ライフサイエンスコーパス: sequence diversity

1 and for quantitating other viruses with high sequence diversity.

2 merous host ligands that exhibit significant sequence diversity.

3 membrane domain, their small size, and their sequence diversity.

4 methods to make accurate predictions of the sequence diversity.

5 alysis of mammalian tRNAs due to their large sequence diversity.

6 veloping customizable DNA standards of known sequence diversity.

7 ellular immunologic coverage of global HIV-1 sequence diversity.

8 MHC molecules, CD1 proteins exhibit limited sequence diversity.

9 cal function that depends on MSA lengths and sequence diversity.

10 hat is strongly influenced by the underlying sequence diversity.

11 avoidance are the ones that display the most sequence diversity.

12 wed by next-generation sequencing, to reveal sequence diversity.

13 dies require the measurement of nucleic acid sequence diversity.

14 specially selected from CATH v.2.4 to ensure sequence diversity.

15 adoceran crustacean Daphnia and examined DNA sequence diversity.

16 lt to accommodate within the remaining 1% of sequence diversity.

17 RNA-dependent RNA polymerases exhibit great sequence diversity.

18 the patterns and underlying causes of human sequence diversity.

19 s for the functional significance of keratin sequence diversity.

20 ce of genome damage and a means for creating sequence diversity.

21 dulator, albeit less frequently than genomic sequence diversity.

22 nsight into epitranscriptional regulation of sequence diversity.

23 isease and correlate these with evolutionary sequence diversity.

24 oint mutations outside these regions of high sequence diversity.

25 hape and bonding potential, despite dramatic sequence diversity.

26 HIV-1 pathogenesis but is hampered by viral sequence diversity.

27 the TPS domains of all TpsAs, despite their sequence diversity.

28 imens in this region, revealing whole-genome sequence diversity.

29 RNA and Cas9 in bacteria produced remarkable sequence diversity.

30 ecretion by human plasma cells regardless of sequence diversity.

31 geographic location in order to reveal their sequence diversity.

32 n protein function while generating enormous sequence diversity.

33 Surprisingly, however, the greatest sequence diversity (79% identity) was in the less-studie

34 Sequence diversity accumulated subsequently, with the 5'

35 ized to seven variable (V) regions, and tprK sequence diversity accumulates with serial passage in na

36 ithin Stevor and Pfmc-2TM proteins possesses sequence diversity across isolate boundaries.

37 f which each possesses a region of extensive sequence diversity across paralogs and between isolates

38 rolling gene activation exhibit considerable sequence diversity across the eukaryotic domain.

39 We hypothesize that sequence diversity affects the emergence of viable recom

40 Therefore, the existence of sequence diversity among 14-3-3s within a single organis

41 An analysis of whole genome sequence diversity among 153 A:cc5 isolates identified e

42 Sequence diversity among 2A(pro) proteases from differen

43 Despite the wide range of sequence diversity among chemokines, their tertiary stru

44 In conclusion, much greater sequence diversity among EBV isolates derived from NPC b

45 The extent of sequence diversity among functional terminators and the

46 Whether sequence diversity among isodecoder tRNA genes reflects

47 es were chosen because they exhibit very low sequence diversity among maize inbreds and have sequence

48 r potential function (but also with very low sequence diversity among maize inbreds) provided some we

49 Despite the immense sequence diversity among OSS cell piRNAs, our analysis i

50 The nuclear DNA sequence diversity among the three Denisovans is compara

51 The structural and sequence diversity among these domains may be important

52 The sequence diversity among these wild mouse isolates helps

53 0 copies RNA/mL) and in the context of viral sequence diversity analysis in the plasma of viremic con

54 Our results give an insight into sequence diversity and categories of PQ sequences which

55 o these expression patterns, exhibiting both sequence diversity and cell type specificity.

