ライフサイエンスコーパス: seminal

1 the cornerstones for Michaelis' and Menten's seminal 1913 paper.

2 n in the absence of natural selection, was a seminal advance in evolutionary biology.

3 ificantly enhanced public health and spurred seminal advances in both basic and applied immunology.

4 eir basic metabolism, this review highlights seminal advances made over the last decade and identifie

5 cus on encoding and decoding has led to many seminal advances, it has not produced an agreed-upon con

6 ibits the formation of infectivity-enhancing seminal amyloids and remodels preformed fibrils.

7 ities will be explained and exemplified with seminal and cutting-edge in vivo studies.

8 In this Review, we address seminal and recent research on microRNA (miRNA) regulati

9 (1-41 cm(-1) major axis [i.e. brace, crown, seminal, and primary roots]), suggesting that LRBD has v

10 Seminal articles describing new anticoagulant drugs for

11 urces are published pivotal clinical trials; seminal articles on physiology, pharmacology, and neuroi

12 ed into seed-borne tissues (stem and primary seminal axile roots) and stem-borne tissues (tillers and

13 These results also underline the seminal biological relevance of the regulation of electr

14 These studies were inspired by seminal but neglected findings in plant and animal infec

15 ft, water resistant formats uniquely address seminal challenges in biomedicine.

16 KLK3 (prostate-specific antigen) in cleaving seminal clotting proteins, resulting in sperm liquefacti

17 Interventions aimed at reducing seminal CMV and associated immune activation may be impo

18 pheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower pla

19 ed the interactions between (i) asymptomatic seminal CMV replication, (ii) levels of T cell activatio

20 evel HIV replication in blood and high-level seminal CMV shedding, but not presence of asymptomatic S

21 f a 3-gate topoisomerase II-DNA complex, the seminal complex engaged in DNA recognition and capture.

22 ence pointing to insulin autoreactivity as a seminal component in the diabetogenic process.

23 nditions, and Flavodiiron (FLV) proteins are seminal components of this regulatory machinery in cyano

24 es and materials, with a particular focus on seminal contributions and the advantages and disadvantag

25 pioneer and codiscoverer of B-1 cells, whose seminal contributions enhanced our understanding of this

26 takes in leading journals, such as rejecting seminal contributions or accepting mediocre submissions.

27 and public (PubMed) databases, reviewed, and seminal contributions selected.

28 In this review we present some of the seminal contributions that have established the mathemat

29 His seminal contributions to biomedical research were in the

30 Many of these authors continued their seminal contributions to developmental cancer therapy, a

31 It recognizes his seminal contributions to oral immunology, his mentoring

32 Samuel I. Rapaport made seminal contributions to our basic understanding of bloo

33 Journal of Molecular Biology recognizes his seminal contributions to science in general and structur

34 ector: Aleksei Yevgen'evich Chichibabin made seminal contributions to the chemistry of pyridines.

35 ryell articles on hemoglobin represent truly seminal contributions to the field of bioinorganic chemi

36 iew (PubMed) was carried out to identify all seminal contributions to the study of esophageal adenoca

37 ns an Ir-N triple bond, similar to Bergman's seminal Cp*Ir(N(t) Bu) imido complex.

38 posure to cigarette smoke is associated with seminal defects and with congenital anomalies and childh

39 Unprotected intercourse and seminal discharge are powerful activators of the mucosal

40 here the quest for cause and cure has led to seminal discoveries in cancer biology.

41 This review provides an overview of seminal discoveries made through the use of GEM models f

42 Seminal discoveries of recent years have expanded this c

43 A decade after the seminal discovery of an activating mutation in the tyros

44 Since the seminal discovery of the SMA-causing gene in 1995, resea

45 We thus made the seminal discovery that sCLU expression in M-MDSCs accoun

46 However, as Kuhn (1962) argued in his seminal discussion of paradigm shifts, an old paradigm c

47 This seminal document inspired efforts by governments, nongov

48 to platelet biology is still in its infancy, seminal earlier studies have shaped our knowledge of how

49 This Review both discusses the seminal early studies and explores cutting-edge novel te

50 While a brief mention of seminal early work will be included, this current review

51 Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease.

