ライフサイエンスコーパス: septicemia

1 l varied from 1.3% (skin infection) to 5.1% (septicemia).

2 get for developing drugs against LPS-induced septicemia.

3 agic colitis, hemolytic uremic syndrome, and septicemia.

4 ical care anemia as well as a model of acute septicemia.

5 essant factor in children with meningococcal septicemia.

6 somni to breach alveolar barriers and cause septicemia.

7 us infections result in abscesses as well as septicemia.

8 ipheral blood of children with meningococcal septicemia.

9 the knockout animals led to peritonitis and septicemia.

10 the host, causing meningococcal disease and septicemia.

11 mostly from blood samples from patients with septicemia.

12 ity to cause life-threatening meningitis and septicemia.

13 tizing pneumonia, necrotizing fasciitis, and septicemia.

14 and often fatal wound infections and primary septicemia.

15 icus causes severe wound infection and fatal septicemia.

16 th Revision, Clinical Modification codes for septicemia.

17 tic exacerbation of disease leading to fatal septicemia.

18 major organs of the mice, resulting in fatal septicemia.

19 ich leads to starvation, or B. thuringiensis septicemia.

20 r reimbursement for patients with documented septicemia.

21 y to systemic infection and life-threatening septicemia.

22 donors following recovery from meningococcal septicemia.

23 models of invasive soft-tissue infection and septicemia.

24 meningitidis causes bacterial meningitis and septicemia.

25 isease severity and outcome in meningococcal septicemia.

26 There were no cases of septicemia.

27 cent years were the principal antecedents of septicemia.

28 of pneumonia, otitis media, meningitis, and septicemia.

29 eter blockage can lead to pyelonephritis and septicemia.

30 ve increased susceptibility to V. vulnificus septicemia.

31 genesis of pneumococcal bronchopneumonia and septicemia.

32 rug to use in the treatment of Gram-negative septicemia.

33 gen able to cause meningitis, pneumonia, and septicemia.

34 necrotizing fasciitis, which can progress to septicemia.

35 disposed people may experience highly lethal septicemia.

36 depressant factors present in meningococcal septicemia.

37 ifesting as perihepatitis, pericarditis, and septicemia.

38 o cardiovascular collapse that can accompany septicemia.

39 ial cell death is occurring in meningococcal septicemia.

40 s of myocardial dysfunction in meningococcal septicemia.

41 , have only rarely been reported in cases of septicemia.

42 minating pneumonia sometimes associated with septicemia.

43 % of mice fed ad libitum died from infection/septicemia.

44 curring with high frequency in Gram-negative septicemia.

45 of infants on PN at high risk of sepsis and septicemia.

46 collected from adult patients with suspected septicemia.

47 diarrhea, wound infections, and death due to septicemia.

48 sponsible for fulminant and frequently fatal septicemia.

49 collected from adult patients with suspected septicemia.

50 5% for wound infections, and 44% for primary septicemia.

51 llergies, cancer, cardiovascular disease and septicemia.

52 lung, and a 2.25-fold higher rate of lethal septicemia.

53 SV, pneumococcal pneumonia, and pneumococcal septicemia.

54 e full virulence of the microorganism during septicemia.

55 C3a to C5a is also illustrated in models of septicemia.

56 %) cases, and 70 of 110 (64%) presented with septicemia.

57 flammation and mortality in a mouse model of septicemia.

58 pathogen and leading cause of meningitis and septicemia.

59 n also cause life-threatening meningitis and septicemia.

60 ylococcus aureus infection in the context of septicemia.

61 ibrinogen could be advantageous in S. aureus septicemia.

62 nfections such as pneumonia, meningitis, and septicemia.

63 ,12,i:-, which is frequently associated with septicemia.

64 s a leading cause of neonatal meningitis and septicemia.

65 ted pneumonia, 3.1% [n=644]; isolated sepsis/septicemia, 0.5% [n=99]; isolated deep sternal wound inf

66 tinitis, 32.6% saphenous harvest site, 35.0% septicemia, 0.5% thoracotomy, 6.8% multiple sites).

