ライフサイエンスコーパス: self-renewal

1 of LDH activity rescued AMPKalpha1(-/-) MuSC self-renewal.

2 heir population for extended periods through self-renewal.

3 the maintenance of embryonic stem cell (ESC) self-renewal.

4 t manner to promote ES cell pluripotency and self-renewal.

5 carcinoma cells and has been linked to their self-renewal.

6 STAT3 axis and enhances tumor stem-like cell self-renewal.

7 ansferase to promote p53 degradation and MPC self-renewal.

8 um, and the adult heart is capable of modest self-renewal.

9 gnaling, a key determinant of satellite cell self-renewal.

10 CML LSCs depend on Tcf1 and Lef1 factors for self-renewal.

11 Like PHB, HIRA is required for hESC self-renewal.

12 cretion for this pathway of hypoxia-mediated self-renewal.

13 ptional activator of genes that regulate CSC self-renewal.

14 ocalization, longevity, and the capacity for self-renewal.

15 miR-99 as a critical regulator of stem cell self-renewal.

16 nt signaling are proliferation and stem cell self-renewal.

17 ptional regulatory network in sustaining ESC self-renewal.

18 ut through the control of stem or progenitor self-renewal.

19 lated by Foxo1, whose deficiency impairs SSC self-renewal.

20 the efficiency of mouse embryonic stem cell self-renewal.

21 hat early progenitors have acquired extended self-renewal.

22 Myc/Mycn gene activity and glycolysis in SSC self-renewal.

23 A independent of its catalytic domain in ESC self-renewal.

24 ivisions producing daughter cells capable of self-renewal.

25 ta-catenin/Hoxa9/Prmt1 in governing leukemic self-renewal.

26 creases in apoptosis and impaired ability of self-renewal.

27 r on MB-HSCs to promote their quiescence and self-renewal.

28 es and signalling requirements for long-term self-renewal.

29 ain is dispensable for ESC proliferation and self-renewal.

30 f the cell, controls muscle stem cell (MuSC) self-renewal.

31 -derived MLL-CSCs and helps sustain leukemic self-renewal.

32 eases DNA damage response (DDR) and inhibits self-renewal.

33 signaling, a key governor of satellite cell self-renewal.

34 op between AURKA and FOXM1, crucial for BCSC self-renewal.

35 the subpopulations of cells that support CSC self-renewal.

36 mbryonic stem cells (mESCs) does not disrupt self-renewal.

37 ical for alveolar epithelial cell growth and self-renewal.

38 attenuated RAS-ERK-dependent BTIC growth and self-renewal.

39 R increased SCP/neurofibroma-initiating cell self-renewal, a surrogate for tumour initiation, and act

40 Our data suggest that defective self-renewal ability and leukemogenesis of MLL-Af4 myelo

41 PDK1 counteracts H19-mediated glycolysis and self-renewal ability in vitro and in vivo.

42 fective inhibition of the tumorigenicity and self-renewal ability of BCSCs.

43 s ectopic overexpression of p62 enhanced the self-renewal ability of breast cancer cells in vitro.

44 so reduces sphere formation and inhibits the self-renewal ability of breast cancer cells, resulting i

45 ritical for maintaining the stemness and the self-renewal ability of CSCs, resulting in the reduction

46 negatively affecting their repopulation and self-renewal ability, partly through the accumulation of

47 vidual human epidermal cells differ in their self-renewal ability.

48 ations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potential.

49 with POT1a protein prevents DDR, maintained self-renewal activity and rejuvenated aged HSCs upon ex

50 omodimerization, Sox2 heterodimerization and self-renewal activity.

51 exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171.

52 g (Hh) pathway transcriptional activator and self-renewal agonist, and promotes immunomodulatory drug

53 wo-way street: Sox2, a major mediator of CSC self-renewal, also governs the metastatic process.

54 lly heterogeneous and whether differences in self-renewal and activation reflected differential kinet

55 e direct input from FGF signaling to balance self-renewal and cell fate determination.

56 stem cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes a

57 che) regulates hematopoietic stem cell (HSC) self-renewal and commitment.