52 ion of the amyloid beta-protein (Abeta) is a seminal event in Alzheimer's disease.

53 One of the seminal events in the history of a tissue is the establi

54 These seminal events led to the expansion of the workforce, cr

55 In a seminal example, Schonecker showed that copper and O2 pr

56 This review surveys seminal examples of PSMet to highlight the broad scope o

57 This tutorial review opens by highlighting seminal examples of synthetic molecular machines.

58 devices are based on porphyrin derivatives, seminal examples of the application of corroles or other

59 We found that seminal exosome (SE) preparations contain a substantial

60 Since Thomas Hunt Morgan began his seminal experiments over a century ago (Table 1), the Dr

61 Seminal factors such as semen-derived enhancer of virus

62 A seminal finding in monkey research is that neurons in th

63 A seminal finding was the dependence of allergic airway in

64 In this review, we summarize some of the seminal findings that yield important insight into the c

65 ase (EVD) survivor who showed Ebola virus in seminal fluid 531 days after onset of disease.

66 Seminal fluid a2NTD levels were significantly correlated

67 Seventy-six of 86 males requiring seminal fluid analysis as part of a separate study were

68 d the hypothesis that NlSPATA5 occurs in BPH seminal fluid and it operates in fecundity via mating.

69 id changes in sperm velocity are mediated by seminal fluid and the effect of seminal fluid on sperm v

70 of male survivors clear Ebola virus RNA from seminal fluid at 115 days (90% prediction interval 72-16

71 Participants provided samples of seminal fluid at follow-up every 3-6 weeks, which we tes

72 offspring of ablating the plasma fraction of seminal fluid by surgical excision of the seminal vesicl

73 Across a diversity of animals, male seminal fluid coagulates upon ejaculation to form a hard

74 les during and after mating are triggered by seminal fluid components in conjunction with female-deri

75 These findings show that paternal seminal fluid composition affects the growth and health

76 e to sperm damage and partly to an effect of seminal fluid deficiency on the female tract, because in

77 Seminal fluid does more than transport sperm.

78 firmed reports of Zika virus (ZIKV) in human seminal fluid for months after the clearance of viremia

79 lastic adjustment of ejaculate quality, that seminal fluid harbours the mechanism for the rapid adjus

80 , and subsequent life-span decrease, whereas seminal fluid induces DAF-16-dependent life-span decreas

81 an ideal habitat for microbes or a potential seminal fluid microbiome (SFM).

82 mean clearance rate of Ebola virus RNA from seminal fluid of -0.58 log units per month, although the

83 n by mosquitoes, ZIKV can be detected in the seminal fluid of affected males for extended periods of

84 e potential impacts of male PHF7, existed in seminal fluid of Nilaparvata lugens (NlPHF7), on fecundi

85 mediated by seminal fluid and the effect of seminal fluid on sperm velocity directly impacts paterni

86 analyse the dynamics of virus persistence in seminal fluid over time.

87 ickly lead to a change in the quality of the seminal fluid produced by a male Chinook salmon as he re

88 as immunosuppressive [12, 13], and the male seminal fluid protein Sex Peptide (SP) activates JH bios

89 Seminal fluid proteins (SFPs) are emerging as fundamenta

90 Male Seminal Fluid Proteins (SFPs) transferred during copulat

91 Cross-species transfer of sperm and active seminal fluid proteins including HP-I may contribute to

92 We found that specific seminal fluid proteins or female secretions mediate some

93 melanogaster, mating and the receipt of male seminal fluid proteins results in reduced resistance to

94 We enrolled 26 participants and tested 130 seminal fluid specimens; median follow up was 197 days (

95 ale reproductive glands secrete signals into seminal fluid to facilitate reproductive success.

96 N: Time to clearance of Ebola virus RNA from seminal fluid varies greatly between individuals and cou

97 scribe the diverse features and functions of seminal fluid, and its role in evolution and medicine.

98 ted from five diverse sources (i.e., plasma, seminal fluid, dendritic cells, mast cells, and ovarian

99 ribe the dynamics of Ebola virus RNA load in seminal fluid, including clearance parameters.

