ライフサイエンスコーパス: sensitize @2 to

1 n two cohorts of allergen sensitized and non-sensitized 3- to 11-year-old children (conducted at Univ

2 that up to 53% of subjects with AD were food sensitized, and up to 15% demonstrated signs of FA on ch

3 g as water oxidation catalysts (WOCs) on the sensitized electrodes, led to a 4-fold enhancement in ph

4 FliP expression sensitizes cells to a number of chemical agents, and mut

5 e may allow the design of NEK specific chemo-sensitizing agents to act in conjunction with chemo- or

6 In ALD, chronic ethanol exposure sensitizes Kupffer cells to activation by lipopolysaccha

7 tachment of epithelial cells did not further sensitize them to Ad-E1A12-induced apoptosis, suggesting

8 mesenchymal cells limited mTOR signaling and sensitized them to Ad-E1A12-induced cell killing.

9 ls in EC could interact with Env and thereby sensitize these cells to ADCC.

10 e so the combined absence of these two genes sensitized infected cells to ADCC.

11 nify high levels of genomic instability that sensitize cancer cells to additional genotoxicity.

12 ing may offer a new therapeutic approach for sensitizing CRPC to ADT and radiation.

13 enhanced PpIX mitochondrial accumulation and sensitized cancer cells to ALA-PDT.

14 eta1-Ser108 on the regulatory beta1-subunit, sensitizing AMPK to allosteric drugs, and activates sign

15 (TRAIL) and its receptor, death receptor 4, sensitizing cells to an autocrine loop of TRAIL-mediated

16 diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.

17 superior to combined PD-1/CTLA-4 blockade in sensitizing tumors to anti-ErbB2 mAb therapy.

18 nd that small-molecule CD4-mimetic compounds sensitize HIV-1 to antibodies that can be elicited in va

19 increase the exposure of these epitopes and sensitize infected cells to antibody-dependent cellular

20 We found that stable knockdown of 6PGD sensitizes leukemia cells to antimalarial agent dihydroa

21 Paradoxically, the pneumococcal capsule sensitizes the bacterium to antimicrobial peptides found

22 llenges with the DENV in a subcytotoxic dose sensitized endothelial cells to apoptosis.

23 We found that DNA-PKcs loss in the mouse sensitized neuronal progenitors to apoptosis after ioniz

24 Given that arresting cells in S-phase sensitizes cells to apoptotic insult, this study suggest

25 lation of AE2 in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activa

26 These perturbations uncover 'shared sensitized positions' localized to areas around the hydr

27 suppressors that, when inhibited, similarly sensitized cells to ATM inhibition.

28 s required to modulate Ca(2+) binding and to sensitize HeLa cells to ATP-induced Ca(2+) release.

29 eric enamide and imine functionalities under sensitized irradiation leads to azetidine products in go

30 now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains

31 mors and specific knockdown of Mcl-1 broadly sensitizes glioblastoma cells to Bcl-xL inhibition-media

32 eukemia-initiating cells (CML LICs), thereby sensitizing them to BCR-ABL tyrosine kinase inhibitors,

33 he resulting reduction of BET protein levels sensitized cancer cells to BET inhibitors.

34 disrupting the functionality of ENL further sensitized leukaemia cells to BET inhibitors.

35 apoptotic BH3 family members MCL1 and BCL-XL sensitizing PTCL cells to BH3 mimetic drugs.

36 s issue, Baeyens et al. show that blood flow sensitizes endothelial cells to BMP9 signaling by trigge

37 Interestingly, RSK2 inhibition also sensitized MM cells to bortezomib, melphalan, and dexame

38 e presence of the isolated truncated HC that sensitizes plasma cells to bortezomib through an elevate

39 ally unrelated foods, but patients are often sensitized and allergic to both, for reasons that are no

40 r tissue damage, organisms typically display sensitized responses to both noxious or normally innocuo

41 sion robustly activated the MAPK pathway and sensitized cells to BRAF and MEK inhibitors.