56 y expands the boundary of known Cryptomycota sequence diversity and characterizes the phylogenetic di

57 teriocins, this is because of high levels of sequence diversity and difficulties in distinguishing th

58 Here, we report the estimates of DNA sequence diversity and divergence in a newly isolated nu

59 ine performance against the backdrop of DENV sequence diversity and evolution.

60 als, the tapasin gene appears to have little sequence diversity and few alleles and is located distal

61 a four-stranded beta-sheet domain, in which sequence diversity and glycosylation are largely segrega

62 Clone members showed high intraclonal sequence diversity and high intraclonal versatility in I

63 current vaccines are not easily adaptable to sequence diversity and immune evasion.

64 veal heterogeneity in patterns of nucleotide sequence diversity and levels of linkage disequilibrium

65 We analyzed patterns of sequence diversity and linkage disequilibrium in nine lo

66 and close-to-capping units tend to have more sequence diversity and more conformational variation, it

67 nd are themselves protected by extraordinary sequence diversity and N-linked glycosylation.

68 Sequence diversity and pairwise linkage disequilibrium (

69 genes have been identified, with somatic IgH sequence diversity and peripheral H chain receptor editi

70 virus content, (ii) infectious titer, (iii) sequence diversity and polymorphism frequency by single-

71 The high levels of sequence diversity and rapid rates of evolution of HIV-1

72 Extraordinary viral sequence diversity and rapid viral genetic evolution are

73 sion in adult LMAN induced increases in song sequence diversity and slower song tempo more similar to

74 optimized and driven to apparent completion, sequence diversity and species abundance in the input sa

75 eriophage parABS cassettes span considerable sequence diversity and specificity, providing a suite of

76 ke vaccine design problematic, including the sequence diversity and structural variability of the sur

77 However, due to sequence diversity and the dynamics of influenza virus e

78 HIV sequence diversity and the propensity of eliciting immun

79 shed light on the relationships between CDR3 sequence diversity and the structural stability of the V

80 One strategy to address such sequence diversity and to improve the magnitude of neutr

81 The sequence diversity and variation in element patterns led

82 d from individuals with greater intrapatient sequence diversity and were associated with changes in p

83 ribution among bacterial species, amino acid sequence diversity, and features indicative of horizonta

84 These genes were analyzed for functional and sequence diversity, and good indications that natural al

85 herently applicable to antigens that exhibit sequence diversity, and its accuracy was found to correl

86 The designs vary in parent scaffold, sequence diversity, and orientation of docked ligand, su

87 distances (p-distances) based on nucleotide sequence diversity, and plotted the median p-distance fo

88 ising from their remarkable stability, broad sequence diversity, and range of bioactivities.

89 positive selection for increased amino acid sequence diversity, and surprisingly, so does Cmicro2.

90 his diversity can be modulated by tuning the sequence diversity, and that this method compares favora

91 netic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8(+) T cel

92 nd structural properties despite substantial sequence diversity, apparently indicating a delicate bal

93 Patterns of nucleotide sequence diversity are analyzed for three duplicate alco

94 the efficiency of natural selection and DNA sequence diversity are expected to depend upon the effec

95 Rapid evolution and high intrahost sequence diversity are hallmarks of human and simian imm

96 nt of mechanistic variation as a function of sequence diversity are largely unknown.

97 Sequence diversity around these residues modulates TCR l

98 14 inbred lines and chose 35 genes with zero sequence diversity as potential targets of selection.

99 es indicated that HSV-1 genomes exhibit more sequence diversity, as well as geographical clustering.

100 NS5B sequence diversity assessed by deep sequencing can diffe

101 sminogen activation and contains a region of sequence diversity associated with infection and disease

102 To assess their variability, we examined sequence diversity at 11 H. ducreyi loci, including viru

103 The species also exhibit sequence diversity at a number of surface protein-encodi

104 ns were highly positional and independent of sequence diversity at other positions.

