ライフサイエンスコーパス: sequence

1 ino acids close to each other in the protein sequence.

2 lation sites and their clustering in the Tau sequence.

3 pes using reads mapped to a reference genome sequence.

4 ructure element rather than by local primary sequence.

5 nal level, by properties of the transcript's sequence.

6 transgene carries a floxed, synthetic exon 1 sequence.

7 g time by eliminating the need to perform T1 sequences.

8 for the genome-wide detection of AARS coding sequences.

9 eptibility were determined from whole genome sequences.

10 fic ultra-short motifs from a set of aligned sequences.

11 aberrations, including changes in nucleotide sequences.

12 nes, which retained interstitial TMPRSS2/ERG sequences.

13 ion of paralogous genes, and long repetitive sequences.

14 Neighbour2) distance matrices given a set of sequences.

15 Positive results were confirmed by sequencing.

16 by applying single-molecule real-time (SMRT) sequencing.

17 methylated regions, using bisulfite amplicon sequencing.

18 confirmatory Wayne's assay, and whole-genome sequencing.

19 nd tissue response were assessed through RNA sequencing.

20 n the off-target reads from deep whole-exome sequencing.

21 ategy might prove useful for next generation sequencing.

22 erted to a sequencing library for paired-end sequencing.

23 ted for scanning electron microscopy and RNA sequencing.

24 or slippage at slippage-prone template motif sequence 3' of such 'slippage-stimulatory' structures.

25 t certain RNA template structures and G-rich sequences, ahead of diverse reverse transcriptases can b

26 SSMs are built from the query-based multiple sequence alignment (MSA) implied by the pairwise alignme

27 y sequences and database hits using pairwise sequence alignment.

28 the study of human genetic disease when DNA sequencing alone is not sufficient to reveal the underly

29 Sequence analyses of various GAS M-Prts have shown that

30 mbryos and performed whole transcriptome RNA sequencing analyses.

31 Sequence analysis of T-cell receptors of CD8(+) T cells

32 A trio-based whole exome sequencing analysis in the first family detected a homoz

33 Next-generation sequencing analysis of chromosomal copy number changes a

34 Genome-wide chromatin immunoprecipitation-sequencing analysis reveals that LSD1 binding sites over

35 RNA sequencing analysis was performed and 263 genes were dif

36 ines was subjected to transcriptome-wide RNA sequencing analysis.

37 roximal sites, and this suggests that target sequence and chromatin state modulate cleavage and repai

38 rial phyla and varies widely in both protein sequence and corresponding crRNA sequence conservation.

39 oderms are not interchangeable, although the sequence and function of Domain 2 are highly conserved.

40 lates true sequence similarity between query sequences and database hits using pairwise sequence alig

41 (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes.

42 case, we analyzed gene expression using RNA sequencing and assessed differences between conditions b

43 Sequencing and comparing the genomes of two pathogenic s

44 riants were identified with massive parallel sequencing and confirmed with Sanger sequencing in the p

45 We used whole-genome sequencing and phylogenetic analysis to investigate the

46 ies using chromatin immunoprecipitation with sequencing and RNA sequencing, we identify a novel B-lym

47 nome sequencing, RNA-seq, ChIP-seq, targeted sequencing and single-cell whole-genome sequencing, with

48 led oral gluten challenge, which had a fixed sequence, and biopsy cohorts had a gastroscopy with duod

49 y, where DNA is sheared into smaller pieces, sequenced, and then computationally reordered and analyz

50 te-onset degradation: miR-430 seeds, AU-rich sequences, and Pumilio recognition sites.

51 e samples by standard PCR cloning and Sanger sequencing, and showed that both methods similarly demon

52 ut a history of periodontitis through a deep-sequencing approach.

53 ons in the CTLA-4 pathway identified by gene-sequencing approaches.