42 Experimental modulation of histone marks sensitizes genome regions to breakage by endonuclease ch

43 thermore, the re-expression of gamma-catenin sensitized NSCLC cells to c-MET inhibitor-mediated growt

44 We show that chronic alcohol feeding sensitizes rat hepatocytes to Ca(2+) -mobilizing hormone

45 ting with actin and/or the myosin S2 domain, sensitizing thin filaments to calcium and governing maxi

46 l cyclase and PKA, which activates TRPV4 and sensitizes nociceptors to cause inflammation and pain.

47 ficantly down-regulated sCLU expression, and sensitized these cells to cDDP.

48 Second, parental vocal feedback sensitizes infants to certain features of those sounds,

49 accumulation threshold underlying division, sensitizing cell length to changes in SA/V requirements.

50 l modification of the chromatin template can sensitize the genome to changing environmental condition

51 e, instigating tumor infiltration by T cells sensitized tumors to checkpoint inhibition and controlle

52 nP@pyro photodynamic therapy (PDT) treatment sensitizes tumors to checkpoint inhibition mediated by a

53 ation and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestina

54 es atherosclerotic lesion formation by hyper-sensitizing monocytes to chemokine-induced recruitment,

55 burst release Dox using NIR-responsive HGNPs sensitized cancer cells to chemotherapeutic compound, wh

56 uces loss of serial transplant capacity, and sensitizes animals to chemotherapeutic injury.

57 Moreover, blocking cholesterol uptake sensitizes cells to chemotherapeutic drugs and potentiat

58 hough hyperthermia offers clinical appeal to sensitize cells to chemotherapy, this approach has been

59 istone deacetylase inhibitor vorinostat, may sensitize tumors to chemotherapy and enhance outcomes.

60 sting was previously shown to differentially sensitize tumors to chemotherapy while protecting normal

61 herapy-driven cell death; blocking of VEGFR2 sensitized chemoAML to chemotherapy (re-)treatment and i

62 L6 feedback loop prevented CSC induction and sensitized preexisting CSCs to chemotherapy.

63 hemoresistant NB cells rich in this receptor sensitized them to chemotherapy-induced apoptosis and in

64 overexpression protected while YAP knockdown sensitized UCC cells to chemotherapy and radiation effec

65 1-expressing tumor cells, 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induce

66 Importantly, H2A.Z.2 deficiency sensitizes melanoma cells to chemotherapy and targeted t

67 and the potential use of PIM1 inhibitors for sensitizing TNBC to chemotherapy-induced apoptotic cell

68 Moreover, we show that sT sensitizes MCPyV replication to cidofovir inhibition.

69 enes demonstrated that loss of GAS6 or L1CAM sensitized cells to cisplatin, but that loss of HMGA2 di

70 treatment, and inhibition of Akt activation sensitized cells to cisplatin.

71 or currently undergoing clinical evaluation, sensitized chemoresistant cells to cisplatin.

72 NR4A3 re-expression in GC cell lines sensitized the cells to cisplatin, and inhibited tumor g

73 Inhibiting AP-1 or BMI1 sensitized tumors to cisplatin-based chemotherapy, and i

74 tumors reduced Jab1/Csn5 expression, thereby sensitizing NPC cells to cisplatin-induced apoptosis bot

75 ng evidence that HMGB4 plays a major role in sensitizing TGCTs to cisplatin, consistent with shieldin

76 We demonstrate that defects in ARID1A sensitize tumour cells to clinical inhibitors of the DNA

77 Inhibition of MCL-1 or mTORC1 signaling sensitized cells to clinically relevant doses of sunitin

78 n of EST promotes oestrogen deactivation and sensitizes mice to CLP-induced inflammatory response.

79 We found a sensitized locomotor response to cocaine in rats that ga

80 neurons in the mouse nucleus accumbens in a sensitized locomotor response to cocaine.

81 , IRAK inhibition reduced MCL1 stability and sensitized T-ALL to combination therapy.

82 or progenitor cells from bone marrow and to sensitize cancer cells to conventional chemotherapy and

83 knockdown of p62 or inhibition of NF-kappaB sensitized tumor cells to CQ, resulting in increased apo

84 In addition, KIND1 loss sensitized keratinocytes to cytokine and UV-induced NF-k

85 se that defects in beta-spectrin and tau may sensitize neurons to damage.

