ライフサイエンスコーパス: semen

1 28 to 41) and 81 days (95% CI, 64 to 98) in semen.

2 ecrease the inflammatory response induced by semen.

3 detecting the presence of Ebola virus RNA in semen.

4 lly occurring peptide fragments derived from semen.

5 blood was 4.0 log IU/mL higher than that in semen.

6 cleavage of prostatic acidic phosphatase in semen.

7 -107) recognize endogenous amyloids in human semen.

8 es targeting the viral-enhancing activity of semen.

9 be a key virus-enhancing component of human semen.

10 tted through contact with infected blood and semen.

11 y virus type 1 (HIV) compartmentalization in semen.

12 an immunodeficiency virus (HIV) RNA decay in semen.

13 sive set of proteins expressed in ejaculated semen.

14 rate and precise for detecting EBOV in whole semen.

15 xplanation for the presence of SEVI in human semen.

16 tes of cell-free and cell-associated HIV and semen.

17 RNA suggests replication in cells present in semen.

18 id tissue, gut-associated lymphoid tissue or semen.

19 virus as they continuously shed EAV in their semen.

20 nfected monocytes and lymphocytes present in semen.

21 ast milk (16 months [preliminary data]), and semen (18 months).

22 105 from mouth, 17 from the rectum, one from semen, 69 from urine, and 21 from the vagina.

23 ented for the detection of fructose in human semen, a marker of seminal vesicle function.

24 ermethylation and three independent types of semen abnormalities.

25 men in this study, ZIKV RNA was cleared from semen after about 3 months.

26 the neutralization of the mucus by alkaline semen, after sexual intercourse, allows virions to cross

27 which gallic acid modifies the properties of semen amyloids, we performed biophysical measurements (a

28 rmed scrotum, and results of one or multiple semen analyses must be documented in all men with varico

29 en from Chicago who had previously undergone semen analyses.

30 rm production have been well documented with semen analysis data.

31 es on the quantity and quality of his sperm, semen analysis is generally used as the proxy to estimat

32 We did semen analysis on 214 adult male survivors of childhood

33 nce microscopy, and correlated with clinical semen analysis parameters, and data on embryo developmen

34 Semen analysis was performed and serum levels of FSH and

35 nto routine clinical use in place of the WHO semen analysis.

36 ced limits of detection of 1000 copies/mL in semen and 275 copies/mL in blood.

37 for detection of fructose in real samples of semen and agrees well with values obtained from conventi

38 HCV RNA levels were correlated in semen and blood (r(2) = 0.142).

39 Limits of detection for both semen and blood increased with longer intervals between

40 ated 11 HIV-infected individuals with paired semen and blood samples and 4 individuals with paired CS

41 Paired semen and blood samples were assayed for HCV RNA levels.

42 r EBOV RNA detection was validated for whole semen and blood using samples obtained from uninfected d

43 espective diffusivities of viruses and Ab in semen and CVM.

44 the long-term presence of Ebola virus RNA in semen and declining persistence with increasing time aft

45 e fertility preservation techniques, such as semen and embryo cryopreservation, are established and s

46 sistence of the virus in body fluids such as semen and saliva for longer periods of time than in seru

47 reproductive risk assessment methods rely on semen and serum hormone analyses, which are not easily c

48 tted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been docume

49 key, HIV-enhancing amyloid species in human semen and underscore the dynamic nature of semen's HIV-e

50 adily detected in plasma (until day 5 or 7), semen and urine (until days 7 and 14), and saliva (until

51 re from blood, saliva, urine, aqueous humor, semen, and breast milk from infected or convalescent pat

52 e at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent.

53 by the parasite have Nosema spores in their semen, and queens artificially inseminated with either N

54 M1(86-107) amyloids are naturally present in semen, and synthetic SEM1(86-107) fibrils bind virions a

55 We collected serum, urine, saliva, semen, and vaginal secretions weekly for the first month

56 is, reduced spermatozoa concentration in the semen, and, eventually, reduced fertility.

57 TCM formula is Ding-chuan-tang, or Xing-ren (Semen Armeniacae Amarum) for the single herb.

58 Our results establish semen as a body fluid that naturally contains amyloid fi

59 ntaining the fertilizing potential of frozen semen as it is manipulated, transported and stored is cr

60 had detectable CMV DNA in saliva, plasma, or semen at baseline.

