ライフサイエンスコーパス: sequence motif

1 ylation and explain why NTMT1 prefers an XPK sequence motif.

2 its specificity for its cognate 5-base-pair sequence motif.

3 d specific peptide substrates with a defined sequence motif.

4 ns are very diverse and they share no common sequence motif.

5 two consecutive repeats of a conserved octad sequence motif.

6 without requiring a cholesterol recognition sequence motif.

7 T sequencing and each recognizes a novel DNA sequence motif.

8 rectly with an evolutionarily conserved Spir sequence motif.

9 teract through the N-terminal small-X3-small sequence motif.

10 but MldC lacks obvious conserved domains or sequence motifs.

11 a Pro at position 2, together with adjacent sequence motifs.

12 when the ribosome encounters specific short sequence motifs.

13 ro) residue and the 5-residue-long adjacent sequence motifs.

14 stem (ES) cells with over 1000 mammalian TF sequence motifs.

15 RNA folding motifs rather than the conserved sequence motifs.

16 in binding, chromatin modifications, and DNA sequence motifs.

17 have a preference for binding phosphorylated sequence motifs.

18 ypic DNA containing short and genus-specific sequence motifs.

19 , which showed significant enrichment of two sequence motifs.

20 specifically to two completely distinct DNA sequence motifs.

21 n template performance is linked to specific sequence motifs.

22 of primary isolates in vivo rely on the same sequence motifs.

23 bodies that recognize specific substrates or sequence motifs.

24 capable of digesting genomic DNA at defined sequence motifs.

25 er or promoters containing ISRE or NF-kappaB sequence motifs.

26 scription factors (TFs) bind to specific DNA sequence motifs.

27 ads and reads matching a large dictionary of sequence motifs.

28 n of multiple sequence alignments (MSAs) and sequence motifs.

29 f gene transcription by binding to short DNA sequence motifs.

30 tructures of the 5'UTR, including particular sequence motifs.

31 of trans-acting factors to cis-localized DNA sequence motifs.

32 marks, transcription factor binding, and DNA sequence motifs.

33 al reactivity better than Bw4/Bw6 amino acid sequence motifs.

34 peptides we created that included 3 repeated sequence motifs.

35 class I alleles, corresponding to amino acid sequence motif 77 to 83, produced clustering of HLA mole

36 at least two compartments that differ in TCR sequence motifs, affinity, and coreceptor expression.

37 data mining based on the search for specific sequence motifs allowed the identification of two genes

38 lowing us to predict binders from a specific sequence motif alone.

39 Sequence motif analysis identified 8-bp motifs somewhat

40 Sequence motif analysis revealed the consensus for a 9-m

41 ural-network training and used to smooth the sequence motif and accommodate the physicochemical packi

42 ent study, we investigated the roles of this sequence motif and glycosylation of the E protein in the

43 the AP2 domain of AP2IX-9 binds a CAGTGT DNA sequence motif and is capable of binding cis-regulatory

44 otein that binds to an AT-rich conserved DNA sequence motif and regulates both the shape and the gene

45 e Insv BEN domain binds specifically to this sequence motif and that Insv directly regulates transcri

46 is domain contains a conserved "P[F/P]AAAPP" sequence motif and the well-described amino acid 627, wh

47 Analysis of sequence motifs and 6-mer enrichment patterns show that

48 that is formed by conserved DEAD-box protein sequence motifs and accommodates A-form but not B-form d

49 s1 and Ets2 bind to apparently identical DNA sequence motifs and are thought to regulate overlapping

50 Our analyses show that static sequence motifs and dynamic phosphoproteomics data are c

51 ng amino acid proline, they contain repeated sequence motifs and extensive posttranslational modifica

52 s in the training dataset that share similar sequence motifs and extract effective predictive feature

53 ched over 3' untranslated regions at defined sequence motifs and marks unstable transcripts, includin

54 ation, functional genomics, chromatin state, sequence motifs and molecular quantitative trait loci al

55 Here, we quantitatively define UbiB-specific sequence motifs and reveal their positions within the cr

56 remodeling complex collaborates with two DNA sequence motifs and sequence-specific general regulatory

57 Overall, our results suggest a joint role of sequence motifs and specific chromatin states beyond mer

58 acterized by conserved C-terminal amino acid sequence motifs and their cognate receptors were examine

59 e also uncover a collection of protein-bound sequence motifs, and identify their structural contexts,

60 o two-fold symmetric fold, several canonical sequence motifs, and similar splicing mechanisms.

