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1 se a suicide inhibition mechanism to inhibit self-splicing.
2 ing group stabilization during both steps of self-splicing.
3 at catalyzes the two sequential reactions of self-splicing.
4 re NanGIR1 to group I introns that carry out self-splicing.
5 erved for protein-facilitated group I intron self-splicing.
6 ease reaction analogous to the first step of self-splicing.
7  processes ranging from DNA synthesis to RNA self-splicing.
8 f the ligated exons after the second step of self-splicing.
9  at the 3'-splice site in the second step of self-splicing.
10 e metal ion cluster, catalyzes both steps of self-splicing.
11  significantly more dynamic and complex than self-splicing.
12 -dependent splicing, relative to the rate of self-splicing.
13 interferes with protein binding but not with self-splicing.
14 ween 4 and 50 mM Mg(2+), where the intron is self-splicing.
15                  Exon mutations that inhibit self-splicing 100-fold in vitro were fully rescued when
16          During the initial event in protein self-splicing, a peptide bond to the nitrogen atom of an
17  the tRNA-Leu intron and tested the in vitro self-splicing ability of a diverse collection of these r
18                                        Thus, self-splicing activity is supported in the mammalian cel
19  HIV-1 TAR element was synthesized using the self-splicing activity of a group I permuted intron-exon
20 an evolutionary process in which the loss of self-splicing activity was compensated by the recruitmen
21  the bI4 group I intron and facilitating its self-splicing activity.
22 ange in the intron core that correlates with self-splicing activity.
23 f a ribozyme (D135) that is derived from the self-splicing ai5gamma intron from yeast mitochondria.
24 at excise themselves at the protein level by self-splicing, allowing the formation of functional, non
25                   To determine their role in self-splicing and in protein-assisted splicing, several
26                The mechanisms underlying the self-splicing and mobility of a few model group I intron
27  the first reports that certain RNAs mediate self-splicing and precursor tRNA processing reactions in
28 on with P10 after the first chemical step of self-splicing and release of the ligated exons after the
29 oup II introns, capable of carrying out both self-splicing and retromobility reactions, is hypothesiz
30 ly active structures that catalyze their own self-splicing and subsequent transposition into DNA.
31 s at the 5'-splice site in the first step of self-splicing, and P10 forms at the 3'-splice site in th
32  recover >60% enzymatic activity upon intein self-splicing at temperatures >59 degrees C.
33 mostable xylanase (XynB) with a thermostable self-splicing bacterial intein to control the xylanase a
34  unrecognized role of the G.U wobble pair in self-splicing: breaking cooperativity in base pair forma
35    Most mutations at either position inhibit self-splicing, but can be suppressed by CYT-18.
36 est that a high Mg(2+) concentration induces self-splicing by globally stabilizing tertiary structure
37 des intron sequence, subclass, resident ORF, self-splicing capability, host gene, protein factor(s) i
38 ible reaction analogous to the first step of self-splicing: CCCUCUA (S) + [UC]G right harpoon over le
39    The psbA intron is the first example of a self-splicing chloroplast group II intron from any organ
40                   In addition, even the best self-splicing constructs, which produced half as much mR
41                         Here we evaluate the self-splicing efficiency of group I introns from transcr
42 by 1,000-fold, both resulting in compromised self-splicing efficiency.
43 by concomitant invasion of genes by group II self-splicing elements (which were to become introns in
44 an intron into foreign RNA or DNA by reverse self-splicing, followed by reverse transcription and rec
45                  Group I introns are mobile, self-splicing genetic elements found principally in orga
46     There are four major classes of introns: self-splicing group I and group II introns, tRNA and/or
47    The Tetrahymena ribozyme derived from the self-splicing group I intron binds a 5'-splice site anal
48 rahymena L-21 ScaI ribozyme derived from the self-splicing group I intron catalyzes a reversible reac
49         Biochemical reactions catalyzed by a self-splicing group I intron derived from Pneumocystis c
50                        A circularly permuted self-splicing group I intron from Anabaena was used to g
51                                       In the self-splicing group I intron from Tetrahymena thermophil
52 llel with the catalytic strategy used by the self-splicing group I intron from Tetrahymena.