105 ne annotation and allow in-depth analysis of sequence diversity at the 5' regions of mRNA transcripts

106 At the same time the sequence diversity at the common footprints allows for b

107 he tooth, we investigated the association of sequence diversity at the SAG-binding gene of S. mutans,

108 I analyzed sequence diversity at three chitinases, a well-studied c

109 The sequence diversity between genomes within a cluster vari

110 have previously published data demonstrating sequence diversity between hosts.

111 Despite high sequence diversity between the different genera, most pa

112 tural groups with a high level of amino acid sequence diversity between them.

113 Sequence diversity between VSGs facilitates escape of a

114 to develop a more complete understanding of sequence diversity both within and between haplogroups.

115 First, libraries with the same sequence diversity but built around different "framework

116 functional rationale for this long-observed sequence diversity by demonstrating that differences amo

117 with significantly increased coverage of HIV sequence diversity by including alternative amino acids

118 We conclude that naturally occurring sequence diversity can be used to identify positions tha

119 agenic recombination rapidly creates protein sequence diversity compared with random mutation, but li

120 ed to compile a comprehensive database of P8 sequence diversity compatible with assembly into the wil

121 ng the distal breakpoint exhibit patterns of sequence diversity consistent with neutral evolution, ye

122 While much is understood about how sequence diversity contributes to this remarkable feat o

123 e mitochondrial, X chromosome, and autosomal sequence diversity data are available for our closest re

124 Examination of sequence diversity demonstrated a significant positive a

125 Patterns of sequence diversity differed between naive and vaccinated

126 idated thermostable CBH II enzymes have high sequence diversity, differing from their closest natural

127 general method for assessing human antibody sequence diversity displayed on phage using massively pa

128 troduce a quantitative measure of amino acid sequence diversity (DIVAA) that has a simple, intuitive

129 We have estimated the sequence diversity due to substitutions and insertions/d

130 sequences revealed nonlinear accumulation of sequence diversity during the course of infection.

131 ct (1) homogeneity in patterns of nucleotide sequence diversity, especially between closely linked lo

132 roughout a protein family to explore natural sequence diversity for desirable biocatalytic transforma

133 le novel mutagenesis strategies to introduce sequence diversity for engineering and discovery.

134 Sequence diversity for env within a host rarely exceeded

135 ophila melanogaster, the ratio of silent DNA sequence diversity for X-linked loci to that for autosom

136 s circularly permuted proteins with distinct sequence diversity from existing methods.

137 The ability to study sequence diversity from world populations has allowed ex

138 dscape irrespective of transcript length and sequence diversity, Grad-seq promises to define function

139 etween various physical characteristics: DNA sequence diversity, hair-wavelength-specific reflectance

140 s) is a challenging task because of the high sequence diversity, heavy glycosylation, and inherent me

141 The pattern of sequence diversity here does not support a model of stro

142 from the United Kingdom, revealed amino acid sequence diversity higher than that of any protein codin

143 To fully capture this sequence diversity, however, libraries containing millio

144 cular recognition, little is known about how sequence diversity impacts antibody dynamics, which is a

145 phages and their phylogeny, distribution and sequence diversity imply lateral transfers between bacte

146 Analysis of sequence diversity in 10.9 kb covering the complete codi

147 By studying SIV sequence diversity in 44 MHC-typed SIV-infected pigtail

148 We describe patterns of DNA sequence diversity in a newly identified sex-linked gene

149 The most commonly reported estimates of DNA sequence diversity in animal populations are haplotype d

150 play, libraries can be designed that present sequence diversity in architecturally distinct, biologic

151 struction suggested relatively low bacterial sequence diversity in both ice samples, metagenomic anal

152 solates were due to introgression in mapA or sequence diversity in ceuE The results of this study ill

153 crease in human immunodeficiency virus (HIV) sequence diversity in drug resistance surveillance speci

154 describe contrasting levels and patterns of sequence diversity in genes encoding three MSP-1-associa

