ライフサイエンスコーパス: seminiferous

1 , but result from rupture of normally formed seminiferous cords beyond e20.5.

2 olutely required for the construction of the seminiferous cords of the testis.

3 ggregation, ectopic Sertoli cells, malformed seminiferous cords) is not evident until after the MPW.

4 ee of these are expressed in a region of the seminiferous epithelia (SE) rich in meiotically active c

5 The seminiferous epithelial cycle and spermatogenic wave are

6 od-testis barrier (BTB) at stage VIII of the seminiferous epithelial cycle for further development.

7 that occur concurrently at stage VIII of the seminiferous epithelial cycle of spermatogenesis are unk

8 (BTB) restructuring at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis to faci

9 ring its cyclic restructuring throughout the seminiferous epithelial cycle of spermatogenesis.

10 extensive restructuring at stage VIII of the seminiferous epithelial cycle to facilitate the transit

11 gical barrier breakdown in all stages of the seminiferous epithelial cycle, except at stage VIII when

12 esponsible for the early onset of the severe seminiferous epithelial degeneration observed in SRC-1(+

13 s is compromised, germ cells detach from the seminiferous epithelium and infertility often results.

14 connexin43, which was present throughout the seminiferous epithelium and not restricted to the BTB as

15 and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, resp

16 d to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave.

17 poral order of gene transcription within the seminiferous epithelium are poorly understood.

18 inus, was found to be transported across the seminiferous epithelium at stages VIII-IX of the epithel

19 otic germ cell development take place in the seminiferous epithelium behind the BTB.

20 e same stage in development, stage IV of the seminiferous epithelium cycle, equivalent to mid-pachyne

21 ogonia located in a niche at the base of the seminiferous epithelium delimited by Sertoli cells and p

22 that reside at the basal compartment of the seminiferous epithelium differentiate into more advanced

23 The localization of Cx43 in the seminiferous epithelium during (i) the normal epithelial

24 posing ends of adjacent Sertoli cells in the seminiferous epithelium during spermatogenesis.

25 uring that occur at the opposite ends of the seminiferous epithelium during spermatogenesis.

26 s cellular events that take place across the seminiferous epithelium during the epithelial cycle of s

27 modeling near the BM at opposite ends of the seminiferous epithelium during the epithelial cycle, kno

28 ce) to coordinate cellular events across the seminiferous epithelium during the epithelial cycle.

29 es to enter the adluminal compartment of the seminiferous epithelium for development into spermatozoa

30 Although the cycle and the wave of the adult seminiferous epithelium have been well characterised, pa

31 ression, shows that PDE8 is expressed in the seminiferous epithelium in a stage-specific manner.

32 o critical cellular events that occur across seminiferous epithelium in mammalian testis during sperm

33 tects against late-onset degeneration of the seminiferous epithelium in mice and inhibits Leydig cell

34 Cellular events that occur across the seminiferous epithelium in the mammalian testis during s

35 of molecules between cells, and separate the seminiferous epithelium into basal and adluminal compart

36 hree MAPKs regulate adhesion function in the seminiferous epithelium is also presented.

37 ion of spermatids and their release from the seminiferous epithelium is AR dependent and maximally se

38 Its expression at the BTB in the seminiferous epithelium is stage specific, being lowest

39 ctions between adjacent Sertoli cells in the seminiferous epithelium near the basement membrane.

40 S) is an actin-rich adherens junction in the seminiferous epithelium of adult mammalian testes.

41 expression was the highest at the ES in the seminiferous epithelium of adult rat testes, most notabl

42 hosphorylation-dependent localization in the seminiferous epithelium of adult rat testes.

43 ith the TJ proteins occludin and ZO-1 in the seminiferous epithelium of adult rats.

44 co-localized to the site of apical ES in the seminiferous epithelium of the rat testis in immunohisto

45 specific adherens junction (AJ) type] in the seminiferous epithelium of the rat testis, we sought to

46 oses a challenge to deliver any drugs to the seminiferous epithelium of the testis, such as a nonhorm

47 iminate expression of a reporter gene in the seminiferous epithelium of transgenic mice, whereas the

48 as an adhesion and maturation factor of the seminiferous epithelium orchestrating spermiogenesis.

