ライフサイエンスコーパス: sentrin

1 also known as SUMO-1, GMP1, SMTP3, PIC1, and sentrin).

2 , also known as UBL1, GMP1, SMTP3, PIC1, and sentrin.

3 g FADD (MORT-1), DAXX, RIP, FAF-1, FAP-1 and Sentrin.

4 omain and the C-terminal Gly-Gly residues of sentrin.

5 We further showed that both sentrin-1 and sentrin-2 could covalently modify RanGAP1,

6 e disappearance of the high molecular weight sentrin-1 conjugates also coincided with an increase in

7 ssed with SENP1, the higher molecular weight sentrin-1 conjugates were completely removed.

8 8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.

9 her proteins in a pattern similar to that of sentrin-1 conjugation and had similar C-terminal process

10 ates also coincided with an increase in free sentrin-1 monomers.

11 When HA-tagged sentrin-1 was co-expressed with SENP1, the higher molecu

12 Sentrin-1, also called SUMO-1, is a protein of 101 resid

13 ST)-NEDD8, but not with GST-ubiquitin or GST-sentrin-1.

14 that is 46% identical and 66% homologous to sentrin-1.

15 Western blot analysis showed that sentrin-2 could be transferred to other proteins in a pa

16 We further showed that both sentrin-1 and sentrin-2 could covalently modify RanGAP1, a Ran GTPase-

17 Immunocytochemical analysis showed that sentrin-2 derivatives were highly enriched in the nucleu

18 d by expressing hemagglutinin epitope-tagged sentrin-2 in COS cells.

19 Sentrin-2 is a 95-amino acid polypeptide that is 46% ide

20 Taken together, our results demonstrate that sentrin-2 is another protein modifier for the sentriniza

21 Northern blot analysis showed that the sentrin-2 message was expressed in all tissues, but was

22 The ability of sentrin-2 to conjugate to other proteins was tested by e

23 is also active against proteins modified by sentrin-2, but not those modified by ubiquitin or NEDD8.

24 Members of the Sentrin (also known as SUMO)-specific protease (SENP) fa

25 The interaction between sentrin and Ubc9 required the ubiquitin domain and the C

26 o screen a human placenta cDNA library using sentrin as bait.

27 Two-hybrid interaction assays reveal that sentrin associates only with the signal-competent forms

28 alpha could be restored by overexpression of sentrin, but not by retinoic acid treatment.

29 n mutants in COS cells demonstrated that the sentrin C terminus is cleaved, which allows it to be con

30 We have reported previously that sentrin can be conjugated to other proteins in a manner

31 Overexpression of either DAP-1 or sentrin causes apoptosis of TNF-sensitive L929 fibroblas

32 A beta-mercaptoethanol-sensitive Ubc9-sentrin conjugate could also be identified in the in vit

33 y serine abolished the formation of the Ubc9-sentrin conjugate.

34 In vitro translated sentrin could be precipitated by a GST-Ubc9 fusion prote

35 s interaction appears to be specific because sentrin could only interact weakly with UbcH5B, but coul

36 alently modified by all three members of the sentrin family of ubiquitin-like proteins.

37 PML-RARalpha, is covalently modified by the sentrin family of ubiquitin-like proteins.

38 In this report, a second member of the sentrin family was characterized in detail.

39 es that encode proteins highly homologous to sentrin have been reported to GenBankTM.

40 Sentrin is a novel protein of 101 amino acids with homol

41 Sentrin is a novel ubiquitin-like protein that can be co

42 Sentrin is a novel ubiquitin-like protein that protects

43 Sentrin is a ubiquitin-like molecule that has been shown

44 SUMO (also called Sentrin) is a ubiquitin-like protein that plays an impor

45 It is not known whether these sentrin-like proteins could also function as protein mod

46 the covalent modification of RanGAP1 by the sentrin member of ubiquitin-like proteins.

