ライフサイエンスコーパス: sensitization

1 arrier defects can lead to systemic allergen sensitization.

2 cantly attenuated ultraviolet injury-induced sensitization.

3 ive transfer of gammadelta T cells prevented sensitization.

4 and risk factors for early and late onset of sensitization.

5 aspergillosis and severe asthma with fungal sensitization.

6 isease, food sensitization, and aeroallergen sensitization.

7 iated with eczema and possibly also with IgE sensitization.

8 known about the mediators that drive central sensitization.

9 ull and wild-type mice following aspergillus sensitization.

10 s significantly associated with early age at sensitization.

11 aspergillosis and severe asthma with fungal sensitization.

12 only promotes bone diseases but also type I sensitization.

13 allergens may be a risk factor for cutaneous sensitization.

14 between mold or dampness indicators and IgE sensitization.

15 t not proteases, induced TNF during allergic sensitization.

16 sensitization and clinically relevant double sensitization.

17 we cannot rule out an association with food sensitization.

18 nsitization to allergic disease and allergic sensitization.

19 ponsiveness following intranasal aspergillus sensitization.

20 This effect was independent of allergic sensitization.

21 , could identify individuals with esophageal sensitization.

22 levant symptoms of rhinitis related to their sensitization.

23 tized to HDM than in AD patients without HDM sensitization.

24 ve foods prior to age 3 with evidence of IgE sensitization.

25 anced eosinophilic inflammation and allergic sensitization.

26 re underrepresented among subjects with food sensitization.

27 ormation and for cocaine-mediated behavioral sensitization.

28 erentiated individual dissection of relevant sensitization.

29 little is known about the importance of LTP sensitization.

30 albicans colonization and likely subsequent sensitization.

31 ere assessed along with patterns of allergen sensitization.

32 ly greater in participants with Cladosporium sensitization.

33 8% of multimorbidity was attributable to IgE sensitization.

34 ding prevention of the onset of new allergen sensitizations.

35 AIT in preventing the onset of new allergen sensitizations.

36 on animals that had undergone injury-induced sensitization, 2-AG and anandamide diminished sensitizat

37 .63-9.95]), eczema (2.89[1.08-7.76]) and cat sensitization (5.65[1.92-16.6]) among offspring, but was

38 To study whether maternal allergen sensitization affects offspring susceptibility to food a

39 p 3 can be used as a marker allergen for LTP sensitization also in Central European patients.

40 Age of aeroallergen sensitization also influenced asthma risk; 65% of childr

41 stronger association between dietary TAC and sensitization among children with low traffic-related ai

42 s Registry to elucidate the associations and sensitizations among patients with concomitant AD and AC

43 deficiency results in increased aeroantigen sensitization and airway hyperresponsiveness.

44 ing burden of food allergen and aeroallergen sensitization and allergic disease was noted across stud

45 y a role in the development of allergen poly-sensitization and allergic multimorbidity.

46 tion between bacterial colonization and food sensitization and allergy suggests that the microbiome m

47 tudy on the effects of PHO withdrawal on IgE sensitization and anaphylaxis reporting.

48 luence the development of childhood allergic sensitization and atopic diseases.

49 This effect is independent of fungal sensitization and can be reconstituted with beta-glucan

50 tions of an antibody to TNF before or during sensitization and challenge phase of colitis induction.

51 However, after in vivo intranasal sensitization and challenge with HDM, DC-specific Jagged

52 ors showed reduced anaphylaxis upon allergen sensitization and challenge, irrespective of the allerge

53 ated bronchoconstriction induced by allergen sensitization and challenge.

54 de a neurophysiological mechanism of central sensitization and chronic pain associated with spasticit

55 e unable to distinguish between asymptomatic sensitization and clinically relevant Hymenoptera venom

56 in the expression of AMPH-induced locomotor sensitization and CPP.

57 guously separate the electroporation-induced sensitization and desensitization effects.