86 The absence of JB12 sensitized Huh-7 to death caused by proteotoxic agents a

87 IKKalpha/IKKbeta or its upstream activators sensitizes cells to death by inducing RIPK1 kinase-depen

88 owever, components of animal venoms also can sensitize individuals to develop severe IgE-associated a

89 inhibited in the DAP3-depleted cells, which sensitizes cells to different types of death stimuli.

90 mice, which prevents paraspeckle formation, sensitized preneoplastic cells to DNA-damage-induced cel

91 Expression of L209P FEN1 sensitizes cells to DNA damage, resulting in endogenous

92 Loss of DEK induces genome instability and sensitizes cells to DNA double strand breaks (DSBs), sug

93 ntration of the p53 family member TAp63alpha sensitizes them to DNA damage-induced apoptosis.

94 As BRCA1 deficiency sensitizes tumors to DNA cross-linking agents and poly(A

95 inhibits dox-induced NF-kappaB activity and sensitizes NB cells to dox-induced apoptosis.

96 ed with p53-deficient HCT116 cells, and also sensitizes tumour cells to doxorubicin and 5-Fluorouraci

97 15 and its derivatives may have potential in sensitizing cancer cells to DR5 activation-based cancer

98 ed by cytotoxic drugs, whereas YAP knockdown sensitizes CC cells to drug-induced apoptosis.

99 thought to be unusually hypoxic, which might sensitize them to drugs that are activated under hypoxic

100 in homeostasis (proteostasis) network, which sensitizes cancer cells to drugs targeting protein quali

101 DSBs, which inhibits BRCA1 recruitment, and sensitizes cells to DSBs from IR or stalled replication

102 Moreover, Xrn1 depletion sensitizes uninfected cells to dsRNA treatment.

103 Olig2 deletion further sensitizes glioma cells to EGFR inhibitors and extends t

104 Inhibition of autophagy sensitizes HNSCC cells to EGFR blockade.

105 ization was far more likely if the baker was sensitized also to either flour or alpha-amylase.

106 light-protected TiO2 |MnP cathode with a CdS-sensitized photoanode to enable solar-light-driven CO2 r

107 lic abnormalities of DIO can be mitigated by sensitizing animals to endogenous leptin, and they indic

108 1/2-deficient cells, unlike wild-type cells, sensitizes these cells to endoplasmic reticulum (ER) str

109 Deletion of endothelial PGC-1alpha sensitized mice to endothelial dysfunction and hypertens

110 We tested the hypothesis that loss of LKB1 sensitizes NSCLC cells to energetic stress induced by tr

111 S-protein mutations sensitized viruses to entry-activating serine proteases

112 , xenograft PCa models, and they effectively sensitized CRPC tumors to enzalutamide, without overt to

113 Ceapins sensitize cells to ER stress without impacting viability

114 Loss of ER stress-induced CMA activation sensitizes cells to ER stress-induced death.

115 by reducing AP-1-dependent transcription and sensitizing cells to ER stress-dependent apoptosis.

116 ery of miR-124 could reduce tumor growth and sensitize cells to etoposide, suggesting a clinical appl

117 ed a model of gastric eosinophilia in peanut-sensitized piglets to evaluate the efficacy of epicutane

118 hitecture of these pigment-protein scaffolds sensitizes them to external perturbations, for example,

119 he activation of HR repair, disruption of HR sensitized cells to FdUrd, especially when UNG was disab

120 epletion of the uracil DNA glycosylase (UNG) sensitizes tumor cells to FdUrd.

121 As a consequence, ARF expression sensitizes cells to ferroptosis in a p53-independent man

122 we show that p53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non-apoptotic form of

123 igh FGFR1 protein-expressing cancers further sensitized them to FGFR inhibitor.

124 tor glucose 6-phosphate dehydrogenase (G6PD) sensitizes AML cells to FLT3 inhibitor induced apoptosis

125 ers of the RAS superfamily did not uniformly sensitize cells to fluvastatin, indicating that increase

126 structural changes in the nucleus which may sensitize them to future mechanical loading events and d

127 -specific inhibitor, or STAT3-specific siRNA sensitized resistant cells to gefitinib.

