ライフサイエンスコーパス: sepsis

1 tics to improve the outcome of patients with sepsis.

2 ts designed to reduce the burden of neonatal sepsis.

3 tributes to the immunosuppression induced by sepsis.

4 .8-10.3) vs 3.5 (95% CI, 2.2-5.5) for severe sepsis.

5 ll unplanned ICU admissions in patients with sepsis.

6 ease in arterial LPS and a susceptibility to sepsis.

7 CI 2.07-2.68] relative to (-)transfusion/(-)sepsis.

8 ty in early risk stratification of pediatric sepsis.

9 iated survival advantage in murine models of sepsis.

10 we determined the role of DJ-1 in bacterial sepsis.

11 vir as a prophylactic agent in patients with sepsis.

12 PI3K delta is essential for survival during sepsis.

13 n and puncture when given after the onset of sepsis.

14 29% received a transfusion and 4% developed sepsis.

15 via the airways to induce pneumonia-derived sepsis.

16 in a cohort of critically ill patients with sepsis.

17 llateral damage to the host and the risk for sepsis.

18 Parkin and DJ-1 pathways of mitophagy during sepsis.

19 and we were unable to estimate NDI after GBS sepsis.

20 varying intensities over the time course of sepsis.

21 n an external acute care hospital for severe sepsis.

22 ers in cardiomyocytes isolated after 24-hour sepsis.

23 ity in patients following ICU admission with sepsis.

24 h resulted from non-hepatic diseases such as sepsis.

25 function predicts mortality in patients with sepsis.

26 logy of U.S. emergency department visits for sepsis.

27 ntipseudomonal beta-lactams in patients with sepsis.

28 respiratory failure, acute kidney injury, or sepsis.

29 clearance on procoagulant activity (PCA) in sepsis.

30 ess syndrome in critically ill patients with sepsis.

31 flammation and in splenocytes from mice with sepsis.

32 is highly elevated in helminth infection and sepsis.

33 nfluence the clinical expression of neonatal sepsis.

34 international database of ICU patients with sepsis.

35 g patient encounters with community-acquired sepsis.

36 appropriate antibiotics for the treatment of sepsis.

37 outcome of patients admitted to the ICU with sepsis.

38 pregnancy, vaginitis or vulvovaginitis, and sepsis.

39 or hypotension, and in inpatient-presenting sepsis.

40 d they are more susceptible to Gram-negative sepsis.

41 an in vivo baboon model of Escherichia coli sepsis.

42 ly recommended changes to the definitions of sepsis.

43 task force recently redefined the concept of sepsis.

44 ost response in critically ill patients with sepsis.

45 n was 0.3% (95% CI, 0.01-0.6%; P = 0.04) for sepsis, 0.4% (95% CI, 0.1-0.8%; P = 0.02) for severe sep

46 Among patients with sepsis, 1.9% received starch, and among patients with se

47 econd cohort of 94 consecutive patients with sepsis, 11 severity-matched intensive care patients, and

48 [2%]) with pacritinib, and anaemia (5 [5%]), sepsis (2 [2%]), and dyspnoea (2 [2%]) with BAT.

49 ess (5 cases), multiple sclerosis (3 cases), sepsis (3 cases), and Lyme disease (2 cases).

50 The Sepsis-3 Criteria emphasized the value of a change of 2

51 critically ill children and to evaluate the Sepsis-3 definitions in patients with confirmed or suspe

52 According to the Sepsis-3 definitions, 1231 patients (14.1%) were classif

53 and sepsis and septic shock according to the Sepsis-3 definitions.

54 o determine the outcomes of patients meeting Sepsis-3 septic shock criteria versus patients meeting t

55 RATIONALE: The Sepsis-3 Task Force updated the clinical criteria for se

56 sus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria in the emergency department setting.