58 ific IgG was administered to mice undergoing sensitization and desensitization to the model food alle

59 life have been linked with risk of allergic sensitization and disease.

60 nal associations of 25(OH)D levels with both sensitization and eczema.

61 OA-NO2 injections administered 18 h prior to sensitization and elicitation suppresses ACD in both pre

62 response is affected by subsequent allergen sensitization and exposure.

63 versity measures did not differ between food sensitization and food allergy cases and controls.

64 At age 10 years, inhalant allergic sensitization and food-allergic sensitization were measu

65 Allergen sensitization and high frequencies of comorbid allergic

66 nside the SR locally, leading to luminal RyR sensitization and lowering of the cytosolic Ca(2+) activ

67 between prevalent asthma, rhinitis, and IgE sensitization and mold or dampness indicators were asses

68 Central sensitization and network hyperexcitability of the nocic

69 mediated apnea and bradycardia through TRPV1 sensitization and neuronal excitation, which may contrib

70 DRG neurons and leads to spinal cord central sensitization and neuropathic pain symptoms.

71 r T cells (iNKTs) are involved in CM allergy sensitization and now examine their role in OIT.

72 ith ovalbumin (OVA) followed by epicutaneous sensitization and oral challenge of their offspring with

73 ectrophysiological properties of nociceptive sensitization and potentially related conditions such as

74 endotoxin and to the development of allergic sensitization and recurrent wheeze assessed at age 3 yea

75 associated with the development of allergic sensitization and recurrent wheeze.

76 rgic rhinitis and eczema up to 18 years, and sensitization and reduced lung function at 12 years.

77 There were small differences in sensitization and reported allergic reactions for select

78 Early life aeroallergen sensitization and RV wheezing had additive effects on as

79 greater risk for developing asthma, FE, and sensitization and should hence be monitored.

80 approach to reduce oxaliplatin-induced TRPV1-sensitization and the hyperexcitability of sensory neuro

81 ilonRI is primarily responsible for allergic sensitization and the inflammatory response, while IgE b

82 o cannabis allergens may trigger a C. sativa sensitization and/or allergy.

83 on the development of allergic disease, food sensitization, and aeroallergen sensitization.

84 nesses, presence and pattern of aeroallergen sensitization, and asthma diagnosis at age 13 years were

85 of bladder tumor, chemotherapy for radiation sensitization, and external beam radiotherapy has emerge

86 ystemic toxicity, endocrine disruption, skin sensitization, and many others.

87 of allergy, but the routes and mechanisms of sensitization are not fully understood.

88 tudies about the natural history of allergic sensitization are rare.

89 Multiple allergic sensitizations are common in persistent childhood asthma

90 ntive effect of primary sensitization or new sensitizations are poorly understood.

91 n induced by SCI.SIGNIFICANCE STATEMENT Pain sensitization associated with spinal cord injury (SCI) i

92 D concentrations and the risk for concurrent sensitization at age 0.5, 2, and 3 years, and mixed-effe

93 sitive pasteurized raw egg challenge and egg sensitization at age 12 months.

94 prevalent asthma, rhinitis, and aeroallergen sensitization at age 16 years and with incidence of asth

95 nt of 300 cells/muL or more and aeroallergen sensitization at age 2 years were each associated with i

96 or recurrent wheeze or food or environmental sensitization at age 3 years.

97 ng of direct peanut introduction, and peanut sensitization at age 7 years.