49 a show that the cycle and wave of the murine seminiferous epithelium originate at a much earlier stag

50 ) conferred by adjacent Sertoli cells in the seminiferous epithelium segregates post-meiotic germ cel

51 od-testis barrier (BTB) restructuring in the seminiferous epithelium that occur concurrently at stage

52 y disrupts Sertoli-germ cell adhesion in the seminiferous epithelium to facilitate germ cell migratio

53 Sepp1 trafficking in the seminiferous epithelium was studied using conventional m

54 d Sertoli cells as the only cell type in the seminiferous epithelium with detectable ApoER2 expressio

55 permiogenesis, age-dependent degeneration of seminiferous epithelium, and disorder of cholesterol hom

56 and sloughing off of spermatogenic cells in seminiferous epithelium, and lack of mature spermatids i

57 sloughing of postmeiotic germ cells from the seminiferous epithelium, and marked reduction in the num

58 n the transport of synthetic F5-peptide into seminiferous epithelium, and thus Slc15a1 is a novel tar

59 In the seminiferous epithelium, Eps8 is localized to actin-base

60 involvement in junction restructuring in the seminiferous epithelium, especially at the ectoplasmic s

61 ed Sertoli cells, a somatic component of the seminiferous epithelium, exhibited significantly lower a

62 to survey all laminin chains in cells of the seminiferous epithelium, it was noted that alpha 2, alph

63 triking testicular pathology, with disrupted seminiferous epithelium, multinucleated giant cells, unc

64 In the seminiferous epithelium, Sertoli cells express TNFR1, wh

65 preferentially expressed in stages VII-VIII seminiferous epithelium, the androgen-dependent stages d

66 tact during the transit of spermatids in the seminiferous epithelium, which is associated with extens

67 averse the blood-testis barrier (BTB) in the seminiferous epithelium, which is reminiscent of viral p

68 morphology in postmeiotic germ cells in the seminiferous epithelium, which led to the complete arres

69 hich leads to germ cell exfoliation from the seminiferous epithelium.

70 occurs within a highly organized tissue, the seminiferous epithelium.

71 tis in germ cells at the basal aspect of the seminiferous epithelium.

72 ween spermatids and Sertoli cells within the seminiferous epithelium.

73 t by controlling the microenvironment of the seminiferous epithelium.

74 function, leading to germ cell loss from the seminiferous epithelium.

75 ype A spermatogonia in the basal part of the seminiferous epithelium.

76 d germ cells at the basal compartment in the seminiferous epithelium.

77 .g., residual bodies, phagosomes) across the seminiferous epithelium.

78 express stage-specifically at the BTB in the seminiferous epithelium.

79 epresenting spermatogenic development in the seminiferous epithelium.

80 totic germ cells by Sertoli cells lining the seminiferous epithelium.

81 with apical ES and BTB restructuring in the seminiferous epithelium.

82 or of cell adhesion and BTB integrity in the seminiferous epithelium.

83 s, in which spermatids are released into the seminiferous lobule lumen (SLL), where they develop into

84 ure separating this species from its closest seminiferous relative, Festuca ovina.

85 normality in which vegetative shoots replace seminiferous (sexual) inflorescences.

86 istinct, periodic, and limited to particular seminiferous stages.

87 KI male homozygotes are infertile because of seminiferous tubular dysmorphogenesis in the testis, sim

88 rain neurons, primitive inner ear cells, and seminiferous tubular epithelium.

89 cele affects Leydig cell function as well as seminiferous tubular function, and is a risk factor for

90 lls migrated to the basement membrane of the seminiferous tubule and were maintained similar to SSCs.

91 Treatment of mice with JQ1 reduced seminiferous tubule area, testis size, and spermatozoa n

92 Focal seminiferous tubule atrophy accompanied by Leydig cell h

93 Seminiferous tubule basement membrane (STBM) plays an im

94 , we observed a lower mutation frequency for seminiferous tubule cell preparations, which contain all

95 tion studies, non-selected, freshly isolated seminiferous tubule cells were transferred to the testis

96 optosis of germ cells, spermatogenic arrest, seminiferous tubule degeneration, and infertility.

97 ce have excessive spermatocyte apoptosis and seminiferous tubule degeneration.

98 tion, there was some impairment of renal and seminiferous tubule development.

99 ndrogen effects, such as testicular atrophy, seminiferous tubule diameter reduction and hyperplasia o

100 ter testicular atrophy and decreased average seminiferous tubule diameter when compared with K48R-age

101 ls and hyperplastic Leydig cells, leading to seminiferous tubule dilation and degeneration of germ ce

102 animals produces sexual hormone dysfunction, seminiferous tubule dystrophy and spermatogenesis blocka

103 ired in PTM-ARKO males, indicated by reduced seminiferous tubule fluid production and reduced express

104 ermatids, and the bicarbonate present in the seminiferous tubule may be a signal that regulates cAMP

105 m cells caused their premature exit from the seminiferous tubule niche, resulting in germ cell deplet

106 s while OSKM cells that remained outside the seminiferous tubule proliferated extensively and formed

107 Seminiferous tubule staging shows that stages X to XII,

108 l stem cells from other species to the mouse seminiferous tubule to generate spermatogenesis.