57 ernational Consensus Definitions Task Force (Sepsis-3) recently recommended changes to the definition

58 sus Definitions for Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (

59 vided data on 2632 patients, of whom 794 had sepsis (30.2 septic patients per 100 ICU beds, 95% CI 28

60 treatment), progressive disease (43 [17%]), sepsis (36 [14%]; two related to treatment), pneumonia (

61 te kidney injury; 6) The role of exosomes in sepsis; 7) Limitations of exosome isolation protocols; a

62 tion diagnosis of septicemia (038.x), severe sepsis (995.92), or septic shock (785.52), as well as al

63 Sepsis, a potentially life-threatening complication of a

64 id boluses and vasopressors in patients with sepsis across different low- and middle-income clinical

65 IL-33, released during tissue injury in sepsis, activates type 2 innate lymphoid cells, which pr

66 Sepsis, acute kidney injury, and acute respiratory failu

67 Of 2562 sepsis admissions, 101 had possible, probable, or defini

68 sions with 90-day mortality in patients with sepsis admitted to the ICU.

69 ciated with shorter survival, independent of sepsis, after colon cancer resection.

70 Nineteen patients with sepsis and 19 age-matched healthy controls.

71 can occur during inflammation, ischaemia or sepsis and cause severe organ dysfunction.

72 ntensive care unit patients with and without sepsis and CD14(neg)CD15(pos) low-density granulocytes/g

73 1 patients (14.1%) were classified as having sepsis and had a mortality rate of 12.1%, and 347 (4.0%)

74 r I-A (NFI-A) controls MDSC expansion during sepsis and impacts survival.

75 lable and have the promise to better control sepsis and maintain fecal continence.

76 r, its overall benefits in reducing clinical sepsis and mortality remain uncertain.

77 th Evaluation (APACHE) II score, severity of sepsis and renal function were enrolled.

78 hird International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria in the emerg

79 hird International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) uses the Sequential O

80 dysfunction measured by the pSOFA score, and sepsis and septic shock according to the Sepsis-3 defini

81 Sepsis and septic shock are common and, at times, fatal

82 a quality improvement initiative for severe sepsis and septic shock focused on the resuscitation bun

83 Consecutive sample of all severe sepsis and septic shock patients (defined: infection, >/

84 early crystalloid resuscitation provided to sepsis and septic shock patients at initial presentation

85 Adult sepsis and septic shock patients captured in a prospecti

86 ticosteroids in critically ill patients with sepsis and septic shock, acute respiratory distress synd

87 sed for empirical treatment of patients with sepsis and septic shock, that is, moxifloxacin, meropene

88 eatment on mortality in patients with severe sepsis and septic shock.

89 edical and surgical ICU patients with severe sepsis and septic shock.

90 Sixty-one patients with sepsis and severe sepsis from two large U.K. hospitals a

91 During sepsis and shock states, mitochondrial dysfunction occur

92 0.4% (95% CI, 0.1-0.8%; P = 0.02) for severe sepsis, and 1.8% (95% CI, 0.8-3.0%; P = 0.001) for shock

93 group [metabolic encephalopathy, neutropenic sepsis, and acute myeloid leukaemia]).

94 estigated the association among transfusion, sepsis, and disease-specific survival in postoperative p

95 ost common being sepsis, septic shock, viral sepsis, and pneumonia).

96 antagonist group during the first 6 hours of sepsis, and there was a significant reduction in loss of

97 sregulated neutrophil functions with age and sepsis are described.

98 Host responses during sepsis are highly heterogeneous, which hampers the ident

99 suscitation and difficulty recognizing early sepsis are major barriers to preventing AKI after burn i

100 aling events leading to immunosuppression in sepsis are not well defined.

101 ic inflammatory response syndrome (SIRS) and sepsis at low risk for organ dysfunction and death is a

102 rane oxygenation for respiratory failure and sepsis between the service being established for adults

103 eviously derived and validated the Pediatric Sepsis Biomarker Risk Model (PERSEVERE) to estimate base

104 ed to understand the temporal association of sepsis biomarkers in relation to systemic hemodynamics,

105 ratio, 2.67; CI, 1.74-4.09), initial 3-hour sepsis bundle compliance (odds ratio, 1.57; CI, 1.07-2.3

106 Precise estimates of neonatal sepsis burden vary by setting.

107 oes not directly augment the pathogenesis of sepsis but enables the development of septic shock by ma

108 fiber atrophy develops in response to severe sepsis, but it is unclear as to how the proteolytic path

109 Exogenous IL-15 exacerbates the severity of sepsis by activating NK cells and facilitating IFN-gamma

110 ter, they were subjected to LPS (2 mg/kg) or sepsis by cecal ligation and puncture (CLP).