61 Thus, diverse sequence motifs are capable of forming amyloidal signali

62 The problematic sequence motifs are confined to the nascent peptide resi

63 nzees, and there is little evidence that any sequence motifs are enriched in hotspots.

64 These sequence motifs are expected to be overrepresented in nu

65 s applied to each cluster to determine which sequence motifs are overrepresented in each geometry.

66 Whereas these sequence motifs are quite accurate descriptions of DNA b

67 Sequence motifs are short, recurring patterns in DNA tha

68 We used a DOPA-containing sequence motif as the starting point for generation of a

69 We identify sequence motifs associated with carbon source-specific T

70 tural properties are shown to correlate with sequence motifs associated with replication origins and

71 es and characterization of known and de novo sequence motifs associated with variation in chromatin a

72 ng either the Bw4 or Bw6 epitope (defined by sequence motifs at positions 77 to 83) were generated us

73 d we identified significant enrichment in G4 sequence motifs at the transcription start site and 5' e

74 itutions in a region of the highly conserved sequence motif B in the fingers domain on replication fi

75 al approach to the detection of specific DNA sequence motifs based on similarities between the promot

76 l functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold.

77 We find that DpnI cuts other sequence motifs besides the canonical GATC restriction s

78 TIFA incorporated the observed genome and sequence motif bias of the miniHimar transposon.

79 stants and that variants lacking the minimal sequence motif bind competitively with consensus RNA.

80 lysis reveals (1) differential complexity of sequence motifs bound by GATA1, GATA2, and PU.1; (2) the

81 ot only identifies a new structurally biased sequence motif but also directly demonstrates the role p

82 aX does not show any of the typical relaxase sequence motifs but is the prototype of a unique family

83 NA binding proteins (RBPs) bind specific RNA sequence motifs, but only a small fraction ( approximate

84 -type clients, HSP90 did not bind particular sequence motifs, but rather associated with intrinsicall

85 andful of potential recombination-associated sequence motifs, but the associations are generally tenu

86 Conventional programs identified some sequence motifs, but these are found in less than 5-10%

87 n humans and mice via recognition of hotspot sequence motifs by a variable tandem-repeat zinc finger

88 n such cases, it would be helpful to predict sequence motifs by using experimental data from closely

89 o NRPs through a carboxy (C)-terminal, basic sequence motif (C-end Rule or CendR motif).

90 stitution that creates a new N-glycosylation sequence motif can result in the gain of glycosylation.

91 Although individual mutations in bound sequence motifs can influence TF binding, most binding d

92 ng locations for each TF assayed, from which sequence motifs can then be derived.

93 NAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends, representing the si

94 ent of Ty1 insertion sites revealed a strong sequence motif centered on but extending beyond the targ

95 d that it was highly conserved and contained sequence motifs characteristic of genes that are subject

96 rth beta-strand of Sma0114 houses a PFxFATGY sequence motif, common to many HWE-kinase-associated rec

97 Dozens of consensus sequence motifs containing predicted transcription facto

98 (ChIP-seq) and uncovered overrepresented DNA sequence motifs corresponding to known and novel PPARGC1

99 hich includes three evolutionarily conserved sequence motifs: CP2, CP, and T.

100 iscuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, at

101 al feature conserved across all groups was a sequence motif critical for cell-killing that is general

102 on its targets using a conserved N-terminal sequence motif (D-motif).

103 Whereas TCR sequence motifs define CD1d-reactive NKT cells, the avai

104 s poorly understood, in part because the DNA sequence motifs do not conform to a well-defined symmetr

105 ted toward involvement of a highly conserved sequence motif, E1XXE2RFXYY (from here on referred to as

106 on to poly(A) tails, Nab2 can also recognize sequence motifs elsewhere in transcripts in which adenos

107 sgRNA efficiency is associated with specific sequence motifs, enabling the prediction of more effecti

108 (2) zinc finger protein PRDM9 binds to a DNA sequence motif enriched in hotspots of recombination, po

109 Two of the cis sequence motifs enriched in the PREs are cognate binding

110 e positioning around the TF-binding regions, sequence motifs enriched in the regions and the distance

111 nce-specific transcription factor occupancy, sequence motif enrichment, and biological functions.