155 ealogies, but the extremely low Y chromosome sequence diversity in horses has prevented the reconstru

156 rison of these sequences revealed amino acid sequence diversity in MAP1 (89% identity), which is know

157 model enables an assessment of the expected sequence diversity in new HIV-1 infections originating f

158 The role of BES sequence diversity in parasite virulence can best be und

159 The findings suggest that sequence diversity in Pfhrp2 and Pfhrp3 genes in Indian

160 ltiple different ancestral origins increases sequence diversity in plasma for reasonable fitness land

161 puleucel-T treatment resulted in greater TCR sequence diversity in resected prostate tissue in sipule

162 classification and fine characterization of sequence diversity in the 6 CDRs are presented.

163 tudy, e.g. 25% of the core genes with higher sequence diversity in the Campylobacter jejuni and Neiss

164 ese genes showed very low degrees of allelic sequence diversity in the coding regions, introns, and f

165 Tracing sequence diversity in the gene encoding domain 1 of the

166 tigated the evolution of MHC class II E beta sequence diversity in the genus Peromyscus.

167 Despite the sequence diversity in the immunodominant regions of both

168 We also compared mitochondrial sequence diversity in the Malagasy with a manually curat

169 uced vlhA allele switching indirectly drives sequence diversity in the passenger sialidase gene of M.

170 However, functional sequence diversity in the RBS has not been fully explore

171 There was no DNA sequence diversity in the sequenced portions of the seve

172 them vulnerable to false negatives caused by sequence diversity in the template.

173 f gastroenteritis is hampered by the lack of sequence diversity in those regions of the genome chosen

174 (d)/AH1-specific T cells and an expansion of sequence diversity in treated mice.

175 r characterization of profiles of nucleotide sequence diversity in viral populations.

176 represent a novel mechanism contributing to sequence diversity independently of DNA mutations.

177 g a toggle-peptide approach, which takes HIV sequence diversity into account, and a novel, boosted cy

178 troelements (DGRs) introduce vast amounts of sequence diversity into target genes.

179 The sequence diversity introduced through shuffling efficien

180 HIV-1 sequence diversity is a major barrier limiting the capab

181 HIV-1 sequence diversity is affected by selection pressures ar

182 ance and an overwhelming amount of small RNA sequence diversity is contributed by distinct classes of

183 It is thus of interest to test whether Aly8 sequence diversity is elevated due to close linkage to t

184 B cell receptor sequence diversity is generated by a random recombinatio

185 s that bind the desired class of ligands and sequence diversity is introduced at residues typically i

186 Sequence diversity is lowest in a 2-kb portion of intron

187 This functional sequence diversity is made possible by pervasive epistas

188 We show here that mitochondrial DNA sequence diversity is reduced in non-ratite birds compar

189 Together, the data suggest that ITAM sequence diversity is required for optimal TCR signal tr

190 ades of independent passage, only minor tprK sequence diversity is seen among the Nichols strains fro

191 osely related prokaryotic groups reveal that sequence diversity is typically organized into distinct

192 ith complementarity-determining region (CDR) sequence diversity, length variability, and main-chain c

193 the footprints of SA polymorphisms, based on sequence diversity levels in S. latifolia PAR genes iden

194 othesized that viral characteristics such as sequence diversity may play a role in driving HIV-associ

195 improve the accuracy and reproducibility of sequence diversity measurements.

196 ate receptors, ligands, and catalysts having sequence diversities nearer to that displayed by protein

197 The sequence diversity necessary for WC1 genes to function a

198 ration dynamics can help explain the low DNA sequence diversity observed among isolates of M. tubercu

199 persistent problem, due to the high level of sequence diversity observed in human variable domains an

200 orders of magnitude higher than the level of sequence diversity observed in the human population, and

201 ies S. dioica as an explanation for the high sequence diversity observed.

