ライフサイエンスコーパス: sensory nerve

1 (which inhibits the function of perivascular sensory nerves).

2 ., with the sympathetic, parasympathetic, or sensory nerves).

3 cal pain states arising from injuries to the sensory nerve.

4 tralateral supratrochlear nerve as the donor sensory nerve.

5 ated peptide (CGRP), a marker of nociceptive sensory nerves.

6 tenuation of sympathetic vasoconstriction by sensory nerves.

7 are significantly reduced after depletion of sensory nerves.

8 ctively, in response to brief stimulation of sensory nerves.

9 ex resulting from activation of these airway sensory nerves.

10 y coaptation of all main available motor and sensory nerves.

11 c pain is the result of abnormal activity in sensory nerves.

12 flex, which is dependent on intact cutaneous sensory nerves.

13 ed with symptoms attributed to activation of sensory nerves.

14 y and mechanosensitivity of gastrointestinal sensory nerves.

15 bs are differentially expressed in motor and sensory nerves.

16 om an increased expression of TRPV1 in these sensory nerves.

17 gery is known to cause damage to the corneal sensory nerves.

18 disorder affecting long peripheral motor and sensory nerves.

19 els, thereby impairing impulse conduction in sensory nerves.

20 d plays a role in regulating the function of sensory nerves.

21 ctural and functional correlation of DCs and sensory nerves.

22 a mandatory participation of mast cells and sensory nerves.

23 ontribute to the excitatory action of OEA on sensory nerves.

24 nding the brain and is heavily innervated by sensory nerves.

25 trical and involves activation of peripheral sensory nerves.

26 central nervous systems, including in airway sensory nerves.

27 ithin developing eyefronts and on trigeminal sensory nerves.

28 ptor potential vanilloid 1 (TRPV1) on airway sensory nerves.

29 V4, which reduced the expression of TRPV4 in sensory nerve, abolished Taxol-induced mechanical hypera

30 rom the contralateral sensory cortex and the sensory nerve action potential (SNAP) was recorded from

31 showed a significant decrease of the caudal sensory nerve action potential amplitude for all cytosta

32 tabolic syndrome associated with lower sural sensory nerve action potential amplitudes.

33 ld be measured in all patients compared with sensory nerve action potentials (11 patients [73%; 95% C

34 The sensory nerve action potentials (SNAPs) remained dispers

35 l-D-aspartate receptor 1, synaptophysin, and sensory nerve action potentials 23 and 25 in the stellat

36 Patients with altered sensory nerve action potentials and intraepidermal nerve

37 nated and small unmyelinated axons, although sensory nerve action potentials were not significantly d

38 Sensory nerve action potentials were reduced in nearly a

39 Sensory nerves activate Hedgehog signaling in normal tou

40 -705498 were profiled against capsaicin in a sensory nerve activation assay and in vivo potency estab

41 to investigate a role for TRPV4 in mediating sensory nerve activation in vagal afferents and the poss

42 we demonstrate its effectiveness in imaging sensory nerve activation in vivo in the human median ner

43 el that assesses depolarization (a marker of sensory nerve activation) of human vagus.

44 inhibitory activity of theophylline on vagal sensory nerve activity and the cough reflex.

45 ther tiotropium can directly modulate airway sensory nerve activity and thereby the cough reflex.

46 Sensory nerve activity can be enhanced during inflammati

47 ure, the basic techniques used for recording sensory nerve activity have not advanced greatly in 50 y

48 f theophylline on human and guinea pig vagal sensory nerve activity in vitro and on the cough reflex

49 Afferent sensory nerve activity was recorded during fin ray bendi

50 In vivo natural voiding behaviour, sensory nerve activity, urothelial cell function, muscle

51 ng evidence exists for a neuropathy of vagal sensory nerves after upper-respiratory viral infections

52 europathy manifest by a decrease in the foot sensory nerve amplitude (FSA; control = 20 +/- 0.1 micro

53 of erythropoietin prevented the reduction in sensory nerve amplitude characteristic of diabetic neuro

54 uditory prostheses, both at the level of the sensory nerve and at the brainstem, can restore patterns