53 inii is a mammalian pathogen that contains a self-splicing group I intron in its large subunit rRNA p
54 equence involved in rDNA-homing of a mobile, self-splicing Group I intron in Physarum was exploited.
55            Here we report the insertion of a self-splicing group I intron in the coding sequence of t
56 A potential RNA target in C. albicans is the self-splicing group I intron in the LSU rRNA precursor.
57    The P4-P6 domain RNA from the Tetrahymena self-splicing group I intron is an independent unit of t
58                     The discovery of the RNA self-splicing group I intron provided the first demonstr
59 the CTD of an ancestral fungal mtTyrRS and a self-splicing group I intron was "fixed" by an intron RN
60                                              Self-splicing group I introns come in two flavours - tho
61 ribe the presence and characteristics of two self-splicing group I introns in the sole 23S rRNA gene
62 nas reinhardtii, the psbA gene contains four self-splicing group I introns whose rates of splicing in
63                                              Self-splicing group I introns, like other large catalyti
64 amino acids (Orf142) is interrupted by three self-splicing group I introns, providing the first examp
65      P. carinii, but not humans, contain RNA self-splicing group I introns, so these functionally imp
66 ucleotide bulge are conserved in many of the self-splicing group I introns.
67 n imaging study, we selected a member of the self-splicing group II intron family, which is hypothesi
68 tion pathway executed by the spliceosome and self-splicing group II intron ribozymes has prompted the
69 ver thirty years ago, after the discovery of self-splicing group II intron RNAs, the snRNAs were prop
70 ly, we have designed a derivative of a yeast self-splicing group II intron that is able to catalyze t
71                                              Self-splicing group II introns are found in bacteria and
72 erial endosymbiosis through fragmentation of self-splicing group II introns into a dynamic, protein-r
73                                              Self-splicing group II introns may be the evolutionary p
74 are adjacent folded hairpin substructures of self-splicing group II introns that appear to interact w
75  studied intensely is domain 5 (D5) from the self-splicing group II introns, which is at the heart of
76 he NMR and crystal structures of domain 5 of self-splicing group II introns.
77                                We cloned the self-splicing group II Ll.LtrB intron from Lactococcus l
78  terminus of domain 6, during the folding of self-splicing group IIB intron constructs.
79                      An in vitro form of the self-splicing group-I intron interrupting the Azoarcus t
80                         In the first step of self-splicing, group I introns utilize an exogenous guan
81 ted for the recent, horizontal transfer of a self-splicing, homing group II intron from a cyanobacter
82 ns had surprisingly strong effects on Cr.LSU self-splicing; however, splicing of all but the P6 mutat
83                                              Self-splicing in optimal Mg2+ (>/= 150 mM) was tenfold s
84          The absence of introns that are not self-splicing in prokaryotes and several other lines of
85 adenosine base positions that compromise RNA self-splicing in the bI5 group I intron.
86 ied extensively under optimal conditions for self-splicing in vitro (42 degrees C and high magnesium
87 U) and ND1 introns, which are not detectably self-splicing in vitro.
88 long exon sequences are a major obstacle for self-splicing in vitro.
89 ron in vivo, although most mutations reduced self-splicing in vitro.
90                Both introns were found to be self-splicing in vivo and in vitro even though the termi
91 es a reaction analogous to the first step of self-splicing, in which a 5'-splice site analogue (S) an
92 gher Mg(2+) concentrations were required for self-splicing, indicating that compaction occurs before
93            They have also been identified in self-splicing inteins (protein introns).
94                           Thus, this mobile, self-splicing intron also contains its own promoter for
95 ing and reverse cyclization reactions of the self-splicing intron from Tetrahymena thermophila.