67 revision, Clinical Modification diagnosis of septicemia (038.x), severe sepsis (995.92), or septic sh

68 kin infections (1.50; 95% CI, 1.45 to 1.55), septicemia (1.60; 95% CI, 1.53 to 1.67), and tuberculosi

69 ociated with significantly decreased risk of septicemia (10.9% vs 13.4%; RR, 0.76; 95% CI, 0.59-0.97)

70 occal septicemia), 19.2% (38.2, pneumococcal septicemia), 15.0% (518.81, respiratory failure), 14.2%

71 is (51%), wound infections (24%), or primary septicemia (17%).

72 occal pneumonia), 20.4% (38.0, streptococcal septicemia), 19.2% (38.2, pneumococcal septicemia), 15.0

73 hospitalizations, gastroenteritis (61%) and septicemia (23%) were the most common Salmonella diagnos

74 0% occurred before or on the day of CPR, and septicemia (26.7%), ventilator dependence (22.1%), signi

75 Of 397 unimicrobial episodes of septicemia, 354 were detected with both pairs, 30 were d

76 lure (2.7% vs. 1.6%, P=0.003), and sepsis or septicemia (4.0% vs. 2.8%, P=0.01).

77 ension (38%), tachycardia (14%), rash (29%), septicemia (5%), thrombocytopenia (29%), elevated transa

78 rted; 45% were wound infections, 43% primary septicemia, 5% gastroenteritis, and 7% from undetermined

79 d parasitic diseases (4.1; 95% CI, 1.7-8.5), septicemia (6.8; 95% CI, 2.2-15.8), small intestinal can

80 One patient died of septicemia 97 days after transplantation; 5 patients wer

81 gnosis codes were used to compare first-year septicemia admission rates in annual incident cohorts fr

82 s), incidence of sepsis (AF 29%; NF 6%), and septicemia (AF 22%; NF 2%) were significantly greater in

83 human pathogen, can cause potentially fatal septicemia after consumption of undercooked seafood.

84 oracotomy or vein harvest site infection, or septicemia) after coronary artery bypass grafting.

85 3.8 in the initial 6 mo after admission for septicemia and 1.7, 2.0, 2.0, and 1.6 after 5 yr, respec

86 nitoba, Canada, that resulted in 36 cases of septicemia and 3 deaths.

87 ected mice from otitis media, pneumonia, and septicemia and averted the cytokine storm associated wit

88 e factors and have long been associated with septicemia and avian colibacillosis.

89 coli exacerbates lymphopenia associated with septicemia and could impair the chances to survive sepsi

90 nduced multiple nodular panniculitis without septicemia and describe common features among all 6 case

91 ulence factor by contributing to hemorrhagic septicemia and diarrhea.

92 , while systemic dissemination can result in septicemia and elicitation of systemic immune responses.

93 includes strains from both clinical cases of septicemia and from such environmental sources such as s

94 have been classified into two major groups: septicemia and gastroenteritis.

95 rogenitors in the granulopoietic response to septicemia and how alcohol affected this response.

96 loss of which results in rapidly progressing septicemia and impaired macrophage activation.

97 In epidemiological studies, primary septicemia and inflammation-mediated septic shock caused

98 , Clinical Modification (ICD-9-CM) codes for septicemia and major organ dysfunction, we identified 8,

99 findings and course are not unlike those of septicemia and meningitis due to N meningitidis.

100 isseria meningitidis causes 500 000 cases of septicemia and meningitis worldwide annually, with appro

101 sseria meningitidis is an important cause of septicemia and meningitis.

102 casionally invades to cause life-threatening septicemia and meningitis.

103 is a Gram-positive bacterium that can cause septicemia and meningitis.

104 cters are important human pathogens, causing septicemia and occasionally abortion, premature labor, o

105 , Clinical Modification (ICD-9-CM) codes for septicemia and organ dysfunction, we identified 87,675 p

106 en implicated in human infections, including septicemia and peritonitis.

107 s a range of manifestations, including acute septicemia and pneumonia.

108 ality by >40% due to prevention of primarily septicemia and pneumonia.

109 oidosis characterized by pneumonia and fatal septicemia and prevalent in Southeast Asia.

110 erance resulting in persistent inflammation, septicemia and septic shock.

111 sive care in 101 children with meningococcal septicemia and serially in 37 children.

