ライフサイエンスコーパス: semialdehyde

1 ation (alpha-amino adipic and gamma-glutamic semialdehyde).

2 te decarboxylase (Kgd) and produces succinic semialdehyde.

3 tRNA-bound glutamate to produce glutamate 1-semialdehyde.

4 tRNA-bound glutamate to produce glutamate 1-semialdehyde.

5 version of trans-3-haloacrylates to malonate semialdehyde.

6 of 3-bromo- and 3-chloroacrylate to malonate semialdehyde.

7 a-ketoglutarate decarboxylation was succinic semialdehyde.

8 he conversion of lysine to alpha-aminoadipic semialdehyde.

9 for d-glycerate biosynthesis from tartronate semialdehyde.

10 pha-hydroxy- delta-carboxymethyl cis-muconic semialdehyde.

11 xin propionate 3-nitronate (P3N) to malonate semialdehyde.

12 g gamma-aminobutyrate conversion to succinic semialdehyde.

13 nia, inorganic phosphate, and 2-aminoadipate semialdehyde.

14 ion of cis-3-haloacrylates to yield malonate semialdehyde.

15 ysine degradation product, alpha-aminoadipic semialdehyde.

16 somers of 3-chloroacrylate to yield malonate semialdehyde.

17 eptane-1,7-dioate into pyruvate and succinic semialdehyde.

18 roxyanthranilate to 2-amino-3-carboxymuconic semialdehyde.

19 eta-hydroxy acid substrates to corresponding semialdehydes.

20 A) which is rearranged to ALA by glutamate 1-semialdehyde-2,1-aminomutase (GSA-A) in the second step.

21 eductase, and the second enzyme, glutamate-1-semialdehyde-2,1-aminomutase, are encoded by the nuclear

22 ulted in an increased synthesis of glutamate semialdehyde, 5-aminolevulinic acid, magnesium-porphyrin

23 the activity of alpha-aminoadipic acid-delta-semialdehyde (AAS) dehydrogenase in liver and plasma lev

24 e condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, w

25 ermined that glutamate, rather than succinic semialdehyde, accounts for the metabolic phenotype of ga

26 dation of vitamin B(6) and produces succinic semialdehyde, acetate, ammonia, and carbon dioxide from

27 etamidomethylene)succinate to yield succinic semialdehyde, acetic acid, carbon dioxide, and ammonia.

28 the quantitation of glutamic and aminoadipic semialdehydes after their reduction to hydroxyaminovaler

29 The lysyl oxidation product adipic semialdehyde (allysine, ALL) and its oxidized end-produc

30 The latter is due to alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase deficiency, asso

31 ideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase.

32 chlorophyll biosynthetic enzyme glutamate 1-semialdehyde aminotransferase (GSAT), is specifically in

33 he level of transcripts encoding glutamate-1-semialdehyde aminotransferase (GSAT), phytoene desaturas

34 sis relating to the mechanism of glutamate 1-semialdehyde aminotransferase (GSAT).

35 tly, GSA is rearranged to ALA by glutamate-1-semialdehyde aminotransferase (GSAT).

36 chlorophyll biosynthetic enzyme glutamate 1-semialdehyde aminotransferase was previously shown to be

37 on of RNA secondary structure, and glutamate semialdehyde aminotransferase, an enzyme involved in ini

38 binant Chlamydomonas reinhardtii glutamate-1-semialdehyde aminotransferase.

39 elta(1)-pyrroline-5-carboxylate to glutamate semialdehyde and a protected conduit for the transport o

40 ble to capture the substrates aspartate-beta-semialdehyde and phosphate as an active complex that doe

41 needed to synthesize L-lysine from aspartate semialdehyde and pyruvate have been identified in a numb

42 he biosynthesis of L-lysine from L-aspartate semialdehyde and pyruvate in bacteria.

43 ion-independent decarboxylation of malonate semialdehyde and represents one of three known enzymatic

44 Succinic semialdehyde and succinate are also identified as produc

45 ation (alpha-amino adipic and gamma-glutamic semialdehydes) and Schiff base cross-links.

46 ically to release 2 mol of ammonium, malonic semialdehyde, and carbon dioxide.

47 y-5-ketofructose 1-phosphate and l-aspartate semialdehyde are precursors to DHQ.