58 CD55 regulated self-renewal and core pluripotency genes via ROR2/JNK si

59 nowledge of the population structure and how self-renewal and de novo influx contribute to the mainte

60 cell marker, controlling the balance between self-renewal and differentiation and as a key oncogenic

61 criptional changes associated with stem cell self-renewal and differentiation and followed the matura

62 and exerts control over the decision between self-renewal and differentiation at the transcriptional,

63 lls (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therap

64 ing morphology, gene expression and in vitro self-renewal and differentiation capacity of human tips.

65 The balance between self-renewal and differentiation ensures long-term maint

66 their progeny, which promotes translation of self-renewal and differentiation factors by directly bin

67 sults show that Aub binds the mRNAs encoding self-renewal and differentiation factors in cultured GSC

68 The balance between self-renewal and differentiation is controlled by a vari

69 The balance between HSC self-renewal and differentiation is maintained by variou

70 Although the mechanisms that balance self-renewal and differentiation of a stem cell lineage

71 Controlling self-renewal and differentiation of SSCs could apply to

72 rgets enables quantitative assessment of the self-renewal and differentiation patterns of these cells

73 in adult mouse airway basal cells results in self-renewal and differentiation phenotypes.

74 Given their unique function in self-renewal and differentiation potential, stem cells m

75 of matrix mechanics in regulating stem cell self-renewal and differentiation processes.

76 chy are long-term HSCs endowed with lifelong self-renewal and differentiation properties.

77 enitors tightly regulate the balance between self-renewal and differentiation to give rise to all nep

78 stem/progenitor cells (MSPCs) undergo rapid self-renewal and differentiation, contributing to fast s

79 anding of the networks controlling stem cell self-renewal and differentiation, however, has not yet b

80 ient mice revealed that ZFP521 regulates HSC self-renewal and differentiation.

81 ermatogonial stem cells (hSSCs) must balance self-renewal and differentiation.

82 o control transcription of genes involved in self-renewal and differentiation.

83 ulated balance between renal progenitor cell self-renewal and differentiation.

84 ntrol the transcription of genes involved in self-renewal and differentiation.

85 ance our ability to control pluripotent cell self-renewal and differentiation.

86 RhoGAP-ROS-TGF-beta-p38(MAPK) balances HSPC self-renewal and differentiation.

87 ng functions to coordinate between states of self-renewal and differentiation.

88 arious tissues with efficient capability for self-renewal and differentiation.

89 of a key transcription factor for basal cell self-renewal and differentiation: SOX2.

90 s promotes a preleukemic state with enhanced self-renewal and dysregulated differentiation.

91 y identifies Sam68 as a key regulator of NPC self-renewal and establishes a novel link between modula

92 ifies Wnt/beta-catenin signalling to enhance self-renewal and expand the ISC compartment.

93 Methods for maintaining self-renewal and expansion in vivo of PGCs and controlli

94 trol cells in vitro, indicating reduction of self-renewal and expansion of neural progenitors by IE2.

95 The vascular niche drives a robust self-renewal and expansion phase of rEC-HSCs (days 20-28

96 rget genes were implicated in ESC and cancer self-renewal and fell into two distinct groups: those de

97 ESCs lacking Oct1 show normal appearance, self-renewal and growth but manifest defects upon differ

98 Here we report that Aub promotes GSC self-renewal and GSC progeny differentiation.

99 of Notch-mediated maintenance of type II NB self-renewal and identity, but also reveals a novel func

100 their role is nonredundant in regulating HSC self-renewal and in myeloid transformation.

101 ting purine synthesis abrogated BTIC growth, self-renewal and in vivo tumor formation by depleting in

102 Nephron endowment is determined by the self-renewal and induction of a nephron progenitor pool

103 caused LIF induction commensurate with GCSC self-renewal and inhibition of differentiation.

104 fate, with a high glycolytic flux supporting self-renewal and inhibition of glycolysis stimulating di

105 o, epidermal PRMT1 loss abolished progenitor self-renewal and led to premature differentiation.

106 ighly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro.

107 U.1-a key master regulator for hematopoietic self-renewal and lineage specification-requires HDAC act

108 These cells were also capable of self-renewal and maintained their phenotypic and functio

109 eural stem cell fate ensuring adequate NSPCs self-renewal and maintenance during development.

