ライフサイエンスコーパス: sense strand

1 ond makes a base-specific contact to the DNA sense strand.

2 cripts is suppressed by transcription of the sense strand.

3 ted with reduced off-target silencing by the sense strand.

4 mediated by siRNA knockdown of TNFR1 via its sense strand.

5 blocked by a cDNA expressing the E2F4 3'-UTR sense strand.

6 smembrane proteins, are transcribed from the sense strand.

7 ated more than 250-fold upon addition of the sense strand.

8 anscripts carrying seed matches to the shRNA sense strand.

9 ding protein which binds the pyrimidine-rich sense strand.

10 ly bound nuclear proteins on its purine-rich sense strand.

11 reverse transcriptase which cleaves the anti-sense strand.

12 ere well tolerated in both the antisense and sense strands.

13 gh proportion of human protein-coding region sense strands.

14 a bias towards low internal stability at the sense strand 3'-terminus, lack of inverted repeats, and

15 standard were hybridized to a set of 21,807-sense strand 60-mer oligonucleotides on each slide repre

16 pair mismatches in the central region of the sense strand (9-12 nt), significantly improve the potenc

17 s concern with a novel strategy that reduces sense strand activity of vector-encoded shRNAs via codel

18 However, in principle, the sense strand also possesses silencing capacity that may

19 a bifunctional TuD against an anti-HCV shRNA sense strand and an HCV-related cellular miRNA.

20 lex unwinding and degradation of the unwound sense strand and RNA-induced silencing complex formation

21 Four consecutive T residues in the sense strand are sufficient to terminate transcription b

22 e) that were endogenously generated from the sense strand at Map2b, antisense strand at Nefl, and bot

23 d 3'-terminus, lack of inverted repeats, and sense strand base preferences (positions 3, 10, 13 and 1

24 When inverted into the sense strand by a site-specific recombinase, the COIN mo

25 excised intron RNA, which cleaves the DNA's sense strand by partial reverse splicing; and the intron

26 process was found to be facilitated through sense strand cleavage, there is evidence for an alternat

27 For aI2, sense-strand cleavage occurs mainly by a partial reverse

28 by the intron-encoded endonuclease, with the sense strand cleaved by partial or complete reverse spli

29 AS ODNs containing eight mismatches, or the sense strand controls (P < 0.0001).

30 betaMyHC distal negative regulatory element-sense strand (dbetaNRE-S) element is markedly increased

31 specific to the distal region of the betaNRE sense strand (dbetaNRE-S; -332 to -311).

32 nzymatic ligation reaction (leaving the anti-sense strand dissociable).

33 we extend this model, showing that positive-sense strands do accumulate in LuDelta2 infections as pa

34 y which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the

35 Expanded (GAA)n repeats in the sense strand for transcription caused a significant decr

36 al- and carrier-size (TTC)n repeats into the sense strand for transcription led to the appearance of

37 nt only when the (CTG)(n) tracts were in the sense strand for transcription.

38 the cells harboring the target RNA, whereas sense strand gets degraded.

39 y which antisense RNA might give rise to new sense-strand globin mRNA.

40 n of TuDs can sequester and inactivate shRNA sense strands in human cells selectively without affecti

41 Whereas both DNA strands are sense strands in the Drosophila gene, the coding region

42 litates insertion of the 3' end of the minus-sense strand into the template channel.

43 The sense strand is nicked at variable distances from the TT

44 s biphasic, so that accumulation of positive-sense strands is ultimately suppressed, probably because

45 ied two p40 binding sites on the full-length sense strand L1Hs RNA.

46 ive chromatin to further regulate or enhance sense-strand mRNA expression.

47 mical modification and mismatches within the sense strand of 736 also inhibited silencing activity.

48 rming helix-destabilizing complexes with the sense strand of an asymmetric polypurine-polypyrimidine

49 Expressed signatures were derived from the sense strand of at least 19,088 of 29,084 annotated gene

50 Okazaki fragments were incorporated into the sense strand of exon 4, replacing the normal sequence.

51 ssing SH-SY5Y cells, we demonstrate that the sense strand of PPy/u interacts with a major nuclear pro

52 ies of related factors with affinity for the sense strand of PRR.

