ライフサイエンスコーパス: sequence conservation

1 ponses not elicited by VACV despite complete sequence conservation.

2 stinct NP binding profiles despite extensive sequence conservation.

3 ities to bind and activate each other and on sequence conservation.

4 t function, when combined independently with sequence conservation.

5 n-single-copy genes, and they exhibit higher sequence conservation.

6 the use of relative entropy as a measure of sequence conservation.

7 ructure across species despite low levels of sequence conservation.

8 onarily conserved, despite a lack of overall sequence conservation.

9 may be placed on RNA structure more so than sequence conservation.

10 amework can identify ncRNAs that lack strong sequence conservation.

11 r of domains comprising a var gene and their sequence conservation.

12 conserved secondary structures, rather than sequence conservation.

13 f <1, which is indicative of high amino acid sequence conservation.

14 nserved genomic locations without detectable sequence conservation.

15 with functionality conserved despite limited sequence conservation.

16 r/enhancer region by examining cross-species sequence conservation.

17 f race and ethnicity, mutation location, and sequence conservation.

18 d genes, however, Nanog shows relatively low sequence conservation.

19 we reasoned that this would be reflected in sequence conservation.

20 cation from genomic sites that lack apparent sequence conservation.

21 oth protein sequence and corresponding crRNA sequence conservation.

22 vast fungal lineage, with a 300aa region of sequence conservation.

23 conformational flexibility, and evolutionary sequence conservation.

24 virus, but they do not share any substantial sequence conservation.

25 omplexes with DNA segments that share little sequence conservation.

26 and two internal helices with high codon and sequence conservation.

27 spatial orientation of residues that drives sequence conservation.

28 f the GRD that displays the highest level of sequence conservation.

29 nserved nested double-pseudoknot and minimal sequence conservation.

30 o regions of DNA that are AT-rich, with poor sequence conservation.

31 ound fatty acid desaturases based on overall sequence conservation.

32 for enhancer activity without assumptions on sequence conservation.

33 henotypes for TgRan, despite a high level of sequence conservation.

34 reactivity and influenced by T cell epitope sequence conservation.

35 s and functions in the absence of underlying sequence conservation.

36 h these N-terminal regions have only limited sequence conservation.

37 ed by combining correlation information with sequence conservation.

38 ent studies, would then be less dominated by sequence conservation.

39 rising homology to MMACHC despite their poor sequence conservation.

40 ha for 14 substrates with varying degrees of sequence conservation.

41 ytosolic domain is conserved despite limited sequence conservation.

42 NP proteins share a relatively high level of sequence conservation.

43 enerally exhibited more-stringent amino acid sequence conservation (2 substitutions identified) than

44 Analysis of the similarity in patterns of sequence conservation across a large set of eukaryotes c

45 Rep N terminus that displays high amino acid sequence conservation across all geminivirus genera.

46 within the hindlimb, and in their degree of sequence conservation across animals.

47 omeric structure in mature virions with high sequence conservation across different IAV subtypes, whi

48 ntal conditions can show similar patterns of sequence conservation across phylogenetic clades.

49 Sequence conservation across species and a higher abunda

50 ination consistent with the relative lack of sequence conservation across species within the CD86 cyt

51 d adult human retinal neurons based on their sequence conservation across species.

52 Examination of the sequence conservation across vertebrate and invertebrate

53 hese sites in multiple species indicate that sequence conservation alone is insufficient to identify

54 Sequence conservation also indicates highly conserved su

55 Absolute sequence conservation among 28 orthologs of residues at

56 Extensive sequence conservation among carrier proteins suggests th

57 Given the high degree of sequence conservation among GP of Ebola viruses, it woul

58 ls in heterosubtypic protection, despite low sequence conservation among known MHC-II restricted epit

59 There is strong sequence conservation among most of the put sequences, b

60 We show that lack of sequence conservation among orthologs of CG15460 and CG1

61 ibed region of APeg3 displays high levels of sequence conservation among placental mammals, but witho

62 Despite low primary sequence conservation among the archaeal Nop56/58 homolo

63 ies varied markedly despite a high degree of sequence conservation among the theta-defensins tested.

64 f pathogenic SFG rickettsiae and, due to its sequence conservation among these species, we predict th

65 ed human micro-exons exhibit a high level of sequence conservation, an indicator of functionality.

66 Sequence conservation analysis confirms the importance o

67 Structure-based sequence conservation analysis reveals a conserved hydro

68 These data combined with sequence conservation analysis suggest that Glu-292 is t

69 Sequence conservation analysis suggested that this regio

70 e several features of active miRNAs, such as sequence conservation and AGO1 association.