100 cles (prostasomes) that can be isolated from seminal fluid, urine, and blood.

101 Seminal fluid, which affects female reproductive tract g

102 Such effects could be due to the seminal fluid, which is slightly basic and enriched with

103 extracellular TRY-5 protease present in male seminal fluid.

104 d into prostatic fluid, a major component of seminal fluid.

105 in the mother's breast milk and the father's seminal fluid.

106 eting males; both are usually transferred in seminal fluids and represent forms of chemical mate guar

107 capacitate females physically from receiving seminal fluids by a second male.

108 rus are rendered temporarily unattractive by seminal fluids containing myristyl acetate and geranylge

109 10 d, viral RNA was detectable in saliva and seminal fluids until the end of the study, 3 weeks after

110 Male Anopheles mosquitoes coagulate their seminal fluids via cross-linking of a substrate, called

111 or of interferon genes) has been found to be seminal for controlling cytosolic-DNA induced cytokine p

112 al stoichiometries at high pressure has been seminal for highlighting a promising line of research on

113 Since Shannon derived the seminal formula for the capacity of the additive linear

114 Seminal G-CSF, which influences neutrophil survival, T-c

115 These avenues of research have made seminal gains, including the latest use of Wolbachia to

116 t lethal stress originally identified during seminal genetic experiments that defined the SecY-depend

117 n that in blood specimens from those without seminal HCV RNA (P = .001).

118 as associated with an increased frequency of seminal HCV RNA detection.

119 Elevated seminal HCV RNA levels could contribute to sexual transm

120 Seminal HCV RNA was detected in >/=1 sample for 26 of 35

121 RNA level in blood specimens from those with seminal HCV RNA was higher than that in blood specimens

122 We aimed to characterize seminal hepatitis C virus (HCV) RNA dynamics in human im

123 s presented significantly increased rates of seminal HHV shedding compared with HIV-uninfected contro

124 ven subjects (9.6%) had detectable levels of seminal HIV (median, 2.1 log10 copies/mL), and 72 (63.2%

125 6) in semen to be associated with detectable seminal HIV levels.

126 Seminal HIV RNA and DNA from 7 human herpesviruses (HHVs

127 common and was significantly associated with seminal HIV RNA shedding.

128 ostly intermittent, but its association with seminal HIV RNA was the strongest.

129 semen was the only significant predictor for seminal HIV shedding.

130 the frequency, magnitude, and correlates of seminal HIV-1 RNA shedding in HIV-1-infected African men

131 Seminal HIV-1 RNA shedding was infrequent and present at

132 in SP are sufficient to contribute to rapid seminal HIV-1 RNA suppression.

133 Seminal HIV-1 RNA was detected in 24% (37 of 155), 10% (

134 When blood HIV-1 levels were suppressed, seminal HIV-1 RNA was detected in 8% (16 of 195), and 82

135 synthesis of alkyl boronic esters, from the seminal hydroboration methods of H.

136 The seminal importance of detecting ions and molecules for p

137 udy, we showed that mitochondria also have a seminal influence on cells' energy metabolism and on pho

138 Such studies have yielded many seminal insights about the mechanisms of immune regulati

139 tructures of the PRC2 core complex, yielding seminal insights into its catalytic mechanism, substrate

140 s yet to be shown that SIV- or SHIV-infected seminal leukocytes can transmit infection in vivo.

141 Furthermore, endogenous seminal levels of SEM1(86-107) correlate with donor-depe

142 eory of the laser spectrum, generalizing the seminal linear model of Schawlow and Townes.

143 ears ago this month, Thomas Gold published a seminal manuscript suggesting the presence of a "deep, h

144 RNA viruses, and the multiple, seminal mentors who taught me their secrets, have define

145 ve thiosemicarbazone and its zinc complex as seminal metal-free and transition-metal-free examples.

