ライフサイエンスコーパス: semaphorin 3A

1 n leads to ischemia and angiogenesis through Semaphorin 3A.

2 chemia and pathological angiogenesis through Semaphorin 3A.

3 d myelin-associated glycoprotein, but not to semaphorin 3A.

4 ve guidance molecules, such as ephrin-A2 and semaphorin 3A.

5 towards the retina is guided by netrin-1 and semaphorin 3a.

6 h cone collapse in response to ephrin-A2 and semaphorin 3A.

7 Semaphorin 3A, a chemorepellent known to inhibit integri

8 These included semaphorin 3a, a guidance cue in neural development with

9 E7 to E12 semaphorin 3A and 3F and ephrin A2 and A5 expressions di

10 The guidance molecules Semaphorin 3A and 3F, already known to direct oligodendr

11 lacking the mediators of sensory pathfinding semaphorin 3A and neuropilin-1.

12 epulsive signal composed at least in part of semaphorin 3A and semaphorin 3F.

13 ce neuropilin-1 (NRP1), a receptor shared by semaphorin 3A and vascular endothelial growth factor (VE

14 Neuropilin-1 (Np-1), a receptor for semaphorin 3A and vascular endothelial growth factor, is

15 ntiates the signaling pathways stimulated by semaphorin 3A and VEGF-A in neuronal and endothelial cel

16 helly et al. show that the axon guidance cue Semaphorin 3A can promote dendrite growth by inhibiting

17 ), cell migration (Ret and EdnrB signalling, semaphorin 3A, cell adhesion molecules, Rho GTPases), an

18 NGF- or semaphorin 3A-coupled beads caused a significant increas

19 evealed that decorin-mediated suppression of semaphorin 3A critically depends on erythroblastic leuka

20 nistration of a ligand of plexin-A4, Sema3A (semaphorin 3A), exacerbates the cytokine storm caused by

21 Semaphorin 3A expression was observed in deep dorsal and

22 how that decorin has the ability to suppress semaphorin 3A expression within adult rat cerebral corte

23 We show that loss of Semaphorin 3A function or specific deletion of NRP1 in B

24 HMGB1 bound at the semaphorin 3A genomic locus, promoted hetrochromatin for

25 nse of dorsal root ganglion (DRG) neurons to Semaphorin 3A gradients can be divided into two steps: g

26 stem scar associated axon growth inhibitors, semaphorin 3A has been shown to be strongly expressed by

27 glycans, decorin has the ability to suppress semaphorin 3A in the injured central nervous system.

28 europilin-1 and suppressed the expression of semaphorin 3a in the podocyte.

29 In the present study, we first showed that semaphorin 3A-induced growth cone collapse in cultured h

30 Raft manipulation also blocked Semaphorin 3A-induced growth cone repulsion, inhibition,

31 These results indicate that semaphorin 3A initiates growth cone collapse via activat

32 st from beta3GnT2(-/-) OSNs and axons, while semaphorin-3A ligand expression is upregulated.

33 orrespondingly, Ndr2-null mutant mice show a Semaphorin 3A(-/-)-like phenotype of premature dendritic

34 We further determined that semaphorin 3A-mediated calpain activation and growth con

35 Thus, our results indicate that semaphorin 3A-mediated growth cone collapse is mediated

36 Here, we demonstrate that semaphorin 3A-mediated growth cone collapse is reduced i

37 ridization and immunostaining confirmed that semaphorin 3A messenger RNA expression and protein level

38 days resulted in a significant reduction of semaphorin 3A messenger RNA expression within injury sit

39 ecorin treatment decreased the expression of semaphorin 3A messenger RNA in cultured rat leptomeninge

40 y into avascular tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with

41 on cultured retinal ganglion cell axons, of semaphorin 3A on dorsal root ganglion sensory axons, and

42 d in axonal outgrowth and a component of the semaphorin 3A pathway, in switching GTPase signaling whe

43 However, myelin-associated glycoprotein and semaphorin 3A regulate axonal levels of different mRNAs

44 ; in fact, treatment of primary neurons with Semaphorin 3A rescues Ndr2 knock-down-induced dendritic