71 Sequence conservation and co-variation of base pairs are

72 dozen subfamilies, of which we profile both sequence conservation and composition.

73 imensional structure and the other utilizing sequence conservation and detecting all types of effects

74 zation of these 44 strains demonstrated both sequence conservation and diversity among simian PBVs an

75 tes an uninterrupted species-centric view of sequence conservation and enables the discovery of conse

76 ons about the relationship between noncoding sequence conservation and function and the evolution of

77 To test the relationship between sequence conservation and function, chromatin of LNCaP p

78 ic scope influences the relationship between sequence conservation and function.

79 aches are revealing the relationship between sequence conservation and functional use of cis-regulato

80 hese findings identify a direct link between sequence conservation and genomic function of regulatory

81 Sequence conservation and homology modeling suggested th

82 ancers is of greater importance than overall sequence conservation and is indicative of enhancer func

83 identified lincRNAs showed little signal for sequence conservation and mapped antisense to clusters o

84 The high degree of sequence conservation and mapped disease-associated muta

85 and two tolerant species, revealed extensive sequence conservation and microcolinearity, but grouping

86 Incorporating sequence conservation and network-level features, we hav

87 subject to skipping in S. pombe reveals high sequence conservation and perfect length conservation wi

88 (rtCD80/86) that shows the highest degree of sequence conservation and phylogenetic relationship with

89 cessary to truncate both constructs based on sequence conservation and predicted secondary structural

90 e was no overall strong relationship between sequence conservation and replicative capacity.

91 We used sequence conservation and ribosome binding site models t

92 mplete sequences under a model using primary sequence conservation and secondary structure informatio

93 Seed enhancers have increased sequence conservation and show preferential usage in dow

94 et genes they control, even though they lack sequence conservation and sometimes produce divergent pa

95 al implications for the relationship between sequence conservation and structural similarity.

96 However, some types of ncRNA lack strong sequence conservation and tend to be missed or mis-align

97 ulence is surprising given the high level of sequence conservation and the wide range of phenotypic t

98 , frequency, location, statistical strength, sequence conservation, and other properties offers a uni

99 Based on direct cloning, sequence conservation, and predicted secondary structure

100 Sequence conservation, animal models, and protein struct

101 proteins (NgTet1), which shares significant sequence conservation (approximately 14% identity or 39%

102 ecause of their repeat structure and lack of sequence conservation, are difficult to assemble and com

103 stinctive structural features that, based on sequence conservation, are likely to be characteristic o

104 Using phylogenetic sequence conservation as a guide, we have identified sev

105 These observations have led to the use of sequence conservation as a proxy for functional conserva

106 Synteny and sequence conservation, as well as deletions and insertio

107 ntation facilitates the determination of the sequence conservation at residue positions of interest,

108 Despite only moderate sequence conservation at the protein level, key features

109 However, sequence conservation based approaches have limited abil

110 Consistent with sequence conservation-based predictions, we show that SA

111 ived TFBS would be missed using the kinds of sequence conservation-based screens, such as phylogeneti

112 Remarkably, despite the high degree of sequence conservation between actn2 and actn3, the pheno

113 Additionally, there is no sequence conservation between BV- and HSV-encoded miRNAs

114 Here, we report that, despite extensive sequence conservation between Cdk4/cyclin D1 (hereafter

115 a single input sequence an enhanced view of sequence conservation between evolutionarily distant spe

116 Until recently, the high sequence conservation between homoeologous genes, togeth

117 Although there is no sequence conservation between human and zebrafish RPT, a

118 The sequence conservation between NgTet1 and mammalian Tet1,

119 Relatively high sequence conservation between plant CESAs allowed mappin

120 Differences in sequence conservation between plants and animals are lik

121 s not expected given the very high degree of sequence conservation between promoters.

122 distribution, tissue-specific regulation and sequence conservation between species, as well as to pre

123 human and 804 mouse miRNAs and showed strong sequence conservation between species.

124 st conformational flexibility show the least sequence conservation between TEG sulfotransferases.