146 Sixty years after the seminal Miller-Urey experiment that abiotically produced

147 olecules, thus defining a "protocell," was a seminal moment in the emergence of life on Earth and lik

148 ur results highlight the important role that seminal monocytes may play in HIV transmission in vivo,

149 tion factor" because of previously published seminal mouse genetic studies; however, mutations in MIT

150 nd Other Enterobacteriaceae) has contributed seminal multicenter data describing risk factors and cli

151 domesticated accessions demonstrate similar seminal network properties, they show distinct community

152 a-protein peptide (Abeta), thought to be the seminal neuropathogenetic agent in AD, its fast aggregat

153 ein (Abeta) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer's disease (AD

154 This seminal observation led to significant advances in our u

155 d FBXW7 in a majority of patients has been a seminal observation.

156 benzyne itself, being the basis of Wittig's seminal observations on biphenyl synthesis from phenyl l

157 ver, it has taken over a century since these seminal observations were made to delineate the molecula

158 f this area with a focus on what we consider seminal opportunities for the chemistry community to con

159 Since a seminal paper by Crick and Koch (1998) claimed that a sc

160 with limbic encephalitis, and the subsequent seminal paper describing the clinical phenotype and immu

161 this journal, Krogh and Lindhard published a seminal paper highlighting the importance of the brain i

162 as been reported in the literature since the seminal paper of Sailor and co-workers (1997) on the use

163 e year when Beven and Binley published their seminal paper on uncertainty analysis in hydrological mo

164 arch, using topic-specific search terms, (3) seminal paper search.

165 om (UK) from 2004 to February 2012 and older seminal papers identified in search (3), identifying a t

166 enter, who was the lead author on one of the seminal papers on quantitative BAL fluid culture, to exp

167 re we revisit the experimental paradigm from seminal papers supporting trajectory control to illustra

168 In a pair of seminal papers, Sewall Wright and Gustave Malecot introd

169 f age-associated cellular stressors may be a seminal pathogenetic mechanism in the development of inv

170 these signals are generated by a variety of seminal peptides, many produced by the accessory glands

171 Glucagon (Gcg) 1 serves a seminal physiological role in buffering against hypoglyc

172 ral blood mononuclear cells (PBMCs; n = 72), seminal plasma (n = 20), cerebrospinal fluid (CSF; n = 3

173 = 0.09) and more frequent shedding of CMV in seminal plasma (p = 0.002).

174 HIV-1 RNA was measured in seminal plasma (SP) and blood plasma (BP) at baseline, o

175 etroviral drug families on viral kinetics in seminal plasma (SP) of treatment-naive HIV-infected pati

176 HIV-RNA was quantified in seminal plasma (spVL) and in blood plasma (bpVL) from 2

177 in these assays are typically purified from seminal plasma and contain many molecular forms (intact

178 In multivariate analysis, the presence of seminal plasma CMV (P = 0.04), detectable 2-long termina

179 the possibility that endometrial exposure to seminal plasma could contribute to endometriotic disease

180 Standardization of seminal plasma derived PSA calibrant molecular form mass

181 Pooled human seminal plasma enhanced E. coli growth in vitro in a dos

182 These data suggest that seminal plasma enhances the formation of endometriosis-l

183 Exposure to seminal plasma from HIV-1-infected and uninfected men wi

184 Given that seminal plasma is an abundant source of transforming gro

185 beta, we evaluated the effect of exposure to seminal plasma on the growth of endometrial lesions.

186 Human endometrial explants were exposed to seminal plasma or to control medium before transfer to P

187 To this end, seminal plasma purified PSA standards from different com

188 Xenografts exposed to seminal plasma showed an eightfold increase in volume an

189 Seminal plasma stimulated the production of a variety of

190 Absence of seminal plasma was accompanied by down-regulation of the

191 os developed in female tracts not exposed to seminal plasma were abnormal from the early cleavage sta

192 in part, enhancement of bacterial growth by seminal plasma.

193 s for the quantitation of HIV RNA in CSF and seminal plasma.

194 ivation status did not change in response to seminal plasma.

195 is acquired as the result of exposure to the seminal plasma.

196 ction persisted when HSV-2 was introduced in seminal plasma.

197 had at least 1 herpesvirus detected in their seminal plasma.