112 disease virus that the TURBS contains three sequence motifs essential for reinitiation.

113 that consider a single type of data, such as sequence motifs, evolutionary conservation, or the bindi

114 le kernel learning approach to integrate DNA sequence motifs, evolutionary patterns, and diverse func

115 e interconnected loops, one of which carries sequence motifs expected of an EPRV (including the gag a

116 ns and to derive a statistically significant sequence motif for phospho-Ser autophosphorylation.

117 There is no well-defined sequence motif for TPST sulfation, and the underlying de

118 ins, which contain multiple repeats of short sequence motifs, form a large but seldom-studied group o

119 In addition, the sequence motifs found in the potential branch-point regi

120 ional approaches based on kinase recognition sequence (motifs) from known substrates, protein structu

121 actor (TF) binding, evolutionarily conserved sequence motifs, gene expression, and chromatin modifica

122 the CMP-binding site and implicate a unique sequence motif (GGS/TX(5)GXNXLE) in Kdo binding.

123 identify candidate regulatory marks such as sequence motifs, H3K36Me3 and Pabpc1 that are isoform de

124 Although the consensus sequence motif has been identified and used to explain s

125 an iterative motif-finding algorithm through sequence motifs identified in 2708 known allergens.

126 id 52 of VP1, an isoleucine located within a sequence motif IDPWI in the S domain that is highly cons

127 pe led to the identification of a C-terminal sequence motif important for substrate tolerance and spe

128 upy promoters harboring the newly identified sequence motif in cell in a methyl-dependent manner and,

129 identified a new and functionally important sequence motif in EL5 containing a conserved tyrosine re

130 We report a novel DNA sequence motif in human and mouse genomes.

131 TGTG)-3', corresponding to the most abundant sequence motif in irregular telomeric DNA from Saccharom

132 ith Microprocessor and binding to a specific sequence motif in pri-miRNAs.

133 miR-155 targeted a conserved sequence motif in the 3'UTR of TRF1, resulting in its tr

134 autorepressed conformation and define a key sequence motif in the Atro box that is essential for TLX

135 and an Arg residue within a highly conserved sequence motif in the channel leading to the RNase catal

136 Recognition of a sequence motif in the untranslated region of RAD51 trans

137 out by a conserved twin arginine-containing sequence motif in their signal peptides.

138 RRM to miRNA precursors containing the same sequence motif in their terminal loops, including miR-20

139 ated that coding sequences harbor regulatory sequence motifs in addition to encoding for protein.

140 ly target cytosine within distinct preferred sequence motifs in DNA, with specificity largely conferr

141 The existence of over- and under-represented sequence motifs in genomes provides evidence of selectiv

142 We identified 2 short-sequence motifs in human NTCP that were required for spe

143 Here we addressed which domains and sequence motifs in KCTD proteins regulate desensitizatio

144 tegrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA.

145 timate cooperation between E boxes and other sequence motifs in SHM targeting to Ig loci and perhaps

146 In this approach, specific sequence motifs in single DNA molecules are fluorescentl

147 erved receptor domains to recognize specific sequence motifs in substrates, such as D and KEN boxes.

148 Importantly, the sequence motifs in the transmembrane domain that are ass

149 -residue globular prodomain with a conserved sequence motif including a cysteine engaged in "cysteine

150 These methylated bases were located in five sequence motifs, including three novel targets for type

151 ired for fusogenic activity, and we identify sequence motifs, including two hydrophobic segments, tha

152 rf.gov, catalogs predicted non-B DNA-forming sequence motifs, including Z-DNA, G-quadruplex, A-phased

153 ably, this nuclear localization signal (NLS) sequence motif is also important for interacting with tR

154 1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential.

