ライフサイエンスコーパス: self-complementary

1 This method is applied to a model set of self-complementary 10-base-pair sequences in which the p

2 The reaction of the self-complementary 12-mer duplex 5'-[d(ATATGTACATAT)(2)]

3 The reactions of (15)N-1 with the self-complementary 12-mer duplexes 5'-[d(ATATGTACATAT)(2

4 sis (FSCE) has been used to separate two non-self-complementary 12mer oligonucleotide duplexes: d(AAA

5 the free state and Hiwi1 PAZ domain bound to self-complementary 14-mer RNAs (12-bp + 2-nt overhang) c

6 In this article the self-complementary 16 bp oligodeoxynucleotide (CATGTGACG

7 employed to determine the structures of four self-complementary 16 bp oligonucleotides including LTR

8 Derivatives of the self-complementary 2-guanidiniocarbonyl pyrrole 5-carbox

9 uble-stranded DNA molecules derived from the self-complementary 5'-d(TTACGTACGTAA) sequence following

10 by ultraviolet-activated cross-linking of a self-complementary 5-bromodeoxyuridine (5BrU)-substitute

11 sistance we determined crystal structures of self-complementary A-form DNA decamer duplexes containin

12 the fates of single-strand rAAV (ssAAV) and self-complementary AAV (scAAV) genomes in cell lines def

13 arization-dependent and orientation-specific self-complementary AAV (scAAV) vectors as a reporter sys

14 Self-complementary AAV (scAAV) vectors have been develop

15 n-label trial (NCT02161380), the study drug (self-complementary AAV [scAAV]2(Y444,500,730F)-P1ND4v2)

16 Self-complementary AAV cassettes containing codon optimi

17 SMA-like disease with a human SMN-expressing self-complementary AAV vector - a vector that leads to e

18 The self-complementary AAV vector preparation appears to con

19 fferent coding regions of HBV delivered by a self-complementary AAV vector showed better antiviral ef

20 nd full capsids for both single-stranded and self-complementary AAV vectors indicate that the genomes

21 were equally evident for single-stranded and self-complementary AAV vectors.

22 rates for site-specific integration than are self-complementary AAV vectors; the absence of DNAPKcs d

23 Neither single-stranded nor self-complementary AAV2/9 triggered a microglia-mediated

24 Here, we show that self-complementary AAV9, bearing MeCP2 cDNA under contro

25 an unprecedented stability for dimers of its self-complementary acceptor-acceptor-donor-donor (AADD)

26 Concurrently, we generated a self-complementary adeno-associated viral (AAV) vector c

27 acy of peripheral venous administration of a self-complementary adeno-associated viral vector encodin

28 , Mokola and Ross River viral envelopes) and self-complementary adeno-associated viral vectors, serot

29 We recently demonstrated that self-complementary adeno-associated virus 9 (scAAV9) can

30 delivery approach for JNCL by generating two self-complementary adeno-associated virus 9 (scAAV9) con

31 explored a gene delivery approach using two self-complementary adeno-associated virus 9 (scAAV9) con

32 evaluated the ability of single-stranded and self-complementary adeno-associated virus pseudotype 2/9

33 We then generated the virus particle, self-complementary adeno-associated virus serotype 2 car

34 B, gene therapy that is mediated by a novel self-complementary adeno-associated virus serotype 8 (AA

35 a survival motor neuron-1 transgene using a self-complementary adeno-associated virus serotype 9 abo

36 Administration of a self-complementary Adeno-Associated Virus vector express

37 ately into plasmid vectors for generation of self-complementary adeno-associated virus.

38 en validated this combination approach using self-complementary adenoassociated virus serotype 9 (scA

39 d a single dose of a serotype-8-pseudotyped, self-complementary adenovirus-associated virus (AAV) vec

40 The host structure is composed of two self-complementary alpha,gamma-cyclic peptides bearing a

41 duced by bleomycin-catalyzed cleavage of the self-complementary alternating copolymer poly(dGdC).

42 ingle-stranded, 80-mer oligonucleotides with self-complementary, alternating purine-pyrimidine sequen

43 oxylic acid.pyridine hydrogen bond and (2) a self-complementary amide.amide hydrogen-bond interaction

44 The oligonucleotides are designed to be self-complementary and have the same chemical compositio

45 nsduction enhancement among single-stranded, self-complementary, and fragment vectors and found that

46 es, pair with themselves to form an unusual "self-complementary" antiparallel duplex containing (GGA)

47 permits the formation of a steric zipper-two self-complementary beta sheets that form the spine of an

48 Previously, we inserted two self-complementary beta-hairpin enhancing motifs into a

49 ed through the spontaneous assembly of ionic self-complementary beta-sheet oligopeptides under physio

50 l in which a dimeric duplex is formed at the self-complementary CATG tetranucleotide sequence with ex

51 melting analysis and NMR, using hybrids with self-complementary CG zipper arms or non-self-complement

52 Self-complementary chimeric oligonucleotides (COs) compo

53 Self-complementary chimeric oligonucleotides that consis

54 These ODN have a self-complementary core sequence and a 3' end poly(G) tr

55 mers of the form d(ATTA-XGCX-TAAT) and their self-complementary counterparts suggest that actinomycin

56 within a (G-C-G-C).(G-C-G-C) segment in the self-complementary d(A1-A2-G3-C4-G5-C6-T7-T8) duplex.