96 BCV-1 has at least three types of introns, a self-splicing intron in a transcription factor-like gene
97  PBCV-1 has at least two types of introns--a self-splicing intron in a transcription factor-like gene
98                                            A self-splicing intron in the tRNA(fMet) gene of Synechocy
99                               Insertion of a self-splicing intron into nickase blocks interference de
100                     The Tetrahymena pre-rRNA self-splicing intron is shown to function in the unnatur
101 f substrate by the ribozyme derived from the self-splicing intron of Tetrahymena thermophila involves
102  the P4-P6 domain of the Tetrahymena group I self-splicing intron to yield the folding transition tim
103                           There is a group I self-splicing intron within the gene encoding the D1 pro
104 mains 5 and 6 of the yeast ai5gamma group II self-splicing intron, revealing an unexpected two-nucleo
105 r interaction within the Tetrahymena group I self-splicing intron.
106  transpoviron, and the previously identified self-splicing introns and inteins constitute the complex
107                     CPR organisms often have self-splicing introns and proteins encoded within their
108     Mechanistic comparisons between group II self-splicing introns and the spliceosome are therefore
109                                     Group II self-splicing introns are phylogenetically diverse retro
110                 How homing endonucleases and self-splicing introns associate to form a composite self
111 omparative sequence analysis to show that in self-splicing introns belonging to subgroup IIB, the sit
112                                     Group II self-splicing introns catalyze autoexcision from precurs
113                                      Group I self-splicing introns catalyze their own excision from p
114         Our results show that both these non-self-splicing introns form most of the short range pairi
115         Interference analysis of the group I self-splicing introns from Tetrahymena and Azoarcus indi
116 potential for antisense targeting of group I self-splicing introns in fungal pathogens.
117 sted the presence of at least two additional self-splicing introns in this phage genome.
118 sive and ongoing horizontal gene transfer of self-splicing introns into extant fungal populations.
119                   The active site of group I self-splicing introns occurs at the interface of two pro
120 rita namibiensis, regularly contain numerous self-splicing introns of variable length.
121  route to branched RNA that does not require self-splicing introns or spliceosomes would substantiall
122                                              Self-splicing introns populate several highly conserved
123 of retrotransposons are thought to be mobile self-splicing introns that actively propagate themselves
124 phates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme
125  (ORFs) are frequently inserted into group I self-splicing introns.
126 teins that are encoded by genes with mobile, self-splicing introns.
127 e with homology to the maturases of group II self-splicing introns.
128 ns of genetic diversity in exons that border self-splicing introns.
129 introns, including spliceosomal and group II self-splicing introns.
130 hinery for both the spliceosome and group II self-splicing introns.
131 tential binding of drugs that target group I self-splicing introns.
132 ion, kinetic analysis reveals that AV intron self-splicing is activated only at elevated temperatures
133          However, we find that the extent of self-splicing is greatly influenced by sequences flankin
134 fied an allosteric group I ribozyme, wherein self-splicing is regulated by a distinct riboswitch clas
135 l tyrosyl-tRNA synthetase that also promotes self-splicing of group I intron RNAs by stabilizing the
136                                      Reverse self-splicing of group I introns has been demonstrated i
137                                              Self-splicing of Tetrahymena pre-rRNA proceeds in two co
138            We examined the role of omegaG in self-splicing of the 249-residue group I intron of the A
139                                              Self-splicing of the group I IVS from Tetrahymena thermo
140 ing experiments were performed and confirmed self-splicing of the introns.
141 re two distinct pathways for group II intron self-splicing: one involves 2'-OH attack and another inv
142 teins are mobile genetic elements capable of self-splicing post-translationally.