111 rt that B-1a cells play a beneficial role in sepsis by mitigating exaggerated inflammation through a

112 phase, overall compliance with the Surviving Sepsis Campaign (SSC) bundle and appropriateness of init

113 More rapid completion of a 3-hour bundle of sepsis care and rapid administration of antibiotics, but

114 endent predictor of mortality and may aid in sepsis care.

115 study was to use a broad method of capturing sepsis cases to estimate 2004-2013 trends in risk-adjust

116 ationality for the potential usage of MCL in sepsis caused by G(+) bacteria (e.g., S. aureus) and ant

117 stacle to therapy in intensive care units is sepsis caused by severe infection.

118 ice and applied 2 stringent animal models of sepsis: cecal ligation and puncture as well as intraperi

119 lt emergency department visits using updated sepsis classifications.

120 Retrospective, consecutive sample sepsis cohort over 10 months.

121 es isolated from patients with Gram-negative sepsis compared with healthy control subjects.

122 s significantly reduced clinically diagnosed sepsis compared with silver-impregnated cuffs (RR, 0.54

123 Sepsis continues to present a major burden to U.S. emerg

124 actors, and management goals (closure versus sepsis control).

125 f C5 cleavage during the bacteremic stage of sepsis could be an important therapeutic approach to pre

126 9% for group 6 and percentage meeting Angus sepsis criteria increased from 20% to 40%.

127 ted efforts to automate earlier detection of sepsis, current techniques rely exclusively on using eit

128 y to inform efforts to reduce disparities in sepsis deaths.

129 y response syndrome (SIRS) criteria from the sepsis definition.

130 In response to a need for better sepsis diagnostics, several new gene expression classifi

131 lidation cohorts) and patients admitted with sepsis due to community-acquired pneumonia to 29 ICUs in

132 ult patients admitted to intensive care with sepsis due to fecal peritonitis (n = 117) or community-a

133 died because of adverse events (mainly from sepsis, eight [8%]; and pneumonia, five [5%]); four deat

134 Detection of sepsis endotypes might assist in providing personalised

135 Task Force updated the clinical criteria for sepsis, excluding the need for systemic inflammatory res

136 e needed to conduct physiologically relevant sepsis experiments.

137 d-resuscitated, long-term (3 d) rat model of sepsis (fecal peritonitis) and recovery was used to unde

138 Sixty-one patients with sepsis and severe sepsis from two large U.K. hospitals and 20 healthy cont

139 e the existence of the idea of noninfectious sepsis given that critically ill humans never exist in a

140 The sepsis group was subjected to a cecal ligation and perfo

141 elusive nature of the infecting organism in sepsis has limited efforts to understand the effect of d

142 Cancer and sepsis have surprisingly similar immunologic responses a

143 om the same site and organism as the initial sepsis hospitalization.

144 re for infection at the same site as initial sepsis hospitalization.

145 al coronary heart disease (CHD) events after sepsis hospitalizations among community-dwelling adults.

146 We assessed the associations between sepsis hospitalizations and future acute and fatal CHD e

147 From 2004 to 2013, sepsis hospitalizations for all racial/ethnic groups inc

148 2013 were similar for white (92.0 per 1,000 sepsis hospitalizations), black (94.0), and Hispanic (93

149 +)transfusion: HR 1.18, 95% CI 1.04-1.33; (+)sepsis: HR 1.63, 95% CI 1.14-2.31; (+)transfusion/(+)sep

150 +)transfusion: HR 1.21, 95% CI 1.14-1.29; (+)sepsis: HR 1.76, 95% CI 1.48-2.09; (+)transfusion/(+)sep

151 , 95% confidence interval (CI) 1.09-1.30; (+)sepsis: HR 1.84, 95% CI 1.44-2.35; (+)transfusion/(+)sep

152 HR 1.63, 95% CI 1.14-2.31; (+)transfusion/(+)sepsis: HR 2.04, 95% CI 1.58-2.63], and overall survival

153 HR 1.84, 95% CI 1.44-2.35; (+)transfusion/(+)sepsis: HR 2.27, 95% CI 1.87-2.76], cardiovascular disea

154 HR 1.76, 95% CI 1.48-2.09; (+)transfusion/(+)sepsis: HR 2.36, 95% CI 2.07-2.68] relative to (-)transf

155 1-120 minutes, or more than 120 minutes from sepsis identification.