48 sults indicate that glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-ca

49 The pathway uses aspartate beta-semialdehyde as the aminopropyl group donor and consists

50 small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easily prepared by

51 condensation of pyruvate and beta-aspartate semialdehyde (ASA) to form a cyclic product which dehydr

52 icolinate from pyruvate and L-aspartate beta-semialdehyde (ASA).

53 umophila by disruption of the aspartate-beta-semialdehyde (asd) gene.

54 of the reaction was confirmed to be malonate semialdehyde by (1)H and (13)C NMR spectroscopy, and kin

55 -aminoadipic acid to alpha-aminoadipic-delta-semialdehyde by a complex mechanism involving two gene p

56 , malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-CoA reductase

57 ly to glutamate and alpha-aminoadipate-delta-semialdehyde by SDH.

58 verts trans-3-chloroacrylic acid to malonate semialdehyde by the addition of H(2)O to the C-2, C-3 do

59 zation of the C-3 carbonyl group of malonate semialdehyde by the cationic Pro-1.

60 the C269S/glutamine and CPS/glutamate gamma-semialdehyde complexes, which serve as mimics for the Mi

61 Urinary L-alpha-aminoadipic semialdehyde concentration was determined by liquid chro

62 idino group and conversion to gamma-glutamyl semialdehyde, consistent with previous metal-catalyzed o

63 of measurement of urine L-alpha-aminoadipic semialdehyde/creatinine ratio and mutation analysis of A

64 yme alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) as a potential mechan

65 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) has revealed that thi

66 Alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is a widespread enzym

67 cens alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase (ACMSD) is critically depende

68 alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is the key enzyme reg

69 yme alpha-amino-beta-carboxy-muconic-epsilon-semialdehyde decarboxylase (ACMSD) plays an important ro

70 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) show a five-coordinat

71 Malonate semialdehyde decarboxylase (MSAD) from Pseudomonas pavon

72 Malonate semialdehyde decarboxylase (MSAD) from Pseudomonas pavon

73 Malonate semialdehyde decarboxylase (MSAD) has been identified as

74 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase could regulate the enzyme act

75 of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase from Pseudomonas fluorescens

76 -1, of which 85% are present in the malonate semialdehyde decarboxylase subgroup.

77 led that of alpha-amino-beta-carboxymuconic--semialdehyde decarboxylase, a class III amidohydrolase,

78 Succinate semialdehyde dehydrogenase (ALDH5A1, encoding SSADH defi

79 is superfamily, the enzyme 2-aminomuconate-6-semialdehyde dehydrogenase (AMSDH), is a component of th

80 Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes a critical

81 Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes the second

82 ate in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase (ASADH) from Haemophilus infl

83 The structure of aspartate-beta-semialdehyde dehydrogenase (ASADH) from Methanococcus ja

84 Aspartate-beta-semialdehyde dehydrogenase (ASADH) lies at the first bra

85 Aspartate beta-semialdehyde dehydrogenase (ASADH) lies at the first bra

86 se of this bifunctional enzyme and aspartate semialdehyde dehydrogenase (ASADH), the enzyme that cata

87 SC608 is an aspartate semialdehyde dehydrogenase (asd) derivative of SC602 (ic

88 enes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-depen

89 etermined for Eschericia coli aspartate beta-semialdehyde dehydrogenase (ecASADH), an enzyme of the a

90 sociated with reduced expression of succinic semialdehyde dehydrogenase (encoded by ALDH5A1), and wit

91 e transaminase (GabT and PuuE), and succinic semialdehyde dehydrogenase (GabD and PuuC).

92 otype, while a null mutant of methylmalonate semialdehyde dehydrogenase (MMSD, At2g14170) resulted in

93 aeruginosa, which encodes methylmalonic acid semialdehyde dehydrogenase (MSDH) and is involved in val

94 The structure of the methylmalonate semialdehyde dehydrogenase (MSDH) from Bacillus subtilis

95 glutarate decarboxylase (Sll1981), succinate semialdehyde dehydrogenase (Slr0370), and/or in gamma-am

96 Inherited succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hyd

97 Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare

98 Succinic semialdehyde dehydrogenase (SSADH) deficiency, a rare me

99 The gene encoding succinate semialdehyde dehydrogenase (UGA5) was identified and fou

100 kely MSI target genes to be the aminoadipate-semialdehyde dehydrogenase AASDH and the solute transpor

101 dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase active sites.