109 testis and was localized to a region of the seminiferous tubule where secondary spermatocytes and ea

110 eir radial migration to the periphery of the seminiferous tubule where the spermatogenic niche will f

111 not DeltaNp73KO mice, display a "near-empty seminiferous tubule" phenotype due to massive premature

112 expressed in both the podocyte and the basal seminiferous tubule, suggesting that the loss of CD2AP i

113 roliferate and migrate within the developing seminiferous tubule, with proper niche interaction and m

114 is in the fluctuating environment within the seminiferous tubule.

115 re elongate spermatids into the lumen of the seminiferous tubule.

116 als, including human, can replicate in mouse seminiferous tubules after transplantation, the growth f

117 rm counts and a high frequency of degenerate seminiferous tubules and abnormal sperm.

118 Testes from PTU-treated male tadpoles had seminiferous tubules and advanced stage male germ cells,

119 the establishment of the avascular nature of seminiferous tubules and after puberty androgens may fur

120 stem cells reside in specific niches within seminiferous tubules and continuously generate different

121 were evident in light micrographs of testis' seminiferous tubules and epithelial cells lining the epi

122 e when administered intratesticularly enters seminiferous tubules and exerts effects beyond BTB is cu

123 PAC1R(3a) mRNA is preferentially detected in seminiferous tubules and is expressed at the highest lev

124 ar space, creating a microenvironment within seminiferous tubules and providing immune privilege to m

125 fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts.

126 the testes of adult males showed dilation of seminiferous tubules and reduction in their density when

127 nockout resulted in disruption of developing seminiferous tubules and subsequent progressive loss of

128 , almost all Sertoli cells are lost from the seminiferous tubules and the Leydig cell population is r

129 scent protein (GFP) transgenic mice into the seminiferous tubules and the testicular interstitium of

130 ules were approximated by a cross-section of seminiferous tubules arranged in a hexagonal pattern, wi

131 Rat seminiferous tubules at stages I, II-III, IV-V, VI, VIIa

132 ically significant decrease in the number of seminiferous tubules containing germ cells.

133 In isolated 7 days postpartum seminiferous tubules containing mostly germ line stem ce

134 c expression of I-CREBs in germ cells of the seminiferous tubules correlates with the cyclical down-r

135 ertile by 3 mo of age and eventually exhibit seminiferous tubules devoid of germ cells.

136 from the basal to apical compartments of the seminiferous tubules for further development and maturat

137 h spermatozoa formation in 13% to 17% of the seminiferous tubules formed in the grafts.

138 ed by GFP fluorescence in squashes of living seminiferous tubules from adult testes, and the presence

139 hese pathological responses are conserved in seminiferous tubules from Gravin(-/-) mice where an over

140 males are infertile and the analysis of the seminiferous tubules identified disrupted acrosomal deve

141 n of germ cells in a substantial fraction of seminiferous tubules in aged mice.

142 e adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells.

143 tis barrier showed increased permeability of seminiferous tubules in the Arid4a(-/-)Arid4b(+/-) teste

144 ial for the maintenance of Sertoli cells and seminiferous tubules in the developing testes.

145 d mild interstitial edema and closely packed seminiferous tubules in the left testes, indicating reve

146 Histological analysis of seminiferous tubules in the testes, caput and corpus epi

147 tive dysfunction associated with hypoplastic seminiferous tubules in the testis and perturbed corpus

148 Here we show that cells from adult seminiferous tubules interact with mammary epithelial ce

149 showed hypoplastic and dysgenic testes, with seminiferous tubules lacking spermatogonia.

150 In the seminiferous tubules of busulfan-treated mice, GFP-posit

151 Consistent with enhanced apoptosis in seminiferous tubules of C/C testes, we recorded a drasti

152 of undifferentiated iPSCs directly into the seminiferous tubules of germ cell-depleted immunodeficie

153 spermatogenesis was totally compromised, as seminiferous tubules of homozygous mutant animals were d

154 , identifiable mutations directly within the seminiferous tubules of human testes.

155 at clump-forming rabbit germ cells colonized seminiferous tubules of immunodeficient mice, proliferat

156 8(Ink4c) and p19(Ink4d) are expressed in the seminiferous tubules of postnatal wild-type mice, being

157 hest level of expression was detected in the seminiferous tubules of testis.

158 nor cells established spermatogenesis in the seminiferous tubules of the host, and normal spermatozoa

159 genesis takes place in the epithelium of the seminiferous tubules of the testes, producing millions o

160 on becomes XY-specific and restricted to the seminiferous tubules of the testis as gonadogenesis proc

161 ransdifferentiation to structures resembling seminiferous tubules of the testis, including Sertoli-li

162 larin family, is expressed at high levels in seminiferous tubules of the testis, specifically in Sert

163 d that both mRNAs were strongly expressed in seminiferous tubules of the testis.