128 roduction, and pharmacologic blockade of IGF sensitized pancreatic tumors to gemcitabine.

129 reen, we isolated a rad50-V1269M allele that sensitizes tel1Delta cells to genotoxic agents.

130 from podocytes decreased H3K27me3 levels and sensitized mice to glomerular disease.

131 Attenuation of FAK-enhanced glycolysis re-sensitizes cancer cells to growth factor withdrawal, dec

132 induced by retinoids that may be pivotal to sensitizing CTCL cells to growth arrest and apoptosis.

133 mechanism to maintain cell proliferation and sensitize cells to HDAC inhibition.

134 f PC-specific B cells in the lungs following sensitizing exposure to HDM as adults.

135 overexpression exacerbated glucotoxicity and sensitized cardiomyocytes to HG, whereas its deletion pr

136 SL radiofrequency pulse was set to 120 Hz to sensitize the sequence to high gamma oscillations presen

137 rane permeability due to PE19 overexpression sensitizes M. tuberculosis to host immunity.

138 JB5 in CCA cells that overexpressed MIR21 re-sensitized them to HSP90 inhibitors.

139 We find that deletion of UBP7 sensitizes cells to hydroxyurea and cisplatin and demons

140 lizes an autoinhibitory subunit interaction, sensitizing mast cells to IgE-independent vibration-indu

141 The upregulated IL-1RI, therefore, sensitizes AM to IL-1beta and results in pyroptosome for

142 kens SPB-microtubule attachment in vitro and sensitizes cells to increased SPB stress in vivo.

143 Whether expanded gammadeltaT17 cells sensitize distant sites to inflammation has been unknown

144 Conversely, knockdown of CK2alpha sensitized cells to inhibitor treatment.

145 ration of prostate cancer cells in vitro and sensitized them to inhibitors of androgen receptor signa

146 no effect on insulin action in lean mice but sensitizes the liver to insulin during the challenge of

147 B cells were depleted in HDM-sensitized animals to investigate the importance of B ce

148 resistance, certain drugs have been found to sensitize cells to ionizing radiation (IR).

149 viding the impetus to develop molecules that sensitize cells to ionizing radiation.

150 s DSB joining during V(D)J recombination and sensitizes the cells to ionizing radiation exposure.

151 sistance, while an allosteric CRAF inhibitor sensitizes tumour cells to ionizing radiation or genotox

152 iosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation.

153 Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation

154 CD47 signaling protects normal tissues while sensitizing tumors to ionizing radiation.

155 Furthermore, ATG7 knockout did not sensitize cells to irradiation or to several anticancer

156 mplex in the heart-is impaired in aging that sensitizes the heart to ischemic insults, young C57BL/6

157 in cardiomyocytes increased cAMP levels and sensitized cardiomyocytes to isoprenaline-induced augmen

158 To identify genetic targets that can sensitize AML cells to killing by FLT3 inhibitors, we pe

159 al for growth of D. radiodurans, its absence sensitizes the bacterium to killing by ionizing radiatio

160 iscovered transactivating function of AURKA, sensitizing resistant BCSC to kinase inhibition.

161 after heparin exposure, but only a subset of sensitized patients progress to life-threatening complic

162 Importantly, BAY-320 and BAY-524 treatment sensitized cells to low doses of Paclitaxel, impairing b

163 More importantly, this treatment sensitized ovarian tumors to low cisplatin concentration

164 y shows that a herpes viral infection of FMs sensitizes the tissue to low levels of bacterial LPS, gi

165 moke increased ER stress in acinar cells and sensitized the pancreas to LPS-induced pathology.

166 egulation of NKG2D receptor ligands, thereby sensitizing melanoma cells to lysis by natural killer ce

167 rculosis infection, loss of Atg5 in PMNs can sensitize mice to M. tuberculosis.