156 in-1 receptor treatment at the initiation of sepsis improved survival in cecal ligation and puncture

157 ated incidence, prevalence, and mortality of sepsis in adult Brazilian intensive care units (ICUs) an

158 in the cecal ligation and puncture model of sepsis in adult female outbred mice.

159 This quality improvement initiative in sepsis in an emerging country was associated with a redu

160 sceptibility to urinary tract infections and sepsis in burn patients.

161 Polymicrobial sepsis in mice causes myocardial dysfunction after gener

162 MDSCs expand during the later phases of sepsis in mice, promote immunosuppression, and reduce su

163 The Sepsis in Obstetric Score performed similarly to all the

164 Sepsis in Obstetric Score, Acute Physiology and Chronic

165 The Sepsis in Obstetric Score, Acute Physiology and Chronic

166 the combination group (diarrhoea and urinary sepsis in one patient, and acute renal failure and respi

167 A performed better than both SIRS and severe sepsis in predicting in-hospital mortality, with an area

168 Sepsis incidence, outcomes, and trends from 2009-2014 we

169 care for what was initially suspected to be sepsis, including a minimum of 30 mL/kg of IV fluids, in

170 Sepsis induced cardiac dysfunction (SIC) is a severe com

171 nd inflammatory processes may be involved in sepsis-induced immune suppression, but their clinical im

172 an important therapeutic approach to prevent sepsis-induced inflammation, consumptive coagulopathy, a

173 with bleomycin, cigarette smoke, silica, or sepsis-induced lung injury.

174 RA101295 abolished sepsis-induced surges in proinflammatory cytokines and a

175 , mTOR alterations in the pathophysiology of sepsis-induced T cell alterations.

176 gic agonists improved 72-hour survival after sepsis induction, with ELA providing the best clinical o

177 in multiple pathophysiologic processes like sepsis, inflammation, vascular dysfunction, and thrombos

178 elerated organ injury in two mouse models of sepsis-intra-peritoneal lipopolysaccharide and cecal lig

179 Sepsis is a leading cause of death and is the most expen

180 Sepsis is a life-threatening condition caused by dysregu

181 Sepsis is a prevalent health issue that can lead to cent

182 The mortality caused by sepsis is high following thermal injury.

183 ce, prevalence, and mortality of ICU-treated sepsis is high in Brazil.

184 Sepsis is life-threatening organ dysfunction due to dysr

185 oung infants (aged 0-59 days) with suspected sepsis is sometimes not available or feasible in countri

186 ation in adults with respiratory failure and sepsis is steadily increasing, but the knowledge on long

187 t renal function at day 30, while infection/ sepsis is the leading cause of mid-term mortality.

188 A distinctive feature of sepsis is the reduced capacity of leukocytes to release

189 hagy in both cell types resulted in a lethal sepsis-like environment, which included tissue inflammat

190 potentially shifting the current paradigm of sepsis management.

191 Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any be

192 ents with noninfectious inflammation for the Sepsis MetaScore, the FAIM3-to-PLAC8 ratio, and the Sept

193 n recently published, including the 11-gene "Sepsis MetaScore," the "FAIM3-to-PLAC8" ratio, and the S

194 ects of Lactobacillus rhamnosus L34 in a new sepsis model of oral administration of pathogenic bacter

195 ficacies, using either the mouse peritonitis-sepsis model or the thigh infection model.

196 In a rodent sepsis model, trabecular bone strength is functionally r

197 In-hospital sepsis mortality rates adjusted for patient and hospital

198 004-2013 trends in risk-adjusted in-hospital sepsis mortality rates by race/ethnicity to inform effor

199 fter adjusting for hospital characteristics, sepsis mortality rates in 2013 were similar for white (9

200 interleukin-6 (IL-6) levels, bacteremia, and sepsis mortality.

201 a (n = 126), and of control subjects without sepsis (n = 10).