164 on spermatogenesis, which takes place in the seminiferous tubules of the testis.

165 ed mainly by spermatocytes and spermatids in seminiferous tubules of the testis.

166 However, this was not found in the seminiferous tubules of W/W(v) mice.

167 tis and mechanisms by which the virus enters seminiferous tubules remain unclear.

168 More detailed analysis of specific cells in seminiferous tubules shows localization of Atr to the nu

169 UB1 is involved in cellular functions in the seminiferous tubules such as spermatogenesis.

170 meiotic spermatids are the only cells of the seminiferous tubules that express HIP1.

171 Focal vacuolization in some of the seminiferous tubules was observed in 4-week-old mutant t

172 The seminiferous tubules were divided into concentric layers

173 uptake into the testis as a whole and to the seminiferous tubules where the germ cells are located.

174 n Leydig cells (somatic cells outside of the seminiferous tubules).

175 IKV to establish persistent infection in the seminiferous tubules, an immune-privileged site in the t

176 ased apoptotic cells within the walls of the seminiferous tubules, and a decrease in the number, moti

177 Rfx2-null round spermatids detached from the seminiferous tubules, forming large multinucleated giant

178 tis displayed typical signs of aging (patchy seminiferous tubules, germ cell depletion, and vacuoliza

179 ced testis size and numbers of germ cells in seminiferous tubules, increased germ cell apoptosis, and

180 lls, which are an important component of the seminiferous tubules, is robust and induces a strong ant

181 decreased number of germ cells, degenerating seminiferous tubules, maturation arrest and apoptosis, i

182 s of cells: (i) epithelial germ cells of the seminiferous tubules, primarily spermatids and spermatoc

183 e Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche throu

184 how impaired testis development, degenerated seminiferous tubules, reduced sperm count and low fertil

185 are small, compared with the diameter of the seminiferous tubules, resulting in high energy depositio

186 was small, compared with the diameter of the seminiferous tubules, resulting in high energy depositio

187 sues only in the developing spermatocytes of seminiferous tubules, suggesting that mSgy is a spermato

188 n the Sertoli-Sertoli tight junctions in the seminiferous tubules, the approximately 32 kDa murine JA

189 iremia, ZIKV must establish infection in the seminiferous tubules, the site of spermatozoon developme

190 Adult testicular cells, isolated from seminiferous tubules, were mixed with limiting dilutions

191 ed that the testes were composed of atrophic seminiferous tubules, whereas germ cells were found in 1

192 The testis cords give rise to the adult seminiferous tubules, whereas steroidogenic Leydig cells

193 n culminates in complete degeneration of the seminiferous tubules, which become acellular, empty spac

194 unostaining for Mamu-AG5 in cells within the seminiferous tubules, which was corroborated by localiza

195 is normally provided by Sertoli cells of the seminiferous tubules, whose function depends on testoste

196 icle-stimulating hormone receptor within the seminiferous tubules.

197 ce of active spermatogenesis in 24 +/- 7% of seminiferous tubules.

198 oimaging, and in situ confocal microscopy of seminiferous tubules.

199 n of germ cells localized at the base of the seminiferous tubules.

200 ressed primarily in Sertoli cells within the seminiferous tubules.

201 Both radionuclides gained access to the seminiferous tubules.

202 sulting in cell death and destruction of the seminiferous tubules.

203 testicular size and no spermatozoa in their seminiferous tubules.

204 reduced sperm counts, and disruption of the seminiferous tubules.

205 within the thin vascular layer overlying the seminiferous tubules.

206 storage vesicles within Sertoli cells of the seminiferous tubules.

207 stmeiotic round spermatid compartment of the seminiferous tubules.

208 permatocytes in the basal compartment of the seminiferous tubules.

209 rized by calcifications within the lumina of seminiferous tubules.

210 questered behind the Sertoli cell barrier in seminiferous tubules.

211 in the kidney collecting tubules and testis seminiferous tubules.

212 g, oviduct, epididymis, ductus deferens, and seminiferous tubules.

213 erstitial tissue that normally surrounds the seminiferous tubules.

214 aled that UT3 is located in Sertoli cells of seminiferous tubules.

215 ble to generate spermatogenesis in recipient seminiferous tubules.

216 creased mitotic index and disorganization of seminiferous tubules.

217 ring formation of structures resembling male seminiferous tubules.

218 , which are however found in the wall of the seminiferous tubules.

219 a PEDF, may prevent vascularization of human seminiferous tubules.

220 d18 foci were increased in the lumina of the seminiferous tubules.

221 r for the identification of Sertoli cells in seminiferous tubules.

222 ecifically in the nuclei of Sertoli cells in seminiferous tubules.

223 study mechanisms of virus persistence in the seminiferous tubules.

224 es, which in turn are composed of convoluted seminiferous tubules.