125 In spite of the high degree of amino acid sequence conservation between TraM proteins, many of the

126 Due to their short lengths and low sequence conservation, BH3 motifs are not detected using

127 in architecture resembles, despite a lack of sequence conservation, both trigger factor, a ribosome-b

128 Most prediction methods exploit evolutionary sequence conservation but do not consider the interdepen

129 wide spectrum of protein features that lack sequence conservation but have similar amino acid charac

130 Mononegavirales phosphoproteins lack sequence conservation, but contain all large disordered

131 antification of evolutionary constraints via sequence conservation can be leveraged to annotate genom

132 However, despite genomic sequence conservation, changes in protein interactions c

133 (a PSSM or HMM) that captures the pattern of sequence conservation characteristic to a protein family

134 of 17 sequence hexamers exhibiting increased sequence conservation combined with evidence of position

135 location, gene expression, and evolutionary sequence conservation data to score putative gene neighb

136 ese RPEL(MAL):G-actin structures explain the sequence conservation defining the RPEL motif, including

137 it a broad range of domain architectures and sequence conservation, demonstrating that our method is

138 nt decoys that reproduce natural patterns of sequence conservation dictated by protein secondary stru

139 ultiple criteria including motif enrichment, sequence conservation, direct sequence pileup, nucleosom

140 se data provide a clear case where a lack of sequence conservation does not imply a lack of conservat

141 cal role in neuronal firing and their strong sequence conservation during evolution, it is not surpri

142 Despite extensive sequence conservation, each leukotoxin has unique proper

143 to detect from sequence data because of low sequence conservation, few known conserved catalytic sit

144 the limitations inherent in the use of deep sequence conservation for identifying functional sequenc

145 othesis in Salmonidae, which predicts higher sequence conservation for mORs than ora.

146 The graphic output shows the profile of sequence conservation for the query and the most similar

147 his result was unexpected due to the limited sequence conservation found in these noncoding regions.

148 Although these sites rarely showed sequence conservation from fish to mammals, surprisingly

149 differ in expression level, 3'UTR length and sequence conservation from unlocalized mRNAs.

150 tructure, and we found that, on the basis of sequence conservation, functionally important residues m

151 The observed associations between sequence conservation, gene architecture and repertoire

152 Integrating sequence conservation, gene expression data, gene functi

153 As predicted by polypeptide sequence conservation, Gon4l interacted and co-localized

154 contain this domain, but their generally low sequence conservation has made functional classification

155 Extreme noncoding-sequence conservation has successfully predicted enhance

156 A study of D1 protein sequence conservation highlighted features shared with m

157 tes has been suggested to lie behind loss of sequence conservation; however this has not been experim

158 Structure and sequence conservation imply that other paramyxovirus mat

159 or sRNA-induced growth inhibition along with sequence conservation in a related Caulobacter species l

160 surface loops on BirA, two of which exhibit sequence conservation in all biotin protein ligases and

161 tagenesis results versus those inferred from sequence conservation in an alignment of 156 class A bet

162 RtcB sequence conservation in archaea and in eukaryotes impli

163 established human p53 REs analyzed, 91% had sequence conservation in at least one nonprimate species

164 nding sites, coinciding with regions of high sequence conservation in beta-trefoil domains 1 and 3.

165 ation and helps explain the apparent lack of sequence conservation in chloroplast TPs.

166 ovide surprising evidence that, despite deep sequence conservation in DNA-binding domains, the functi

167 roperties were suggested by a high degree of sequence conservation in functionally important regions

168 Strong protein sequence conservation in mammalian lineages, particularl

169 This pattern corresponded to sequence conservation in nontuberculous mycobacteria (NT

170 correlation with serological reactivity and sequence conservation in other allergens.

171 from ORFeome annotation solely based on low sequence conservation in other species.

172 Overall, our results show that sequence conservation in Ras depends strongly on the bio

173 etween tissues was associated with increased sequence conservation in regulatory regions and with gen

174 ulohumeral muscular dystrophy, FSHD) despite sequence conservation in repeat units throughout the arr

175 However, there is sequence conservation in some of the ferlin family in re

176 These data, as well as sequence conservation in SpoIIID binding sites, were use

177 so have used RNA-Seq to assess the degree of sequence conservation in tandem array genes and found th

178 N-Ins docking, as well as the examination of sequence conservation in the active site suggests simila

179 In contrast to complete amino acid sequence conservation in the AR DNA and ligand binding d

180 all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions respons

181 l developmental gene, even in the absence of sequence conservation in the fish genome.

182 Judged from sequence conservation in the known GatCAB sequences, the

183 s the extent of loop nucleotide evolutionary sequence conservation in the Psi-modified P6.1 structure

184 WIP epitopes corresponded to regions of high sequence conservation in the verprolin family.

185 Next we investigate sequence conservation in the vicinity of editing sites b

186 psid proteins, and similar organizations and sequence conservation in their DNA packaging machinery a

187 alian-expressed lincRNAs show higher primary sequence conservation in their promoters and exons, incr

188 issues in basic transcription mechanisms and sequence conservation in these algae.