110 P plays an important role in regulating aNSC self-renewal and maintenance in the adult brain, which m

111 formation, indicating that JNK promotes CSC self-renewal and maintenance in TNBC.

112 ssion of their activity is necessary for the self-renewal and maintenance of muscle stem cells (satel

113 conditional Jak1 loss in HSCs reduces their self-renewal and markedly alters lymphoid/myeloid differ

114 Stemness, as "self-renewal and multipotency," seems not to be limited

115 rogenitors, FLT3(ITD) simultaneously induces self-renewal and myeloid commitment programs via STAT5-d

116 ), a well established regulator of stem cell self-renewal and neurogenesis.

117 mek/Mbd3/NuRD axis-mediated control of NPCs' self-renewal and neuronal differentiation during mammali

118 d3) and the complex plays a critical role in self-renewal and neuronal differentiation of NPCs.

119 tion and show no decrease in repopulation or self-renewal and no increase in DNA damage, even in the

120 NA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predominant

121 hypothesized to account for the 'stemness' - self-renewal and pluripotency - shared between embryonic

122 e cellular functions, such as maintenance of self-renewal and pluripotency of stem cells.

123 ption factors play a major role in stem cell self-renewal and pluripotency, their integration with si

124 role in controlling embryonic stem (ES) cell self-renewal and pluripotency.

125 found that Twist overexpression augments CSC self-renewal and population and that Skp2 inhibition rev

126 ly, SOX1 over-expression moderately promotes self-renewal and proliferation in GSCs.

127 were more tumorigenic, had a higher rate of self-renewal and proliferation, and were more sensitive

128 d GSCs and conventional cell lines decreases self-renewal and proliferative capacity in vitro and tum

129 et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic ste

130 histone deacetylation in stem cells enables self-renewal and rapid restriction of developmental pote

131 on in aged muscles, decreased satellite cell self-renewal and regenerative potential, and increased n

132 As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occ

133 ial cells (ECs) from young mice promoted HSC self-renewal and restored immune cell content in aged mi

134 hages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at

135 ey were less dependent on growth factors for self-renewal and showed a reduced capacity to differenti

136 ty in regulating ESC differentiation but not self-renewal and suggests the existence of context-speci

137 In addition, the RB family is required for self-renewal and survival of human embryonic stem cells

138 d nuclear role in hESCs that is required for self-renewal and that it acts with HIRA in chromatin org

139 CD55 as a unique signaling node that drives self-renewal and therapeutic resistance through a bifurc

140 erived bone morphogenetic proteins (BMPs) on self-renewal and therefore facilitates metastasis initia

141 , and the inhibition of migration, invasion, self-renewal and tumor formation of these two cancer typ

142 stem cells (CSCs), which are responsible for self-renewal and tumor growth in heterogeneous cancer ti

143 and we demonstrate that IMP3 contributes to self-renewal and tumor initiation, properties associated

144 has been shown to significantly promote GSC self-renewal and tumor progression.

145 overexpressed and participated in stem cells self-renewal and tumorigenesis initiating of prostate ca

146 onal regulation plays key roles in stem cell self-renewal and tumorigenesis.

147 type, the Wnt pathway can promote stem cell self-renewal and/or direct lineage commitment.

148 nic stem cells whose quiescence, activation, self-renewal, and differentiation are influenced by oxyg

149 The homeostatic balance between quiescence, self-renewal, and differentiation of HSCs is strongly de

150 n driven by BCL-XL modulation of RAS-induced self-renewal, and during which apoptotic resistance is n

151 ion factors, is necessary and sufficient for self-renewal, and is suppressed by TLR4 overexpression i

152 ut in order to specify survival, DNA repair, self-renewal, and proliferation.

153 ristics such as clonal expansion, longevity, self-renewal, and robust recall responses to antigenic o

154 synergistic tumor cytotoxicity, blunting of self-renewal, and strong anti-tumor responses, in vivo i

155 this study, we show that differentiation and self-renewal arise as opposing outcomes of sibling CD4(+

156 required for normal haematopoietic stem cell self-renewal, Asxl2 loss promoted AML1-ETO leukemogenesi

157 hich tumor cells maintain abnormal states of self-renewal at the expense of normal maturation.