98 ong distance and probably contributes to the sensitization at shorter distances along with the triple

99 ve a good understanding of the mechanisms of sensitization at the periphery during inflammation, litt

100 timulation, high molecular weight HA reduces sensitization, attenuating inflammatory and neuropathic

101 Sensitization before age 7-8 years was independently ass

102 risk difference in the onset of new allergen sensitizations between patients treated with AIT and pha

103 SE sensitization, but not S. aureus carriage, was associate

104 AIT in preventing the onset of new allergen sensitizations, but high-quality studies could change th

105 breast cancer xenografts highly amenable to sensitization by cotreatment with a miR-139-5p mimetic.S

106 Although the utility of triplet sensitization by energy transfer has long been known as

107 e show that the excitation energy for Yb(3+) sensitization can be carefully adjusted to lower energy

108 IgE sensitization can occur through an impaired skin barrier

109 ptimizing nsPEF delivery protocols to induce sensitization can reduce the dose and adverse side effec

110 M1 or a control peptide was performed during sensitization, challenge, or both with HDM in mice.

111 BALB/c mice without and with ovalbumin sensitization/challenge were infected with candidate bac

112 ciation studies on self-reported allergy and sensitization comprising a total of 62,330 subjects.

113 Feeding high doses of peanut before sensitization decreased percentages of CD3(+)CD4(+)IL-13

114 We hypothesized that sensitization develops as specific patterns with respect

115 prostate cancer cells to DNA damage and the sensitization did not require p53.

116 Skin sensitization did not require prior skin damage or enzym

117 have offered insights into pathways of food sensitization, differences between rodent and human immu

118 We sought to explore latent patterns of sensitization during the first 6 years of life and inves

119 etween peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduc

120 is that chiral Lewis acid catalyzed triplet sensitization enables the synthesis of highly enantioenr

121 high degree of comorbid conditions, allergic sensitization, exacerbations, and very poorly controlled

122 action represents a central step in visceral sensitization following colonic inflammation, thereby id

123 tively inhibited the expression of locomotor sensitization following repeated injections of AMPH and

124 n to evoke sustained nociceptor activity and sensitization following tissue damage, respectively.

125 ed predominantly by type and multiplicity of sensitization (food vs inhalant), allergen combinations,

126 dates and is used as the official measure of sensitization for allocation of points in the US Kidney

127 Atopic dermatitis and allergic sensitization had significant interactions on both the a

128 ), histamine release assay (HR), and passive sensitization histamine release assay (passive HR) in th

129 ecific CD4(+) T cells and prevented allergic sensitization in a mouse allergy model.

130 gated the presence and mechanism of neuronal sensitization in a unique cohort of individuals who deve

131 f neuroinflammatory signaling and microglial sensitization in aging, its implications in psychologica

132 n the development of atopic eczema or atopic sensitization in breastfed infants and toddlers.

133 We investigated the role of LTP sensitization in Central European patients displaying st

134 eczema (PSE), FLG mutation, or both and IgE sensitization in childhood.

135 creases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 year

136 : the Prevention of Allergy Risk factors for Sensitization in Children Related to Farming and Anthrop

137 dermatitis (1.9 [1.0-3.4]) in childhood, and sensitization in early adulthood (2.2 [1.1-4.3]).

138 rthweight (0.6 [0.4-1.0]) were predictive of sensitization in early adulthood compared to average bir

139 wheezing illnesses with RV and aeroallergen sensitization in early life.

140 correlates with bone abnormalities and pain sensitization in fibrodysplasia ossificans progressiva.

141 ing to improved lipid metabolism and insulin sensitization in mice.

142 arriers of bacterial antigens leading to IgE sensitization in patients suffering from atopic dermatit

143 We compared allergic sensitization in patients with food allergy or Wiskott-A

144 Elevated hs-CRP is associated with allergic sensitization in school-aged children suggesting systemi

145 The development of specific allergic sensitization in the skin of those patients followed by

146 ction between atopic dermatitis and allergic sensitization in their effects on food allergy risk (rel

147 cticable way to diagnose clinically relevant sensitization in vespid venom allergy.

148 ctivation, play different roles for allergen sensitization in vivo and may represent attractive thera

149 rus (RV) wheezing illnesses and aeroallergen sensitization increase the risk of asthma at school age.

