ライフサイエンスコーパス: sensory hair cell

1 high-fidelity information transfer from the sensory hair cell.

2 ction channels at the tip of hair bundles in sensory hair cells.

3 rchitecture in the developing stereocilia of sensory hair cells.

4 tube closure and misorientation of inner ear sensory hair cells.

5 ts that include the degeneration and loss of sensory hair cells.

6 s; no connexin expression occurs in auditory sensory hair cells.

7 ogical properties similar to those of native sensory hair cells.

8 spase-dependent apoptotic death in inner ear sensory hair cells.

9 Our sense of hearing requires functional sensory hair cells.

10 also contributes to pathological changes in sensory hair cells.

11 suggesting that some may be newly generated sensory hair cells.

12 he unique actin-rich structures of inner ear sensory hair cells.

13 part from electrical tuning intrinsic to the sensory hair cells.

14 cuticular plate and stereocilia of cochlear sensory hair cells.

15 l production of endolymph, the fluid bathing sensory hair cells.

16 a travelling wave, stimulating the cochlea's sensory hair cells.

17 he unique actin-rich structures of inner ear sensory hair cells.

18 ving from ion-channel resonance within their sensory hair cells.

19 toh1, plays a key role in the development of sensory hair cells.

20 otransduction in the hair bundle of auditory sensory hair cells.

21 cal transduction of sound is accomplished by sensory hair cells.

22 that project from the apical surface of the sensory hair cells.

23 nels and mediate the electrical responses of sensory hair cells.

24 ctor, Anc80L65, shown to transduce 80-90% of sensory hair cells.

25 that project from the apical surface of the sensory hair cells.

26 rgan of birds lead to robust regeneration of sensory hair cells.

27 the ribbon synapse, in developing zebrafish sensory hair cells.

28 tion to the organ of Corti, as well as fewer sensory hair cells.

29 s onto immotile kinocilia that protrude from sensory "hair" cells.

30 asal cochlea without a corresponding loss of sensory hair cells, 5) significantly delayed auditory br

31 How and when sensory hair cells acquire the remarkable ability to det

32 nce suggests that synaptic rearrangements on sensory hair cells also contribute to auditory functiona

33 rgan of the inner ear, contains two types of sensory hair cells and at least seven types of supportin

34 -based cilia that extend from the surface of sensory hair cells and attach to biomineralized 'ear sto

35 he development, maintenance, and function of sensory hair cells and auditory neurons.

36 erventions for the prevention of the loss of sensory hair cells and cochlear synaptopathy.

37 enzymatic dissociation of styryl dye-labeled sensory hair cells and non-sensory cells is a valid meth

38 try was used to generate pure populations of sensory hair cells and non-sensory cells.

39 lian cochlea contains an invariant mosaic of sensory hair cells and non-sensory supporting cells remi

40 ory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arran

41 n cochlea is composed of a regular mosaic of sensory hair cells and nonsensory supporting cells.

42 aused by the irreversible damage of cochlear sensory hair cells and nonsensory supporting cells.

43 The morphology of sensory hair cells and otoacoustic emissions that depend

44 n central auditory pathways and in inner ear sensory hair cells and skeletal and smooth muscle cells.

45 Gipc3 localizes to inner ear sensory hair cells and spiral ganglion.

46 d a dissociated cell culture system in which sensory hair cells and supporting cells can be generated

47 The sensory hair cells and supporting cells of the organ of

48 hes, so as to generate a balanced mixture of sensory hair cells and supporting cells.

49 tonotopic map during the differentiation of sensory hair cells and the auditory pathway.

