ライフサイエンスコーパス: semaphorin

1 utonomously sensitizes ORN axons to external semaphorins.

2 exinA4 homolog, PLX-1, and two transmembrane semaphorins.

3 uit through the repulsive action of secreted semaphorins.

4 eptors that bind the axon guidance molecules semaphorins.

5 cues, such as the cell surface glycoproteins Semaphorin 1a (Sema 1a) and Fasciclin I (Fas I), as embr

6 yl cyclase Gyc76C genetically interacts with Semaphorin 1a (Sema-1a) and physically associates with t

7 e neuropil expressed the cell surface marker semaphorin 1a.

8 The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together t

9 The Drosophila transmembrane semaphorin-1a (Sema-1a) is a repulsive guidance cue that

10 redundant functions of N-Cadherin (CadN) and Semaphorin-1a (Sema-1a).

11 ying upregulation of axon-axon attraction by Semaphorin-1a (Sema1a) reverse signaling in the developi

12 reviously found that levels of transmembrane Semaphorin-1a, which acts as a receptor, instruct PN den

13 Here we show that semaphorin 2b (Sema2b) is a target-derived signal that a

14 Semaphorin 3A (Sema 3A), a member of semaphorin family,

15 linear regression model, rs139438618 at the semaphorin 3A (SEMA3A [OMIM 603961]) locus was significa

16 ressed genes and we investigated the role of semaphorin 3A (Sema3A) and neuropilin-1 (Nrp-1) in lymph

17 Here, we show that semaphorin 3A (Sema3A) expression overcomes the proinvas

18 Semaphorin 3A (Sema3A) is a secreted factor known to gui

19 ic genes, and that ventral astrocyte-encoded semaphorin 3a (Sema3a) is required for proper motor neur

20 our laboratory has shown that VEGF-A165 and semaphorin 3A (Sema3A) promote vessel maturation through

21 Semaphorin 3A (Sema3A), in addition to its function as a

22 We found that semaphorin 3A (SEMA3A), previously shown to act as a sup

23 Semaphorin 3A (Sema3A), which lies adjacent to this turn

24 Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepe

25 ugh the liberation of repulsive guidance cue semaphorin 3A (Sema3A).

26 etic retinopathy (PDR) had elevated vitreous semaphorin 3A (SEMA3A).

27 protein that binds the secreted guidance cue Semaphorin 3A (Sema3A).

28 p1), which is sensitive to the repellent cue Semaphorin 3A (Sema3A).

29 helly et al. show that the axon guidance cue Semaphorin 3A can promote dendrite growth by inhibiting

30 how that decorin has the ability to suppress semaphorin 3A expression within adult rat cerebral corte

31 We show that loss of Semaphorin 3A function or specific deletion of NRP1 in B

32 HMGB1 bound at the semaphorin 3A genomic locus, promoted hetrochromatin for

33 glycans, decorin has the ability to suppress semaphorin 3A in the injured central nervous system.

34 These results indicate that semaphorin 3A initiates growth cone collapse via activat

35 ridization and immunostaining confirmed that semaphorin 3A messenger RNA expression and protein level

36 ecorin treatment decreased the expression of semaphorin 3A messenger RNA in cultured rat leptomeninge

37 ; in fact, treatment of primary neurons with Semaphorin 3A rescues Ndr2 knock-down-induced dendritic

38 orrespondingly, Ndr2-null mutant mice show a Semaphorin 3A(-/-)-like phenotype of premature dendritic

39 nistration of a ligand of plexin-A4, Sema3A (semaphorin 3A), exacerbates the cytokine storm caused by

40 These included semaphorin 3a, a guidance cue in neural development with

41 ), cell migration (Ret and EdnrB signalling, semaphorin 3A, cell adhesion molecules, Rho GTPases), an

42 Here, we demonstrate that semaphorin 3A-mediated growth cone collapse is reduced i

43 n leads to ischemia and angiogenesis through Semaphorin 3A.

44 chemia and pathological angiogenesis through Semaphorin 3A.

45 y into avascular tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with

46 (rs277470) located in a region encoding the semaphorin-3A (SEMA3A) binding domain (meta-analysis p v

47 Semaphorin-3A (Sema3A) is a major guidance cue in the de

48 Semaphorin-3A (Sema3a), a guidance protein secreted by p

49 st from beta3GnT2(-/-) OSNs and axons, while semaphorin-3A ligand expression is upregulated.