112 arine pathogen that has been associated with septicemia and serious wound infections in patients with

113 nterleukin-6 receptor in acute meningococcal septicemia and the relationship with disease severity.

114 Septicemia and ventilator-associated pneumonia are two o

115 was present in 48% of patients with primary septicemia and was associated with a fatal outcome in bo

116 B. holmesii had been associated mainly with septicemia and was not thought to be associated with res

117 s occurring in the presence of meningococcal septicemia and whether it correlated with the degree of

118 ad little seasonal variation, 91% of primary septicemias and 86% of wound infections occurred from Ap

119 infection (respiratory or wound infection or septicemia) and ischemic outcomes (myocardial infarction

120 act infections, 0.21 (95% CI, 0.01-0.41) for septicemia, and 0.16 (95% CI, 0.10-0.22) for heat stroke

121 nteritis, 34% were wound infections, 5% were septicemia, and 2% were from other exposures.

122 act infections, 1.06 (95% CI, 1.00-1.11) for septicemia, and 2.54 (95% CI, 2.14-3.01) for heat stroke

123 athogen responsible for meningoencephalitis, septicemia, and abortion in susceptible and immunocompro

124 us Yersinia, the causative agents of plague, septicemia, and gastrointestinal syndromes, use a type I

125 ers, renal failure, urinary tract infection, septicemia, and heat stroke were statistically significa

126 ers, renal failure, urinary tract infection, septicemia, and heat stroke.

127 esponsible for respiratory tract infections, septicemia, and meningitis and continues to produce nume

128 emic infection causing spontaneous abortion, septicemia, and meningitis, studies have not been perfor

129 terium that can induce spontaneous abortion, septicemia, and meningitis.

130 success rate was 98%; one patient developed septicemia, and no major hemorrhage occurred.

131 detection of mediastinitis, before onset of septicemia, and ongoing improvements in the critical car

132 Vascular thromboses, bowel perforation, septicemia, and retransplantation, each independently in

133 Overall HAIs included pneumonia, sepsis/septicemia, and surgical site infections, including deep

134 ria responsible for bacterial meningitis and septicemia, and the sexually transmitted disease gonorrh

135 infections including pneumonia, meningitis, septicemia, and urinary tract infections.

136 al meningitis, urinary tract infections, and septicemia are collectively known as extraintestinal pat

137 ildren in 24% of children with meningococcal septicemia at admission and in 62% of patients within 48

138 from a 54% increase for the method combining septicemia, bacteremia, and fungemia codes (P < .001 for

139 ogens causing invasive bacterial infections (septicemia, bacteremia, meningitis, etc) was initiated.

140 conditions such as erythroblastosis fetalis, septicemia, biliary atresia, and other causes of hyperbi

141 DS, neutropenia, thrombocytopenia, bacterial septicemia, black race, female sex, prescription of zido

142 al role in the pathogenesis of highly lethal septicemia by modulating transcription of many innate an

143 ture, PCR-ESI-MS enhances the diagnostics of septicemia by shortening test turnaround time and improv

144 an pathogen causing more than a tenth of all septicemia cases and often superficial and deep infectio

145 with the highest mortality for Gram-negative septicemia cases, 29.5%.

146 ever (BPF) is a recently described pediatric septicemia caused by a strain of Haemophilus influenzae

147 We report the first case of pneumonia and septicemia caused by B. thailandensis in the United Stat

148 We report on the first case of fatal septicemia caused by Bordetella hinzii.

149 ithin 10 h after infection rescues mice from septicemia caused by S. aureus and S. pneumoniae, wherea

150 nt developed severe dehydrating diarrhea and septicemia compared to 100% of those inoculated with the

151 Comparative MR data for cases where septicemia complicated another diagnosis were available

152 of patients were male, and 96% with primary septicemia consumed raw oysters.

153 roup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158

154 ng for sepsis has become more inclusive, and septicemia diagnoses are increasingly being applied to p

155 Sixty-one percent with primary septicemia died; underlying liver disease was associated

156 implicated in the development of hemorrhagic septicemia during vibriosis, a fatal fish disease.