55 s cough model in guinea pigs, isolated vagal sensory nerve and isolated airway neuron tissue- and cel

56 type 2 diabetic GK rats, and defects in the sensory nerve and/or tear film may contribute to diabeti

57 ion channel receptor primarily localized on sensory nerves and activated by specific stimuli to init

58 These data suggest (1) sensory nerves and BKCa channels play major roles in the

59 individual and combined contributions of (1) sensory nerves and large-conductance calcium activated p

60 otential analgesic and/or counterirritant at sensory nerves and may also influence nicotine's actions

61 Our data suggest that sensory nerves and neovessels inhibit each other in the

62 he paraneoplastic disorders of the motor and sensory nerves and neurons, and their immunologic associ

63 or and cannabinoid CB2 receptors can inhibit sensory nerves and prevent cough.

64 volving peripheral neural elements, visceral sensory nerves and rapid neural transmission.

65 mitochondria at the peripheral terminals of sensory nerves and the sensitivity of transient receptor

66 The sensory nerves are all derived as branches of the trigem

67 Peripheral terminals of sensory nerves are densely packed with mitochondria; thu

68 Taken together, our data show that DCs and sensory nerves are located in close proximity.

69 ting in leakage and activation of underlying sensory nerves are potential causative factors of bladde

70 t that purinergic P2 receptors on thin fibre sensory nerves are stimulated and evoke this reflex, hum

71 In the sensory nerve/BKCa protocol: (1) EMLA cream (EMLA, appli

72 mechanisms, which include the involvement of sensory nerves, but only in the presence of nitric oxide

73 satiety factor that excites peripheral vagal sensory nerves, but the mechanism by which this occurs a

74 urposes, are known to excite and desensitize sensory nerves by acting on two members of transient rec

75 implicated in the activation of nociceptive sensory nerves by capsaicin, noxious heat, protons, brad

76 ase ECE-1 as a negative regulator of itch on sensory nerves by directly regulating ET-1-induced pruri

77 TRPV1 was detected in extracts of peripheral sensory nerves by Western blotting.

78 uring an allergic reaction can interact with sensory nerves, change processing in the central nervous

79 nsistent with phenotypic switching in airway sensory nerves comparable with the cough responses obser

80 Treatment also restored the duration of sensory nerve compound potentials.

81 ssentially corrected thermal hypoalgesia and sensory nerve conduction deficit without affecting motor

82 orrected sciatic motor and hind-limb digital sensory nerve conduction deficits and sciatic nerve ener

83 They also had motor and sensory nerve conduction deficits, tactile allodynia, an

84 tcomes, both local to the wrist (i.e. median sensory nerve conduction latency) and in the brain (i.e.

85 oth diabetic and galactose-induced motor and sensory nerve conduction slowing and nerve energy failur

86 functional recovery as assessed by motor and sensory nerve conduction velocities and sciatic function

87 METHODS AND We found that motor and sensory nerve conduction velocities, blood flow, and cap

88 cterized by significant slowing of motor and sensory nerve conduction velocities.

89 uction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits, therm

90 pairments accompanied by decreased motor and sensory nerve conduction velocity and reduced compound m

91 iated with significant lowering of motor and sensory nerve conduction velocity but no alteration in t

92 al hypoalgesia, tactile allodynia, motor and sensory nerve conduction velocity deficits, and reductio

93 l tunnel syndrome, but not healthy controls, sensory nerve conduction velocity for Digits 2 and 3 was

94 nerve conduction velocity, hindlimb digital sensory nerve conduction velocity, and sciatic nerve con

95 blood flow, significantly improved motor and sensory nerve conduction velocity, prevented the develop

96 6% reductions in sciatic motor and saphenous sensory nerve conduction velocity, which were 62 and 78%

97 Peripheral motor and sensory nerve conduction, central motor conduction, a cl

98 IgG fusion protein fully restored motor- and sensory-nerve conduction velocities and maintained the a

99 tivity to spared peripheral inputs following sensory nerve damage.