54 Complex DNA sequences are difficult to detect and profile, but are i

55 ally by the presence of fewer GR recognition sequences, arguing for the existence of additional mecha

56 Mapping of the sequenced arms to a reference transcriptome identifies t

57 This approach also performs sequence assembly across multiple breakpoints simultaneo

58 m, and flower tissues, and performed de novo sequence assembly, yielding 98,613 unique transcripts wi

59 correcting capabilities, and capture target sequences at an average ratio of 29.2% by targeting both

60 essible chromatin coupled to high-throughput sequencing (ATAC-seq) data, we found that the latent HIV

61 Sequence-based analyses revealed that clone SA possesses

62 ubility in a cell-free expression system, 35 sequence-based properties are calculated.

63 pattern and handedness was observed when the sequence begins with a beta-hGly residue instead of a (S

64 without fitting parameters, with genomic DNA sequence being the only input, we further validate that

65 ears with a computer generated randomisation sequence (blocks of six) to receive either two intranasa

66 -quadruplexes formed by, e.g., telomeric DNA sequences, but are also interesting targets for supramol

67 ated RNAs (caRNAs) with their target genomic sequences by proximity ligation, forming RNA-DNA chimeri

68 Although sequence capacity has been extensively studied using lat

69 ith earlier theoretical work, the calculated sequence capacity is positively correlated with the size

70 Using chromatin immunoprecipitation sequencing (ChIP-seq) combined with assay for transposas

71 ith the chromatin immunoprecipitation (ChIP) sequencing (ChIP-Seq) data shows that the domain boundar

72 bryonic day 12.5 followed by next-generation sequencing (ChIP-seq).

73 oPrecipitation associated to high-throughput sequencing (CLIP-seq).

74 an interaction between a red-giant or a main-sequence companion and ejecta from a white-dwarf explosi

75 eighted and diffusion-weighted imaging pulse sequences compared with that of a standard multiparametr

76 Sequence comparison of the VP7 gene of G9 strains identi

77 scovery as a viral microRNA bearing complete sequence complementarity to the mRNA for the important v

78 ructures formed from protein segments of low sequence complexity/intrinsic disorder.

79 are based on a combination of structural and sequence components of the antisense lncRNA.

80 RNA sequencing confirmed that Hh-mediated transcription is i

81 Transcriptomic sequencing confirmed the effect of hDBR1 on RNA splicing

82 Given the high degree of sequence conservation among GP of Ebola viruses, it woul

83 Despite sequence conservation, there are significant structural

84 oth protein sequence and corresponding crRNA sequence conservation.

85 s developed to be both agglomerative, to add sequences containing similar functional site features, a

86 These results highlight the importance of sequence context for alt-EJ repair and have important im

87 oss of RER in B. subtilis causes strand- and sequence-context-dependent GC --> AT transitions.

88 ted OG would preferentially form in 5'-GG-3' sequence contexts after exposure to reactive oxygen spec

89 high level of molecular precision or monomer sequence control confers potential for molecular targeti

90 Finally, viral sequences corresponding to anelloviruses, human pegiviru

91 two were complete denitrifiers, which genome sequencing corroborated.

92 hat shows how pairings between long repeated sequences could be efficiently rejected even though most

93 and which potentially contribute to gaps in sequence coverage of proteins.

94 obtains very good performance already on 5x sequencing coverage and outperforms the fastest availabl

95 le molecular systems, wherein specific input sequences create distinct outputs.

96 r of self-sustained epidemics from any viral sequence data.

97 Technical advances in single-cell sequencing data and their application to greater samples

98 High-throughput sequencing data are widely collected and analyzed in the

99 Here using a large whole-genome sequencing data bank, cancer registry and colorectal tum

100 -scale mapping of the branchpoints from deep sequencing data in three different species and in the SF

101 Analysis of next-generation sequencing data often results in a list of genomic regio

102 nown and putative SSP genes based on 144 RNA sequencing data sets covering various stages of macronut

103 As the size of bio-sequence databases grows exponentially, the computationa

104 of the largest published microbial 16S rRNA sequence dataset.

105 ructures is a major factor, which determines sequence-dependent behavior of peptides in HILIC.