50 Semaphorin 3B (SEMA3B) is a secreted axonal guidance mol

51 e growth factor binding protein-3 (IGFBP-3), semaphorin-3B, transforming growth factor (TGF)-beta, he

52 A neurovascular guiding factor, Semaphorin 3c (Sema3c), is required for the development

53 Thus, semaphorin 3C/3D signaling is an evolutionarily conserve

54 We find that semaphorin-3C (sema3C) induces the collapse of the cytos

55 we show that the secreted guidance molecule semaphorin 3d (Sema3d) is crucial for the normal pattern

56 t guide these axons to the CZ, we found that Semaphorin 3D (Sema3D) is expressed in the anterior bulb

57 We showed recently that semaphorin 3d (Sema3d) mediates endothelial cell repulsi

58 receptor for the vascular guidance molecule semaphorin 3d (Sema3d).

59 domain (Ig), short basic domain, secreted, (semaphorin) 3D (SEMA3D) was significant (P = .0083) and

60 ow that the interaction between the secreted semaphorin 3E (Sema3E) and its receptor Plexin-D1 is a c

61 lecules that convert the interaction between Semaphorin 3E (Sema3E) and PlexinD1 into cellular behavi

62 Semaphorin 3e (Sema3e) has been shown previously to repe

63 Semaphorin 3E (Sema3E) has emerged as an essential media

64 e have identified a shared point mutation in semaphorin 3E (SEMA3E) in 2 brothers with Kallmann syndr

65 ariboni and colleagues identify mutations in semaphorin 3E (SEMA3E) in two brothers with Kallmann syn

66 Semaphorin 3E (Sema3E) plays a crucial role in axon guid

67 the striatonigral pathway involving PlexinD1-Semaphorin 3e (Sema3e) signaling.

68 idence revealed that a class III semaphorin, semaphorin 3E (Sema3E), and its receptor Plexin-D1 also

69 possible role of a secreted chemorepellent, Semaphorin 3E (Sema3E), in neutrophil migration.

70 Semaphorin 3E (Sema3E), initially identified as a neuron

71 the traditional repulsive axon guidance cue, semaphorin 3E (Sema3E).

72 RORalpha modulates semaphorin 3E transcription and neurovascular interactio

73 Here we show that Semaphorin-3E (Sema3E) is a natural negative regulator o

74 We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plex

75 It was found that Semaphorin 3F (SEMA3F), a potent inhibitor of metastasis

76 a (RORalpha) as a transcription regulator of semaphorin 3F (SEMA3F), a suppressive microenvironmental

77 st, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpress

78 on with neuropilin-2 (Npn-2) is critical for semaphorin 3F (Sema3F)-induced guidance of thalamocortic

79 The sensitivity of growth cones to semaphorin 3F and Eph receptor B2, two repulsive guidanc

80 Semaphorin 3F, a repulsive ligand to Nrp2, regulates bot

81 helial growth factor (VEGF), VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, a

82 f primary visceral SMCs with the NRP2 ligand semaphorin-3F (SEMA3F) were accompanied by inhibition of

83 addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN proc

84 are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes pr

85 ing proteins have been identified, including semaphorins [4, 5], brain-derived neurotrophic factors (

86 n this study, we show that the transmembrane semaphorin 4A (Sema4A) can also function as a receptor,

87 (T reg) cells in the absence of pDC-derived semaphorin 4a (Sema4a).

88 e show that the immune-cell-expressed ligand semaphorin-4a (Sema4a) and the Treg-cell-expressed recep

89 , protein O-fucosyltranferase 1, Notch1, and semaphorin 4B.

90 We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, pla

91 Semaphorin 4D (Sema4D) is a proangiogenic cytokine produ

92 We recently reported that Plexin B1, the Semaphorin 4D (Sema4D) receptor, is a tumor-suppressor p

93 clasts express the repulsive guidance factor Semaphorin 4D and induce contact inhibition of locomotio

94 proteins, suggesting that both plexin-B1 and semaphorin 4D are important in the promotion of PNI.