198 on marmoset (Callithrix jacchus) has taken a seminal position in neurobiological research, fueled in

199 Neutron dark-field imaging constitutes a seminal progress in the field of neutron imaging as it c

200 ed in 1948, the Framingham Heart Study was a seminal prospective cohort study of 5,209 adult resident

201 Ms, the major components of the coagulum, by seminal proteases.

202 The seminal protein ovulin increases ovulation rates after m

203 Seminal protein-unbound DTG concentrations exceeded the

204 ysiological or molecular mechanisms by which seminal proteins effect these changes.

205 find that separate aspects of mating (sperm, seminal proteins, and physical effects) independently mo

206 intima, suggesting a mechanism for entry of seminal proteins, or other exogenous components, into th

207 ns aim at maximizing their own gains, recent seminal psychological work suggests that our behavior is

208 One decade has passed since seminal publications described macrophage infiltration i

209 isuospatial attention has been shown by four seminal, published studies in monkeys (Macaca mulatta) p

210 he thyroid and with thyroid cancers, raising seminal questions about the role of the immune system in

211 Seminal recent studies that have shed new light on the r

212 With drought, 100% of TRL was seminal, regardless of line because nodal roots were alm

213 RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibit

214 Seminal replication of multiple HHVs is common in our HI

215 eview and analysis of new data, we replicate seminal reports of EBO in ASD relative to classical HC n

216 details several current reports and several seminal reports prior to 2012.

217 preparing nanoporous carbon spheres and the seminal research that has inspired their development, pr

218 ful 2D polymerization strategies, as well as seminal research that inspired their development.

219 Those results are extensions of Singer's seminal result answering a question of Kaplansky, as app

220 Following this seminal result, much effort is put into the improvement

221 bly in vivo The tumor suppressor p53 plays a seminal role in cancer development.

222 uripotency regulators (Sox2 and Oct4) play a seminal role in embryonic stem (ES) cell-specific gene r

223 stals, thin films and nanostructures plays a seminal role in expanding the frontiers of quantum mater

224 l behavior of phylloxanthobilins will play a seminal role in identifying biological roles of phyllobi

225 ligand-metal cooperative effects and plays a seminal role in the heterolytic hydrogenation mechanism.

226 vious work from our laboratory demonstrate a seminal role of Pax6 in the development of all cerebella

227 All lines developed one seminal root that varied, with branch roots, from 31% to

228 n) genes rtcs (rootless concerning crown and seminal roots) and rtcl (rtcs-like) emerged from an anci

229 This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San D

230 Primary Infection Resource Consortium and 67 seminal samples from HIV-negative healthy controls.

231 nce of asymptomatic STIs, is associated with seminal shedding of HIV in men receiving ART, conferring

232 Predictors of HIV seminal shedding were determined for the entire cohort,

233 Attention is given to the seminal stoichiometric organometallic studies which led

234 Although earlier, seminal studies demonstrated that the gut per se has the

235 While seminal studies established primary reactivity patterns,

236 Seminal studies have defined the bacterial and cellular

237 ins have been studied by (19)F NMR since the seminal studies of Hull and Sykes in 1974.

238 ahl, Aziz Sancar, and Paul Modrich for their seminal studies of the mechanisms by which cells from ba

239 Seminal studies of the thalamocortical circuit in the vi

240 These seminal studies opened a flourishing area of research, y

241 Seminal studies showed that CRISPR-Cas systems provide a

242 del, we simulate experimental data from four seminal studies that microstimulated or inactivated a ke

243 It has been central to a number of seminal studies, particularly in the context of HIV-1 an

244 This review summarizes and evaluates these seminal studies.

245 In a seminal study of gene-environment interaction, childhood

246 Since the seminal study of Goodale and Milner (1992), there is gen

247 y of human populations by Harry Harris, this seminal study provided the first relatively unbiased pic

248 We examine how this seminal study was pivotal to our understanding of CME an

249 and review the scientists who introduced the seminal terminology, concepts, methodological approaches

250 organization of society lies at the core of seminal theories in human geography that have strongly i

251 rt in two-dimensional systems given that the seminal theory for transport in disordered metals predic

252 inking of a substrate, called Plugin, by the seminal transglutaminase AgTG3.