106 The local sequence-dependent features of DNA found in high-resolut

107 e sequencing, with a minimal requirement for sequencing depth (>0.5X).

108 -only and water-only imaging provide, in one sequence, diagnostic performance similar to that of the

109 e, we show that NAGC slows down as duplicate sequences diverge-until an eventual "escape" of the sequ

110 (d)/AH1-specific T cells and an expansion of sequence diversity in treated mice.

111 and for quantitating other viruses with high sequence diversity.

112 Reactivation of hippocampal place cell sequences during behavioral immobility and rest has been

113 t was randomly assigned to 1 of 3 equivalent sequences, each comprising 6 study periods, during which

114 subsequent exposures, thereby resulting in a sequence effect-but only when toxicodynamic recovery was

115 e treatment did not discernibly increase the sequencing efficiency of PV isolates.

116 Sphagnome Project encompasses a genus-level sequencing effort that represents a new type of model sy

117 r monomer-monomer contacts, this six-residue sequence element also turns into a well-defined structur

118 iral catalyst with a Rawal diene renders the sequence enantioselective.

119 These studies reveal hotspots for sequence evolution with implications for targeting and s

120 t codon while the bulk of the protein-coding sequence evolved through a CAG repeat expansion.

121 We find that the majority of sequences examined display p53-dependent enhancer activi

122 We sequenced exons of this gene in DNA from a total of 134

123 ChIP-sequencing experiments using an anti-O-GlcNAc antibody r

124 trate the importance of the barley reference sequence for breeding by inspecting the genomic partitio

125 thelium swabs (matched control subjects) was sequenced for the V1-V3 region using Illumina's 2 x 300

126 t of the standard combination of morphologic sequences for the detection of probable spinal bone meta

127 ed ES, as well as conserved VSG 3'UTR 16-mer sequences for the generation of functional levels of VSG

128 ly done by random priming, creating multiple sequencing fragments along each transcript.

129 l extracellular RNA (exRNA) was isolated and sequenced from 183 plasma samples, 204 urine samples and

130 In the past, this diverse collection of sequences from human as well as model and non-model orga

131 es diverge-until an eventual "escape" of the sequences from its influence.

132 s have enabled the generation of millions of sequences from microorganisms.

133 ynthesis pathway, we generated transcriptome sequences from the root, leaf, stem, and flower tissues,

134 e we establish, through fine mapping, genome sequencing, genetic complementation, and gene editing, t

135 y, we combine de novo transcriptome data and sequenced genomes from an economically important group o

136 , we performed a cgMLST analysis of 92 newly sequenced genomes, plus an additional 142 strains with g

137 enomes, however, the 158-Mb Spirodela genome sequence has not been resolved to chromosomes, and impor

138 Although next-generation sequencing has revolutionized the ability to associate v

139 quencing technologies, specifically Nanopore sequencing, have made possible the rapid identification

140 Thus, sequence homology between T cell epitopes of 2 self-prot

141 share the same architecture on the basis of sequence homology.

142 Whole exome sequencing identified a single mutation in SLC30A9 withi

143 e named species that share 99% 16S rRNA gene sequence identity.

144 strate that pol beta contains a specific NLS sequence in the N-terminal lyase domain that promotes tr

145 ative antioxidant response element consensus sequence in the sterol regulatory-element binding protei

146 use a library of Xenopus tropicalis genomic sequences in bacterial artificial chromosomes (BAC) to a

147 Nature precisely manipulates primary monomer sequences in biopolymers.

148 etter than existing methods when classifying sequences in eukaryotic de novo assemblies.

149 e advantage of including population-specific sequences in imputation panels and exemplify the power g

150 Although unique sequences in plasma or liver were observed, in the major

151 arising from expanded polyglutamine (polyQ) sequences in the exon-1 region of mutant huntingtin play

152 hort tandem repeats (STRs) are hyper-mutable sequences in the human genome.

153 the query model (PSSM, HMM) and the subject sequences in the library.

154 arallel sequencing and confirmed with Sanger sequencing in the patient.