95 attracted to nerves that express its ligand, semaphorin 4D, in a Rho/Rho kinase-dependent manner.

96 ficant association to an intergenic SNP near Semaphorin 5A (SEMA5A) and provided evidence for reduced

97 Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene;

98 the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted

99 Deletion of neuronal Nrf2 results in semaphorin 6A (Sema6A) induction in hypoxic/ischemic ret

100 Here, we show that the murine transmembrane semaphorin 6A (Sema6A) is expressed in a subset of On di

101 Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical fo

102 expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs.

103 tified direction-selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of O

104 embryonic arteriogenic program and activated semaphorin 6A-dependent endothelial cell-cell repulsion.

105 specific spatial and temporal expression of semaphorin 6B (Sema6B) in chick commissural neurons sugg

106 ype B EAE due to neuronal damages induced by semaphorin 6B upregulation on CD4(+) T cells.

107 Semaphorin 7a (Sema 7a) participates in lymphocyte activ

108 DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being highly expressed on acti

109 Semaphorin 7A (Sema7A) is a membrane-associated/secreted

110 Semaphorin 7A (Sema7A) is an atypical member of the sema

111 We determined Semaphorin 7a (Sema7a) localization and abundance in nai

112 report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-in

113 n of bdnf, ngf, and the axon growth promoter semaphorin 7a (sema7a), and as a consequence, their prod

114 lso uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a

115 diated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility

116 Semaphorin 7a is a glycophosphatidylinositol membrane-an

117 ng tumor metastasis; we have identified that semaphorin 7a is a potent driver of ductal carcinoma in

118 Our results suggest that semaphorin 7a may be novel target for blocking breast tu

119 reated with an anti-Plexin C1 antibody and a Semaphorin 7A peptide reduced hepatic ischemia-reperfusi

120 nd semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen a

121 ditional role in EMT via the ERF, regulating Semaphorin-7a and providing a new interconnection betwee

122 Forced expression of Semaphorin-7a in ERF-overexpressing EpRas cells reestabl

123 In contrast, inhibition of Semaphorin-7a in the parental EpRas cells inhibited thei

124 ERF suppressed the TGF-beta-induced EMT via Semaphorin-7a repression.

125 ed phosphorylation of RPS6 and IL-3-enhanced semaphorin-7A translation.

126 o induce the production of proteins, such as semaphorin-7A, without affecting mRNA levels suggests a

127 Together, the results suggest that semaphorin activates plexin by disrupting an inhibitory

128 bladed beta-propeller (sema) domains of both semaphorin and plexin, suggests that a common mode of in

129 Thus, PlexinA1 mediates both Semaphorin and Slit signaling, and Slit processing gener

130 SEMA3F is a secreted semaphorin and tumor suppressor downregulated by TGF-bet

131 ins (NRPs), which have well-defined roles in Semaphorin and VEGF signaling, positively regulate HH pa

132 europilin 1 (Nrp1), a coreceptor for class 3 semaphorins and growth factors, is highly expressed in v

133 However, semaphorins and plexins are also expressed in the adult

134 Repulsive signaling by Semaphorins and Plexins is crucial for the development a

135 and receptors, such as ephrins and Ephs, and semaphorins and plexins, and through expression of clast

136 tute a family of transmembrane receptors for semaphorins and represent critical regulators of various

137 Here we report that Mical directly links semaphorins and their plexin receptors to the precise co

138 Semaphorins and their receptors plexins have diverse rol

139 The semaphorins and their receptors, the plexins, compose a

140 gulates other cell interaction genes such as semaphorins and their receptors, which also play a funct

141 Response to high doses of semaphorins and to all doses of ephrin-A5 is protein syn

142 Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neurona

143 europilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF

144 ) is well known as a co-receptor for class 3 semaphorins and vascular endothelial growth factors, inv

145 re transmembrane receptors that bind class 3 semaphorins and VEGF family members to regulate axon gui

146 an originally defined coreceptor for class 3 semaphorins and VEGF, plays important roles in the immun

147 The semaphorins are a family of secreted or membrane-bound p

148 Semaphorins are a large family of axon guidance molecule

149 Semaphorins are among the largest families of axon guida

150 Semaphorins are an essential family of guidance cues ubi

151 Semaphorins are dimeric molecules that activate plexin b

152 Semaphorins are key regulators of neural circuit assembl

153 Semaphorins are members of these axon guidance molecules

154 Semaphorins are one of the largest families of guidance

155 Semaphorins are phylogenetically conserved proteins expr

156 Semaphorins are secreted and membrane-bound proteins inv

157 Although class-6 semaphorins are transmembrane proteins, they have been i

158 different cell types translate extracellular semaphorin binding into intracellular signaling remains

159 f PlexinA4 and its response to activation by semaphorin binding.