61 In this manner, infectious HIV-1 in semen becomes an adventitious traveler on the pathway le

62 ozen semen is mishandled, characteristics of semen biology associated with fertility are negatively a

63 ments can better maintain characteristics of semen biology that correlate with fertility when it is m

64 genetically diverse PRRSV isolates in serum, semen, blood swabs, and oral fluids collected from exper

65 easure the recovery of DNA from human blood, semen, buccal cells, breastmilk, and earwax in addition

66 saliva, urine, cerebrospinal fluid (CSF) and semen, but transiently in vaginal secretions.

67 HIV virions are released into semen by various cells of the male genital tract, as wel

68 In semen collection, semen quality is higher with the penil

69 ation and T-cell activation were observed in semen compared with blood.

70 ower raltegravir concentrations in blood and semen, compared with complete HIV-1 suppression (P = .03

71 Semen contained higher concentrations of proinflammatory

72 Unlike other human biological fluids, semen contains multiple types of amyloid fibrils in the

73 Semen contains relatively ill-defined regulatory compone

74 In summary, the elevated semen content of SPTRX3 in men from ART couples coincide

75 Several cytokines in semen correlated with HIV shedding (G-CSF, tumor necrosi

76 tence of an HIV concentration front near the semen/CVM interface, far from the vaginal epithelium.

77 Semen-derived enhancer of viral infection (SEVI), an amy

78 ctron microscopy and NMR results showed that semen-derived enhancer of viral infection fibrils formed

79 arbonate buffer remain stable over time, but semen-derived enhancer of viral infection fibrils formed

80 est characterized of these fibrils are SEVI (semen-derived enhancer of viral infection), made up of r

81 ibrils contained in semen, known as SEVI, or semen-derived enhancer of viral infection, have been sho

82 Seminal factors such as semen-derived enhancer of virus infection (SEVI) fibrils

83 ciency virus-1 (HIV-1) infection in cells by semen-derived enhancer of virus infection (SEVI) fibrils

84 In addition, the ability of the semen-derived enhancer of virus infection (SEVI) to enha

85 tain factors identified within semen, termed semen-derived enhancers of virus infection (SEVI), have

86 d individuals; however, some men shed HIV in semen despite suppressed levels in blood.

87 Following semen donation, specimens are either used immediately or

88 hat accurately identified the race of all 18 semen donors in the calibration data set, as well as sev

89 tential to differentiate Caucasian and Black semen donors using chemometrics.

90 0 nt fractions of SE RNA separately from six semen donors.

91 esults from a study to determine the race of semen donors.

92 On the other hand, treating commercial semen doses intended for artificial insemination with th

93 HCV RNA was detected in semen during both acute and chronic HCV infection.

94 mic changes in the HIV-enhancing activity of semen during extended liquefaction, we identified SEM1(8

95 und that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at

96 Select PFCs were associated with certain semen end points, with the most significant associations

97 Semen enhances HIV infection in vitro, but how long it r

98 asma IL-2, eotaxin, MIP-1beta, and IL-15 and semen eotaxin and granulocyte colony-stimulating factor

99 demonstrate that early during liquefaction, semen exhibits maximal HIV-enhancing activity that gradu

100 Immediately postejaculation, semen exists as a semisolid coagulum, which then convert

101 In prior work, we found that semen exosomes (SE) from healthy donors who do not use i

102 he female reproductive tract (FRT) following semen exposure.

103 Semen fibrils are made up of multiple naturally occurrin

104 A small molecule screen for antagonists of semen fibrils identified four compounds that lowered sem

105 healthy ones, suggesting that deposition of semen fibrils in the lower FRT facilitates clearance of

106 In the presence of semen fibrils, damaged and apoptotic sperm were more rap

107 ence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

108 espective of illicit drug use or duration of semen freezing.

109 Semen from 550 Holstein bulls of high (>/= 1.7; n = 288)

110 e demonstrated that amyloid fibrils found in semen from healthy and HIV-infected men, as well as seme

111 simple technological improvements to protect semen from inadvertent thermal fluctuations that occur w

112 ted evidence of the genital origin of HIV in semen from therapy naive individuals and men receiving s

113 he method depicted here for the detection of semen fructose is indeed superior to the existing method

114 on changes the chemokine-cytokine network in semen, further enriching it in cytokines that modulate i

115 monstrate that the HIV-enhancing activity of semen gradually decreases over the course of extended li

116 Subjects with detectable CMV in semen had approximately five times higher average levels

117 V-1) transmission events occur in women when semen harboring infectious virus is deposited onto the m

118 Semen harbors amyloids that enhance human immunodeficien

119 icient, the role of cell-associated virus in semen has been surprisingly poorly investigated in nonhu

120 t has been shown that short-term freezing of semen has no effect on SE-mediated HIV-1 inhibition.