50 located in homologous positions between the sensory hair cells and the cation secretory epithelial c

51 2a was found to localize to the kinocilia of sensory hair cells and the primary cilia of nonsensory s

52 Sensory hair cells and their associated non-sensory supp

53 dwide, produced primarily by the loss of the sensory hair cells and their associated spiral ganglion

54 ube closure and the orientation of inner ear sensory hair cells, and is mediated by a conserved nonca

55 s proneuromast cells the potential to become sensory hair cells, and lateral inhibition mediated by D

56 TRPML3 is expressed by inner ear sensory hair cells, and we were intrigued by the fact th

57 timeline of aminoglycoside-induced inner ear sensory hair cell apoptotic death that includes an 18-ho

58 tereociliary bundle orientation in inner ear sensory hair cells - appear to be mechanistically relate

59 brations of the stereociliary bundles on the sensory hair cells are converted into electrical signals

60 Sensory hair cells are coordinately oriented within each

61 Sensory hair cells are exquisitely sensitive vertebrate

62 Sensory hair cells are mechanoreceptors of the auditory

63 At the inner ear, sensory hair cells are refined to enhance sensitivity, d

64 Sensory hair cells are the essential mechanotransducers

65 Mechanosensitive sensory hair cells are the linchpin of our senses of hea

66 underlying the maintenance of these delicate sensory hair cells are unknown.

67 The receptor potential of sensory hair cells arises from the gating of mechanosens

68 he cochlea, adorned with precisely patterned sensory hair cell arrays and uniformly oriented hair bun

69 DH15) is required for mechanotransduction in sensory hair cells as a component of the tip link.

70 trate that dopamine receptors are present in sensory hair cells at synaptic sites that are required f

71 l for p-AMPKalpha significantly increased in sensory hair cells at that time.

72 the mammalian cochlea relies not only on the sensory hair cells, but also on the surrounding non-sens

73 the mammalian cochlea relies not only on the sensory hair cells, but also on the surrounding nonsenso

74 ithelia, and a unique orientation pattern of sensory hair cell ciliary bundles on the saccular sensor

75 be present in only a few tens of copies per sensory hair cell, compounding the difficulty.

76 Sensory hair cells convert mechanical motion into chemic

77 Inner ear sensory hair cells convert mechanical stimuli into elect

78 air change in the seed region of miR-96, the sensory hair cells crucial for hearing fail to develop f

79 auses of sensorineural hearing loss, induces sensory hair cell damage in the cochlea.

80 ian vertebrates remains quiescent even after sensory hair cell damage.

81 Here, we investigate pathomechanisms of sensory hair cell death and suggest a novel target for p

82 sitive to cisplatin-induced hearing loss and sensory hair cell death in the organ of Corti, the mamma

83 molecular mechanisms involved in regulating sensory hair cell death is critical towards developing e

84 causes permanent hearing loss as a result of sensory hair cell death.

85 Auditory sensory hair cells depend on stereocilia with precisely

86 e-loxP fate mapping, we show that vestibular sensory hair cells derive from a previously neurogenic r

87 ng pathways and factors function to modulate sensory hair cell development and regeneration.

88 Myo7a is expressed very early in sensory hair cell development in the inner ear.

89 Sensory hair cells die after acoustic trauma or ototoxic

90 In the developing cochlea, sensory hair cell differentiation depends on the regulat

91 Barhl1 is expressed in all sensory hair cells during inner ear development, 2 days

92 ated transport of GLUT4, mechanosensation in sensory hair cells, endocytosis, transcription of DNA in

93 The timing of apoptotic signaling in sensory hair cells following systemic aminoglycoside tre

94 lian cochlea and are thought to originate in sensory hair cells from the intrinsic nonlinearity assoc

95 e in the selection and/or differentiation of sensory hair cells from within the established primordiu

96 Recent studies of sensory hair cells have highlighted the possible molecul

97 e zebrafish mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell surviva

98 Sensory hair cell (HC) loss is a major cause of permanen

99 Sensory hair cells (HC) in the cochlea detect and transd

100 ner ear cochlear supporting cells (SCs) into sensory hair cells (HCs) after damage, thus causing perm

101 tory sensory epithelium, composed of mechano-sensory hair cells (HCs) and highly specialized glial-li