160 ctures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1.

161 ystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with sem

162 he resulting bivalent 2:2 complex (monomeric semaphorin binds plexin but fails to trigger signalling)

163 Sema3C is cleaved, like other class-3 semaphorins, by furin-like pro-protein convertases (FPPC

164 studies indicate that certain transmembrane Semaphorins can also function as guidance receptors to m

165 hese substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that is polysialylated on its O-g

166 Semaphorins/collapsins were characterized in part on the

167 Semaphorins comprise a large family of ligands that regu

168 Plexins and semaphorins comprise a large family of receptor-ligand p

169 Semaphorins contribute to the balance between excitatory

170 functions in VEGF-dependent angiogenesis and semaphorin-dependent axon guidance, controlling signalin

171 In a semaphorin-dependent manner, PLX-1 is concentrated at th

172 ted alleles with loss-of-function defects in semaphorin dimerization and binding to their cognate neu

173 f wild-type and mutant proteins, reveal that semaphorin dimers independently bind two plexin molecule

174 in-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) a

175 c-receptor signalling pathway, namely immune semaphorins, facilitating immune cell interactions and t

176 endothelial growth factor (VEGF) and class 3 semaphorin families through its extracellular domain, it

177 Indeed, several semaphorin family members have been shown to have potent

178 Semaphorin family proteins are well-known axon guidance

179 rin 7A (Sema7A) is an atypical member of the semaphorin family that is GPI-linked, expressed principa

180 d is not an axon guidance cue of the class 3 semaphorin family, but VEGF164, the neuropilin-binding i

181 that a secreted guidance cue of the class 3 semaphorin family, SEMA3A, is essential for the developm

182 Semaphorin 3A (Sema 3A), a member of semaphorin family, serves as a guidance clue during embr

183 nd rescue experiments indicate that secreted semaphorins from degenerating larval ORN axons direct de

184 ng allele on chromosome 7 within the class 3 Semaphorin gene cluster.

185 svirus, (iii) it contains interleukin-10 and semaphorin genes (the first time these have been reporte

186 ing their description as axon guidance cues, semaphorins have been implicated in multiple aspects of

187 Recently, semaphorins have been implicated in the cell-cell commun

188 Semaphorins have crucial roles in several diseases; ther

189 tleneck to define roles for glial Netrin and Semaphorin in pioneer- and follower-axon guidance, respe

190 These results reveal a novel role for semaphorins in dendrite patterning and illustrate how ep

191 However, the potential contribution of semaphorins in the regulation of neutrophil migration is

192 plexin-A1-dependent manner, while most other semaphorins, including antiangiogenic semaphorins such a

193 On the other hand, a peptoid named SICHI (semaphorin-induced chemorepulsion inhibitor), which is p

194 The plexin GAP is activated by semaphorin-induced dimerization, the structural basis fo

195 midline crossing and can mediate precrossing semaphorin-induced repulsion in vitro.

196 How premature semaphorin-induced repulsion of precrossing axons is sup

197 the hybrid domain interface with the plexin-semaphorin-integrin (PSI) domain in different orientatio

198 Pathogenic hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of inactive, beta3 inte

199 T Sema domain fused to the adjacent Plexins, Semaphorins, Integrins domain (MET Sema-PSI), and the HG

200 Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepellent that disrupts neural patt

201 Neuropilin1 (Npn1), a receptor for class 3 semaphorins, is required to generate appropriate afferen

202 el endothelial cells and is the only class 3 semaphorin known to be capable of signaling via a plexin

203 Here, we show that mutations in the semaphorin ligand sema-2b lead to a dramatic increase in

204 the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic

205 Cell-cell signalling of semaphorin ligands through interaction with plexin recep

206 Therefore, this immune semaphorin links nerve regeneration and inflammatory pro

207 hat the Rac GAP beta2-Chimaerin is needed in Semaphorin-mediated axonal pruning but not growth cone r

208 ebble and RhoGAPp190 transduce transmembrane semaphorin-mediated guidance cue information that regula

209 These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB

210 data demonstrate that attenuating myelin or Semaphorin-mediated inhibition of axon growth is insuffi

211 subsequent down-regulation, and allowing for semaphorin-mediated repulsion of post-crossing axons.