143  large family of phylogenetically widespread self-splicing protein catalysts that colonize diverse ho
144                                              Self-splicing protein elements (inteins) are attractive
145                                     Inteins, self-splicing protein elements, interrupt genes and prot
146                                We redirected self-splicing protein inteins to create 'tadpoles', chim
147                                     Inteins (self-splicing 'protein introns') might offer a solution
148 the relationship between Hh proteins and the self-splicing proteins (i.e., proteins containing intein
149               The protein environment within self-splicing proteins appears to redirect the actions o
150         Inteins are phylogenetically diverse self-splicing proteins that are of great functional, evo
151 The percentage of transcripts that underwent self-splicing ranged from 0 to 50%, depending on the con
152 r for each splicing step and has a decreased self-splicing rate in vitro.
153 site for the first step of the RNA-catalyzed self-splicing reaction and thus is a model of a potentia
154 ate our understanding of the ribozyme to the self-splicing reaction and to further the mechanistic di
155  is also a suicide inhibitor of the intron's self-splicing reaction in vitro.
156   The transition state of the group I intron self-splicing reaction is stabilized by three metal ions
157  we are able to extend the mechanism for the self-splicing reaction of this intron by proposing two d
158                               As part of its self-splicing reaction, this ribozyme catalyzes phosphor
159 s and raises new questions about the overall self-splicing reaction.
160 tore host protein function through a protein self-splicing reaction.
161  been used to dissect aspects of the group I self-splicing reaction.
162 helix that position the P1 substrate for the self-splicing reaction.
163                                              Self-splicing reactions also accompany the maturation of
164 n contrast to results reported for analogous self-splicing reactions using a Tetrahymena ribozyme.
165 chanism are conserved between Hh-C17 and the self-splicing regions of inteins, permitting reconstruct
166 e the 5'-exon-intron recognition duplex of a self-splicing ribozyme as a model system to study the in
167  The Tetrahymena ribozyme is a model group I self-splicing ribozyme that has been shown to be useful
168              Our findings indicate that some self-splicing ribozymes are not selfish elements but are
169                                      Group I self-splicing ribozymes commonly function as components
170                         Group II introns are self-splicing ribozymes that catalyze their own excision
171                         Group II introns are self-splicing ribozymes that share a reaction mechanism
172  intron ribozymes and a catalytically active self-splicing RNA containing full-length intron and shor
173                   Folding of the Tetrahymena self-splicing RNA into its active conformation involves
174                  The Tetrahymena thermophila self-splicing RNA is trapped in an inactive conformation
175                         Group II introns are self-splicing RNA molecules that also behave as mobile g
176                         Group II introns are self-splicing RNA molecules that are of considerable int
177                 We show that the Tetrahymena self-splicing RNA partitions into a population that rapi
178 zoarcus tRNA(Ile) is an exceptionally stable self-splicing RNA.
179 ng 43B site; and (c) the group I intron is a self-splicing RNA.
180                         Group II introns are self-splicing RNAs found in eubacteria, archaea, and euk
181                                              Self-splicing RNAs must evolve to function in their spec
182                         Group II introns are self-splicing RNAs that are commonly found in the genes
183                       Since the discovery of self-splicing RNAs, it has been suspected that the snRNA
184 yme catalyzing 5' maturation of tRNAs) and a self-splicing rRNA of Tetrahymena, respectively.
185                  Use of the naturally split, self-splicing Synechocystis sp. PCC6803 DnaE intein perm
186                                          The self-splicing system that we describe should facilitate
187 2.8 A crystal structure of one domain of the self-splicing Tetrahymena group I intron was reported.
188  reporter ribozyme constructs consist of the self-splicing Tetrahymena thermophila group I intron rib
189  of these oligonucleotides inhibit precursor self-splicing via a suicide inhibition mechanism.
190 e tested for their ability to inhibit intron self-splicing via a suicide inhibition mechanism.
191 e binding steps of Tetrahymenagroup I intron self-splicing, which have positive or zero DeltaH terms,
192  strongly in CBP2-dependent splicing than in self-splicing, yield a cost for protein facilitation of

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