150 Conversely, atopic dermatitis with allergic sensitization increased the risk of asthma more than 7-f

151 th the exception of some markers of allergic sensitization, indicating a need to develop better marke

152 ight underlie a peripheral mechanism of pain sensitization induced by SCI.SIGNIFICANCE STATEMENT Pain

153 and lateral-dorsal nerve branches, and that sensitization induced by tissue damage was mediated cent

154 However, unlike therapy-induced antibodies, sensitization-induced IgG did not show IgE-blocking acti

155 This sensitization is achieved through the sustained dopamine

156 The sensitization is achieved with a broad range of visible

157 derlying clinical observations that allergic sensitization is associated with increased susceptibilit

158 erculosis infection is low and environmental sensitization is high.

159 Accurate assessment of atopic sensitization is pivotal to clinical practice and resear

160 tion on allergic multimorbidity and allergic sensitization is unclear.

161 dominant pan-allergens known to cause cross-sensitization, leading to clinical symptoms such as poll

162 ociations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma

163 Due to the relatively natural sensitization method and conserved molecular actions, we

164 with rFlaA:Betv1 in an experimental Bet v 1 sensitization model.

165 l humoral responses in a peanut allergy oral sensitization model.

166 The way in which peanut sensitization occurs has been explored, such as via mate

167 Our findings suggest that M. sexta's sensitization occurs through central signal amplificatio

168 ve activation of p53, inhibition of XIAP and sensitization of cancer cells to apoptosis.

169 ntibodies (CGRP-mAbs) prevent activation and sensitization of high-threshold (HT) but not wide-dynami

170 chological stress may also induce aging-like sensitization of microglia and increase reactivity to se

171 We provide direct evidence of ongoing sensitization of neuronal signaling in the bowel of pati

172 Injury-induced sensitization of nociceptors contributes to pain states

173 iene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a se

174 phosphorylation site mediating EGFR-induced sensitization of the channel to stimulate signaling path

175 heral nerves responsible for nociception and sensitization of the defensive behavior in M. sexta.

176 Thus, sensitization of the photovoltage by rod inner segment c

177 Lipin-2 also inhibits the activation and sensitization of the purinergic receptor P2X7 and K(+) e

178 tions (>0.5 mum) and BLT2 agonists abolished sensitization of the TRPV1-mediated calcium increases.

179 at sensitivity thus provides a mechanism for sensitization of thermal channels.

180 that metabotropic glutamate receptor-induced sensitization of TRPA1 nociceptors stimulates targeted m

181 Calcium imaging revealed a sensitization of TRPV1-mediated calcium increases in a r

182 wever, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic se

183 needed to define the impact of pretransplant sensitization on lung transplant recipients.

184 Early IgE sensitization onset, parental hay fever, and higher expo

185 g at 4 to 6 months of age prevents hen's egg sensitization or allergy.

186 cts of CpG when administered before allergen sensitization or challenge.

187 hanisms for the preventive effect of primary sensitization or new sensitizations are poorly understoo

188 ll increased risk of eczema but not allergic sensitization or physician-diagnosed allergy at age 10 y

189 0.998; P = 0.041), a lower risk of allergic sensitization (OR = 0.92, 95% CI: 0.84, 1.02; P = 0.117)

190 patients followed by the gradual decrease in sensitization over 50 days was also documented.

191 ion was associated with an increased risk of sensitization (P interaction = .003).

192 ing were shown to be largely specific to the sensitization pathway and not associated with changes in

193 associated with a broader polymolecular IgE sensitization pattern.

194 ity were generated from clinical factors and sensitization patterns (CRD- and extract-based).

195 polysensitization, but no other specific IgE sensitization patterns were found.