121 naturally occurring amyloid fibrils found in semen have been implicated as mediators that can facilit

122 having higher levels of HIV RNA in blood and semen, having lower CD4(+) T cell counts, having bacteri

123 pared with 25 controls who started sART, the semen HIV-1 load in 13 subjects who started iART was mor

124 In semen, HIV-1 particles may exist as free-floating virion

125 , isolated shedding of HIV type 1 (HIV-1) in semen (IHS) can occur in the absence of detectable virem

126 We report the presence of Ebola virus RNA in semen in a cohort of survivors of EVD in Sierra Leone.

127 ent levels in serum, urine, breast milk, and semen in adults did not identify clinically meaningful d

128 as a source of infected cells and virions in semen in the absence and presence of HAART, and suggest

129 Previous studies have shown that semen induces an acute inflammatory response at the fema

130 A validated assay for EBOV RNA detection in semen informs the care of male survivors of Ebola, as we

131 Semen is a complex body fluid containing many factors th

132 rs refrain from unprotected sex unless their semen is confirmed to be EBOV free.

133 recovery and long-term viral persistence in semen is confirmed.

134 We found that (1) semen is enriched in cytokines and chemokines that play

135 Understanding the complex viral milieu in semen is important for HIV transmission but might also p

136 We show that when frozen semen is mishandled, characteristics of semen biology as

137 However, semen is not just a mere passive transporter of virions

138 The virus in semen is present in different forms: as free virus parti

139 Virus in semen is replication-competent with no change in viral g

140 Semen is the main carrier of sexually transmitted viruse

141 Semen is the main vector for HIV transmission and contai

142 Semen is the main vector for human immunodeficiency viru

143 Although semen is the principal vector of human immunodeficiency

144 rom healthy and HIV-infected men, as well as semen itself, can markedly enhance HIV infection rates.

145 wed by blood swabs (kappa value of 0.97) and semen (kappa value of 0.80).

146 Amyloid fibrils contained in semen, known as SEVI, or semen-derived enhancer of viral

147 We hypothesized that semen levels of SPTRX3 are reflective of treatment outco

148 ptidase 2 (KLK2) is a key serine protease in semen liquefaction and prostate cancer together with KLK

149 Our findings suggest that amyloid fibrils in semen may play a role in reproduction by participating i

150 Concurrently, contact with semen may transiently increase susceptibility to HIV-1 b

151 ch far outnumber lymphocytes in HIV-infected semen, may contribute to sexual transmission of HIV from

152 tive assays on the effects of gallic acid on semen-mediated enhancement of HIV infection and inflamma

153 as a non-polyanionic compound that inhibits semen-mediated enhancement of HIV infection and suggest

154 In addition, gallic acid decreased semen-mediated enhancement of HIV infection but did not

155 brils identified four compounds that lowered semen-mediated enhancement of HIV-1 infectivity.

156 Moreover, CLR01 abrogates semen-mediated enhancement of viral infection by prevent

157 T intensification with medications active in semen might prevent IHS.

158 Semen naturally undergoes physiological changes over tim

159 human immunodeficiency virus type 1 (HIV) in semen occurs despite effective antiretroviral therapy (A

160 ucleic acid (RNA) potentially present in the semen of a large number of survivors of Ebola virus dise

161 Ebola virus RNA was detected in the semen of all 7 men with a specimen obtained within 3 mon

162 ission, in which HIV is transferred from the semen of an infected male to an uninfected partner.

163 Ebola virus has been detected in semen of Ebola virus disease survivors after recovery.

164 at HIV-RNA can be detected intermittently in semen of HIV-1 infected MSM despite successful cART.

165 e monocytes far outnumber lymphocytes in the semen of HIV-infected individuals.

166 in women occurs via genital exposure to the semen of HIV-infected men.

167 (EBV) were the most commonly detected HHV in semen of HIV-infected participants.

168 and dolutegravir (DTG) concentrations in the semen of HIV-infected patients receiving DTG-based first

169 of combined antiretroviral therapy (cART) in semen of human immunodeficiency virus type 1 (HIV-1) inf

170 are known to be significantly reduced in the semen of infertile men.

171 deled the presence of Ebola virus RNA in the semen of male Ebola survivors participating in the Poste

172 Ebola virus has been detected in the semen of men after their recovery from Ebola virus disea

173 inseminated with either Nosema spores or the semen of Nosema-infected males became infected by the pa

174 ere was persistent viral RNA detected in the semen of the patient, accompanied by epididymitis, sugge

175 e investigated the influence of cytokines in semen on local HIV burden and activated T cells.

176 erved among vaccine recipients, primarily in semen (P = .04).