100 he CNTF-specific receptor CNTFRalpha induced sensory nerve degeneration and retarded regeneration in

101 c mice, there was a substantial reduction in sensory nerve density and the number of intraepithelial

102 In Old MAs, sensory nerve density was reduced and RAMP1 (CGRP recept

103 obromine directly inhibits capsaicin-induced sensory nerve depolarization of guinea-pig and human vag

104 endent on TRPA1 activation being mediated by sensory nerve-derived dilator neuropeptides CGRP and sub

105 These data demonstrate that sensory nerve-derived peptides mediate psoriasiform dend

106 Sensory nerves detect an extensive array of somatosensor

107 The lateral line and its associated sensory nerves develop from cephalic epithelial thickeni

108 Evidence that sensory nerves direct arteriogenesis and that the membra

109 to hypoxia evokes long term facilitation of sensory nerve discharge (sLTF) of the carotid body in ro

110 on and to evaluate whether it contributes to sensory nerve discharge during distention.

111 The sensory nerve discharges evoked by distention were poten

112 er molecule, TRPV4 protein is transported in sensory nerve distally toward the peripheral nerve endin

113 It is well recognized that this sensory nerve dysfunction can be caused by traumatic, to

114 vention of C-fiber pathology and nociceptive sensory nerve dysfunction.

115 ve demyelination, axonal loss, and motor and sensory nerve dysfunction.

116 progressive axon degeneration and motor and sensory nerve dysfunction.

117 Sensory nerves emanating from the dorsal root extensivel

118 mily of ion channels, which are expressed in sensory nerve endings and in skin, respond to distinct t

119 estored the branching of diabetes-suppressed sensory nerve endings and regeneration in the diabetic c

120 The effects of capsaicin on sensory nerve endings are well known; however, little is

121 This depolarizes the sensory nerve endings by simultaneously closing M-type p

122 TRPM3, and indicate that TRPM3 activation in sensory nerve endings can contribute to neurogenic infla

123 alpha-motor axons in SOD1(G93A) mice, Ia/II sensory nerve endings degenerate in the absence of obvio

124 nates following the activation of peripheral sensory nerve endings following damage or exposure to in

125 ation results from the excitation of primary sensory nerve endings in the skin, but the underlying mo

126 ver, the way in which it excites nociceptive sensory nerve endings is still unclear.

127 Sensory nerve endings located close to the lumen of the

128 el, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might parti

129 We have shown that the VR1 is expressed on sensory nerve endings of the heart.

130 ent strategies that target TRPA1 channels on sensory nerve endings to achieve chemical deterrence.

131 another group, we blocked 5-HT3 receptors on sensory nerve endings with tropisetron (300 microg kg(-1

132 dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivatio

133 hiocyanate) to the skin activates underlying sensory nerve endings, thereby producing pain, inflammat

134 ng at CB1 cannabinoid receptors localized on sensory nerve endings.

135 ds, arrector pili muscles, Merkel cells, and sensory nerve endings.

136 tivating TRPA1, an excitatory ion channel on sensory nerve endings.

137 activating capsaicin-sensitive perivascular sensory nerve endings.

138 tussive mediators and activation of afferent sensory nerve endings.

139 s and modulate their sensitivity directly in sensory nerve endings.

140 Capsaicin (10 mum; to inhibit sensory nerves) enhanced MA constriction to PNS (P 0.05)

141 Airway sensory nerve excitability is a key determinant of respi

142 terminal mitochondrial dysfunction on airway sensory nerve excitability.

143 he ion channels that underpin the changes in sensory nerve excitability.

144 hannel, since Cav3.2 plays a central role in sensory nerve excitability.

145 f large myelinated fibers, its role in small sensory nerve fiber degeneration and neuritic dystrophy

146 ions in sudomotor, vasomotor, pilomotor, and sensory nerve fiber densities in capsaicin-treated subje

147 ns and to investigate whether IL-31 promotes sensory nerve fiber outgrowth.

