ライフサイエンスコーパス: self-inactivating

1 developed murine leukemia virus (MLV)-based self-inactivating and self-activating vectors to show th

2 We developed a novel conditional self-inactivating (C-SIN) vector, TL-SN, by replacement

3 Substrate-initiated, self-inactivating, cell-penetrating poly(disulfide)s (si

4 To overcome this limitation, we developed a self-inactivating DeltaG-rabies virus (SiR) that transcr

5 A self-inactivating EIAV minimal lentiviral vector that ex

6 omegalovirus minimal promoter, the vector is self-inactivating, eliminating transcription from the lo

7 n H synthase (PGHS) is a self-activating and self-inactivating enzyme.

8 Using a panel of self-inactivating gamma-retroviral vectors that express

9 We recently developed an insulated self-inactivating gammaretroviral vector, RMSinOFB, whic

10 Spleen Focus Forming Virus promoter within a self-inactivating HIV-based lentiviral vector.

11 use of cellular promoters in "enhancerless" self-inactivating integrating vectors.

12 alovirus (CMV) immediate-early promoter in a self-inactivating lentiviral vector (CSCG) is 4- to 15-f

13 reatment of children with a state-of-the-art self-inactivating lentiviral vector (LV-w1.6 WASp) has r

14 vitro fertilized ova were transduced with a self-inactivating lentiviral vector and transferred into

15 c progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding a full-leng

16 A self-inactivating lentiviral vector harboring these targ

17 e when inserted into the first intron, but a self-inactivating lentiviral vector with an internal cel

18 odeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV vi

19 such an approach using a therapeutic grade, self-inactivating-lentiviral vector, encoding codon opti

20 such an approach using a therapeutic grade, self-inactivating-lentiviral vector, encoding codon-opti

21 row and peripheral blood CD34+ cells using a self-inactivating lentivirus vector (CS-Rh-MLV-E) bearin

22 to 10-fold greater than that utilizing a non-self-inactivating lentivirus vector bearing the cytomega

23 ly integrated reporter system derived from a self-inactivating lentivirus vector, we showed in a BRG1

24 Given the shift toward self-inactivating long terminal repeats with weaker prom

25 l vectors, including lentiviral vectors with self-inactivating long terminal repeats, have been shown

26 rom the chicken beta-globin locus within the self-inactivating long-terminal repeat.

27 ressed full-length type VII collagen using a self-inactivating minimal lentivirus-based vector.

28 We have developed a self-inactivating PiggyBac transposon system for tamoxif

29 A recent study employed a self-inactivating rabies (SiR) virus that enables record

30 We developed self-inactivating retroviral vectors that incorporate ge

31 eveloped a reporter assay system employing a self-inactivating retrovirus and analyzed the cystatin C

32 We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X

33 In addition, using a self-inactivating retrovirus luciferase reporter constru

34 Fifteen self- inactivating (SIN) lentiviral vectors using 4 eryt

35 nsduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high

36 e United States to evaluate treatment with a self-inactivating (SIN) gamma-retrovirus vector containi

37 terestingly, the polyadenylation signal of a self-inactivating (SIN) HIV-1 vector was as leaky as tha

38 by use of a high-throughput screen involving self-inactivating (SIN) human immunodeficiency virus typ

39 ted using VSV-G-pseudotyped, 3rd-generation, self-inactivating (SIN) lentivector encoding gp91(phox).

40 no LTR-directed transcription and are called self-inactivating (SIN) lentivectors.

41 Via a self-inactivating (SIN) lentiviral vector a 3' RNA trans

42 oth separately and together into a series of self-inactivating (SIN) lentiviral vector backbones.

43 ells are transduced with a minimum amount of self-inactivating (SIN) lentiviral vector containing a p

44 globulin promoter and enhancer elements in a self-inactivating (SIN) lentiviral vector should lead to

45 utside of its normal MLV genome context in a self-inactivating (SIN) lentiviral vector.

46 Self-inactivating (SIN) lentiviral vectors have been dem

47 Although self-inactivating (SIN) lentiviral vectors with or witho

48 othelial-specific, and doxycycline-inducible self-inactivating (SIN) lentiviral vectors.

49 roviral/lentiviral vectors (gammaRV/LV) with self-inactivating (SIN) long terminal repeats (LTRs) and

50 nternal promoters, chromatin insulators, and self-inactivating (SIN) long terminal repeats (LTRs) may

51 The distinguishing feature of self-inactivating (SIN) retroviral vectors is the deleti

52 A self-inactivating (SIN) vector was constructed by deleti

53 The use of self-inactivating (SIN) vectors in which a deletion of t

54 added safety modification that renders them self-inactivating through the deletion of the 3' U3 enha

55 These effects were abrogated with a self-inactivating vector.

56 omoter and Deltagag(871-1612) were used in a self-inactivating-vector setting that has a further dele

57 Self-inactivating vectors devoid of viral long-terminal-

58 Self-inactivating vectors with internal heterologous reg

59 The resulting self-inactivating viruses drive global and persistent ge