53 ause of the common cold, contains a positive-sense strand of RNA which is translated into a large pol

54 residues, e.g., 2'-O-Me and 2'-O-MOE, in the sense strand of siRNA did not show a strong positional p

55 ctive for RNAi we modified the 3' end of the sense strand of siRNA with a nuclease-resistant DNA hair

56 gene, and the Y box protein MSY-1 bound the sense strand of the -83- to -69-bp region.

57 mbly of the dimeric Purbeta repressor on the sense strand of the ACTA2 enhancer is dictated by the as

58 clear protein that binds specifically to the sense strand of the C-rich sequence overlapping the Sp1

59 more sensitive to mismatch insertions on the sense strand of the DNA binding site, especially within

60 cells with a VSV recombinant expressing the sense strand of the enhanced green fluorescent protein g

61 -R cDNA, which is fully complementary to the sense strand of the EPO-R gene from 2.5kb 3' to the sens

62 The sense strand of the hybridized duplex DNA could be coval

63 in which the excised intron RNA cleaves the sense strand of the recipient DNA by reverse splicing, w

64 c-length virus- and virus-complementary (vc)-sense strands of all WMoV genomic RNAs accumulated asymm

65 t much higher frequency than expected in the sense strands of introns >20 kb, but they are found only

66 )]-nucleoside residues) in the antisense and sense strands of short interference RNA (siRNA) was perf

67 in rat testis that binds specifically to the sense strands of the PhGPx and GPx 3' UTRs.

68 The message (sense) strand of the IRP1 operator (5'-TTAGGTTAGCCAAACCT

69 The message (sense) strand of the IRP3 operator (5'-TTAGGTGAGACGCACCC

70 Also, the intron RNA cleaves the sense-strand of the recipient DNA by a reverse splicing

71 tion upon annealing with a 20-nucleotide DNA sense strand oligo, representing the greatest activation

72 mation, which is activated upon binding of a sense strand oligonucleotide to the antisense module.

73 A fluorescent sense strand PNA probe binding to RNAi duplex guide stra

74 actions (aPCR), using an excess of one short sense-strand primer to be extended and a limiting amount

75 bone indicate that enzymatic cleavage of the sense strand prior to strand dissociation is not require

76 ASOs targeting sense strand repeat-containing RNAs do not correct this

77 I and LuDelta2) packaged 47 and <8% positive-sense strands, respectively.

78 A transgene encoding a translatable sense-strand RNA from the 5' end of iaaM silenced the ia

79 d of the siRNAs bind directly to DNA or to a sense-stranded RNA transcript corresponding to the known

80 Retroviral genomes are assembled from two sense-strand RNAs by noncovalent interactions at their 5

81 oviral genomes are dimeric, comprised of two sense-strand RNAs linked at their 5' ends by noncovalent

82 Retroviral genomes contain two sense-strand RNAs that are noncovalently linked at their

83 Within nuclei, sense-strand RNAs were preferentially localized within n

84 plex internal stability and siRNA sense/anti-sense strand secondary structure.

85 ocked by attaching a partially complementary sense strand (sODN) via a heterobifunctional photocleava

86 inker (PL) to partially complementary 20-mer sense strands (sODNs).

87 gion alter the distribution of RNAPII on the sense strand, suggesting that the barrier observed after

88 t alter ratios of positive-sense to negative-sense strands, suggesting that entry rather than replica

89 GGCCCC) direction, which are not affected by sense strand-targeting ASOs.

90 d specific nucleotide positions in the siRNA sense strand that could be modified with a corresponding

91 taining cholesteryl modifications within the sense strand that were used for in vivo studies.

92 eparate from its complementary passenger (or sense) strand to generate the active RISC complex.

93 h was confirmed by in vitro translation of a sense-strand transcript, producing a protein of approx.

94 led with sequence analyses revealed that the sense-strand transcription of the retrocopies often lead

95 HeT-A produces only sense-strand transcripts of the full-length element, whe

96 binding at the distal region of the betaNRE sense strand was antigenically distinct from cellular nu

97 tion, and complementary PNAs targeted to the sense strand were also inactive.

98 Multiple ANA modifications within the sense strand were also well tolerated.

99 the methylation-susceptible cytosines in the sense strand were replaced by thymine displayed marked l