168 This change in nuclear stiffness sensitized MSCs to mechanical-loading-induced calcium si

169 o a traumatic event, and patients often show sensitized reactions to mild stressors associated with t

170 s are utilized for both donor excitation and sensitized acceptor emission to minimize the sample abso

171 of cells that died during mitotic arrest and sensitized cancer cells to mitotic poisons.

172 ic behavior with cell fate, we show that Myc sensitizes cells to mitotic blockers and agents that acc

173 rved in cancer and linked to poor prognosis, sensitized embryos to MTH1 inhibition.

174 nail function restores 4E-BP1 expression and sensitizes cancer cells to mTOR kinase inhibitors by enh

175 in3B inactivation impairs HSC quiescence and sensitizes mice to myelosuppressive therapy.

176 tion of gamma1-AMPK, the lack of gamma2-AMPK sensitizes the heart to myocardial ischemia/reperfusion

177 ficant increase of total IgE was observed in sensitized compared to naive animals (61.1 +/- 13.3 vs 2

178 NAPRT silencing sensitized cells to NAMPT inhibitors both in vitro and i

179 Sestrin2 inactivation sensitizes cells to necroptotic cell death that is assoc

180 e exposure of the conserved gp41 domains and sensitized the virus to neutralizing antibodies and gp41

181 Sensitized responses to non-nociceptive stimuli were una

182 Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives

183 tested a model that altered Pol II activity sensitizes cells to nucleotide depletion.

184 KCP loss sensitized the mice to obesity and associated complicati

185 Pooled sera from five children sensitized or allergic to oilseed rape and turnip rape s

186 ted TOPBP1 as a novel determinant whose loss sensitized human cells to olaparib, an inhibitor of poly

187 ette use, may induce epigenetic changes that sensitize the brain to other drugs and prime it for futu

188 th dysregulation of the exocytotic machinery sensitizing beta-cells to overt diabetes after unfolded

189 educing capacity of target bacteria, thereby sensitizing them to oxidative stress.

190 nd breaks, and a deficiency of BRCA proteins sensitizes cancer cells to PARP inhibition.

191 various HR-associated genes, impairs DDR and sensitizes MLL leukemia to PARP inhibitors (PARPis).

192 momas, produce high amounts of IFN-gamma and sensitize tumors to PD-1/programmed cell death ligand 1

193 n sufficed to attenuate barrier function and sensitize endothelium to permeability mediators.

194 urthermore, with the field shifting from dye sensitized solar cells to perovskite solar cells, the ro

195 Sustained protein synthesis sensitized cells to pharmacological induction of the UPR

196 genetic screen to identify genes whose loss sensitizes human cells to phenformin, a complex I inhibi

197 418, a geranylgeranyl transferase inhibitor, sensitizes xenotransplanted tumours to photodynamic ther

198 of p14ARF could suppress p53 aggregation and sensitize cancer cells to platinum treatment.

199 inhibition of CREB1 phosphorylation potently sensitized resistant cells to platinum therapy and was e

200 down to microbial scales, killing corals by sensitizing them to predation, above-average temperature

201 mitochondrial apoptosis and synergistically sensitized leukemic cells to priming with the BCL-2 inhi

202 strate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a su

203 Knockdown of PA28gamma sensitized cells to proteasome inhibitor-mediated growth

204 oid-induced changes in Ras activity, thereby sensitizing mice to psychomotor and rewarding effects of

205 late respiratory metabolism is sufficient to sensitize cells to quinolone killing.

206 High levels of FTO sensitize leukemic cells to R-2HG, whereas hyperactivati

207 fering RNA-mediated knockdown (k/d) of eIF4E-sensitized CRPC cells to RAD001+bicalutamide, whereas eI

208 the upstream kinase-regulating Mnk1/2, also sensitized CRPC cells to RAD001+bicalutamide.

209 , 3E10, was previously shown to inhibit HDR, sensitize tumors to radiation, and mediate synthetic let

210 In addition, we show that KD of E6AP sensitizes cells to radiation-induced death.

211 Furthermore, blocking LIG4 sensitizes CRC cells to radiation.

212 Knockdown of MDA-9/Syntenin sensitizes GBM cells to radiation, reducing postradiatio

213 UTR, leading to tumor growth inhibition, and sensitizes NPC tumors to radiation in vivo.

214 ADT sensitizes prostate cancer to radiotherapy-induced death

215 s, in avoiding metastatic pathways and/or in sensitizing tumour cells to radiotherapy.