157 Children with meningococcal septicemia exhibit abnormal plasma iron chemistry and de

158 ge/hematoma complications following PCI, and septicemia following PCI and PAN when compared with low-

159 MN migration and the role of inflammation in septicemia following pneumococcal lung infection.

160 trol patients (referred to as other-organism septicemia), giving a specificity of 96% (95% CI, 86.5 t

161 ver, patients with more severe meningococcal septicemia (GMSPS, >10; n = 12) had significantly dimini

162 ge groups, whereas mortality with underlying septicemia had a contribution from influenza in children

163 0.0001) and severe coinfection (pneumonia or septicemia; hazard ratio, 13.46; 95% CI, 2.26-80.01; P<0

164 on; acute and unspecified renal failure; and septicemia (HCV only).

165 nfectious (pneumonia, hepatitis, meningitis, septicemia, herpes zoster, and poliomyelitis), and infla

166 We estimate that the cost to Medicare for septicemia hospitalizations in 1997 was >$1.8 billion.

167 for all methods), whereas the proportion of septicemia hospitalizations with positive blood cultures

168 manifests as toxemia, rapidly disseminating septicemia, immune collapse, and death.

169 inability to colonize the air sac and cause septicemia in 2-week-old white Leghorn chickens.

170 or cause of community-acquired pneumonia and septicemia in adults.

171 ntly to the development of both diarrhea and septicemia in animal models.

172 nterobacteriaceae family that causes enteric septicemia in channel catfish (Ictalurus punctatus).

173 mobilizable and confers the ability to cause septicemia in chickens, the ability to cause bacteremia

174 a leading cause of bacterial meningitis and septicemia in children and young adults in the United St

175 In five cases of meningitis or septicemia in children, the causative organism was Neiss

176 e leading causes of bacterial meningitis and septicemia in children.

177 The clinical epidemiology of septicemia in dialysis populations remains poorly define

178 evere dehydrating diarrhea and postdiarrheal septicemia in ETEC infections of swine and demonstrate t

179 ive enteric pathogen that causes hemorrhagic septicemia in fish and both gastrointestinal and extrain

180 ive enteric pathogen that causes hemorrhagic septicemia in fish and gastro- and extraintestinal infec

181 It is associated with wound infections and septicemia in humans and the virulence of V. vulnificus

182 gen that has been identified as the cause of septicemia in humans in Europe and South America.

183 en responsible for severe food poisoning and septicemia in humans, secretes a PFT called V. vulnificu

184 borne gastroenteritis, wound infections, and septicemia in humans.

185 zoonotic agent that can cause meningitis and septicemia in humans.

186 cellular pathogen that causes meningitis and septicemia in immunocompromised individuals and spontane

187 orn species common in shellfish which causes septicemia in immunocompromised individuals, most often

188 unusual bacterial cause of endocarditis and septicemia in immunocompromised patients.

189 ngitidis is a common cause of meningitis and septicemia in infants worldwide.

190 h in vitro and a relative inability to cause septicemia in mice.

191 ion also induced a similar enteric bacterial septicemia in MyD88-deficient mice but not in heterozygo

192 associated with increased risk of sepsis and septicemia in surgical newborn infants.

193 to cause a severe and rapidly disseminating septicemia in susceptible hosts.

194 nfections, respiratory tract infections, and septicemia in susceptible individuals.

195 cus is a human pathogen that produces lethal septicemia in susceptible persons, and the primary virul

196 ty of F4(+) enterotoxigenic E. coli to cause septicemia in swine following oral inoculation.

197 tion with B. pseudomallei, a common cause of septicemia in Thailand.

198 ene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

199 a pathogenic strain causing an outbreak with septicemia in three patients.

200 00,000 in 1992, and the rate of death due to septicemia increased 83% from 4.2 to 7.7 per 100,000.

201 The 1997 rates of septicemia increased with age, from 4.47 per 1000 benefi

202 In particular, the importance of the septicemia induced by the host midgut microbiota is stil

203 less lethal than PAO1, as tested in an acute septicemia infection mouse model, and was cleared more e

204 For primary septicemia infections, oyster trace-backs were performed

205 king, hypertension, diabetes, poststernotomy septicemia, internal mammary artery harvest, use of intr

206 Rates of hospitalization due to septicemia (International Classification of Diseases, Ni

207 gional multiple nodular panniculitis without septicemia is an underreported condition, with only 3 ca

208 Methicillin-resistant Staphylococcus aureus septicemia is associated with significant morbidity and

209 The pathogenesis of neonatal septicemia is still unsolved.

210 sative agent of meningococcal meningitis and septicemia, is an integral outer membrane protein that f

211 ntrol mice developed plague, with an average septicemia level of 9.2 x 10(8) Y. pestis CFU/ml.