189 s, a finding that is supported by the marked sequence conservation in this protein within Plasmodium

190 ozygous cell lines, we demonstrate extensive sequence conservation in two common Asian MHC haplotypes

191 Sequence conservation indicates that these structural fe

192 Sequence conservation indicates that this domain is an i

193 Our results indicate that utilizing sequence conservation information in addition to correla

194 egrating both evolutionary coupling (EC) and sequence conservation information through an ultra-deep

195 T structures based on fold stability, pocket sequence conservation is coincident to native.

196 Sequence conservation is low in the interface and in the

197 ic behavior and demonstrates that amino acid sequence conservation is not required for the conservati

198 PEP mutase sequence conservation is strongly correlated with conser

199 We show that in this case sequence conservation is the dominating factor in SCA, a

200 We reveal that loss of sequence conservation is the result of relaxed selection

201 ins, MYC proteins carry five regions of high sequence conservation known as Myc boxes (Mb).

202 Based on sequence conservation, MAF, and location on a complete m

203 Sequence conservation mapping to the surface of the stru

204 Sequence conservation near the TMD of IFNAR1 is low, sug

205 ordinated regulation of these processes, and sequence conservation of a subset of known regulatory mo

206 The high sequence conservation of druggable pockets of closely re

207 We have analyzed the sequence conservation of enzymes within this family and

208 dies, as well as studies on the evolutionary sequence conservation of eRF1.

209 Spatial and sequence conservation of key residues indicates that thi

210 describe ConsWin, a heuristic that considers sequence conservation of neighboring amino acids, and de

211 s of cleavage are species-specific, with low sequence conservation of PmpD across the genus.

212 In this study, we examined whether sequence conservation of sites resembling GBSs is suffic

213 DNA search for clusters of short motifs and sequence conservation of the -2 kb promoter region of pa

214 The high sequence conservation of the 120 human SH2 domains poses

215 The unique structure and high sequence conservation of the 5' UTR render the IRES RNA

216 Compared to avi- and orthohepadnaviruses, sequence conservation of the core, polymerase, and surfa

217 curacy was found to correlate inversely with sequence conservation of the epitope.

218 Based on the high sequence conservation of the loop-helix domain, our arti

219 Sequence conservation of the MAGE-11 phosphorylation and

220 functional elements, explaining the minimal sequence conservation of the NTDs in the Ulp2/SENP6 fami

221 The high sequence conservation of the residues coordinated to Fe1

222 B-block histidine and for the near absolute sequence conservation of this residue.

223 ic analysis shows a correlation between high sequence conservation of TMDs of cytokine receptors and

224 ard approaches, we could previously identify sequence conservation only in some Paramyxovirinae.

225 Several rules based on sequence conservation or location, relative to a transcr

226 contain multiple SAMP repeats that lack high sequence conservation outside of the Axin-binding motif.

227 member by virtue of its cysteine spacing and sequence conservation over functionally important residu

228 Sequence conservation patterns confirm the importance of

229 the Cl(-) ion and through the observation of sequence conservation patterns in other Cl(-)-dependent

230 s chosen based on structural information and sequence conservation patterns observed among members of

231 e search algorithm was based on evolutionary sequence conservation patterns observed for yeast prion

232 eted a detailed quantitative analysis on the sequence conservation patterns of subdomains of KCNQ1 an

233 at intergenic lncRNA have substantially less sequence conservation patterns than protein-coding genes

234 known Tpx crystal structures and analyze the sequence-conservation patterns among nearly 300 Tpx sequ

235 rium of variants with known GWAS signals and sequence conservation (phastCons), the proposed method p

236 In addition to low sequence conservation, poor understanding of structural

237 lassifications of proteins, based on primary sequence conservation, protein size, and domain architec

238 an be readily produced as a result of strong sequence conservation, providing new insights into the d

239 Conserved CRE function is associated with sequence conservation, proximity to coding genes, cell-t

240 r with their lack of fixed structure and low sequence conservation raise a question about the impact

241 equences are characterized by high levels of sequence conservation, ranging from 66% to 100% similari

242 sperm, involving several processes including sequence conservation, rapid turnover, stochastic losses

243 ses of these genomes demonstrated remarkable sequence conservation, regardless of geographic origin,

244 study was designed to examine in detail CTT sequence conservation relative to gp120 and the gp41 ect

245 About half of the proteins display sequence conservation relative to other Diptera, and low

246 Meanwhile sequence conservation remains by far the most influentia

247 is of position, frequency of occurrence, and sequence conservation revealed significant enrichment an

248 regulatory function in the absence of overt sequence conservation, revealing an entire class of func

249 Analysis of sequence conservation showed that nsSNP at highly conser

250 and by >or=50% over methods that make use of sequence conservation signal only.