196 Detection of individual sensitization patterns with different alpha-Gal-containi

197 To analyze associations between severity and sensitization patterns, patient characteristics and clin

198 We evaluated aeroallergen sensitization, peripheral blood eosinophils, and serum p

199 howed an unprecedented Yb to Tb upconversion sensitization phenomenon resulting in the observation of

200 We sought to assess allergenicity and sensitization prevalence of oleosins obtained from both

201 Oleosin sensitization, prevalence, and impact of thermal process

202 Maternal OVA sensitization prevented food anaphylaxis, OVA-specific I

203 Crucial to the sensitization process is highly efficient transfer of re

204 he majority of participants showed a complex sensitization profile and reacted on average to 9 allerg

205 and investigated possible differences in the sensitization profile between monosensitization and clin

206 aine administration and an altered locomotor sensitization profile, as well as increased responding f

207 pediatric population, the complexity of IgE sensitization profiles against P. pratense molecules is

208 Changes in molecular IgE sensitization profiles to pollen allergens in the young

209 Sensitization profiles were assessed and statistically c

210 evance of cross-sensitization, we correlated sensitization profiles with in vitro and in vivo tests,

211 Primary outcomes were sensitization rates to various patch-tested allergens.

212 effect of BMI on asthma, hay fever, allergic sensitization, serum total immunoglobulin E (IgE), force

213 usters in two models: age of onset, allergic sensitization, severity, and recent exacerbations.

214 sociocultural characteristics, but allergen sensitization shows wide geographical variations.

215 ation of store Ca(2+) that we termed 'Ca(2+) sensitization signal'.

216 IgE sensitization started almost invariably with group A mol

217 ual pollen counts with clinical symptoms and sensitization status to major allergens.

218 Together with sensitization status, this forms the basis for the decis

219 The high prevalence of food and respiratory sensitization supports the clinical guideline recommenda

220 d eosinophilic airway inflammation, allergic sensitization, TH2 cytokine production, and mucous cell

221 With settings optimal for sensitization, the second nsPEF treatment became 2.5 tim

222 It was proposed that TH2 sensitization through the skin occurs when skin barrier

223 effect of glycans and glycan-specific IgE on sensitization to allergens and allergy diagnosis is desc

224 ions of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitiza

225 The sensitization to any allergen when estimated by positive

226 Sensitization to at least one food or inhalant allergen

227 t-based diagnosis is often complicated by co-sensitization to Bet v 1, the major birch pollen allerge

228 PSE was associated with IgE sensitization to both food allergens and aeroallergens u

229 PSE is associated with IgE sensitization to both food allergens and aeroallergens u

230 ) release from the endoplasmic reticulum and sensitization to Ca(2+)-dependent apoptotic stimuli.

231 to investigate whether the recently observed sensitization to Candida albicans in patients with EoE i

232 In addition, sensitization to cannabis allergens can result in variou

233 herapeutic drugs in vitro This MCAM-mediated sensitization to chemotherapy occurred via SOX2-dependen

234 relevant to learning and memory, autism, and sensitization to cocaine; however, the mechanism is not

235 2 conventional DCs as crucial players in TH2 sensitization to common inhaled allergens that enter the

236 The CTX-induced substantial peripheral sensitization to cooling stimuli in Adelta-fibers is par

237 is hypothesized to be an important route of sensitization to dietary antigens and may lead to food a

238 We aimed at assessing whether sensitization to different allergens in the diverse geog

239 Significant resolution of eczema and sensitization to egg and milk occurred in LEAP participa

240 ghting gram-negative bacilli threats through sensitization to endogenous and/or exogenous antibacteri

241 into the diets of high-risk infants reduced sensitization to EW and induced egg-specific IgG4 levels

242 Sensitization to food allergens and aeroallergens was de

243 S. aureus carriage, was associated with poly-sensitization to food and inhalant allergens.

244 evidence that the dysbiosis associated with sensitization to food fails to stimulate protective tole

245 ed asthma or recurrent wheezing and allergic sensitization to food or environmental antigens based on

246 At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, w

247 The primary outcome was sensitization to hen's egg (increased specific serum IgE

248 Early-life sensitization to indoor allergens predicts asthma develo

249 B cells were depleted before HDM sensitization to investigate the role of B cells in T-ce

250 Sensitization to leaf extract was demonstrated in 86% of

251 acteria responsible for the induction of IgE sensitization to microbial antigens.