212 ese findings provide an in vivo link between semaphorin-mediated repulsive axon guidance and alterati

213 In the plexin or semaphorin mutants, synaptic domains from both neurons e

214 CD100, is a constitutively expressed immune semaphorin on T cells and NK cells.

215 Semaphorins, originally discovered as axon guidance cues

216 Our findings suggest that blocking the semaphorin pathway should be investigated as a therapeut

217 lay a role in axonal development through the semaphorin pathway, which may serve as a candidate gene

218 Secreted class III Semaphorins play an important role in guidance of neuron

219 Semaphorins play important regulatory roles in diverse p

220 at a common mode of interaction triggers all semaphorin-plexin based signalling, while distinct inser

221 The complex structures support a conserved Semaphorin-Plexin recognition mode and suggest that Plex

222 Our data uncover semaphorin-plexin signaling as a central regulatory mech

223 Semaphorin-Plexin signaling is critical for many cellula

224 protein 2 (CRMP2/DPYSL2), a mediator of the semaphorin-plexin signaling pathway, as redox-regulated

225 ds on epithelial cell-cell communication via semaphorin-plexin signaling.

226 During neural development, semaphorin-plexin signalling instructs axon guidance and

227 We propose that semaphorin-plexin signalling is an essential platform fo

228 t Mical is both necessary and sufficient for semaphorin-plexin-mediated F-actin reorganization in viv

229 disassembly factor that directly responds to Semaphorin/Plexin extracellular repulsive cues.

230 revealed that Abl allows growth factors and Semaphorin/Plexin repellents to combinatorially increase

231 Focusing on Semaphorin/Plexin repulsion, we identified an interactio

232 er a simple biochemical switch that controls Semaphorin/Plexin repulsive guidance.

233 anism regulating dendrite differentiation is Semaphorin/Plexin signaling, specifically through bindin

234 functioning as a molecular sink to sequester semaphorins, preventing premature repulsion of precrossi

235 , we demonstrate that neuropilin-1 (NRP1), a Semaphorin receptor expressed in BCs, controls both axon

236 ile central nascent islet cells produced the semaphorin receptor neuropilin 2 (Nrp2).

237 Importantly, we found that the semaphorin receptor Nrp-1 is expressed on the perivascul

238 enzyme, binds the cytoplasmic domain of the semaphorin receptor plexin A and mediates semaphorin-sig

239 ads to phosphorylation and activation of the semaphorin receptor Plexin-B1.

240 Plexin-B2 is a semaphorin receptor previously known to act on neuronal

241 We evaluated the contributions of the semaphorin receptor, plexin C1 (PLXNC1), and the exocyti

242 Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nerv

243 nsiderable progress in the identification of semaphorin receptors and their signalling pathways, the

244 though the neuropilins were characterized as semaphorin receptors that regulate axon guidance, they a

245 ression of neuropilin 1 (Nrp1) and Nrp2, two semaphorin receptors that regulate neuronal cell migrati

246 Semaphorins regulate axon guidance through interaction w

247 llapse and guidance at low concentrations of semaphorins rely on local protein synthesis in the axona

248 However, Semaphorin repulsion can be silenced by other distinct c

249 s Ras family GTPase substrate and antagonize Semaphorin repulsion.

250 The mechanisms by which Semaphorin reverse signaling modulates axon-surface affi

251 rfaces are dominated by the insertion of the Semaphorin's 4c-4d loop into a deep groove in blade 3 of

252 n are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b.