216 in vitro repair, and its ectopic expression sensitizes human cells to reactive oxygen species.

217 Thus, by sensitizing viruses to receptor-induced conformational c

218 ciated with membrane perturbation appears to sensitize cells to recognize genomes within incoming vir

219 pression in CC-RCCVHL cells is sufficient to sensitize them to ROCK inhibition.

220 nib therapy restores cytokine dependency and sensitizes leukemic cells to ruxolitinib.

221 e, finally leading to aryl sulfinic acid and sensitized oxidation leading to S-oxidation.

222 Surprisingly, EST ablation sensitizes mice to sepsis-induced death.

223 vivo Galleria mellonella infection model and sensitizes P. aeruginosa to serum complement activity.

224 Further, LY500307 sensitized GBM cells to several FDA-approved chemotherap

225 In the case of Fab-7, we used a novel sensitized background to show that the two Pita-binding

226 the use of methotrexate, an antifolate drug, sensitizes cancer cells to sorafenib, a targeted therapy

227 cell line and patient-derived xenografts and sensitized them to standard-of-care chemotherapy.

228 espectively, restore KCNA5 expression, which sensitizes cells to stress-induced death.

229 esized that overexpression of these proteins sensitizes M. tuberculosis to stress by altering cell wa

230 ufficient to erase the mechanical memory and sensitize MSCs to subsequent exposure to soft substrates

231 disease and be adapted to reduce the risk of sensitizing individuals to subsequent exposure to DENV,

232 cines inducing cross-reactive antibodies and sensitizing people to subsequent DENV infection.

233 ion of tumor-infiltrating CD8(+) T cells and sensitizing tumors to subsequent anti-PD-1.

234 -induced deficiencies in DSB repair pathways sensitized MPN cells to synthetic lethality triggered by

235 Spata2 deficiency sensitizes mice to systemic inflammatory response syndro

236 gamma stimulation, suggesting that IFN-gamma sensitizes these leukemias to T cell killing by mechanis

237 regulated that of connexin 43, both of which sensitized cancer cells to Taxol.

238 tion or TBM mutated TRF1 expression markedly sensitizes cells to telomere oxidative damage as well as

239 wth, survival, and stemness of GSCs and also sensitized them to temozolomide chemotherapy.

240 ine xenografts, prolonged host survival, and sensitized tumors to temozolomide treatment.

241 hich stabilized the TGFbeta Type II receptor sensitizing PDAC cells to TGFbeta-mediated activation of

242 d, widespread changes in gene expression may sensitize cells to the intended tetracycline-controlled

243 hermore, we show that UNG depletion does not sensitize cells to the thymidylate synthase inhibitor (r

244 el extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the manage

245 FSH via PKA acts to sensitize IRS1 to the tyrosine kinase activity of the IG

246 t only induce cell killing but also potently sensitize PEL to the proapoptotic agents tumor necrosis

247 ng (via radio and television) is now used to sensitize the public to the importance of surveillance,

248 tumour microenvironment can be modulated to sensitize tumours to the effects of therapy.

249 deficiency increased complex I abundance and sensitized animals to the hypoglycemic effect of metform

250 This sensitized cells to the cytotoxic DNA lesion O(6)-methyl

251 B-RAFV600E inhibition alone sensitized cells to the mitochondrial pathway of apoptos

252 ibit Tdp1 enzymatic activity in vitro nor it sensitized cells to the PARP1 inhibitor olaparib.

253 methylamine among the four natural pigments sensitized films due to the anthocyanins.

254 Moreover, we showed that inhibition of NF90 sensitized HCC cells to the cyclin-dependent kinase 2 (C

255 absence of IL10R specifically on macrophages sensitized infant mice to the development of colitis.