202 We compared sequence diversity of 30 candidate selected and 15 refer

203 The sequence diversity of a sample is proportional to the pr

204 The sequence diversity of all CDRs was determined from 143 r

205 This method measures the sequence diversity of all clades, classifies genomes fro

206 The sequence diversity of an RNA virus population contribute

207 we review recent evidence that the enormous sequence diversity of both passenger and beta domains be

208 Sequence diversity of diploid and tetraploid Stuberosum

209 The extensive intergenotypic sequence diversity of envelope proteins E1 and E2 of HCV

210 Allelic sequence diversity of G221 and 3.16, as well as of 3.2,

211 Testing this hypothesis, we compared the TCR sequence diversity of gamma(9)delta(2) T cells expanded

212 ned influence of multiple forces shaping the sequence diversity of HCV and other highly variable path

213 The sequence diversity of HIV-1 presents a challenge for the

214 However, the sequence diversity of HRV genotypes poses challenges for

215 The sequence diversity of human immunodeficiency virus type

216 The sequence diversity of human immunodeficiency virus type

217 proaches for accommodating the extraordinary sequence diversity of immune receptors and widely used m

218 a method, called AmpliCot, that measures the sequence diversity of PCR products on the basis of DNA h

219 Methods to measure the sequence diversity of polymerase chain reaction (PCR)-am

220 olecular function often use the evolutionary sequence diversity of protein homologs to rationally gui

221 A binding preferences has been driven by the sequence diversity of short segments of relevant pathoge

222 Here we report that the sequence diversity of the amino-terminal end of the egg

223 The mean levels of sequence diversity of the contiguous genes in this regio

224 Sequence diversity of the enhancer is significantly high

225 First, we report the size and sequence diversity of the families and subfamilies, char

226 ntibody (bnAb) response against the enormous sequence diversity of the HIV-1 envelope glycoprotein (E

227 tator Superfamily (MFS) because of the broad sequence diversity of the members.

228 action with the exit tunnel and maximize the sequence diversity of the proteome, although allowing so

229 TCR V segment utilization, CDR3 length, and sequence diversity of the response to natural HSV-1 infe

230 cleotides either overall or according to the sequence diversity of the resulting chimeras.

231 r immune response to HIV despite significant sequence diversity of the strains of the Env immunogens

232 The size and sequence diversity of these structure-based binding land

233 from women in Malawi and Benin, we assessed sequence diversity of VAR2CSA's ID1-DBL2x region, contai

234 rimary NPC biopsy specimens and revealed the sequence diversity on a whole-genome level among these E

235 ls of viral isolates to assess the impact of sequence diversity on detection as well as quantificatio

236 y understand the role of viral evolution and sequence diversity on KSHV gene functions and pathogenes

237 We detect changes in CRISPR spacer sequence diversity over time that may be attributable to

238 Engineered antibody paratopes with limited sequence diversity permit assessment of the roles played

239 Here, we show that the level of sequence diversity present among these strains is one to

240 lanaceae and their extraordinary spectrum of sequence diversity present an ideal case for understandi

241 at modern cultivars have retained 72% of the sequence diversity present in the Asian landraces but lo

242 most impact was domestication; when the low sequence diversity present in the wild species was halve

243 he MgpB adhesin and the accumulation of mgpB sequence diversity previously observed in persistent hum

244 t share a basic gene structure but show high sequence diversity, primarily due to the mosaic appearan

245 esviruses through genome-wide comparisons of sequence diversity, recombination, allele frequency, and

246 Among healthy donors, circulating TCR sequence diversity remained unchanged over the same time

247 Alignment of LMW SLPs, which exhibit high sequence diversity, reveals a core of conserved residues

248 imilar conserved syntenic gene content, gene sequence diversity signatures, and phylogenetic networks

249 r peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the

250 les over others in hybrid mice and increases sequence diversity specifically at hot spots that become

251 bination events as well as to detect complex sequence diversity, such as that seen in variable multig