102 The succinic-semialdehyde dehydrogenase activity of GabD and its indu

103 Succinic semialdehyde dehydrogenase activity was detected in Mtb

104 hydrogenase Hpd1p, and the putative malonate semialdehyde dehydrogenase Ald6p essentially contribute

105 proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase catalytic modules.

106 As succinic semialdehyde dehydrogenase converts succinic semialdehyd

107 Succinic semialdehyde dehydrogenase deficiency is a rare disorder

108 Succinic semialdehyde dehydrogenase deficiency may be an underrec

109 in sequences indicates that 2-aminomuconic 6-semialdehyde dehydrogenase has a high degree of identity

110 hosphate between aspartokinase and aspartate semialdehyde dehydrogenase in E. coli and suggest that A

111 ined 92 mutated genes, including a succinate-semialdehyde dehydrogenase in the gamma-aminobutyric aci

112 opantetheinylation of the alpha-aminoadipate semialdehyde dehydrogenase involved in lysine catabolism

113 Multiple sequence alignment of various semialdehyde dehydrogenase protein sequences indicates t

114 Based on the paralogous aspartate-beta-semialdehyde dehydrogenase structurally characterized wi

115 The gene encoding 2-aminomuconic semialdehyde dehydrogenase was identified by matching th

116 The iolA (mmsA) gene encoding methylmalonate semialdehyde dehydrogenase was not regulated by IolR.

117 In the present work, 2-aminomuconic semialdehyde dehydrogenase was purified and characterize

118 el 2-oxoglutarate decarboxylase and succinic semialdehyde dehydrogenase were identified in the cyanob

119 r alpha-ketoglutarate decarboxylase/succinic semialdehyde dehydrogenase) plays a minimal role in ener

120 ical arrangement of PRODH, l-glutamate-gamma-semialdehyde dehydrogenase, and C-terminal domains, incl

121 erse metabolic pathways, including aspartate semialdehyde dehydrogenase, arginine decarboxylase gene

122 In mice deficient in succinic semialdehyde dehydrogenase, high plasma concentrations o

123 An enzyme of this pathway, 2-aminomuconate-6-semialdehyde dehydrogenase, is responsible for 'disarmin

124 lutarate decarboxylase, along with succinate semialdehyde dehydrogenase, may form an alternative path

125 tervening reaction in the pathway, aspartate semialdehyde dehydrogenase.

126 carboxylase, GABA-transaminase, and succinic semialdehyde dehydrogenase.

127 h degree of identity with 2-hydroxymuconic 6-semialdehyde dehydrogenases.

128 e alpha-aminoadipic (AAS) and gamma-glutamic semialdehydes (GGS) increased when cooking at 60 degrees

129 glutamate is then converted to a glutamate 1-semialdehyde (GSA) by glutamyl-tRNA reductase (GTR) in a

130 d glutamate is then converted to glutamate 1-semialdehyde (GSA) by glutamyl-tRNA reductase (GTR).

131 ts glutamate of glutamyl-tRNA to glutamate 1-semialdehyde (GSA) which is rearranged to ALA by glutama

132 es resulting from reactions with glutamate 1-semialdehyde (GSA), 4,5-diaminovalerate (DAVA), and 5-am

133 the intermediates P5C and l-glutamate-gamma-semialdehyde (GSA).

134 aldehyde analogs, including 2-hydroxymuconic semialdehyde, hexaldehyde, and benzaldehyde.

135 d the NADH-dependent reduction of tartronate semialdehyde, identifying this protein as a tartronate s

136 ted with a suitably protected glutamyl-gamma-semialdehyde in a Julia-Kocienski olefination reaction.

137 teratively at C5 to yield gamma-Me-Glu-gamma-semialdehyde in equilibrium with the cyclic imine produc

138 minophenol is cleaved to 2-aminomuconic acid semialdehyde in the nitrobenzene-degrading strain Pseudo

139 mediates, gamma-hydroxybutyrate and succinic semialdehyde, inactivated the AttJ repressor in vitro an

140 acetaldehyde, presumably through a malonate semialdehyde intermediate.