102 Sensory hair cells (HCs) are the mechanoreceptors within

103 Hearing and balance rely on specialized sensory hair cells (HCs) in the inner ear (IE) to convey

104 ENT: Hearing and balance rely on specialized sensory hair cells (HCs) in the inner ear (IE) to convey

105 Mechano-sensory hair cells (HCs), housed in the inner ear cochle

106 Sensory hair cells in avian vestibular organs also under

107 mice, both in vitro and in vivo We show that sensory hair cells in Csa(-/-) and Csb(-/-) mice fail to

108 The regeneration of sensory hair cells in lateral line neuromasts of axolotl

109 al tuning confers frequency selectivity onto sensory hair cells in the auditory periphery of frogs, t

110 Recent studies have demonstrated that sensory hair cells in the avian inner ear are reproduced

111 Sensory hair cells in the avian utricle SE are in a cons

112 ical signals occurs at the hair bundles atop sensory hair cells in the cochlea, by means of mechanose

113 of Tmie results in postnatal alterations of sensory hair cells in the cochlea, including defects in

114 Sensory hair cells in the cochlea, like most neuronal po

115 nt extension (CE) and uniform orientation of sensory hair cells in the cochlea.

116 Sensory hair cells in the cochleae of birds are regenera

117 ars to be primarily required for survival of sensory hair cells in the developing ear and lateral lin

118 ) signaling and are prominently expressed in sensory hair cells in the ear.

119 minant calcium-binding protein in a class of sensory hair cells in the frog ear.

120 log 1 (Atoh1) governs the development of the sensory hair cells in the inner ear led to therapeutic e

121 including open neural tube, misalignment of sensory hair cells in the inner ear, and shortened long

122 the orientation of stereociliary bundles of sensory hair cells in the inner ear.

123 Sensory hair cells in the inner ears of nonmammalian ver

124 Sensory hair cells in the mammalian cochlea convert mech

125 Two types of sensory hair cells in the mammalian cochlea signal throu

126 orientation of stereociliary bundles of the sensory hair cells in the mammalian cochlea.

127 li, and detailed ultrastructural analysis of sensory hair cells in the organ of Corti of the inner ea

128 ing pathway regulates the differentiation of sensory hair cells in the vertebrate inner ear [1] [2] [

129 Atoh1 is required for differentiation of sensory hair cells in the vertebrate inner ear.

130 tains cells that can divide and generate new sensory hair cells in vitro.

131 Vestibular sensory hair cells, in contrast, expressed only alpha 9

132 Morphogenesis of sensory hair cells, in particular their mechanotransduct

133 r organ suggests the active motor process in sensory hair cells is ancestral.

134 AMP-activated protein kinase (AMPK) alpha in sensory hair cells is noise intensity dependent and cont

135 Hearing impairment due to the loss of sensory hair cells is permanent in humans.

136 ance of the apical and basal compartments in sensory hair cells is poorly understood.

137 ndrome III), but the role of clarin-1 in the sensory hair cells is unknown.

138 In mammals, damage to sensory hair cells leads to hearing or balance deficits.

139 Sensory hair cell loss is a major contributor to disabli

140 Sensory hair cell loss is the major cause of hearing and

141 up to ~50% of patients by causing selective sensory hair cell loss.

142 Sensory hair cell losses lead to hearing and balance def

143 e deficits due to an inability to regenerate sensory hair cells lost to inner ear trauma.

144 Deflection of the hair bundle atop a sensory hair cell modulates the open probability of mech

145 t to induce ectopic otic vesicles possessing sensory hair cells, neurofilament innervation in a thick

146 In the inner ear, sensory hair cells not only detect but also amplify the

147 enotypes, including heart failure, decreased sensory hair cell numbers in the otic vesicle and neurom

148 In the sensory hair cell of the inner ear, the extracellular st

149 In sensory hair cells of auditory and vestibular organs, th

150 a elongation and actin polymerization in the sensory hair cells of mammals.

151 In auditory sensory hair cells of rats (Sprague Dawley) of either se

152 n situ hybridization revealed alpha9 mRNA in sensory hair cells of the chick cochlea.

