruption

25 nition and non-self-discrimination to direct self-avoidance among vertebrate neurons.

26 ers a local repulsive mechanism required for self-avoidance and demonstrates the molecular complexity

27 read role in neural circuit assembly through self-avoidance and is incompatible with models in which

28 lustered protocadherins (Pcdhs) in dendritic self-avoidance and self/non-self discrimination.

29 form-specific interactions, and mediate both self-avoidance and self/non-self discrimination.

30 rons still exhibited tiling, suggesting that self-avoidance and tiling differ in their recognition an

31 mutually exclusive dendritic domains through self-avoidance and tiling mechanisms.

32 tudies have uncovered the molecular basis of self-avoidance and tiling, two fundamental principles re

33 ereby facilitates contact-mediated dendritic self-avoidance and tiling.

34 mouse indicate that DSCAM functions in both self-avoidance and tiling.

35 ore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic speci

36 They maintained unique territories though self-avoidance, and NG2(+) cell loss though death, diffe

37 hermalized elastic membranes without distant self-avoidance are believed to undergo a crumpling trans

38 evelopment of this organization by promoting self-avoidance at the level of cell types, promoting nor

39 Self-avoidance behavior has been shown to depend on cell

40 rborization suggested that contact-dependent self-avoidance between dendrite branches prevents self-c

41 idence suggests that they play a key role in self-avoidance between sister branches from neurons, whi

42 in mutant neurons, suggesting that dendritic self-avoidance, but not heteroneuronal tiling, may depen

43 Our results suggest that Dscam1-mediated self-avoidance counters extrinsic signals that are requi

44 misregulation of DMA-1 also causes dendritic self-avoidance defects.

45 ic adhesion, as well as self-recognition and self-avoidance, depending on the neuron type, brain regi

46 luding axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and

47 eceptor isoforms on sister dendrites ensures self-avoidance even when only a single isoform is expres

48 g gaps and overlaps within the arborization, self-avoidance facilitates complete coverage of a neuron

49 dicate that mouse DSCAM mediates isoneuronal self-avoidance for arborization and heteroneuronal self-

50 n often lead to repulsion, a process termed "self-avoidance." Here we demonstrate that dendrite self-

51 Dscam1 promotes self-avoidance in dendrites, axons, and prospective post

52 voidance." Here we demonstrate that dendrite self-avoidance in Drosophila da sensory neurons requires

53 ny neurons are patterned by a process called self-avoidance, in which branches arising from a single

54 axonal arbors of many neuronal types exhibit self-avoidance, in which branches repel each other.

55 Remarkably, some neurons that display self-avoidance interact freely with other neurons of the

56 SACs form autapses when self-avoidance is disrupted and fail to form connections

57 In Drosophila, self-avoidance is mediated by a large family of cell rec

58 This intrinsic self-avoidance mechanism ensures unambiguous processing

59 n Molecule (Dscam) is required for dendritic self-avoidance of all four classes of Drosophila dendrit

60 ted molecule Slit2 and its receptor Robo2 in self-avoidance of cerebellar Purkinje cells (PCs).

61 ouse gamma-subcluster (Pcdhg genes) disrupts self-avoidance of dendrites in retinal starburst amacrin

62 borizing their processes, which requires the self-avoidance of neurites from an individual cell, and

63 ance protein UNC-6 (Netrin), is required for self-avoidance of sister dendrites from the PVD nocicept

64 s raise a new set of questions: How does the self-avoidance of synaptic sites along an individual den

65 These isoforms failed to support self-avoidance or did so poorly.

66 Self-avoidance promotes complete territory coverage and

67 Self-avoidance refers to the tendency of branches from t

68 of growth, territory formation, tiling, and self-avoidance requires a quantitative comparison in con

69 Thus, self-avoidance, self/non-self discrimination, and synaps

70 orm-specific homophilic binding and regulate self-avoidance, the tendency of neurites from the same c

71 Self-avoidance, the tendency of neurites of the same cel

72 Although any isoform can promote self-avoidance, thousands are necessary to ensure that n

73 ambling algorithm combined with a variety of self-avoidance thresholds to approximately model helix-c

74 r have functions including cell identity and self-avoidance through repulsion in Drosophila, differen

75 In Drosophila, Dscam1 mediates self-avoidance, whereas Dscam2 mediates tiling.

76 eural circuit assembly, via a process called self-avoidance, whether recognition specificity is essen

77 We conclude that, in contrast to neurite self-avoidance, which requires single-cell identity medi

78 voidance for arborization and heteroneuronal self-avoidance within specific cell types to prevent fas

79 dendritic arborization and reduced dendritic self-avoidance within the OPL.