256 zinc finger E-box binding homeobox 1 (ZEB1) sensitized tumor cells to the antiproliferative activity

257 ];[Gln1476-Gln1478del] overexpression, which sensitizes cells to the endoplasmic reticulum (ER) stres

258 In addition, knockdown of NONO sensitizes cells to the interstrand crosslinking agent,

259 The most common EGFR mutation, EGFRvIII, sensitizes GBM cells to the BET-bromodomain inhibitor JQ

260 ults demonstrate that the presence of nAChRs sensitizes neurons to the neurotoxic action of Abeta thr

261 hic and causes heme deficiency, which likely sensitizes the cells to the HU-induced oxidative stress.

262 from a profound loss in proteostasis, which sensitizes them to the expression of genes that are asso

263 Anti-CD25 mAb treatment sensitizes Treg cell to the biological effect of IL-7, p

264 ly suppresses ovarian tumour progression and sensitizes tumour cells to the treatment of PI3K/AKT inh

265 ng Toll-like receptor signalling, thereby de-sensitizing macrophages to the ingested mitochondria.

266 on and binding of BIM to BCL-2, consequently sensitizing these cells to the BH3 mimetic venetoclax.

267 rises and re-introducing these as adjuvants, sensitizing tumors to the HER3 nanobiologics described h

268 Simply sensitizing surgeons to their outcome has no measurable

269 y, inhibition of autophagy is anticipated to sensitize malignancies to therapy.

270 We hypothesized that PID1 sensitizes brain tumors to therapy.

271 r signatures of chromatin architectures that sensitize the genome to these and other cardiometabolic

272 n and chemotherapy, while depletion of UCHL3 sensitizes cells to these treatments, suggesting a deter

273 ationale for DcR1 targeting as a strategy to sensitize gliomas to this widely used chemotherapy.

274 ibutes to evasion of ADCC, could potentially sensitize infected cells to this immune surveillance mec

275 timulation of nociceptors during development sensitizes nociceptor presynapses to this feedback inhib

276 tated non-small cell lung cancer cells would sensitize the cells to TKI drugs and offers an efficient

277 cells for oncogene knockdown; subsequently, sensitizing it to TKI.

278 nists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-alpha-induced killing while sim

279 hich blocks downstream NF-kappaB activation- sensitized NKT cells to TNF-alpha-induced cell death in

280 tic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors.

281 r stress-resistance transcription factors to sensitize cells to toxins conserved from yeast to mammal

282 for the treatment of RCC, has been shown to sensitize cancer cells to TRAIL-induced apoptosis, in pa

283 An attractive strategy to sensitize resistant malignancies to TRAIL-induced cell d

284 Enforced expression of miR-148a sensitized cells to TRAIL and reduced lung tumorigenesis

285 D1 promoter via NFkappaB and AP-1 sites and sensitized cells to TRAIL-induced apoptosis.

286 ination and caspase-8 enzymatic activity and sensitized normal fibroblasts to TRAIL-mediated apoptosi

287 IR knockdown in TRAIL-resistant PANC-1 cells sensitized them to TRAIL-induced apoptosis.

288 osure of Ras-mutated cancer cells to PLX4032 sensitizes them to TRAIL-induced apoptosis; this is also

289 SGS1 loss increases R-loop accumulation and sensitizes cells to transcription-replication collisions

290 eral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential v

291 Moreover, we demonstrated that RCN2 knockout sensitized HCC cells to tyrosine kinase inhibitors, incl

292 Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhib

293 T1 expression induces lipid peroxidation and sensitizes cells to undergo ferroptosis upon reactive ox

294 ia a pDC- and IFN-I-dependent mechanism that sensitizes ILC3s to undergo CD95/FasL-mediated apoptosis

295 plication of FGF2 to resistant tumor samples sensitized them to virotherapy both in vitro and in vivo

296 with organic pyrenol-based photoacid dyes to sensitize the membranes to visible light and initiate pr

297 is crucial for channel activity, whereas NTE sensitizes this isoform to voltage gating.

298 ented side chain are superior to known TRAIL-sensitizing withanolides belonging to withaferin A class

299 nment and the activating mutations appear to sensitize the tumors to Wnt-Rspo synergy.

300 roplatinate salts are well-known respiratory sensitizing agents leading to work-related sensitization