252 LLV displays up to 25% interclade sequence diversity, suggesting that it has been in the l

253 st 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably li

254 Molecular dating based on sequence diversity suggests an early age, of 175 Mya, fo

255 Analysis of the underlying sequence diversity suggests the presence of at least two

256 ults uncover remarkable depths in retroviral sequence diversity, supported within a phylogenetic cont

257 RBS can accommodate a much greater range of sequence diversity than previously thought, which has si

258 b(5) cytochromes exhibit greater amino acid sequence diversity than their type A (microsomal) counte

259 To illustrate the varying degree of sequence diversity that exists within cytoskeletal gene

260 ur crystal structure rationalize the binding sequence diversity that was uncovered during ChIP-chip a

261 Despite such sequence diversity, these signals are all recognized and

262 nditions for linkage to influence nucleotide sequence diversity through the action of selective sweep

263 sms (T-RFLP) due to 16S ribosomal DNA (rDNA) sequence diversity to rapidly identify bacterial pathoge

264 downstream expression, that have sufficient sequence diversity to reduce homologous recombination wh

265 r simulations consistent with observed human sequence diversity to show that segments of 500-1,000 ba

266 ary piRNAs from cleaved transposon RNAs adds sequence diversity to the piRNA pool, allowing adaptatio

267 Although the contribution of sequence diversity to this molecular recognition has bee

268 cks of SIVmac251 or SIVsmE660 that exhibited sequence diversity typical of early-chronic HIV-1 infect

269 With their sequence diversity, ultra-stable core structural motif,

270 te that the modular genetic architecture and sequence diversity underlying var-mediated host-parasite

271 Most variable regions show increased sequence diversity upon passage.

272 Patterns of DNA sequence diversity vary widely among genes encoding prot

273 puleucel-T treatment reduced circulating TCR sequence diversity versus baseline as measured by the Sh

274 Higher sequence diversity was correlated with areas with increa

275 olecular typing method based on the 16S rRNA sequence diversity was developed for Haemophilus influen

276 Sequence diversity was high with a mean single nucleotid

277 The sequence diversity was introduced into 3-23 (V(H)) only,

278 Moreover, a high level of sequence diversity was observed in the V(H) CDR3 domains

279 gether by phylogenetic analysis, significant sequence diversity was observed in the VP1 gene (66.9%-1

280 Nucleotide sequence diversity was uniformly low and did not change

281 ol of viral replication and the evolution of sequence diversity, we measured EBV gp350-specific antib

282 ve sequence analyses is a direct function of sequence diversity, we propose that the information cont

283 Genotypes and sequence diversity were evaluated.

284 ma has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing

285 e's activation rate is positively associated sequence diversity, which could offer important new insi

286 We conclude that PolA1 promotes genome sequence diversity while playing an essential role in ox

287 The ability to effectively cull sequence diversity while still generating the functional

288 have struggled to reconcile their limitless sequence diversity with their binding to relatively few

289 CR sequences organize into networks based on sequence diversity, with differences in network connecti

290 NA viruses, Wheat streak mosaic virus (WSMV) sequence diversity within and among infected plants is l

291 By examining the patterns of sequence diversity within field isolates, we have identi

292 Overall, we found less glycoprotein sequence diversity within HSV-2 than within the HSV-1 st

293 t therefore exist to differentially generate sequence diversity within select genes, as well as withi

294 en recombination rates and intron nucleotide sequence diversity within species, but no relationship b

295 To define the mechanistic implications of sequence diversity within the ETS family, we characteriz

296 This multiplicity of function arises through sequence diversity within the HS chain.

297 DNA sequence diversity within the human genome may be more g

298 of events that may have led to the enormous sequence diversity within the MFS.

299 le-profile comparison made by COMPASS on the sequence diversity within these alignments.

300 mechanisms responsible for the generation of sequence diversity within these gene families, a charact