148 ut to the central nervous system (CNS) along sensory nerve fibers and initially entered the simian CN

149 anilloid 1 (TRPV1) is primarily localized to sensory nerve fibers and is associated with the stimulat

150 Sensory nerve fibers differ not only with respect to the

151 They are approached by sensory nerve fibers expressing nicotinic acetylcholine

152 Embryonic corneal keratocytes and sensory nerve fibers grow and differentiate according to

153 n epithelium innervation by accompanying the sensory nerve fibers in crossing the basement membrane a

154 he first direct evidence for the presence of sensory nerve fibers in human peritoneal adhesions, sugg

155 lamina propria, where it was associated with sensory nerve fibers in the core of the lingual papillae

156 eriosteum, while it occasionally reaches the sensory nerve fibers in the mouse footpad.

157 herapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolvi

158 This ectopic sprouting occurs in sensory nerve fibers that are in close proximity to colo

159 he hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing ti

160 Nearly all sensory nerve fibers that undergo sprouting also coexpre

161 erve damage may differ between autonomic and sensory nerve fibers treated with capsaicin and enhances

162 Dispersed maturation of sensory nerve fibers with desynchronized inputs to the C

163 nerve fibers), neurofilament 200 kd (NF200; sensory nerve fibers), growth-associated protein 43 (GAP

164 ainst calcitonin gene-related peptide (CGRP; sensory nerve fibers), neurofilament 200 kd (NF200; sens

165 c recordings demonstrated that activation of sensory nerve fibers, either by antidromic stimulation o

166 oy selectively the large-diameter peripheral sensory nerve fibers, leaving motor fibers intact.

167 s and enhanced expression of TRPA1 in dermal sensory nerve fibers, their dorsal root ganglia, and mas

168 n requiring ATP as a transmitter to activate sensory nerve fibers.

169 he JAM-C SC KO animals, on finely myelinated sensory nerve fibers.

170 on contributes to the distal degeneration of sensory nerve fibers.

171 ute to neuropathic dysfunction in peripheral sensory nerve fibers.

172 GRP(+)) and neurofilament 200 kDa (NF200(+)) sensory nerve fibers.

173 athological reorganization of nearby TrkA(+) sensory nerve fibers.

174 n these patients is limited to small-caliber sensory nerve fibers.

175 uronal markers, including those expressed by sensory nerve fibers.

176 ation of the neuronal cell bodies of corneal sensory nerve fibers.

177 Sensory nerve fibres can detect changes in temperature o

178 d result from increased numbers of polymodal sensory nerve fibres expressing TRPV1.

179 how that cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice exhibit p

180 tify TRPA1 channels as infrared receptors on sensory nerve fibres that innervate the pit organ.

181 1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain.

182 vert predators by activating TRP channels on sensory nerve fibres to elicit pain and inflammation.

183 ndothelin excites cutaneous group III and IV sensory nerve fibres.

184 electrical activation of nociceptive primary sensory nerve fibres.

185 currents have been documented in lung vagal sensory nerves fibres, a rigorous comparison of their ex

186 tical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itc

187 This technique allows some sensory nerves from the amputated limb to reinnervate ov

188 approach and consists of rerouting motor and sensory nerves from the residual limb towards intact mus

189 With advanced age, the loss of sensory nerve function and diminished effectiveness of C

190 e development of drugs that directly inhibit sensory nerve function has again become an attractive ta

191 s simplex virus (HSV) establishes latency in sensory nerve ganglia during acute infection and may lat

192 the percentages and types of cells in human sensory nerve ganglia that harbor latent herpes simplex

193 causes varicella and establishes latency in sensory nerve ganglia, but the characteristics of VZV la

194 nergic systems in adult mammalian peripheral sensory nerves has not been established.

195 es are associated with dysfunction of airway sensory nerves has the potential to identify novel thera

196 he specific interaction of ozone with airway sensory nerves has yet to be elucidated.

197 in-predominant symptoms were consistent with sensory nerve hyperexcitability.

198 the airways were used to examine the role of sensory nerves in ozone-induced lung inflammation.

199 Sensory nerves in the airways regulate central and local

200 ntified as receiving monosynaptic input from sensory nerves in the lungs and airways.