251 in fidelity regulation and that, despite low sequence conservation, some determinants of RdRp nucleot

252 By comparison of structure and sequence conservation, some of the FBG domains in Drosop

253 or binding Gbetagamma but not Galphaq, Using sequence conservation, structural analyses, and mutagene

254 Molecular dynamics simulations and primary sequence conservation suggest that the sorting signal-st

255 A IRES also lack extensive RNA structures or sequence conservation, suggesting that this viral IRES a

256 teractions are oppositely charged, and their sequence conservation suggests that IHM is present acros

257 This sequence conservation suggests that the mammalian enzyme

258 Sequence conservation suggests that the principles of PA

259 ignificantly higher mutation rates and lower sequence conservation than disease-susceptible proteins

260 in proteins contain a central region of high sequence conservation that is required for catalytic act

261 tuated with small segments of order and high sequence conservation that serve as substrate-recognitio

262 We find that despite low sequence conservation, the basic Ig fold of modern antib

263 Despite low sequence conservation, the Hp53 and Dmp53 proteins had a

264 ignored and distinguished by lack of primary sequence conservation, the linker is presumed to be intr

265 Despite low sequence conservation, the overall structure of the GRD

266 A high degree of sequence conservation, the presence of unusual tRNAs, an

267 Despite the lack of appreciable sequence conservation, the structure and beta-eliminatio

268 Despite sequence conservation, there are significant structural

269 Although Gcsfa and Gcsfb share low sequence conservation, they share significant similarity

270 n different Drosophila species using overall sequence conservation, this approach has not proven suff

271 Here, we have integrated multispecies sequence conservation, tissue-specific chromatin, in vit

272 sed the ER-binding sites in combination with sequence conservation to identify the statistical enrich

273 ceptor (beta(2)AR), which was predicted from sequence conservation to lie at a position equivalent to

274 ce analysis revealed a site of GII norovirus sequence conservation to reside under the critical alpha

275 We relate the RecA alignment sequence conservation to the following three topics: the

276 able chemical modification patterns, natural sequence conservation/variations in PSTVd isolates and r

277 onserved between RFHVMn and KSHV, and strong sequence conservation was noted in specific promoters an

278 anscriptionally regulated by WT1, regulatory sequence conservation was observed and TF binding in viv

279 Based on domain length and sequence conservation, we identified seven major MCP cla

280 Based on sequence conservation, we propose that Apc7 forms a homo

281 rected mutagenesis, charge distribution, and sequence conservation, we propose that the HhH domain of

282 For pallilysin, lower levels of sequence conservation were observed between this protein

283 hat we used for identifying motifs with high sequence conservation will be increasingly valuable for

284 superfamily does not share any recognizable sequence conservation with other proteins.

285 MCC has strong sequence conservation with propionyl-CoA carboxylase (PC

286 aminergic neurons, although it did not share sequence conservation with regulatory regions of otpa or

287 tone H1.0, whose globular domain shares high sequence conservation with the corresponding globular do

288 pendent inactivation, and exhibits extensive sequence conservation with the corresponding region of t

289 Correlating sequence conservation with the effects of mutations in E

290 n the 40S-binding domain display significant sequence conservation with the HCV IRES.

291 yeast PRELID1 homolog, Ups2p, which contains sequence conservation with the LEA domain of human PRELI

292 e same domain organization and shares strong sequence conservation with the related biotin-dependent

293 mployed a strategy that combines gnathostome sequence conservation with transgenic mouse and zebrafis

294 CNEs exhibit unexplained extreme levels of sequence conservation, with many acting as developmental

295 Analysis of sequence conservation within family GH130, mapped on a t

296 eae species, revealed a high level of global sequence conservation within the family.

297 e characterized to date solely by their high sequence conservation within the GATA DNA-binding domain

298 Sequence conservation within these regions is taken as e

299 Despite relatively little sequence conservation within this domain, ZLD orthologs

300 nstituent proteins exhibiting relatively low sequence conservation; yet the NPC as a whole retains it