153 The function of sensory hair cells of the cochlea and vestibular organs

154 In sensory hair cells of the cochlea, it is associated tran

155 In the sensory hair cells of the cochlea, myosin VI is expresse

156 vestibular ganglion (CVG) that innervate the sensory hair cells of the inner ear are derived from the

157 Sensory hair cells of the inner ear are susceptible to d

158 Sensory hair cells of the inner ear are the mechanoelect

159 aminoglycoside antibiotics are taken up into sensory hair cells of the inner ear by receptor-mediated

160 Sensory hair cells of the inner ear express multiple phy

161 The sensory hair cells of the inner ear undergo apoptosis af

162 i projecting from the apical surfaces of the sensory hair cells of the inner ear, are essential to th

163 In sensory hair cells of the inner ear, mechanical amplific

164 alysis showed that Cdh23 is expressed in the sensory hair cells of the inner ear, where it has been s

165 this phenotype, COMT2 is highly expressed in sensory hair cells of the inner ear.

166 key player in mechanical transduction by the sensory hair cells of the inner ear.

167 hanism linked to the CLRN1(N48K) mutation in sensory hair cells of the inner ear.

168 Sensory hair cells of the mammalian organ of Corti in th

169 aracteristic frequency maximally excites the sensory hair cells of the organ of Corti, which transduc

170 eurons project from the brainstem to inhibit sensory hair cells of the vertebrate inner ear.

171 is often associated with defects in cochlea sensory hair cells, opening an avenue to systematically

172 essential for the generation of the auditory sensory hair cells or the spiral ganglion (SG) neurons t

173 rimordium deposits seven to nine clusters of sensory hair cells, or neuromasts, at intervals along th

174 ffness and numerous individual gradations in sensory hair cell phenotypes, but it is unknown what pat

175 studies reveal a role for glia in regulating sensory hair cell precursors.

176 of Jag2 results in a significant increase in sensory hair cells, presumably as a result of a decrease

177 In the developing mammalian cochlea, the sensory hair cells receive efferent innervation originat

178 Sensory hair cells rely on otoferlin as the calcium sens

179 Sensory hair cells require control of physical propertie

180 of the mechanically sensitive hair bundle of sensory hair cells requires growth and reorganization of

181 Sensory hair cell ribbon synapses respond to graded stim

182 ode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle.

183 into a stereotyped array of inner and outer sensory hair cells separated from each other by non-sens

184 ity.SIGNIFICANCE STATEMENT In the inner ear, sensory hair cells signal reception of sound.

185 In sensory hair cells, sound and movement are transduced by

186 ticular emphasis on early patterning events, sensory hair cell specification and planar cell polarity

187 The maintenance of sensory hair cell stereocilia is critical for lifelong h

188 Jxc1 mRNA was detected in inner ear sensory hair cells, supporting cells, and the acoustic g

189 ent of tight junctions that is necessary for sensory hair cell survival and inner ear homeostasis.

190 This manipulation increased one type of sensory hair cell (tall HCs) at the expense of another (

191 ilia are actin-based protrusions on auditory sensory hair cells that are deflected by sound waves to

192 The patches of sensory hair cells that eventually develop are few and s

193 port the hypothesis that pulsed IR activates sensory hair cells, thus leading to modulation of synapt

194 Localization of mechanotransduction in sensory hair cells to hair bundles requires selective ta

195 primary conveyor of hearing information from sensory hair cells to the brain.

196 in shear modulus in the neighborhood of the sensory hair cells; we argue that this inhomogeneity of

197 the cochlea by vibration of hair bundles on sensory hair cells, which activates mechanotransducer io

198 hearing and balance require intact inner ear sensory hair cells, which transduce mechanical stimuli i

199 nt study links the mechanical stimulation of sensory hair cells with short- and long-term signalling

200 nsory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia o

201 type producing a fine mosaic of two types of sensory hair cells within inner ear epithelia of hemizyg