141 sformation of the 3-haloacrylate to malonate semialdehyde involves Pro-1 as well as an arginine, two

142 2-Aminonumconic 6-semialdehyde is an unstable intermediate in the biodegra

143 Malonate semialdehyde is analogous to a beta-keto acid, and enzym

144 This observation suggests that malonate semialdehyde is the first product released by the enzyme

145 degradation pathway, the substrate, succinic semialdehyde, is shunted towards production of 4-hydroxy

146 nzyme followed by L-alpha-aminoadipate-delta-semialdehyde ( L-AASA) which adds in rapid equilibrium p

147 posed pathways to beta-alanine from malonate semialdehyde, l-alanine, spermine, dihydrouracil, and ac

148 ndent dehydrogenation of l-alpha-aminoadipic semialdehyde/L-Delta1-piperideine 6-carboxylate.

149 es the reduction of succinyl-CoA to succinic semialdehyde onwards in the cycle.

150 is inactive in the ionization of tartronate semialdehyde phosphate (TSP), whereas both E168Q and E21

151 ns- or cis-3-haloacrylates to yield malonate semialdehyde, presumably through unstable halohydrin int

152 gase, two enzymes that synthesize tartronate semialdehyde, producing an operon clearly designed for d

153 ar expression of AKR family member, succinic semialdehyde reductase (AKR7A2) that reduces toxic aldeh

154 er evidence for identification as tartronate semialdehyde reductase is the observation that the codin

155 o-4-deoxy-(D)-glucarate aldolase, tartronate semialdehyde reductase, a glycerate kinase that generate

156 de, identifying this protein as a tartronate semialdehyde reductase.

157 reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyce

158 B is produced from the reduction of succinic semialdehyde (SSA) by the activity of GHB dehydrogenase.

159 showing much higher affinities for succinic semialdehyde (SSA) than does AKR7A1.

160 hydes, including growth-inhibitory succinate semialdehyde (SSA).

161 repressing function is relieved by succinate semialdehyde (SSA).

162 of ALDH1, ALDH2, ALDH4, ALDH10 and succinic semialdehyde (SSDH) genes have been emerged.

163 encoding the antioxidant enzymes aminoadipic semialdehyde synthase (Aass), NAD(P)H quinone oxidoreduc

164 ously been referred to as "alpha-aminoadipic semialdehyde synthase," and we have tentatively designat

165 proline dehydrogenase and alpha-aminoadipic semialdehyde synthase.

166 yield a carbonyl compound (alpha-aminoadipic semialdehyde) that can be further oxidised to alpha-amin

167 In the P5CDH active site, l-glutamate-gamma-semialdehyde (the hydrolyzed form of Delta(1)-pyrroline-

168 with pyridoxamine 5'-phosphate and succinic semialdehyde, the products of a GABA-dependent aminotran

169 AD(+)-dependent oxidation of 2-aminomuconate semialdehyde to 2-aminomuconate.

170 same as that of YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.

171 se superfamily member that converts malonate semialdehyde to acetaldehyde by a mechanism utilizing Pr

172 s an aldol condensation with the l-aspartate semialdehyde to form 2-amino-3,7-dideoxy-D-threo-hept-6-

173 to catalyze the decarboxylation of malonate semialdehyde to generate acetaldehyde.

174 the NAD(+)-dependent oxidation of glutamate semialdehyde to glutamate, which is the final step of pr

175 se that catalyzes the oxidation of glutamate semialdehyde to glutamate.

176 semialdehyde dehydrogenase converts succinic semialdehyde to succinate, an intact gamma-aminobutyrate

177 ected conduit for the transport of glutamate semialdehyde to the P5CDH active site.

178 y-5-ketofructose 1-phosphate and l-aspartate semialdehyde to yield ADH.

179 Aminoadipic semialdehyde was also measured in protein extracts from

180 o catabolic products, glutamate and succinic semialdehyde, we sought to determine which was responsib

181 Glutamic and aminoadipic semialdehydes were also detected in rat liver proteins,

182 an is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvat

183 The product of the reaction is malonate semialdehyde, which was confirmed by its characteristic

184 endent enzyme that degrades GABA to succinic semialdehyde, while reduction of GABA concentration in t

185 r gamma-aminobutyric acid (GABA) to succinic semialdehyde with concomitant conversion of pyridoxal 5'