155 ependencies and utilizing ranked or weighted sequences increasingly available from high-throughput as

156 cotranscriptional SHAPE-Seq by developing a sequence-independent biotin-streptavidin (SAv) roadblock

157 ted with somatic variations, advances in DNA sequencing indicate that cell-specific variants affect a

158 rapid ethnicity annotation from whole exome sequencing individual's data, validated it on 1000 Genom

159 tical methods, particularly the use of exact sequences instead of clustered operational taxonomic uni

160 slational insertion of arbitrary polypeptide sequences into the Sec translocon.

161 ipulation of DNA hairpins with an engineered sequence is used to detect ligand binding as blocking ev

162 /or translation, while changes in the coding sequences lead to mRNAs encoding distinct proteins.

163 nt, and then given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by end

164 lly limited, because of biases due mostly to sequence length effects.

165 chimeric sequences, which are converted to a sequencing library for paired-end sequencing.

166 ramolecular binding to the Vms1 leucine-rich sequence (LRS).

167 Rapid advances in genome sequencing make it possible to identify multiple disease

168 n by the collective hydrogen bonding and the sequence-mandated topology of the molecules.

169 g software, glycan spectra are predominantly sequenced manually.

170 w this accurate and high-coverage repertoire-sequencing method can use as few as 1000 naive B cells.

171 depend on characteristics of the sample, the sequencing methodology and on the questions of interest.

172 Contemporary sequencing methods allow for portrayal of demographic in

173 accharides.Establishing generic carbohydrate sequencing methods is both a major scientific challenge

174 ication efficiency, which can be affected by sequence mismatches in primer/probe binding regions, RT-

175 ons of the Minimum Information about Any (x) Sequence (MIxS).

176 Two of the cis sequence motifs enriched in the PREs are cognate binding

177 The location and surrounding sequence motifs of a PAS appear to differentiate its reg

178 Creating a cDNA library for deep mRNA sequencing (mRNAseq) is generally done by random priming

179 We also show that reporters harboring stall sequences near the initiation codon, which cannot accomm

180 ing of plasma-derived EVs by next generation sequencing (NGS) from limited quantities of patient-deri

181 We compared our dataset to a library of nirS sequences obtained previously from the same samples by s

182 Thyroid cancer is common, yet the sequence of alterations that promote tumor formation are

183 the gene regulatory networks that drive the sequence of cell fate decisions during development.

184 -time sequencing technology to determine the sequence of complete JCPyV genomes in single reads.

185 The sequence of gene activation/expression and receptor edit

186 sis of gene expression to determine both the sequence of lineage choices made by multipotent cells an

187 tific rigor toward a well-planned, step-wise sequence of preclinical and clinical studies, to determi

188 Although the sequence of RAM is poorly conserved, the linear patterni

189 ular dynamics simulation studies defined the sequence of the NDSM as Psi-K-x-E/D-x1-x2-(x3/E/D)-(x4/E

190 s from vaccine and placebo recipients to the sequence of the vaccine itself, a technique called 'siev

191 By comparing the genetic sequence of viruses from vaccine and placebo recipients

192 nt acetylation patterns, but determining the sequences of paCOS and producing paCOS with patterns of

193 Whole-genome sequences of representative highly pathogenic avian infl

194 The portability and long DNA sequences of RTnS offer great potential for field-based

195 s were presented with repeating audio-visual sequences of syllables for immediate serial recall in a

196 enome variation map generated through genome sequencing of 117 diverse accessions.

197 High-throughput sequencing of 16SrRNA genes demonstrated that plants in

198 this issue, we carried out 60x whole-genome sequencing of 26 metastases from four patients with panc

199 ed and analyzed, enables fast and affordable sequencing of full human genomes.