177 egression to estimate the difference in each semen parameter associated with a one unit increase in t

178 ciated with several factors likely to affect semen parameters (such as history of sexually transmitte

179 serum OC concentrations are associated with semen parameters among young Russian men.

180 es showed inverse U-shaped associations with semen parameters and testis size.

181 Semen parameters are variable within individuals, but it

182 There were no differences in mean semen parameters between men's first samples and the rem

183 We investigated testosterone production and semen parameters in farmed Arctic foxes by dietary expos

184 rtal serum organochlorine concentrations and semen parameters in young men: the Russian Children's St

185 Semen parameters were compared to those of historical co

186 Clinical research has shown improved semen parameters, DNA integrity, and assisted reproducti

187 in men with NOA, in terms of improvement in semen parameters, testicular sperm retrieval rates, and

188 ans, and total TEQs were not associated with semen parameters.

189 uality) can lead to short-term variations in semen parameters.

190 trolling for demographic characteristics and semen parameters.

191 corresponding toxic equivalents (TEQs) with semen parameters.

192 ns and PCDD TEQs were associated with poorer semen parameters.

193 tions were observed for serum PCDD TEQs with semen parameters.

194 ticular development may be related to poorer semen parameters.

195 dhood organochlorine (OC) exposure and adult semen parameters.

196 remove all SPTRX3-positive spermatozoa from semen prepared for ART.

197 aturally occurring fragments of the abundant semen proteins prostatic acid phosphatase (PAP) and seme

198 between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples plannin

199 e association between dietary fat intake and semen quality among 701 young Danish men from the genera

200 vacuolar ATPase) is associated with abnormal semen quality and changes in chemokine-cytokine profiles

201 Adverse temporal trends in human semen quality and cryptorchidism in infants have been as

202 No association between semen quality and intake of other types of fat was found

203 yle was associated with testicular function (semen quality and reproductive hormones) independent of

204 aimed at identifying average differences in semen quality between individuals.

205 ed even years after transplantation and poor semen quality decreases the prospect of fertility in men

206 does not contradict the previously reported semen quality deterioration, the effects of which are ca

207 ctanoic acid (PFOA)] were associated with 17 semen quality end points before Box-Cox transformation.

208 s included optimal Box-Cox transformation of semen quality end points.

209 g the relationship between marijuana use and semen quality from young men recruited out of the genera

210 Semen quality has been suggested to be a biological mark

211 Novel tests of semen quality have been developed.

212 xplanations and prospectively assess whether semen quality improves after interventions restoring a n

213 Our study supports the suggestion that semen quality is a strong biomarker of general health.

214 tween persistent environmental chemicals and semen quality is evolving, although limited data exist f

215 In semen collection, semen quality is higher with the penile robe electrical

216 rmations of the genitalia at birth, and poor semen quality later in life.

217 herefore contribute to the decline in canine semen quality that parallels that reported in the human.

218 Semen quality was associated with long-term morbidity, a

219 ctive endocrine function, testicular volume, semen quality, and fertility in adult male patients afte

220 the negative association of marijuana use on semen quality.

221 ay be contributing to recent reports of poor semen quality.

222 e association between sleep disturbances and semen quality.

223 associations between sleep disturbances and semen quality.

224 However, the presence of amyloid fibrils in semen remained to be demonstrated.

225 Ebola virus (EBOV) RNA persistence in semen, reported sexual transmission, and sporadic cluste

226 ter insemination, we propose that polySia in semen represents a cytoprotective element to increase th

227 However, although semen represents one of the most important vehicles for

228 n semen and underscore the dynamic nature of semen's HIV-enhancing activity.

229 Men collected a baseline semen sample and another approximately 1 month later.

230 hin individuals, but it is unclear whether 1 semen sample could represent a man's long-term average v

231 The semen sample from one participant tested positive for Eb

232 ed from blood samples from the patient and a semen sample from the survivor were consistent with dire

233 We conclude that 1 semen sample may suffice for studies aimed at identifyin

234 der than 40 years were more likely to have a semen sample test positive than were men aged 40 years o

235 treatment unit and collection of a positive semen sample was 565 days.

236 men had a physical examination, delivered a semen sample, and had a blood sample drawn.

237 The participants delivered a semen sample, had a blood sample drawn, and underwent a

238 All of the men delivered a semen sample, had a blood sample drawn, underwent a phys

239 They delivered a semen sample, underwent a physical examination, and answ

240 our (22%) of the RTx men had normospermia in semen sample.

241 or determination of sperm concentration in a semen sample.