253 ne production was assessed by measuring host seminal vesicle (SV) weights as an indirect measure over

254 Therefore, we propose OSVIRA (Obstructed Seminal Vesicle and Ipsilateral Renal Agenesis) as an ac

255 ctivation also resulted in transformation of seminal vesicle epithelial cells in Pten-null mice.

256 h divergence in major protein composition of seminal vesicle fluid, suggesting that changes in gene e

257 tion of fructose in human semen, a marker of seminal vesicle function.

258 of seminal fluid by surgical excision of the seminal vesicle gland.

259 (68)Ga-PSMA-11 localized in a lymph node and seminal vesicle in a patient with no abnormal (68)Ga-RM2

260 traprostatic extension (EPE), 452 (18%) with seminal vesicle invasion (SVI), 1,434 (58%) with positiv

261 inimisation algorithm stratifying by risk of seminal vesicle invasion and centre to either the contro

262 xpression in prostate cancer cells decreased seminal vesicle invasion and distant metastases.

263 ilaterally, with extracapsular extension, no seminal vesicle invasion, a 2-mm positive margin at the

264 level, primary Gleason grade greater than 3, seminal vesicle invasion, and higher number of removed a

265 after radical prostatectomy include men with seminal vesicle invasion, Gleason score 8 to 10, extensi

266 ical margin status, extracapsular extension, seminal vesicle invasion, lymph node invasion, and andro

267 se pathologic findings at prostatectomy (ie, seminal vesicle invasion, positive surgical margins, ext

268 ive prostate-specific antigen concentration, seminal vesicle invasion, surgical margin status, extrac

269 Gleason 4 or 5 patterns or extracapsular or seminal vesicle invasion.

270 3aN0M0 prostate cancer, an estimated risk of seminal vesicle involvement less than 30%, prostate-spec

271 a more locally invasive phenotype and causes seminal vesicle obstruction at high penetrance.

272 -independent mechanism according to in vitro seminal vesicle organ cultures.

273 HIP1R mRNA levels were decreased in seminal vesicle tissue from mice bearing miR-23b/-27b-tr

274 ifferentiated nonprostatic mouse epithelium (seminal vesicle) is sufficient for respecification to pr

275 lesion, region (prostate, including bed and seminal vesicle, or extraprostatic, including all lymph

276 bryos were transferred to females mated with seminal vesicle-excised males.

277 ults in obstruction of the proximally placed seminal vesicle.

278 PET/CT correctly detected invasion of seminal vesicles (n = 11 of 21 patients; 52%) with 86% a

279 Volumes of the prostate and seminal vesicles (SV) were calculated by using whole-vol

280 Furthermore, the involvement of seminal vesicles and other extracapsular extension were

281 Proteins expressed from the seminal vesicles evolve more rapidly than those from oth

282 e weights) were observed in the prostate and seminal vesicles, along with minimal repression of circu

283 specified for anatomic locations (prostate, seminal vesicles, local lymph nodes, distant lymph nodes

284 in 20 fractions in 5 weeks) to prostate and seminal vesicles.

285 st in part, to kinetic factors elucidated in seminal work by Hoffmann.

286 Building on seminal work by Poncela et al., which shows how cooperat

287 After a first seminal work describing four different DC subpopulations

288 Following his seminal work in 1953, Stanley Miller conducted an experi

289 the 2015 Nobel Prize in Chemistry for their seminal work in defining DNA repair pathways.

290 Seminal work in Gary Van Hoesen's laboratory at Iowa in

291 locity relationship has been known since the seminal work of A.　V.Hill in 1938.

292 n be traced back about five centuries to the seminal work of Andreas Vesalius.

293 It has been known since the seminal work of Prigogine that the stabilisation of thes

294 Following the seminal work of Purcell and in agreement with the Fermi'

295 In 1979, the seminal work of Wenkert set the standards for the utiliz

296 Just over a century ago, Lewis published his seminal work on what became known as the covalent bond,

297 Seminal work performed several decades ago provided an i

298 erface Bilayers must be functionalised, with seminal work using membrane-inserting toxins, ion channe

299 In this review, we return to seminal works on this topic before summarizing the chang

300 In seminal works, Good and Toulmin constructed an intriguin