253 NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascul

254 e receptors for guidance cues of the class 3 semaphorin (SEMA) family and are expressed in partially

255 known; here we identify candidates to be the Semaphorins (Sema) 3A and 3C, acting via the PlexinA rec

256 A behavioral screen identified roles for Semaphorins (Sema) and Plexins (Plex) in walking behavio

257 Attractive and repulsive molecules such as Semaphorins (Sema) trigger rapid responses that control

258 By analyzing the function of a secreted semaphorin, Sema-2b, in Drosophila olfactory receptor ne

259 Here we show that two secreted semaphorins, Sema-2a and Sema-2b, provide spatial cues f

260 lly characterized as receptors for class III Semaphorin (Sema3) family members, functioning in axon g

261 dothelial growth factor (VEGF) and class III Semaphorin (Sema3) ligand families.

262 endothelial growth factor (VEGF) and class 3 semaphorins (SEMA3).

263 in the timing control of sensitivity to the semaphorin Sema3A in Xenopus laevis retinal ganglion cel

264 We previously reported that the class 3 semaphorin SEMA3A signals through its neuropilin recepto

265 vealed a requirement for VEGF-A, the class 3 semaphorin SEMA3C, and their shared receptor neuropilin

266 The semaphorins Sema3fb and Sema3gb, which are expressed by

267 Class 3 semaphorins (SEMA3s), a group of neuron-secreted axonal

268 eurons, we previously identified the class 4 Semaphorin Sema4D as being required for proper GABAergic

269 We find that the transmembrane semaphorins Sema5A and Sema5B constrain neurites from mu

270 Here we show that the transmembrane semaphorin Sema6A signals through its receptor PlexinA4

271 and that this induction was regulated by the semaphorin Sema7a, interacting in stimulatory or inhibit

272 Genetic evidence revealed that a class III semaphorin, semaphorin 3E (Sema3E), and its receptor Ple

273 The axon guidance cues semaphorins (Semas) and their receptors plexins have bee

274 Transmembrane semaphorins (Semas) serve evolutionarily conserved guida

275 Secreted semaphorins signal through neuropilin-2/plexin-A1 recept

276 he semaphorin receptor plexin A and mediates semaphorin-signaled collapse of the actin cytoskeleton.

277 enes for both steroids and time points, was "Semaphorin Signaling in Neurons," a member of the "Axona

278 ission, and electrical activity can modulate semaphorin signaling in neurons.

279 , DCX, at ser327, and phosphorylation of the semaphorin signaling mediator, CRMP-2, at Thr514 were ma

280 Robo-Slit and Plexin-Semaphorin signaling participate in various developmenta

281 teins (Gfap, Cp, Edn2) as well as Plexna2, a semaphorin signaling receptor, whereas EphrinB receptor

282 d by the combined action of different Plexin/Semaphorin signaling systems, are required for the forma

283 Thus, TRPC5 acts downstream of semaphorin signaling to cause changes in neuronal growth

284 terial-venous patterning via Delta/Notch and semaphorin signaling.

285 ated with these pathways, notably ephrin and semaphorin signaling.

286 s and reveals a previously unknown effect of Semaphorin signalling on spatial distribution of an acti

287 genes encoding synaptic (Cplx2 and Pclo) and semaphorin signalling pathway (Crmp2, PlexinB1, Fes and

288 r a cell-cell signalling mechanism involving semaphorin-stabilized plexin dimerization, possibly foll

289 other semaphorins, including antiangiogenic semaphorins such as sema3A do not.

290 To assess the contribution of class 3 Semaphorins that are expressed by GFAP-negative meningea

291 Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic

292 ivate PlexinA2, which encodes a receptor for semaphorin to guide NCCs into the OFT.

293 2), a multifunctional nonkinase receptor for semaphorins, vascular endothelial growth factor (VEGF),

294 axon guidance molecules in this process, the Semaphorins, was not explored.

295 Class 3 semaphorins were initially described as axonal growth co

296 counterparts of cellular interleukin-10 and semaphorin, which have not been described previously in

297 Semaphorins, which are PlexA ligands, also regulate tiss

298 We believe that the plexins and semaphorins, which are strongly expressed in both axons

299 Class 3 semaphorins, which include Sema3A, are structurally cons

300 and PlexinA4, two key receptors for class 3 Semaphorins, with or without additional NgR1 deletion.

301 K108 is conserved among semaphorins, yet the loss-of-function effects associated