252 In patients with AD, IgE sensitization to most allergens clustered with age, TH1,

253 tokines IL-5 and IL-13, mediated by allergic sensitization to multiple foods.

254 Identifying sensitization to multiple fungal allergens in children w

255 ensitization, 2-AG and anandamide diminished sensitization to nociceptive stimuli although the effect

256 We observed either sensitization to nsPEF or no change (when the conditioni

257 Sensitization to oleosins was observed exclusively in pe

258 t the development of other allergic disease, sensitization to other food allergens and aeroallergens,

259 resistance, and TH2 responses after allergic sensitization to ovalbumin.

260 Sensitization to peach leaves was the cause of occupatio

261 Sensitization to Phl p 7 was a reliable biomarker of ast

262 Sensitization to Phl p 7 was associated with a higher se

263 at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investiga

264 n addition, NMBA sales and prevalence of IgE sensitization to PHO and SUX among 'allergics' were moni

265 ted punctually and have been associated with sensitization to proteins present in both pollen and lea

266 the capacity of the lipid-ligand to promote sensitization to Pru p 3 in vivo, a mouse model of anaph

267 Our primary estimates indicated that sensitization to ragweed will more than double in Europe

268 aphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been

269 Sensitization to SEs may play a role in the development

270 We attributed this phenotype to osteoclastic sensitization to the receptor activator of nuclear facto

271 ted its subsequent signaling, which included sensitization to TNFalpha-induced apoptosis and inhibiti

272 cidence and persistence of airborne allergen sensitization up to young adulthood and risk factors for

273 modulating susceptibility to early allergic sensitization, upper respiratory tract colonization with

274 ated (HCN) channels play in this nociceptive sensitization using the inhibitors MK-801 and AP5 (NMDAR

275 cycloadditions of dienones promoted through sensitization, using a polypyridyl iridium(III) catalyst

276 f evidence that the combination of cutaneous sensitization via a disrupted skin barrier (ie children

277 Sensitization was assessed from blood samples in 3293 ch

278 SE sensitization was associated with allergic multimorbidit

279 The clinical relevance of sensitization was demonstrated by specific bronchial cha

280 ty IgE Fc receptor (FcepsilonRI) in allergic sensitization was evaluated using Was(-/-) Fcer1a(-/-) m

281 Epicutaneous sensitization was found to be driven by 2 variants of in

282 Mite and mold sensitization was low.

283 increased in Kupffer cells by ethanol; this sensitization was normalized by ex vivo treatment with H

284 opic dermatitis without concomitant allergic sensitization was not associated with an increased risk

285 Atopic dermatitis without allergic sensitization was not associated with an increased risk

286 triclosan and paraben exposure and allergic sensitization was observed.

287 B cells in T-cell priming; furthermore, HDM sensitization was performed in mice with MHC class II ex

288 Inflammatory sensitization was produced by intraplantar administratio

289 Strikingly, amphetamine sensitization was reduced and latent inhibition potentia

290 Remission of sensitization was uncommon.

291 allergen and the clinical relevance of cross-sensitization, we correlated sensitization profiles with

292 Two to three hours after sensitization, we found fewer CD8(+) T cells expressing

293 Immunological mechanisms involved in sensitization were analyzed using cytokine reporter mice

294 ant allergic sensitization and food-allergic sensitization were measured by skin prick tests, and phy

295 al hyperreactivity, airway inflammation, and sensitization were significantly different among the 3 g

296 their WT controls at the baseline and after sensitization with house dust mite.

297 Sensitization with OVA plus SEA but not OVA alone induce

298 ject to transient Treg cell depletion before sensitization with OVA plus SEA.

299 definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung f

300 ns (aOR, 1.31; 95% CI, 1.02-1.67; P = 0.04), sensitization without any clinical allergy symptoms (aOR