202 oved survival in cecal ligation and puncture sepsis (neurokinin-1 receptor antagonist survival = 79%

203 ims-based analyses, neither the incidence of sepsis nor the combined outcome of death or discharge to

204 Our study identified 51,078 patients with sepsis, of which, 19,742 received calcium channel blocke

205 d at assessing the long-term consequences of sepsis on T cell function.

206 two [2%]; multiorgan failure, one [1%]; and sepsis, one [1%], all in the 10-day cohort).

207 35 weeks of gestation, and with no signs of sepsis or other morbidity, and monitored them for 60 day

208 uring their hospitalization, 149 (65.0%) had sepsis or septic shock during their course.

209 Consecutive patients presenting with severe sepsis or septic shock from 2011 to 2013.

210 ecutive patients meeting criteria for severe sepsis or septic shock who were admitted to the ICU from

211 sion, Clinical Modification codes for severe sepsis or septic shock.

212 positive adults with critical illness due to sepsis or trauma, ganciclovir did not reduce IL-6 levels

213 is, organ dysfunction plus infection, severe sepsis, or septic shock.

214 testing is prepopulated in the institutional sepsis order set but may be canceled at clinical discret

215 Patients diagnosed with septicemia, sepsis, organ dysfunction plus infection, severe sepsis,

216 tion between calcium channel blocker use and sepsis outcome was determined by multivariate-adjusted C

217 omotes MDSC expansion that adversely impacts sepsis outcome.

218 m channel blockers has been found to improve sepsis outcomes in animal studies and one clinical study

219 (95% CI, 0.59-0.70) for both SIRS and severe sepsis (P < .001; incremental AUROC, 0.15; 95% CI, 0.09-

220 more specifically expanded in patients with sepsis (P < 0.001).

221 ment or GPVI(-/-) mice with the common human sepsis pathogen Klebsiella pneumoniae via the airways to

222 rein, deidentified plasma was collected from sepsis patients (n = 22 subjects) within 48 hours of adm

223 Sepsis patients admitted to the ICU were more frequently

224 e use of balanced fluids in pediatric severe sepsis patients for the first 72 hours of resuscitation

225 Upon ex vivo stimulation, monocytes of sepsis patients were less capable in phosphorylating nuc

226 To identify factors associated with rural sepsis patients' bypassing rural emergency departments t

227 Twenty sepsis patients, 11 ischemic heart disease, nine dilated

228 In neutrophils of sepsis patients, mitogen activated protein kinase phosph

229 hed in peripheral blood mononuclear cells of sepsis patients, whereas p38 mitogen activated protein k

230 I 237.9-351.2) of adult cases of ICU-treated sepsis per year, which yields about 420 000 cases annual

231 In experimental murine sepsis, pHi of blood neutrophils was analogously alkalin

232 hylococcus aureus plays an important role in sepsis, pneumonia, wound infections, and cystic fibrosis

233 tcome predictors in ICU even in an obstetric sepsis population.

234 -Y show potential for the early diagnosis of sepsis post-burn injury.

235 e development of urinary tract infection and sepsis postadmission, regardless of age or gender.

236 Among ICU patients with sepsis, preadmission oral corticosteroids were independe

237 Culture-independent diagnostics, the use of sepsis prediction scores, judicious antimicrobial use, a

238 n and that malfunction of this switch during sepsis promotes MDSC expansion that adversely impacts se

239 Fifteen patients (14.2%) in the sepsis protocol group and 2 patients (1.9%) in the usual

240 practices are a possible strategy to reduce sepsis rates and improve survival after colon cancer sur

241 well as all subsequent hospitalizations and sepsis readmissions within 90 days.

242 ges, and cognitive dysfunction arising after sepsis recovery.

243 eristic curve, 0.62), intermediate for quick Sepsis-related Organ Failure Assessment (median area und

244 Sepsis-related organ failure assessment (SOFA) scores an

245 er operating characteristic curve, 0.60) and Sepsis-related Organ Failure Assessment score (median ar

246 Accuracy of the quick Sepsis-related Organ Failure Assessment score, Sepsis-re

247 psis-related Organ Failure Assessment score, Sepsis-related Organ Failure Assessment score, systemic

248 data, Simplified Acute Physiology Score II, Sepsis-related Organ Failure Assessment, and laboratory

249 hange of 2 or more points in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, i

250 We identified two sepsis response signature (SRS) subgroups in fecal perit

251 ingle dataset yielding 549 unique cases with sepsis response signature assignments.