201 However, the role of sensory nerves in this phenomenon has received scant att

202 aying afferent information from the pudendal sensory nerve, in the dorsal horn and medial cord of L5-

203 aying afferent information from the pudendal sensory nerve, in the dorsal horn and medial cord of L5-

204 cough in three areas: the properties of the sensory nerves, in particular their receptors and membra

205 Motor and/or sensory nerve injuries occurred after seven procedures (

206 -gated calcium channels is upregulated after sensory nerve injury and is also the therapeutic target

207 this treatment is beneficial in humans with sensory nerve injury has not been tested.

208 Peripheral sensory nerve injury results in the up-regulation of alp

209 pain perception in the formalin model of rat sensory nerve injury.

210 Vagal sensory nerves innervate the majority of visceral organs

211 a useful gene delivery vector to target the sensory nerves innervating bone.

212 Sensory nerves innervating the airways play an important

213 TRPA1, but not TRPM8, is expressed in vagal sensory nerves innervating the airways.

214 Sensory nerves innervating the mucosa of the airways mon

215 When whiskers on the snout or the sensory nerves innervating them are damaged during a cri

216 Collectively, our data show that DCs mediate sensory nerve innervation and regeneration through CNTF

217 as, resulting in decreased CNTF and impaired sensory nerve innervation and regeneration.

218 tous responses and remodeling events such as sensory nerve innervation of the skin and induced pathop

219 s related genes may participate in mast cell sensory nerve interactions.

220 There is no evidence of sensory nerve involvement.

221 TRPV1 and TRPM8 are sensory nerve ion channels activated by heating and cool

222 we show that NGF-TrkA signaling in skeletal sensory nerves is an early response to mechanical loadin

223 stimulatory effect of hydrogen ion on these sensory nerves is generated by activation of two major t

224 Peripheral injury to other sensory nerves leads to glial responses at central termi

225 The VR1 on the cardiac sensory nerve may function as a molecular sensor to dete

226 hese reports indicate that P2X3 receptors on sensory nerves may be tonically activated by ATP release

227 ory signalling mediated through perivascular sensory nerves may compromise perfusion of visceral orga

228 htened stimulatory effects of acid on airway sensory nerves may play a part in the manifestation of a

229 n developing eyefronts and on the surface of sensory nerves, may provide guidance cues to nerves duri

230 Cutaneous sensory nerves mediate inflammation and wound healing by

231 potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling.

232 y both capsaicin pretreatment to deplete the sensory nerves of neurotransmitters (pD(2) = 5.86 +/- 0.

233 resence of TRPC channels in glomus cells and sensory nerves of the carotid body suggests a role in fa

234 pinal neurons activated with either pudendal sensory nerve or pelvic nerve stimulation was examined i

235 of the periosteum, capsaicin denervation of sensory nerves or knockdown in vivo of the CGRP-receptor

236 Mutations that eliminate peripheral sensory nerves or Schwann cells prevent proper arterioge

237 Until recently, sensory nerve pathways from the stomach to the brain wer

238 y population High-threshold gastrointestinal sensory nerves play a key role in signalling distressing

239 Sensory nerves play a vital role in maintaining corneal

240 e mitochondrial dysfunction activates airway sensory nerves preferentially via TRPA1 through the acti

241 e further indicates an involvement of airway sensory nerves, presumably the thermosensitive C-fiber a

242 We addressed the hypothesis that mouse vagal sensory nerves projecting to the airways express TRPA1 a

243 r pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SA

244 gents are also known to stimulate peripheral sensory nerves, raising the possibility that they may ex

245 a key osmosensing pathway involved in airway sensory nerve reflexes.

246 tment significantly improved the distance of sensory nerve regeneration achieved after nerve crush in

247 n wounded corneas, diabetes markedly delayed sensory nerve regeneration and reduced the number of inf

248 to test the hypothesis that ES would enhance sensory nerve regeneration following digital nerve trans

249 The contribution of acute inflammation to sensory nerve regeneration was investigated in the murin

250 rves generally regenerated more rapidly than sensory nerves, requiring 40-50 days to return to baseli

251 reduced the degree of axonal degeneration in sensory nerve roots, and improved clinical measures of n

252 We found that NVB sensory nerves secrete Shh protein, which activates Gli1

253 TRPV1, a cation channel on sensory nerves sensitive to heat and capsaicin, plays an

254 m channel blocker CDA54 selectively inhibits sensory nerve signaling associated with neuropathic pain