158 F1alpha/2alpha dKO myoblasts exhibit reduced self-renewal but more pronounced differentiation under h

159 These data suggest that PGCs do not undergo self-renewal but rapidly enter meiosis following transpl

160 gin transcriptional memory in regulating CSC self-renewal, but also reveal a novel molecular network

161 nt proteins are unable to induce Lgr5(+) ISC self-renewal, but instead confer a basal competency by m

162 Aub controls GSC self-renewal by preventing DNA-damage-induced Chk2 activ

163 results suggest that Icaritin enhances mESCs self-renewal by regulating cell cycle machinery and core

164 se embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues.

165 Hence, invasion and self-renewal capabilities were strongly decreased.

166 r a very significant role for PRMT5 in GBMNS self-renewal capacity and proliferation.

167 their CD24(+)/CD44(lo) population, enhanced self-renewal capacity and reduced expression of E-cadher

168 Only EVP cells and not TA and D cells had self-renewal capacity as demonstrated by colony-forming

169 We also demonstrate functional self-renewal capacity for CD34(+) cells to drive the dev

170 osity, decreased bone mass, and impaired MSC self-renewal capacity in mice.

171 es mESCs proliferation while maintains their self-renewal capacity in vitro and pluripotency in vivo.

172 D34(+) CP-CML cells, reducing the number and self-renewal capacity of CML LSC in vitro.

173 on of self-sustained clocks, compromises the self-renewal capacity of mammary epithelia.

174 dies have shown that Hh inhibitors block the self-renewal capacity of SCLC cells, the lack of activat

175 rEC-HSCs have a transcriptome and long-term self-renewal capacity similar to those of adult haematop

176 ut the need for mesenchymal support, exhibit self-renewal capacity, and display additional AEC2 funct

177 g in decreased hematopoietic stem cell (HSC) self-renewal capacity, myeloid skewing, and immune cell

178 pluripotency-associated gene expression and self-renewal capacity.

179 Apc-Grp78 double mutant stem cells had lost self-renewal capacity.

180 last to adipocyte coupled with a decrease in self-renewal capacity.

181 the drug imatinib mesylate, and differential self-renewal capacity.

182 ntains the disease, exhibiting properties of self-renewal, cell cycle quiescence, and chemoresistance

183 paracrine mediators of glioma stem-like cell self-renewal could potentially contribute to the treatme

184 pluripotency '2i' media, suggesting that the self-renewal defect is mediated through pluripotency net

185 ers the expression of genes critical for HSC self-renewal, differentiation and apoptosis in Lin(-)cKi

186 GSC interactions with their niche influence self-renewal, differentiation and drug resistance, altho

187 es on many aspects of HSC biology, including self-renewal, differentiation, ageing, niche, and divers

188 hts into how these networks control potency, self-renewal, differentiation, and aging of highly proli

189 ierarchy, from EVP to TA to D, as defined by self-renewal, differentiation, and molecular profiling o

190 duces aberrant hematopoietic stem cell (HSC) self-renewal/differentiation, implicating TET2 as a mast

191 itide-dependent protein kinase 1 ) augmented self-renewal division, and long-term SSC cultures were d

192 m a nonpermissive strain that showed limited self-renewal division.

193 hronously completes four traceable symmetric self-renewal divisions to expand its size before enterin

194 feration, differentiation, localization, and self-renewal during homeostasis.

195 be essential for CML stem cell survival and self-renewal during imatinib mesylate (IM) treatment.

196 y at the level of proliferation, cell cycle, self-renewal, epithelial-mesenchymal transition, invasio

197 rtant as the intestinal epithelium undergoes self-renewal every 4-7 days through a continuous process

198 features: Hox gene overexpression, enhanced self-renewal, expansion of hematopoietic progenitors, an

199 mammalian stem cells by distinct priming and self-renewal factors, with broad implications for precis

200 ranslationally controlling the expression of self-renewal factors.

201 s that depend on a balance between stem cell self-renewal for continuity and the formation of progeni

202 By contrast, Six2 maintains later progenitor self-renewal from the onset of nephrogenesis.

203 ryptophan residues ablating dimerization and self-renewal function completely.