47 ues of sentrin were changed to Gly-Ala, only sentrin monomer and p90 but not the high molecular mass

48 ell fractionation analysis demonstrated that sentrin monomer is localized predominantly to the cytoso

49 of sentrin revealed the presence of a 18-kDa sentrin monomer, a 90-kDa band (p90), and multiple high

50 t expression of hemagglutinin epitope-tagged sentrin mutants in COS cells demonstrated that the sentr

51 Because sentrin possesses the conserved Gly-Gly residues near th

52 ted in acute promyelocytic leukemia, and the sentrin protein, which associates with the Fas death rec

53 conserved Gly residue near the C termini of sentrin proteins.

54 When overexpressed, sentrin provides protection against both anti-Fas/APO-1

55 Antiserum recognizing the N terminus of sentrin revealed the presence of a 18-kDa sentrin monome

56 UMOylation, we used de-SUMOylation enzyme of sentrin/Small Ubiquitin-like MOdifier (SUMO)-specific pr

57 Two Sentrin/small ubiquitin-like modifier (SUMO)-specific pr

58 ith the induction of a deSUMOylating enzyme, sentrin-specific peptidase 1 (SENP1), in activated macro

59 This effect requires SUMO1/sentrin-specific peptidase 1 (SENP1)-mediated deSUMOylat

60 d ubiquitin-proteasomal degradation of SUMO1/sentrin-specific protease 1 (SENP1).

61 creased the sumoylation of Sp1 by inhibiting sentrin-specific protease 1 expression.

62 over, cardiac overexpression of desumoylase, sentrin-specific protease 2 (SENP2), significantly reduc

63 The identification of a nuclear-localized, sentrin-specific protease will provide a unique tool to

64 Here we report the cloning of a novel sentrin-specific protease, SENP1, which has no homology

65 oes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2, and 5.

66 Ubiquitin-like protein/sentrin-specific proteases (Ulp/SENPs) mediate both proc

67 SUMO/sentrin-specific proteases are able to remove SUMOs from

68 difier-specific isopeptidases (also known as sentrin-specific proteases, or SENPs) with nuclear pore

69 processing and deconjugation are mediated by sentrin-specific proteases/ubiquitin-like proteases (SEN

70 focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are

71 of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horiz

72 cantly elevated with expression of the human sentrin/SUMO-specific protease (SENP1) in the androgen-s

73 te in paralog-selective SUMOylation, whereas sentrin/SUMO-specific protease 1 (SENP1) and 2 may act a

74 ll ubiquitin-like modifier (SUMO) proteases, sentrin/SUMO-specific protease 1 (SENP1) and SENP2, we o

75 Here, we show that SENP1 (sentrin/SUMO-specific protease 1) is highly expressed in

76 we show that mice with partial deficiency of Sentrin/SUMO-specific protease 2 (SENP2) develop spontan

77 on of p53 and ERK5 through downregulation of sentrin/SUMO-specific protease 2 (SENP2) function; howev

78 nd caused by the inability of SUMO peptidase sentrin/SUMO-specific protease 2 (SENP2) to desumoylate

79 These data show the unique role of sentrin/SUMO-specific protease 2 on endothelial function

80 Increasing deSUMOylation with sentrin/SUMO-specific protease SENP1 or SENP2 in wild ty

81 kDa subunit of RPA (RPA70) associates with a Sentrin/SUMO-specific protease, SENP6, in the nucleus to

82 the amplification of insulin exocytosis via sentrin/SUMO-specific protease-1 (SENP1).

83 reduced glutathione, which in turn activates sentrin/SUMO-specific protease-1 (SENP1).

84 rotein-specific proteases (Ulp) in yeast and sentrin/SUMO-specific proteases (SENP) in human.

85 Sentrin/SUMO-specific proteases (SENPs) act as an endope

86 Here we show that among the six known Sentrin/SUMO-specific proteases (SENPs), only SENP2 can

87 zed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs).

88 reversible process regulated by a family of sentrin/SUMO-specific proteases (SENPs).

89 se additional bands represent conjugation of sentrin to other proteins in a manner that is similar to

90 When the conserved Gly-Gly residues of sentrin were changed to Gly-Ala, only sentrin monomer an

91 we report the isolation of a novel protein, sentrin, which interacts with Fas/APO-1 and TNF receptor