155 This novel AR-binding sequence motif is found in regions predicted to be unstr

156 ptamer, which does not contain the conserved sequence motif, is specific for the rRNA binding site of

157 ions is mediated primarily by two amino acid sequence motifs, ITAMs (immunoreceptor tyrosine-based ac

158 ain repeat elements that bind to cognate RNA sequence motifs just 5' to the edited nucleotide.

159 in parallel with evolution of consensus RNA sequence motifs known to be associated with the enzymati

160 alization, was affected by mutating adjacent sequence motifs known to be involved in kindlin binding.

161 Moreover, at least two sequence motifs known to interact with the Sp1 transcrip

162 f 18 residues of WelO5 within the identified sequence motif led to a functional mutant with an expand

163 These differences impact small sequence motifs like transcription factor binding sites

164 tached to lysine 549 with a SUMO-interacting sequence motif located near the active site of Snf1, and

165 We identified a 5-aa-long sequence motif (Lys-Ser-Lys-Thr-Lys) in KRAS4b that may

166 romatin in one cell type to many TFs through sequence motif mapping.

167 We obtain accurate, haplotype-resolved, sequence motif maps hundreds of kilobases in length, res

168 sults show that the vast majority of hexamer sequence motifs measurably influence splice site selecti

169 tide, Ac-c[CVDINNNC]-NH2, containing the key sequence motif mediating the SPSB2-iNOS interaction, whi

170 While sequence motifs mediating this function have been determ

171 ocess, characterized by recombination signal sequence motifs near breakpoints, incorporation of non-t

172 ard genetic code) due to possessing specific sequence motifs near frameshift positions.

173 increasing intramolecular contacts to basic sequence motifs near the N and C termini.

174 class light chains through a five-amino-acid sequence motif necessary for VRC01 light chain recogniti

175 Recently, the sequence motif of almost 400 human TFs have been identif

176 The first site contains a consensus sequence motif of AOPXW (where O is a hydrophobic residu

177 preferential recognition of the four-residue sequence motif of furin.

178 ends on tyrosine 7, located in a cytoplasmic sequence motif of NKp65 resembling a hemi-immunoreceptor

179 of A3H displayed a strong preference for the sequence motif of T-mCpG-C/G, which may suggest a potent

180 can be rewired through the programming of a sequence motif of the general form G-G/F-XXX-G found in

181 The location and surrounding sequence motifs of a PAS appear to differentiate its reg

182 performed a systematic investigation of the sequence motifs of B-class and C-class phosphodiester OD

183 Hotspots were enriched for sequence motifs of key TFs in that cell type and more th

184 matin states of regulators were enriched for sequence motifs of regulators relative to all states, su

185 lutionary analysis, and signature nucleotide sequence motifs of the hemotropic Mycoplasma 16S rRNA an

186 hormone-responsive gene expression; however, sequence motifs of TR that mediate shuttling are not ful

187 A highly conserved sequence motif on helix I contributes to positioning the

188 erous partners need not converge on a single sequence motif or be increasingly constrained in more co

189 quence classification, identification of the sequence motifs or n-grams that can precisely discrimina

190 ficity is based on recognition of either RNA sequence motifs or other sequence properties, no such un

191 The APC/C recognizes short linear sequence motifs, or degrons, on its substrates.

192 rovides binding sites for specific substrate sequence motifs, or degrons.

193 vely spliced exons and a family of conserved sequence motifs overlapping branchpoints we term B-boxes

194 Novel DNA sequences motifs overrepresented in T-DMRs were identifi

195 matic analysis of these RNAs revealed common sequence motifs potentially recognized by PfSR1.

196 nct epigenetic signatures and cis-regulatory sequence motifs predicted to bind putative co-regulatory

197 Finally, sequence motif predictions identified associations with

198 Plant HSFs of subgroup B lack a conserved sequence motif present in the transcriptional activation

199 cient to explain the CDTS, and that flanking sequence motifs provide individual context that is an eq

200 Bhrs have a characteristic sequence motif providing ligand residues for a type of n

201 ompound, c(HS4-4), containing the SE primary sequence motif QKRAA, which was synthesized using a back

202 e range of result types, including BLAST and sequence motif queries.