255 port the hypothesis that agonists of certain sensory nerve specific receptors or mas related genes ma

256 y discovered orphan receptors referred to as sensory nerve specific receptors or products of mas rela

257 Thus, bile acids activate TGR5 on sensory nerves, stimulating the release of neuropeptides

258 Pudendal sensory nerve stimulation resulted in a significant incr

259 With perivascular sensory nerve stimulation, dilatation and inhibition of

260 rdings has allowed direct comparison between sensory nerve studies in animals and human, as well as i

261 TMA contact toxicant reactions increase skin sensory nerve substance P and, in turn, increase itching

262 More than one sensory nerve subtype is thought to subserve pruriceptiv

263 of adenosine on the nerve terminals of vagal sensory nerve subtypes was evaluated in an ex vivo perfu

264 timulator to surgically redirected cutaneous sensory nerves (targeted reinnervation) that once served

265 Peripheral sensory nerve terminals (PSNTs) have a dual function: re

266 smitters and trophic factors from peripheral sensory nerve terminals (PSNTs), yet Ca2+ regulation in

267 calcitonin gene-related peptide (CGRP) from sensory nerve terminals and insulin from isolated pancre

268 among glomeruli, releasing GABA and DA onto sensory nerve terminals and postsynaptic neurons.

269 ry, there are important interactions between sensory nerve terminals and surrounding cells, and that

270 The ion channels expressed within the sensory nerve terminals play an essential role in the ab

271 peripheral neuropathy, such as depletion of sensory nerve terminals, thermal hypoalgesia, and nerve

272 lso activates vanilloid TRPV(1) receptors on sensory nerve terminals, triggering the release of calci

273 of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli

274 receptor-1) and TrkA receptors on nociceptor sensory nerve terminals.

275 and due to a dramatic retraction of corneal sensory nerve termini in the epithelium and the nerve pl

276 at had been treated to expose the underlying sensory nerve termini.

277 channels, including those that are found in sensory nerves that convey nociceptive information.

278 nerve tropism, whether AAV can distribute to sensory nerves that innervate the bone or skeletal tissu

279 ting of non-glabrous skin by sensitizing the sensory nerves that mediate the axon reflex associated w

280 maged or stressed cells, or perhaps from the sensory nerves themselves.

281 conditions by decreasing the excitability of sensory nerves through activation of small- and intermed

282 e that communication between osteoblasts and sensory nerves through NGF-TrkA signaling is essential f

283 ate stretch-activated mechanotransduction in sensory nerves through subcellular stimulation.

284 pofol) general anesthetics excite peripheral sensory nerves to cause pain and irritation upon adminis

285 of pain-related signals from the peripheral sensory nerves to the CNS.

286 Na(v)1.3-LI was particularly intense in sensory nerve tracts such as the mesencephalic trigemina

287 This representation persists after sensory nerve transection, indicating an efferent source

288 In ex vivo motor and sensory nerve trunk preparations, antibody deposits are

289 deeper fibrous layer that contains the main sensory nerve trunks that give rise to numerous branches

290 olimbal epithelial progenitor/stem cells and sensory nerves using a denervated mouse model of NK.

291 landin E2 and bradykinin can activate airway sensory nerves via EP3 and B2 receptors receptively and

292 ion (DRG) neurons following direct injury of sensory nerves, we asked whether such a dysregulation al

293 Two sensory nerves were cut and the distal ends were anastom

294 cularly with regard to the activation of the sensory nerves which relay pain from the gut to the brai

295 leads to activation of guinea pig and human sensory nerves, which are responsible for respiratory sy

296 affect the function of enteric and extrinsic sensory nerves, which can contribute to the development

297 ure activates vagal bronchopulmonary C-fiber sensory nerves, which upon activation can elicit reflex

298 Inactivation of sensory nerves with capsaicin had no effect on vasomotor

299 helium and approximately 19% regeneration of sensory nerves within 96 hours.

300 nels, which are putative channels located on sensory nerves, would attenuate the skin blood flow resp