204 tes, whereby FOXO1 binds to multiple crucial self-renewal genes and is required for their activation.

205 nduction of anchorage-independent growth and self-renewal in 3D-spheroid conditions.

206 Herein, we show that miR-99 regulates self-renewal in both HSCs and LSCs.

207 gehog (Hh) signaling regulates cell fate and self-renewal in development and cancer.

208 ary but distinct roles to fuel unconstrained self-renewal in GBM stem cells via transcriptional contr

209 are required for maintaining satellite cell self-renewal in hypoxic environments.

210 tified S100A4 as a critical regulator of GSC self-renewal in mouse and patient-derived glioma tumorsp

211 ry basal cells but known to be essential for self-renewal in other stem cell populations.

212 esents a critical mechanism driving aberrant self-renewal in preleukemic cells expressing the t(8;21)

213 blast Growth Factor (FGF) signaling promotes self-renewal in progenitor cells by encouraging prolifer

214 plays an important role in the regulation of self-renewal in stem cells.

215 e gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained u

216 ere hypersensitive to IL-7, exhibited marked self-renewal in vitro and in vivo, and were able to init

217 ematopoietic stem and progenitor cell (HSPC) self-renewal in vitro and in vivo.

218 levels of p38(MAPK) activity and loss of HSC self-renewal in vivo.

219 n HSPCs and is correlated with increased HSC self-renewal in vivo.

220 Aberrant proliferation, symmetric self-renewal, increased survival, and defective differen

221 e functional features, including high clonal self-renewal, independence from MEK/ERK signaling, depen

222 increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

223 inhibit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and increased the

224 essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing.

225 f small molecules in modulation of stem cell self-renewal is a promising approach to expand stem cell

226 The enhancement of mESCs self-renewal is characterized by increased population in

227 ferentiation versus returning to quiescence (self-renewal) is crucial for tissue repair.

228 induce similar signaling cascades that drive self-renewal, migration, differentiation or a combinatio

229 Silencing MLK4 suppresses self-renewal, motility, tumorigenesis, and radioresistan

230 oduced owing to persistent activation of the self-renewal network and a lack of termination cytokines

231 n inducible Irf8 and beta-catenin progenitor self-renewal network control the transient formation of

232 functional pathways that mediate growth and self-renewal of alveolar type 2 progenitor cells, includ

233 testinal IR-induced injury by regulating the self-renewal of B1a cells.

234 ed in breast and other cancers, and promotes self-renewal of cancer stem-like cells.

235 y to form tumorspheres, indicating a reduced self-renewal of CCSC due to reduced levels of O-GlcNAc.

236 y secrete factors that promote expansion and self-renewal of CSCs.

237 tion factor CNOT3, which is known to control self-renewal of embryonic stem cells (ESC).

238 4 (iOCT4) supports long-term LIF-independent self-renewal of ES cells cultured in media containing fe

239 methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulati

240 ator of Transcription 3) axis to enhance the self-renewal of glioma stem-like cells.

241 oles in haematopoiesis, including regulating self-renewal of haematopoietic stem cells (HSCs) as well

242 myeloid malignancies by conferring enhanced self-renewal of hematopoietic stem and progenitor cells

243 g pregnancy leads to impairment of long-term self-renewal of hematopoietic stem cells.

244 ays demonstrate that Asxl2 loss enhances the self-renewal of HSCs.

245 d prohibitin (PHB) as an essential factor in self-renewal of human embryonic stem cells (hESCs).

246 nockdown of PAR1 inhibited the expansion and self-renewal of human GBM-derived A2B5(+) TPCs in vitro,

247 g pathways that are sufficient for long-term self-renewal of human tips as differentiation-competent

248 ey role for AC in maintaining malignancy and self-renewal of invasive melanoma cells.

249 d for development and maintenance of AML and self-renewal of leukemia stem/initiation cells (LSCs/LIC

250 esidues is a regulatory mechanism to control self-renewal of LSCs and indicates that PRMT5 may repres

251 Icaritin, a phytoestrogen molecule enhances self-renewal of mouse embryonic stem cells (mESCs).

252 7,8-tetrachlorodibenzo-p-dioxin on long-term self-renewal of murine hematopoietic stem cells.

