ライフサイエンスコーパス: self-tolerant

1 T-cell repertoire that is MHC restricted and self-tolerant.

2 c inhibitory receptors, yet are nevertheless self-tolerant.

3 not regulated by MHC class I and yet remain self-tolerant.

4 hich immature bone marrow B cells can become self-tolerant.

5 mice and TAP-1(-) mice, they are completely self-tolerant.

6 a key role in the generation of a strong yet self-tolerant adaptive immune response, essential in the

7 cyte development and selection important for self-tolerant adaptive immunity.

8 Such NK cells nevertheless remain self-tolerant and exhibit a generalized hyporesponsivene

9 enous Vbeta(+), CD4(+) T cells that are both self-tolerant and functional.

10 s thymocyte development toward production of self-tolerant and functionally competent T cells.

11 Together, these mechanisms ensure a self-tolerant and maximally discriminating NK cell popul

12 ironments responsible for the development of self-tolerant and self-restricted T cells.

13 ure T cell repertoire is MHC restricted, yet self tolerant at the same time.

14 s the development of distinct populations of self-tolerant B cells and ultimately the production of a

15 Generation of a self-tolerant but antigen-responsive T cell repertoire o

16 to regulate the maturation and selection of self-tolerant CD4+ and CD8+ T cells.

17 ypothesis' to explain the mechanism by which self-tolerant cells could kill targets that had lost sel

18 at respond positively to foreign antigen and self-tolerant cells that respond negatively to self-anti

19 icroenvironments regulate the development of self-tolerant conventional CD4(+) and CD8(+) alphabetaT

20 of multiple mechanisms in rendering NK cells self tolerant - including selection for expression of se

21 ecific autoimmune disease, even in otherwise self-tolerant individuals.

22 the transplanted stem cells to develop into self-tolerant lymphocytes.

23 apoptotic signaling during the generation of self-tolerant lymphocytes: the apoptotic death of B and

24 ls survive both of these processes to form a self-tolerant mature repertoire, mice were constructed w

25 tribute to the alloreactive potential of the self-tolerant murine NK cell repertoire.

26 This process results in two types of self-tolerant NK cells--licensed or unlicensed--and may

27 Foxo pathway probably enables a diverse and self-tolerant population of T cells in the steady state,

28 ptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are gener

29 ion of thymocytes during their selection for self-tolerant receptor specificities.

30 on the efficient generation of a diverse but self-tolerant repertoire of T cells by the thymus throug

31 r-specific T cells that are available in the self-tolerant repertoire.

32 We also conclude that a self-tolerant system must have a mechanism of central to

33 maturation of immunocompetent T cells with a self-tolerant T cell antigen receptor repertoire.

34 presenting-cell (APC) subsets in selecting a self-tolerant T cell population remains unclear.

35 print upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities.

36 the basis for selection of a functional and self-tolerant T cell repertoire and is quantified by rep

37 ing in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo.

38 splantation in the generation of a broad but self-tolerant T cell repertoire, but it is exquisitely s

39 own to be critically important for shaping a self-tolerant T cell repertoire, its role in MEC maturat

40 fferentiation and selection of a functional, self-tolerant T cell repertoire.

41 generation and maintenance of a diverse and self-tolerant T cell repertoire.

42 ection) of developing thymocytes generates a self-tolerant T cell repertoire.

43 lection, resulting in a self-MHC-restricted, self-tolerant T cell repertoire.

44 to the thymus medulla, a site that nurtures self-tolerant T-cell generation following positive selec

45 er of immature thymocytes required to form a self-tolerant T-cell pool.

46 rtance of medullary microenvironments during self-tolerant T-cell production in the thymus.

47 Development of a self-tolerant T-cell receptor (TCR) repertoire with the

48 Generation of a diverse and self-tolerant T-cell repertoire requires appropriate int

49 critical for the development of a mature and self-tolerant T-cell repertoire.

50 the development of a self-MHC-reactive, yet self-tolerant, T cell repertoire.

51 function between thymic APCs in shaping the self-tolerant TCR repertoire and reveal an unappreciated

52 Positive selection of diverse yet self-tolerant thymocytes is vital to immunity and requir