57 inding and the curved Scatchard plot for the self-complementary d(CGTCGACG) may thus be attributed to

58 The hairpin conformation, dominant for self-complementary d(T(m)-A(n)) oligos in solution, is d

59 Two series of self-complementary daisy chain monomers, in which a seco

60 The titration of Lambda-Rh into the self-complementary decamer containing the recognition se

61 The alternating self-complementary decamer d(GCACGCGTGC) crystallizes in

62 Daunoform reacts with the self-complementary deoxyoligonucleotide (GC)4 faster tha

63 Three sets of semi-self-complementary deoxyribonucleotide decamers with the

64 The self-complementary design of these modules facilitates t

65 The EryCIII subunits form an extensive self-complementary dimer interface at the center of the

66 The formation and properties of self-complementary dimers and a closed tetrameric square

67 When flanked by conserved sequences, the self-complementary diSSR (AT)n was also associated with

68 A parallel study was performed on the self-complementary diSSRs (AT)n and (GC)n.

69 base mismatch formed by the 8-OG:G pair on a self complementary DNA dodecamer duplex d(CGCGAATT(8-O)G

70 ant single-stranded DNA (ssDNA), or dimeric, self-complementary DNA (scDNA) genomes.

71 The non-self-complementary DNA decamer C-A-A-A-G-A-A-A-A-G/C-T-T

72 the high-resolution solution structures of a self-complementary DNA decamer duplex featuring a single

73 lysis of crystal structures of cLNA modified self-complementary DNA decamer duplexes revealed that th

74 enzymatic, and spectroscopic study of three self-complementary DNA decamer duplexes, d[GCGAATT-3'-3'

75 three-dimensional solution structure of the self-complementary DNA dodecamer (CGT_GACGT_TACG above G

76 monia upon the structure and dynamics of the self-complementary DNA dodecamer [d(CGCAGATCTGCG)]2.

77 An NMR analysis of a self-complementary DNA duplex 5'-labeled with Cy3 shows

78 For this purpose we chose a non-self-complementary DNA duplex containing the biologicall

79 mperature, and self-complementary versus non-self-complementary DNA linker strands (1- versus 2-compo

80 doxorubicin plus formaldehyde react with the self-complementary DNA octamer (GC)4 to yield five drug-

81 mor drugs adriamycin and daunomycin with the self-complementary DNA oligonucleotide GCGCGCGC, (GC)4,

82 These results suggest that annealing of self-complementary DNA sequence engages an alternative t

83 temperature induced melting transition of a self-complementary DNA strand covalently attached at the

84 e Y704A, E562A, and E564A mutants containing self-complementary DNA were compared with virus containi

85 We compared the hydration of self-complementary DNA, RNA and 2'-O-methyl (2'-OMe) oli

86 es of modified oligonucleotides based on the self-complementary dodecamer d(CGCTAATTAGCG) were synthe

87 The crystal structure of the non-self-complementary dodecamer DNA duplex formed by d(CG[5

88 d by (1)H NMR spectroscopy using a series of self-complementary dodecamer oligonucleotides that conta

89 AQS2 bound to a specially designed synthetic self-complementary dodecanucleotide (5'-CGCGAATTCGCG-3')

90 In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit.

91 ee-dimensional solution structure of the RNA self-complementary duplex [formula in text] was derived

92 ee-dimensional solution structure of the RNA self-complementary duplex [sequence: see text] was deriv

93 ons that included the coupled equilibrium of self-complementary duplex and non-self-complementary dup

94 s compared with the crystal structure of the self-complementary duplex d[GCGTATMOEACGC]2, which conta

95 a comparative spectroscopic study of a novel self-complementary duplex decamer, d(GCGAAT-3'-3'-(alpha

96 librium of self-complementary duplex and non-self-complementary duplex denaturation.

97 were investigated for four 40 base pair, non-self-complementary duplex DNA oligomers.

98 were investigated for six 22-base pair, non-self-complementary duplex DNA oligomers.