242 t 18-19 years, 133 young men provided 1 or 2 semen samples (256 samples) collected approximately 1 we

243 We detect amyloid aggregates in all semen samples and find that they partially consist of PA

244 linic in Boston, Massachusetts, provided 768 semen samples as part of the Environment and Reproductiv

245 study, we optimized the Xpert EBOV assay for semen samples by adding dithiothreitol.

246 Serum and semen samples from men (n = 90) 22-44 years old who part

247 gene (TEX11) open reading frame in blood and semen samples obtained from 289 patients with azoospermi

248 Semen samples were collected from 35 healthy donors and

249 Paired blood and semen samples were collected monthly for 6 months from H

250 Semen samples were shipped with freezer packs, and analy

251 Reproductive hormone levels and semen samples were studied and compared to those of 56 a

252 Participants' semen samples were tested for Ebola virus RNA by real-ti

253 ed models to compare values from men's first semen samples with their long-term averages and to calcu

254 usting for confounders and modeling repeated semen samples.

255 he DNA integrity of sperm cells in raw human semen samples.

256 s been used as a metric for the viability of semen samples.

257 e, has been shown to form amyloid fibrils in semen (SEVI), which increase HIV infectivity by up to 5

258 pended in 3 mL of hydroxyethylcellulose gel (semen simulant) with gadoteridol and dosed via artificia

259 0341 was retained when tested in vaginal and semen simulants.

260 Of 210 participants who provided an initial semen specimen for analysis, 57 (27%) had positive resul

261 38 participants (9%) produced at least one semen specimen that tested positive for Ebola virus RNA.

262 Ebola virus RNA was detected in 86 semen specimens from 19 (73%) participants.

263 HCV RNA was detected in semen specimens from 29 of 66 men (43.9%).

264 Semen specimens obtained at baseline were tested by mean

265 bola virus (EBOV) RNA and infectious EBOV in semen specimens of 5 Ebola virus disease (EVD) survivors

266 Of these, 24 (63%) provided semen specimens that tested positive 12 months or longer

267 Ninety-eight semen specimens were obtained for Ebola virus (EBOV) RNA

268 evaluation of donor drug-use and duration of semen storage on SE cargo and bioactivity will advance o

269 ortance of the source of SE and condition of semen storage on SE content and function.

270 us infections, in all tissues, including the semen stored in the spermathecae.

271 ronectin decreased the enhancing activity of semen, suggesting that interfering with the binding inte

272 prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmi

273 rolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservo

274 SPECT/CT and MR analysis showed HIV and semen surrogate distribution with highest signal intensi

275 ing to determine the distribution of HIV and semen surrogates after simulated intercourse without dis

276 Certain factors identified within semen, termed semen-derived enhancers of virus infection

277 (MHSP) offers Ebola virus disease survivors semen testing for Ebola virus.

278 ansmitted Zika virus disease, and results of semen testing for Zika virus from 2 male travelers.

279 behavioural outcomes from the first national semen testing programme for Ebola virus.

280 ted after receiving two consecutive negative semen tests.

281 Finally, we compare semen that has been mishandled in standard and improved

282 -friendly assay for detection of EBOV RNA in semen that is deployable to multiple sites across Wester

283 Semen, the most common vehicle for HIV transmission, enh

284 in neonates, the isolation of Zika virus in semen, the potential for blood-transfusion transmission,

285 Epstein-Barr virus (FDR-adjusted P = .06) in semen to be associated with detectable seminal HIV level

286 d the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quali

287 xtent and duration of shedding in saliva and semen underscore possible concern for additional neurolo

288 lood, conjunctival, forehead, mouth, rectal, semen, urine, and vaginal specimens for presence of Ebol

289 fluctuations that occur when users mishandle semen using standard equipment.

290 near regression analyses were performed with semen variables as outcomes and dietary fat intakes as e

291 lation between alkylating agent exposure and semen variables in adult survivors of childhood cancer.

292 , we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in pe

293 r primary hypothesis, shedding of CMV DNA in semen was associated with increased activation and proli

294 We found that asymptomatic CMV shedding in semen was associated with significantly higher levels of

295 A positive RT-PCR in semen was found in ten (5%) of 188 men, at a maximum of

296 sma HIV <50 copies/mL, high levels of CMV in semen was the only significant predictor for seminal HIV

297 Blood and semen were collected from 42 HIV-negative and 38 HIV-pos

298 Cytokines in semen were highly coregulated in HIV-negative men; howev

299 te and able to transmit the virus along with semen, which occasionally leads to queen infections.

300 Deciphering the exact sources of HIV in semen will be crucial to improving HIV transmission prev