212 LPS exposure occurs repeatedly during septicemia, making strict regulation of gene expression

213 al carriage and increased risk of sepsis and septicemia may be because of the intestinal endotoxin po

214 nal epithelial barrier and enteric bacterial septicemia may contribute to sensitizing MyD88-deficient

215 ytogenes is a foodborne pathogen that causes septicemia, meningitis and chorioamnionitis and is assoc

216 x was strongly associated with isolates from septicemia, meningitis, and arthritis, the ST87 and ST27

217 neous abortion in pregnant women, as well as septicemia, meningitis, and gastroenteritis, primarily i

218 The most common cause of death was septicemia/meningitis in adults (20%, median 76 days) an

219 Streptococcus iniae is a cause of septicemia, meningoencephalitis, and death in farmed fis

220 hinitis (snuffles), pneumonia, otitis media, septicemia, metritis, and death in domestic rabbits.

221 t associated with increased mortality in the septicemia model or in the generalized inflammation mode

222 and preliminary data obtained from a murine septicemia model show that many of the novel tetracyclin

223 In a mouse septicemia model, JG752 killed only 30% of mice, whereas

224 To assess the toxicity of iron in a septicemia model, OF1 mice were simultaneously injected

225 ting in virulence attenuation in a mammalian septicemia model.

226 ficacy of 1-Dox 35/1 is evaluated in a mouse septicemia model; treatment of the infected C57BL/6 mice

227 ding human immunodeficiency virus infection, septicemia, myocardial failure, atherosclerosis, metabol

228 er patients were myocardial infarct (n = 2), septicemia (n = 2), adult respiratory distress syndrome,

229 score, were assessed among the NEC (n = 20), septicemia (n = 40), and control groups (n = 40) in a ca

230 e (n = 544 [44%]), asphyxia (n = 74 [6.0%]), septicemia (n = 61 [4.9%]), and pneumonia (n = 57 [4.6%]

231 r to illness and the majority presented with septicemia (n = 63 [49%]), meningitis (n = 16 [12%]) or

232 nts of the causative agent of meningitis and septicemia, Neisseria meningitidis, we showed that the P

233 deaths of persons with AIDS associated with septicemia, non-AIDS-defining malignancy, chronic liver

234 However, this study was of septicemia, not severe sepsis.

235 typhoid and paratyphoid fever), nontyphoidal septicemia (NTS), and gastroenteritis in humans and othe

236 failure, urinary tract infection, pneumonia, septicemia, nutritional and metabolic disorders, esophag

237 Septicemia (odds ratio [OR], 91.2; 95% CI, 81.2-102.3) a

238 pain (odds ratio, 0.63 [CI, 0.44 to 0.89]), septicemia (odds ratio, 0.76 [CI, 0.64 to 0.91]), and sk

239 hydrophila, the causative agents of enteric septicemia of catfish (ESC) and motile aeromonad septica

240 significantly higher in the NEC than in the septicemia or control group (P < 0.01).

241 te renal failure (OR, 2.2; 95% CI, 1.3-3.9), septicemia (OR, 1.8; 95% CI, 1.2-2.6), platelet transfus

242 bles strongly associated with mortality were septicemia (p < 0.00001), perioperative myocardial infar

243 e-threatening nosocomial infections, such as septicemia, peritonitis, and endocarditis.

244 APACHE II score; septicemia; plasma lactate; TNF-alpha, IL-6, and IL-10 c

245 cus (GBS), is the leading cause of bacterial septicemia, pneumonia, and meningitis among neonates.

246 Early-onset GBS disease (septicemia, pneumonia, or meningitis occurring within 7

247 ing number of chronic conditions, infection (septicemia, pneumonia, tuberculosis), hematological mali

248 was stratified by the Glasgow meningococcal septicemia prognostic score (GMSPS).