99 One strand formed a partial self-complementary duplex that was more stable than the

100 ers d(CGCAAATTTGCG) and d(TCAAGGCCTTGA) form self-complementary duplexes that present distinct target

101 formed between one of three 14-base pair non-self-complementary duplexes with variable GC content and

102 erature or transitions indicative of partial self-complementary duplexes.

103 andard 40 nt ribozyme (MDR40) that lacks the self-complementary ends.

104 The 10mer self-complementary extended oligodeoxynucleotide 5'-d(xA

105 ort regulatory RNAs processed from partially self-complementary foldbacks within longer MIRNA primary

106 novel serotypes AAV7 and AAV8 and containing self-complementary genomes in the nonhuman primate liver

107 were performed for both single-stranded and self-complementary genomes.

108 The nucleobase, having self-complementary H-bonding faces, mimics both T and A

109 ining a pendant lactam functional group form self-complementary hydrogen bonded 'dimers of dimers' in

110 These polymers assemble through self-complementary hydrogen bonding and by physical enca

111 A combination of self-complementary hydrogen bonding and metal-ligand int

112 cal outcome of the assembly is controlled by self-complementary hydrogen bonding between both individ

113 such dimers, which stabilize each other with self-complementary hydrogen bonds, by encapsulation insi

114 rvey of 14 tandem inosine pairs and 8 tandem self-complementary inosine pairs is also provided.

115 ble, and reusable, is comprised of a single, self-complementary, methylene blue-labeled DNA probe pos

116 netically the solution-state assemblies of a self-complementary monomer comprising a BB(4+) ring appe

117 sight into the aggregation behaviour of such self-complementary monomers are presented.

118 opic method for detection of duplex forms of self-complementary nucleic acid sequences has been imple

119 C, G, or T, were synthesized along with the self-complementary octamer (5meCG)4.

120 t despite the absence of a GpC sequence, the self-complementary octamer d(CGTCGACG) binds strongly to

121 gly and cooperatively to a non-GC containing self-complementary octamer d(CGTCGACG) with a 2:1 drug t

122 A self-complementary ODN uniformly substituted with dI and

123 ion structure of an interstrand cross-linked self-complementary oligodeoxynucleotide containing direc

124 investigated as a stable surrogate using the self-complementary oligodeoxynucleotide sequence 5'-d(AG

125 Four self-complementary oligodeoxyribonucleotide sequences we

126 This self-complementary oligomer crystallizes in space group

127 between the 3,6- and 2,7-carbazoles and the self-complementary oligomer d(GCGAATTCGC) have been used

128 -linked benzimidazole derivative, 5, and the self-complementary oligomer d(GCGAATTCGC) have been used

129 CE experiments with the self-complementary oligomers d(CGAGCTCG) and d(CGTCGACG)

130 led the motions of a DNA duplex built from a self-complementary oligonucleotide (5-CTTATPPPZZZATAAG-3

131 15)NH(2))}](4+) (1,1/t,t-6,2,6, 1') with the self-complementary oligonucleotide 5'-{d(ATATGTACATAT)(2

132 Moreover, the self-complementary oligonucleotide alpha-ATATATATAT did

133 nion can selectively oxidize guanines in the self-complementary oligonucleotide duplex d(AACGCGAATTCG

134 l]-1,3-dimethylthiourea (ACRAMTU) to various self-complementary oligonucleotide duplexes has been stu

135 preferred DNA-binding site 5'-AATT within a self-complementary oligonucleotide, 5'-d(CTTAATTCGAATTAA

136 We constructed 34 self-complementary oligonucleotides containing altered c

137 we tested these predictions using synthetic self-complementary oligonucleotides containing variant t

138 mycin A2 (Fe-BLM) to calf thymus DNA and the self-complementary oligonucleotides d(CGCGCG) and d(ATAT

139 Alternating self-complementary oligonucleotides starting with a 5'-p

140 The interactions of self-complementary oligonucleotides with a group of meta

141 In this model, two self-complementary, or palindromic, sequences (PAL1 and

142 nd that, independent of the tether backbone, self-complementary "palindromic" sticky ends readily for

143 and formation mechanism of the structurally self-complementary {Pd84} = [Pd84O42(PO4)42(CH3CO2)28](7

144 A series of partially self-complementary peptide nucleic acid (PNA) oligomers

145 We report here the reassembly of an ionic self-complementary peptide RADARADARADARADA (RADA16-I) t

146 s applied to the design and synthesis of two self-complementary phosphine oxide-iodotriazole hybrids

147 rand DNA synthesis, precluding inhibition of self-complementary rAAV, and did not affect the prior st

148 Using self-complementary recombinant AAV (scAAV) vectors, we g

149 Self-complementary recombinant adeno-associated virus (s

150 urons of the dorsal root ganglia (DRGs) with self-complementary recombinant adeno-associated virus se