200 High-throughput DNA sequencing of microbiota from a diverse collection of fe

201 We further performed whole-genome sequencing of nosocomial MDRPa strains to evaluate genot

202 Whole-genome sequencing of pathogens from host samples becomes more a

203 Using information from deep sequencing of patients with neurological or psychiatric

204 analysis, an unbiased approach based on RNA sequencing of resistant subclones, to discover the molec

205 Pyrosequencing genotyping and sequencing of the voltage gated sodium channel (VGSC) ge

206 a major mitochondrial DNA (mtDNA) survey and sequencing of two nuclear markers (AME and RAG-1) from P

207 is remarkable property is applied to de novo sequencing of underivatized oligosaccharides.Establishin

208 We performed whole exome sequencing on six out of nine members in a three-generat

209 dy [n = 28]) was analyzed by using bisulfite sequencing or Illumina 450K arrays.

210 nt genomic data from all currently available sequenced organisms.

211 res illustrate the flexibility of binding to sequences outside of-but adjacent to-the kinase domain o

212 encing (WES) has become primary strategy for sequencing patient samples and study their genomics aber

213 iNVICT has the capability to handle multiple sequencing platforms with different error properties; it

214 embles endogenous long terminal repeat (LTR) sequences, pointing to a select role of BRD4S-BRG1 compl

215 h unique oligonucleotide barcodes flanked by sequencing primer targets enables quantitative assessmen

216 e (placebo group) according to pre-generated sequences produced on the principle of randomly permuted

217 ating transcription, altering protein-coding sequences, producing noncoding RNAs, and even supporting

218 ravel this puzzle, we employed a poly(A) tag sequencing protocol and uncovered a different poly(A) pr

219 er, recent improvements on alternative pulse sequences provide attractive alternatives to 1D NOESY pr

220 The knowledge of the affected sequences provides novel information for a better charac

221 iptomes of individual cells, single-cell RNA sequencing provides unparalleled resolution to study cel

222 emonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detectio

223 efficient use of the template DNA as well as sequence reads, which are nearly all confined to the amp

224 e quantification relies entirely on counting sequencing reads, detailed studies about the method's ac

225 ry mutations to restore the SLs, but not the sequence, restored strong miR159-mediated silencing.

226 Unsupervised clustering of 16S rRNA gene sequences revealed three clusters (subtypes), one of whi

227 High-throughput sequencing revealed that a 22 nt miRNA with 3G ('22-3G')

228 s all secondary genomic analyses such as RNA sequencing (RNA-Seq), chromatin immunoprecipitation, and

229 (NIKS16) were compared using next-generation sequencing (RNA-Seq).

230 es, including exome sequencing, whole-genome sequencing, RNA-seq, ChIP-seq, targeted sequencing and s

231 differentially expressed (DE) genes from RNA sequencing (RNAseq) studies is among the most common ana

232 Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, mo

233 ethod that uses genotype array data from the sequenced samples, rather than public data such as HapMa

234 e novo, a set of high-fidelity contigs and a sequence scaffold, representing a mean 98% of the target

235 ction to herbicide resistance, transcriptome sequencing showed a high incidence of infection in the N

236 16S rRNA amplicon sequencing showed that the genus Arthrobacter comprised

237 g interacting protein (HHIP) and family with sequence similarity 13 member A (FAM13A) were shown to h

238 ad a common Zn(2+) bimetallo core but little sequence similarity and different auxiliary domains.

239 Our method calculates true sequence similarity between query sequences and database

240 Due to the sequence similarity of several genes on the megaplasmid,

241 Due to a lack of high throughput glycan sequencing software, glycan spectra are predominantly se

242 A multiparametric sequence-specific model for predicting peptide electroph

243 gonucleotides have unique, and in some cases sequence-specific molecular interactions with the surfac

244 interference has been one major approach for sequence-specific regulation of gene expression in eukar

245 hemistry is to explain the causes of protein sequence, structure, and function.