203 ides contain a C-terminal C-end Rule (CendR) sequence motif (R/K)XX(R/K), which is responsible for ce

204 tions were the position of RNA structure and sequence motifs, RBP co-binding and gene region type.

205 modification of selected targets by primary sequence motif recognition.

206 ite many advances in the characterization of sequence motifs recognized by TFs, our ability to quanti

207 We deduced the sequence motifs recognized by the methyltransferase enzy

208 implemented filters based on alignment data, sequence motifs, regional coverage and base quality.

209 ites, shorter flanking introns, and distinct sequence motifs relative to "slow-excluded" and "fast-in

210 osylation and the potential role of specific sequence motifs remain largely unknown.

211 358 that defines APOE4 is located in a short sequence motif repeated several times within exon 4 of a

212 This peptide comprises two sequence motifs: RGD, which binds to alphavbeta3/5 integ

213 We further show that the CNNC primary sequence motif selectively enhances the processing of op

214 We further demonstrate that the sequence motif sensed by TLR8 is clearly distinct from t

215 re promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding transcrip

216 specified for dosage compensation, since DNA sequence motifs shown to be important for dosage compens

217 A-2 binding sites in these cell genes have a sequence motif similar to the sequence known to mediate

218 ng is determined by the presence of specific sequence motifs (SM) and chromatin accessibility, where

219 In addition, a preferred sequence motif spanning most SMG6 cleavage sites has bee

220 ily expansions are facilitated by repeats of sequence motifs such as C2H2 zinc fingers.

221 family members bind to similar or identical sequence motifs, such as G-boxes (CACGTG), so it is diff

222 s promote replication errors in specific DNA sequence motifs suggesting increased misinsertion and in

223 s were most enriched for NF-E2, FLI and RUNX sequence motifs, suggesting that this TF triad controls

224 By analysing sequence motifs surrounding hypermethylated sites across

225 mediate desensitization through a particular sequence motif, T/NFLEQ, which is not present in the H1

226 The sequence motifs targeted by putative methyltranferases w

227 proposed to specify FMRP binding, the short sequence motifs TGGA and GAC were corroborated, and a no

228 Mutation of a sequence motif (TGTWACAW) that was associated with the p

229 gene of each TU tend to have more conserved sequence motifs than those of the other genes inside the

230 similarity of expression depends on a common sequence motif that binds Mirror in vitro and is essenti

231 ur study establishes Pro-Pro-Aro to be a new sequence motif that can stabilize Pro-cisPro peptide bon

232 chemical, and cellular studies reveal that a sequence motif that defines these ligands binds to a hig

233 lu134 residue of the rhodopsin-conserved ERY sequence motif that helps break the cytoplasmic "ionic l

234 elices, we identified a highly amyloidogenic sequence motif that instigates aggregation and forms the

235 d experimentally validate a promoter element sequence motif that is enriched upstream of the transcri

236 tro, and we biochemically define a bipartite sequence motif that is necessary and sufficient to confe

237 ical assays have also identified a substrate sequence motif that is specifically recognized by many r

238 t the shared epitope (SE), an HLA-DRB1-coded sequence motif that is the single most significant genet

239 ion of the UPR, some of which share a common sequence motif that may direct cleavage of these mRNAs.

240 Gbeta(2) interacted with a sequence motif that was present in several transcription

241 angements of the DBD broaden the spectrum of sequence motifs that a TF can recognize.

242 genesis, and concentrated in specific 5-base sequence motifs that are CA- and CT-rich but depleted of

243 enes through binding to genomic regions with sequence motifs that are conserved among mammals and tha

244 ains highly conserved functional domains and sequence motifs that are correlated with the unique biop

245 ed among teleost species and that they share sequence motifs that are critical for RGB cone-specific

246 osed protein surfaces and is associated with sequence motifs that are distinct from those for other t

247 Transcription factors (TFs) recognize short sequence motifs that are present in millions of copies i

248 domly associated with a number of structural/sequence motifs that correlate with paused DNA replicati

249 N terminus of eRF1 contains highly conserved sequence motifs that couple stop codon recognition at th

250 Analyses of enriched DNA sequence motifs that may act as cis-regulatory elements

251 Bcl-2 homology 3 (BH3) domains are short sequence motifs that mediate nearly all protein-protein

252 Nef sequence motifs that modulate these functions have been

253 Furthermore, we identify specific sequence motifs that predict consistent, localized meiot

254 profiles, we located origins and identified sequence motifs that predict origin function.