253 tification of specific factors that regulate self-renewal of normal and cancer stem cells remains lim

254 n region 1 homolog (mouse)] is essential for self-renewal of normal and cancer stem cells.

255 components from natural plant to improve the self-renewal of SSCs.

256 ll proliferation and differentiation and the self-renewal of stem cells by inducing beta-catenin-depe

257 t in understanding the mechanisms that drive self-renewal of stem cells.

258 presenting cell (APC) types that sustain the self-renewal of TH17 cells.

259 homeostasis, and sustains the expansion and self-renewal of this stem cell pool during regeneration.

260 of TEAD4 and p63, two regulators controlling self-renewal of villous cytotrophoblasts.

261 enriches receptors essential for maintaining self-renewal on the cytoplasmic membrane to cope with lo

262 Aid loss does not contribute to enhanced HSC self-renewal or cooperate with Flt3-ITD to induce myeloi

263 of exogenous molecules to control stem cell self-renewal or differentiation has arrived at natural p

264 Understanding and blocking the self-renewal pathway of preleukemia stem cells could pre

265 hPSC self-renewal versus amniogenesis under self-renewal-permissive biochemical conditions.

266 rotein Musashi-2 (MSI2) induces multiple pro-self-renewal phenotypes, including a 17-fold increase in

267 of autophagy; augmentation of GBM stem cell self-renewal; possible implications of GBM-endothelial c

268 ulate a shared network of genes that control self-renewal potential in both stem and mature cells.

269 ACF significantly inhibited growth and self-renewal potential of several glioblastoma neurosphe

270 MLL-Af4 activated a self-renewal program in a lineage-dependent manner, show

271 t that tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as a means

272 ive action of deregulated genes that perturb self-renewal, proliferation, and differentiation.

273 pulation of cancer cells that are capable of self-renewal, proliferation, differentiation, plastic ad

274 ogram hematopoietic stem cells with improved self-renewal properties.

275 LIS2 domains are required to drive increased self-renewal properties.

276 f hematopoietic stem cells (HSCs), including self-renewal, quiescence, differentiation, and migration

277 AMPKalpha1(-/-) MuSCs displayed a high self-renewal rate, which impairs muscle regeneration.

278 y block differentiation and promote aberrant self-renewal remain unclear.

279 ion of the phosphatidylinositol 3-kinase/Akt self-renewal signaling pathway or stimulation of differe

280 ronment-derived survival, proliferation, and self-renewal signals for engraftment of normal and malig

281 f several miRNAs involved in EMT and/or cell self-renewal such as miR-34a-5p, miR-34c-5p, miR-21-5p,

282 the coordination of colonic epithelial cell self-renewal, suggesting this factor as a new biomarker

283 ry to enable Nanog to confer LIF-independent self-renewal, the mechanism of dimerization and the effe

284 ernal-imprinted locus Dlk1-Gtl2 maintain HSC self-renewal through the inhibition of PI3K-mTOR signali

285 thelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial

286 unction and their consequences for stem cell self-renewal, tissue homeostasis, and regeneration.

287 Asymmetric division enables self-renewal to be coupled to production of differentiat

288 ial-mesenchymal transition (EMT) program and self-renewal traits (CSCs) via various signaling pathway

289 acetylase Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the

290 rogenesis and neuroprotection, levels of pro-self-renewal transcripts in hematopoietic and patient-de

291 Microglial self-renewal under steady state conditions constitutes a

292 tance of developmental pathways in promoting self-renewal versus a pathological response to tissue in

293 niche factors act as a switch to toggle hPSC self-renewal versus amniogenesis under self-renewal-perm

294 amage response, for epithelial cell survival/self-renewal via a Dclk1 dependent mechanism, and these

295 tors, as has been previously suggested, this self-renewal was instead WNT-dependent.

296 GSK3beta is sufficient to maintain mouse ESC self-renewal, whereas GSK3alpha inhibition promotes mous

297 th Factor Receptor (EGFR) signaling promotes self-renewal, whereas Notch signaling promotes different

298 form cancer-initiating cells and to undergo self-renewal, which is suggestive of a key role for AC i

299 Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation

300 s) show an age-dependent capacity to balance self-renewal with differentiation.