151 om both single-stranded and double-stranded (self-complementary) recombinant AAV2 vectors preferentia

152 A) reporter-probe biosensor that displaces a self-complementary reporter, while target miRNA binds to

153 orming standard Watson Crick base-pairs with self-complementary residues C16-G17-C18-C19 and A12-G13,

154 By expressing two self-complementary RNA constructions designed to initiat

155 The crystal structure of a self-complementary RNA duplex r(GGGCGCUCC)2with non-adja

156 The equilibrium folding of a series of self-complementary RNA duplexes and the unmodified yeast

157 ters are reported for duplex formation of 48 self-complementary RNA duplexes containing Watson-Crick

158 ters are reported for duplex formation of 40 self-complementary RNA duplexes containing wobble termin

159 Subsequently a self-complementary (sc) AAV serotype 2/8 expressing mG1h

160 Transduction of SMG epithelia with self-complementary (sc) AAV2 expressing fibroblast growt

161 osine to phenylalanine (Y-F) capsid mutant), self-complementary (sc) AAV2/8 (single Y-F capsid mutant

162 We used self-complementary (sc) AAV2/8 vector to develop an RNAi

163 Titer-matched single-stranded (ss) and self-complementary (sc) AAV9 carrying the green fluoresc

164 alysis of murine liver transduced with these self-complementary (sc) vectors demonstrated rapid forma

165 Studies comparing the transduction of short self-complementary (scAAV) to full-length conventional A

166 is sufficient conformational freedom of the self-complementary segment to interact with other molecu

167 Our genome-wide analysis revealed that self-complementary segments are found in almost all prot

168 haperoning effects have evolved to constrain self-complementary segments from interaction with each o

169 ve this, we modified a DNA target, which has self-complementary sequence able to form a hairpin loop,

170 ted to form a stem-loop structure that has a self-complementary sequence at one end.

171 ype 2 (HIV-2) RNA occurs by interaction of a self-complementary sequence exposed in the loop of stem-

172 A dimer initially forms via a self-complementary sequence in the dimer initiation site

173 This effect was not observed in a control self-complementary sequence of identical length and base

174 TLC1 dimerization depends on a unique 6-base self-complementary sequence, which closely mimics palind

175 Despite having self-complementary sequences at their substrate-binding

176 structure shows how even stem-loops without self-complementary sequences can facilitate the intermol

177 e model for bimolecular hybridization of non-self-complementary sequences that can be used to calcula

178 in monomer-length catalytic RNAs which have self-complementary sequences that can occupy their trans

179 IS), competes directly with the annealing of self-complementary sequences to form a metastable kissin

180 In the dimer, two self-complementary sequences, PAL1 and PAL2, form interm

181 ssociation rates is slower than those of the self-complementary sequences, whereas that of the dissoc

182 ighly conserved GACG tetraloops that are not self-complementary sequences.

183 Although a self-complementary serotype 8 adeno-associated virus (sc

184 The melting curve of the self-complementary single strand was also measured in so

185 on the modulation of thrombin activity by a self-complementary single stranded DNA (scssDNA), which

186 Microarrays were fabricated by immobilizing self-complementary single-stranded oligonucleotides, whi

187 the supramolecular polymer with only weakly self-complementary stickers is a solid, whereas the supr

188 s of each DNA single-strand base pair with a self-complementary strand to form an octamer B-DNA duple

189 propyl-2'-deoxyuridine residues (one on each self-complementary strand) lowers the stability of the d

190 hairpin helices (formed from folding of one self-complementary strand).

191 melting analysis of these 19-base, partially self-complementary strands performed in 115 mM Na+ yield

192 ular curvature to favor the assembly of four self-complementary subunits into a pseudo-spherical caps

193 Molecules with self-complementary surfaces interact through weak interm

194 The self-complementary systems based on Thy exhibit lamellar

195 ith self-complementary CG zipper arms or non-self-complementary TC dimer arms.

196 One is a self-complementary tetraloop (H1), but the other two ste

197 ere DNA pentamer sequence TGRAA form stable "self-complementary" [TGRAATGRAA]2 duplexes (R = G or A)

198 tritopic molecule, functionalized with three self-complementary ureidopyrimidinone (UPy) motifs.

199 DNA linker length, solution temperature, and self-complementary versus non-self-complementary DNA lin

200 d rAAV8), and influenced single-stranded and self-complementary virions to comparable extents.

201 mismatches resembles those of strong-binding self-complementary -XGCY- sites which are known to be in

202 tches is comparable to the strong binding of self-complementary-XGCY-sequences.

203 Specifically, we demonstrated that the novel self-complementary Y733F capsid mutant AAV2/8 (sc-Y733F-