255 t CDC6 and Cyclin F interact through defined sequence motifs that promote CDC6 ubiquitylation and deg

256 Identifying DNA sequence motifs that signal the addition of poly(A) tail

257 in terms of associated regulatory elements, sequence motifs, the choice of transcription start sites

258 ARP homology domain missing a PARP consensus sequence motif; the domain has enigmatic functions and a

259 e particular clades of enzymes sharing these sequence motifs; the phylogeny was instead dominated by

260 These peptides contained repeat sequence motifs; their interaction with hmAb 1002-1E03 w

261 single PIF-binding sites, containing single sequence motifs, through multiple PIF-binding sites, eac

262 matin immunoprecipitation (ChIP) data and TF sequence motifs to computationally classify cell type-sp

263 d crystallography showed linkage of TCRalpha sequence motifs to high-affinity recognition of antigen.

264 characteristic germline genes and convergent sequence motifs to recognize overlapping epitopes in the

265 transcription factors recognize specific DNA sequence motifs to regulate transcription.

266 ins, containing a conserved W-x-G amino acid sequence motif, to the growth medium.

267 is tool to identify six position-independent sequence motifs together with their cognate transcriptio

268 able to quantify the contribution of various sequence motifs towards the resulting DNA methylation st

269 Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2.

270 n of transcription factors with enriched DNA sequence motifs upstream of coexpressed genes identify r

271 ok) at its C terminus that binds AT-rich DNA sequence motifs upstream of the promoters it activates.

272 The enrichment of G4 sequence motifs upstream of TSS of non-poised active gen

273 One sequence motif, VNDT, containing an N-linked glycosylati

274 A Smy1-like sequence motif was also identified in a different Bnr1 r

275 his defect was most severe when the upstream sequence motif was altered.

276 No singular sequence motif was identified, instead the required sequ

277 Moreover, a 'TCCCC' sequence motif was specifically enriched in bivalent pro

278 Based on DNA sequence motifs, we propose two distinct mechanisms for

279 A few sequence motifs were found enriched close to the fusion

280 timation suite of tools, BEST, 407 conserved sequence motifs were identified in promoter regions of t

281 rains 26695 and J99-R3, 17 and 22 methylated sequence motifs were identified, respectively.

282 n this work, synthetic peptides with various sequence motifs were used as trypsin substrates.

283 idues in proteins containing C-terminal CAAX sequence motifs (where A is an aliphatic residue and X i

284 an meiotic crossover hot spots to intergenic sequence motifs, whereas budding yeast hot spots overlap

285 rd peptide substrates and recognize specific sequence motifs, whereas MKK6 has little activity or seq

286 ill allow researchers to accurately identify sequence motifs which will lead to a better understandin

287 e Yfh1 interaction with Isu involves the PVK sequence motif, which is also the site key for the inter

288 We identified sequence motifs, which enhance or reduce the ability of

289 wo-thirds of Dorsal target genes contain DPE sequence motifs, which is significantly higher than the

290 reactivity are controlled by particular CDR3 sequence motifs, which would allow thymic selection to c

291 Conserved carboxyl-terminal sequence motifs with class-specific patterns of residue

292 Also, the sequence motifs with successive lysine and/or arginine r

293 interactions between highly diverse receptor sequence motifs with their interacting proteins, such as

294 ted with the presence of a bacterial pausing sequence motif, with reduced SNP density, and with a DNa

295 Primary sequence motifs, with millimolar affinities for binding

296 A di-Arg motif and a long sequence motif within the transmembrane domains were fou

297 This study identifies sequence motifs within ICP0 that are involved in targeti

298 quired for MYC function has been to focus on sequence motifs within MYC that are conserved throughout

299 ENaC channels contain regulatory domains and sequence motifs within their cytosolic domains.

300 identified features, including three primary-sequence motifs, yielded a unifying model defining mamma