246 l within two domains, which are conserved in sequence/structure indicating their importance to the vi

247 The dependence of DHX36 on the 3'-extension sequence suggests that the extent of formation of genomi

248 With the rapid development of deep sequencing techniques in the recent years, enhancers hav

249 We used next-generation sequencing techniques to examine chromosomal rearrangeme

250 h the development of new high-throughput DNA sequencing technologies and decreasing costs, large gene

251 Advances in Next Generation Sequencing technologies have enabled the generation of m

252 Recent advances in long-read DNA sequencing technologies, specifically Nanopore sequencin

253 ed the capacity of single-molecule real-time sequencing technology to determine the sequence of compl

254 Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller

255 iments have identified 5'-flanking conserved sequences that control pancreatic and beta-cell type-spe

256 By contrast, heterochiral sequences that lack such persistence selectively attack

257 5 was physically associated with genomic PSS sequences that were also sufficient to mediate PGBD5-ind

258 Here we sequence the genomes of an Early and End Neolithic dog f

259 pproach to the study of a challenging set of sequences-the bacterial chemotaxis protein CheY, the N-t

260 ur representative regions in China that were sequenced to an average 18.2 x coverage.

261 available for comparison or when genomes are sequenced to low coverage.

262 le bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and all

263 A protocol for mapping amino-acid sequences to coarse-grained beads enables the direct sim

264 Specifically, we utilize 7,444 whole-genome sequences to examine the effect of variants on the targe

265 linum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding,

266 rized pi bonds occur within cascade reaction sequences to provide rapid access to a diverse array of

267 e false genotype rate than using whole-exome sequencing to assess more than 300 genes in all patients

268 udy, we test this hypothesis by applying RNA sequencing to CD4(+), CD8(+), and CD19(+) lymphocyte pop

269 ion, with high-throughput 18 S ribosomal DNA sequencing to elucidate the relationship between eukaryo

270 We used genomic sequencing to identify potentially pathogenic gene varia

271 We then performed RNA sequencing to investigate the effect of E2f3a overexpres

272 The application of single-cell genome sequencing to large cell populations has been hindered b

273 ne novel mouse reporters and single-cell RNA sequencing to reveal the heterogeneity in IL-4-induced I

274 are automatically estimated from TIRFM image sequences, to account for both the lateral diffusion of

275 Nosocomial clones, including epidemic sequence type 258 (ST258), have shown an affinity for ac

276 Genotype (multilocus sequence type) and fluoroquinolone susceptibility were d

277 tricornutum We observed 25 unique centromere sequences typically occurring once per chromosome, a fin

278 finch HVC, a cortical region that generates sequences underlying the temporal progression of the son

279 ful to date, due in part to the virus's high sequence variability leading to immune escape.

280 GI tract clones display extensive sharing of sequence variants among different portions of the tract

281 ome library from DIA data and to query known sequence variants.

282 ng by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighti

283 olar cycloaddition reaction/Cope elimination sequence was developed to access novel 1,4,6,7-tetrahydr

284 Whole-exome sequencing was performed to identify gene variants.

285 Targeted bisulfite sequencing was performed with a subset of placentas, cor

286 In this study, using Illumina sequencing we characterised the mucosa-associated microb

287 transcription and repair by next-generation sequencing, we identified locations of elongation comple

288 immunoprecipitation with sequencing and RNA sequencing, we identify a novel B-lymphoid program for t

289 es the exact integration site and breakpoint sequences were identified.

290 , in the majority of cases the most dominant sequences were shown to be identical in both compartment

291 Recently whole exome sequencing (WES) has become primary strategy for sequenc

292 tics of CM using next-generation whole-exome sequencing (WES).

293 hese outbreaks were analyzed by whole-genome sequencing (WGS) analysis.

294 oratories underwent culture and whole-genome sequencing (WGS), using WGS to identify toxigenic strain

295 resolved spectroscopic imaging (5D EP-JRESI) sequence, which is capable of obtaining two-dimensional

296 proximity ligation, forming RNA-DNA chimeric sequences, which are converted to a sequencing library f

297 for a variety of data types, including exome sequencing, whole-genome sequencing, RNA-seq, ChIP-seq,

298 We use a multi-echo sequence with independent components analysis, which has

299 igand-binding regions but have intracellular sequences with opposing signaling functions.

300 eted sequencing and single-cell whole-genome sequencing, with a minimal requirement for sequencing de