252 correlation between endotype assignment and sepsis response signature membership.

253 r 31, 2012]), (2) multivariable estimates of sepsis risk at birth (learning period [December 1, 2012,

254 onship to changes in bone structure, using a sepsis rodent model.

255 plus ofatumumab group (the most common being sepsis, septic shock, viral sepsis, and pneumonia).

256 dedicated to the early management of severe sepsis/septic shock (SS/SS) in Emergency Department (ED)

257 py has shown discordant survival outcomes in sepsis studies.

258 jective estimates than claims-based data for sepsis surveillance.

259 ssociation between rural hospital bypass and sepsis survival.

260 Moreover, sepsis-surviving patients have more Treg cells, IL-33 an

261 Randomized clinical trial of 212 adults with sepsis (suspected infection plus >/=2 systemic inflammat

262 ealth Evaluation II, ICU residence on day 4, sepsis syndrome severity, antibiotic administration time

263 unexpected dose-limiting toxicities: grade 4 sepsis syndrome, grade 4 hypotension with grade 3 rash a

264 This emphasizes the complexity of sepsis syndromes in relation with comorbid conditions an

265 Risk of fatal CHD was similarly higher for sepsis than nonsepsis individuals (0-1 year adjusted HR,

266 effects of Flunarizine are low and specific sepsis therapeutics that target the dysregulated host re

267 regulating IL-10 production by B-1a cells in sepsis through its nuclear translocation and binding to

268 t included consecutive patients admitted for sepsis to two intensive care units (ICUs) in the Netherl

269 ed national estimate of 717,732) with severe sepsis transferred from another acute care hospital.

270 and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventin

271 services encounters with community acquired sepsis transported to the hospital.

272 Currently, effective sepsis treatments are lacking in the clinic, and care re

273 Sepsis triggers more severe and sustained muscle fiber a

274 Bacterial sepsis triggers robust activation of the complement syst

275 Thus, sepsis unmasks compartment-specific proliferative and ap

276 Patients who initially chose a top-decile sepsis volume hospital were younger (64.7 vs 72.7 yr; p

277 In the time-critical diagnosis of sepsis, waiting for up to 24h to produce sufficient DNA

278 The rate of sepsis was 0.37% in the neoadjuvant group versus 0.46% i

279 a-lactams for the treatment of patients with sepsis was associated with significantly lower mortality

280 a-lactams for the treatment of patients with sepsis was eligible.

281 In clinical data from 409 hospitals, sepsis was present in 6% of adult hospitalizations, and

282 One fatal event of neutropenic sepsis was reported in a patient allocated ramucirumab.

283 Using a mouse model of bacterial sepsis, we found that the numbers of B-1a cells in vario

284 al, 1,060 consecutive patients admitted with sepsis were analyzed, 18.6% of whom used calcium channel

285 After risk adjustment, transfusion and sepsis were associated with worse colon cancer disease-s

286 riables from previous and new definitions of sepsis were collected.

287 dial infarction, vascular complications, and sepsis were identified as independent predictors of 30-d

288 with an admission diagnosis or suspicion of sepsis were included.

289 Fatal infections or sepsis were significantly more common in the canakinumab

290 tion was found in animals with polymicrobial sepsis whereas glomerular damage due to glycerol-induced

291 ysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes.

292 cecal ligation and puncture- and LPS-induced sepsis, which correlated with significantly decreased su

293 o a greater degree in patients who developed sepsis, which was also characterized by elevated IG coun

294 tality was lowest among patients with severe sepsis who were transferred to high-volume hospitals; ho

295 Example of the resulted phenotypes are sepsis with acute kidney injury, cardiac surgery, anemia

296 rt the rationale for targeting metabolism in sepsis with recombinant human IL-7 as a treatment option

297 tal encounters, 2,683 had community-acquired sepsis, with an in-hospital mortality of 11%.

298 Primary endpoint was postoperative pelvic sepsis within 30 postoperative days, including anastomot

299 Of the patients readmitted with sepsis within 90 days, two thirds had infection at the s

300 is a major cause of bacterial meningitis and sepsis worldwide.