249 Septicemia rapidly follows with spread to spleen, liver,

250 re weeks old) and presented as pneumonia and septicemia rather than the primarily diarrheal syndrome

251 Bacterial septicemia remains the leading cause of morbidity and mo

252 h and 1 of cardiac failure in the context of septicemia, respectively, 8 and 12 months after dasatini

253 norrhea and serious bacterial meningitis and septicemia, respectively.

254 ss, he had numerous complications, including septicemia, respiratory failure, and encephalopathy.

255 at causes a life-threatening disorder called septicemia resulting from the unregulated activation of

256 rval [CI], 6.3-127.5; P < .0001) and primary septicemia (RR, 1.9; 95% CI, 1.2-3.1; P < .01).

257 terotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection.

258 hrtiimonas chitiniclastica-induced bacterial septicemia secondary to wound myiasis in a deer in Michi

259 ted linear trends in the annual incidence of septicemia, sepsis, and severe sepsis at 2 academic hosp

260 Patients diagnosed with septicemia, sepsis, organ dysfunction plus infection, se

261 the following age-specific keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmon

262 dicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmon

263 Infection often includes septicemia, shock, pneumonia, and respiratory failure.

264 o induced (ivi) genes of an Escherichia coli septicemia strain by using antibiotic-based in vivo expr

265 ng acute renal failure, pneumonia, bleeding, septicemia, stroke, and 30-day postoperative mortality (

266 ated protein kinase pathway in meningococcal septicemia suggests that this pathway may be an importan

267 ever, blood culture identified more cases of septicemia than PCR among patients with an identified in

268 trograde ureteral instrumentation) developed septicemia that required repeat nephrostomy tube inserti

269 toxin (LPS) is persistently repressed during septicemia; this phenomenon of LPS tolerance is associat

270 ve agents in neonatal infection and causes a septicemia thought to be initiated via the gastrointesti

271 aused widespread epidemics of meningitis and septicemia throughout the 20th century.

272 f clinical manifestations ranging from acute septicemia to chronic localized illness or latent infect

273 Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurologic

274 mids, pXO1 and pXO2, and is characterized by septicemia, toxemia, and meningitis.

275 Viral hemorrhagic septicemia virus (VHSV) and infectious hematopoietic nec

276 Viral hemorrhagic septicemia virus (VHSV) is a pathogenic fish rhabdovirus

277 Viral hemorrhagic septicemia virus (VHSV) is an emerging pathogen that cau

278 necrosis virus (IHNV), and viral hemorrhagic septicemia virus (VHSV).

279 Infection of brown trout with hemorrhagic septicemia virus resulted in early induction of IFN-d, -

280 were bath challenged with viral hemorrhagic septicemia virus, the number of CCR7(+) cells significan

281 Septicemia was associated with developing myocardial inf

282 In vivo efficacy versus a S. aureus septicemia was demonstrated, highlighting the potential

283 An animal model of gram-positive septicemia was developed to evaluate the effects of anti

284 Septicemia was the combination of sepsis and positive bl

285 Mortality rates after septicemia were similar to mortality rates after major c

286 The rates of septicemia were slightly greater among men (7.46 per 100

287 The most likely sites of the origin of the septicemia were the urinary tract (40.1%) and lungs (15.

288 gastroenteritis cases and 83% of the primary septicemias were associated with raw oyster consumption.

289 rn site, all MBL null mice died by 42 h from septicemia, whereas only one-third of wild-type mice suc

290 95% CI, 0.15-0.23), and least prominent for septicemia, which decreased by 54% (RR, 0.46; 95% CI, 0.

291 Septicemia, which is associated with increased cardiovas

292 and restricts granulocyte production during septicemia, which may serve as a novel mechanism underly

293 We report here a case of septicemia with a skin and soft tissue source caused by

294 ningitis, septicemia without meningitis, and septicemia with meningitis, respectively.

295 Septicemia with multiorgan failure is associated with ch

296 overloaded patients, causing a fatal primary septicemia with very rapid progress, resulting in a high

297 ies that has been attributed to two cases of septicemia, with a rare isolate of Klebsiella terrigena

298 ding domain are born alive but die of severe septicemia within 48 h.

299 sified as groups 1-3 that caused meningitis, septicemia without meningitis, and septicemia with menin

300 ingitidis is a major cause of meningitis and septicemia worldwide.