45 Semaphorin 3A (Sema 3A), a member of semaphorin family,

46 Semaphorin 3A (Sema 3A), a molecule that inhibits axonal

47 Semaphorin 3A (Sema 3A; previously known as semaphorin I

48 linear regression model, rs139438618 at the semaphorin 3A (SEMA3A [OMIM 603961]) locus was significa

49 ressed genes and we investigated the role of semaphorin 3A (Sema3A) and neuropilin-1 (Nrp-1) in lymph

50 Neuropilin-1 (Npn-1) is a receptor for both semaphorin 3A (Sema3A) and vascular endothelial growth f

51 Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and a

52 he growth-promoting NGF or growth-inhibitory semaphorin 3A (Sema3a) compared with control green fluor

53 Here, we show that semaphorin 3A (Sema3A) expression overcomes the proinvas

54 We demonstrate here that semaphorin 3A (Sema3A) induces a coordinated rearrangeme

55 Semaphorin 3A (Sema3A) is a membrane-associated secreted

56 Semaphorin 3A (Sema3A) is a secreted factor known to gui

57 ic genes, and that ventral astrocyte-encoded semaphorin 3a (Sema3a) is required for proper motor neur

58 our laboratory has shown that VEGF-A165 and semaphorin 3A (Sema3A) promote vessel maturation through

59 molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), im

60 d to produce cell type-specific responses to Semaphorin 3A (Sema3A), a guidance cue that would be pre

61 Semaphorin 3A (Sema3A), a known inhibitor of axonal spro

62 h factor (VEGF), an angiogenesis factor, and semaphorin 3A (Sema3A), a mediator of axonal guidance.

63 Semaphorin 3A (Sema3A), a secreted guidance cue that pri

64 equired for growth cone collapse elicited by Semaphorin 3A (Sema3A), an axonal guidance cue.

65 Semaphorin 3A (Sema3A), in addition to its function as a

66 We found that semaphorin 3A (SEMA3A), previously shown to act as a sup

67 Semaphorin 3A (Sema3A), which lies adjacent to this turn

68 d FGF-2 increased branching by >50%, whereas semaphorin 3A (Sema3A), which repels cortical axons, inh

69 A major component of this signal is semaphorin 3A (Sema3A), which was previously characteriz

70 Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepe

71 protein that binds the secreted guidance cue Semaphorin 3A (Sema3A).

72 p1), which is sensitive to the repellent cue Semaphorin 3A (Sema3A).

73 te growth cone responses to the guidance cue Semaphorin 3A (Sema3A).

74 exins, promotes axon repulsion by binding to semaphorin 3A (SEMA3A).

75 ugh the liberation of repulsive guidance cue semaphorin 3A (Sema3A).

76 etic retinopathy (PDR) had elevated vitreous semaphorin 3A (SEMA3A).

77 (rs277470) located in a region encoding the semaphorin-3A (SEMA3A) binding domain (meta-analysis p v

78 Semaphorin-3A (Sema3A) is a major guidance cue in the de

79 Semaphorin-3A (Sema3a), a guidance protein secreted by p

80 Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has

81 ystal structure of a secreted 65 kDa form of Semaphorin-3A (Sema3A), containing the full semaphorin d

82 We have demonstrated that semaphorin-3A (Sema3A)-induced growth cone detachment an

83 Furthermore, expression of semaphorin 3A slightly dorsal and lateral to the turning

84 Exposure of growing neurons to thrombin or semaphorin 3A stimulates a receptor-mediated signaling c

85 toration of nociception in both NGF- and NGF/semaphorin 3A-treated rats.

86 NGF and semaphorin 3A treatment also targeted the regeneration o

87 CNCs, cell processes failed to retract with semaphorin 3A treatment.

88 n superficial laminas, adenovirus expressing semaphorin 3A was injected into the ventral spinal cord

89 either of these receptors or the addition of semaphorin 3A (which blocks VEGF-165 binding to Nrp-1) p

90 Moreover, the repulsive guidance cue Semaphorin 3A, which signals through Rac1, destabilizes