ライフサイエンスコーパス: sequence variability

1 (RAVV), is difficult because of substantial sequence variability.

2 directed evolutionary pressure that enhances sequence variability.

3 patibility complex (MHC) molecule of limited sequence variability.

4 viral titer, were consistent with increased sequence variability.

5 in the V3 loop regardless of the amino acid sequence variability.

6 nce, while the remainder of the plasmids had sequence variability.

7 performed to assess the potential effect of sequence variability.

8 performed to assess the potential effect of sequence variability.

9 proteins imposes strong constraints on their sequence variability.

10 n had additional triple overlap with reduced sequence variability.

11 tional domains in the context of significant sequence variability.

12 raries for the study of pathogens with great sequence variability.

13 ided into three variants based on amino acid sequence variability.

14 and in size, in accordance with the observed sequence variability.

15 The gp120s also exhibited low amino acid sequence variability (12%) in V3 and high variability (3

16 quantitate the fitness of HIV-1 Gag based on sequence variability across the protein.

17 Comparing sequence variability across viral genomes allows for the

18 logous Borrelia strains despite considerable sequence variability among DbpA in these strains.

19 protein which displays remarkable amino acid sequence variability among different CMV isolates, sugge

20 Here, we report the analysis of sequence variability among high and low affinity targets

21 The identification of a region of sequence variability among individual isolates of Bacill

22 est that this mechanism is a major source of sequence variability among retrotransposed genetic eleme

23 A major challenge is the extreme viral sequence variability among strains.

24 We have examined the nature of V3 sequence variability among subtype C human immunodeficie

25 The nucleocapsid protein amino acid sequence variability among the members of the Argentinia

26 Sequence variability analysis indicated that both human

27 We discuss the relationship between sequence variability and "evolutionary opportunity" and

28 ropose that CDI systems exploit the inherent sequence variability and active-site plasticity of PD(D/

29 conservation was measured by the amino acid sequence variability and by the ratio of nonsynonymous-t

30 binant CAP256 gp120s displaying high protein sequence variability and changes in PNGS number and posi

31 Because of their extreme sequence variability and extensive domain shuffling, sig

32 We present evidence that sequence variability and functional diversity of a gene

33 These glycoproteins exhibit a high degree of sequence variability and glycosylation, which are used a

34 The intermediate domain contains the highest sequence variability and lacks homology to structural mo

35 ited effectiveness thus far, in part because sequence variability and other structural features of th

36 ld isolate strains for a correlation between sequence variability and sigma1 cleavage.

37 ger fitness effects than those inferred from sequence variability and that contribute most of the sta

38 The effect of DNA sequence variability and the degree of cyclic AMP recept

39 estimation procedure that fully accounts for sequencing variability and show that it outperforms the

40 their genomic origins, biogenesis pathways, sequence variability, and newly identified products such

41 tudies suggest that despite a high degree of sequence variability, antibody recognition sites or anti

42 Sequence variability associated with human immunodeficie

43 tive estimate of the correlation between the sequence variability at a position and the fractional ac

44 n concerned, and has the ability to generate sequence variability at both selected and neutral sites,

45 by providing evolution-based expectations of sequence variability at each genomic locus.

46 by using an HIV-1 database to determine the sequence variability at each position in all expressed H

47 Finally, the sequence variability at residue positions among function

48 mation through internal base pairing limited sequence variability at these sites, an algorithm was de

49 The effect of sequence variability between different types of hepatiti

50 g both epidemics, with no significant G gene sequence variability between samples.

51 Sequence variability between the N-terminal domains of t

52 ts, 19 showed no evidence of intrasubject K1 sequence variability, but, in 7 subjects, all of whom we

53 line-derived sequences and displayed a high sequence variability, confirming that these AHAs underwe

54 arity in structure and the low tolerance for sequence variability, coupled with the multiple critical

55 er, significantly influenced by assay target sequence variability due to natural diversity and rapid

56 dominant, focusing immune responses, despite sequence variability elsewhere.

57 conserved but retain a surprising degree of sequence variability, especially in the nonamer and spac

58 We conclude that sequence variability exists within all toxin serotypes,

59 ed that they would contain useful nucleotide sequence variability for epidemiologic studies.

60 Analysis of nucleotide sequence variability for these in conjunction with anoth

61 ine is that of contending with the extensive sequence variability found in circulating viruses.

62 Despite the enormous sequence variability found within sensor input domains,

63 Thus, sequence variability has a profound effect on the antige

64 Sequence variability has been analyzed in the context of

65 TL, we assessed the impact that intraepitope sequence variability has upon T-cell recognition.

66 Due to its extremely high sequence variability, HCV can readily escape the immune

67 rgence, and hybridization, combined with low sequence variability, however, have prevented phylogenet

68 re selected based on hydrophilicity and high sequence variability identified by sequence comparison w

69 Rpt2-dependent resistance and Rps2 locus DNA sequence variability in a worldwide sample of 27 accessi

70 vity is sufficient to restore high levels of sequence variability in adult birds, suggesting that rec

71 Data on DNA sequence variability in human and plant populations are

72 Sequence variability in MHC class II molecules plays a m

73 arasitic nematode, we found a high degree of sequence variability in proteins predicted to be involve

74 The sequence variability in the ABCA4 locus is extensive and

75 Sequence variability in the amplified segment of the sec

76 cies encode functional CDI systems with high sequence variability in the CdiA-CT and CdiI coding regi

77 rientations that allow it to accommodate DNA sequence variability in the cognate binding sites.

78 (HIV) were studied with regard to nucleotide sequence variability in the E2/NS1 first hypervariable r

79 Because of the unusual sequence variability in the LRRs of this class of protei

80 ly; however, the genetic mechanisms by which sequence variability in the penaeidin gene family is gen

81 ulosis clinical isolates revealed surprising sequence variability in the pks15/1 locus and substantia

82 arental lines allowing the quantification of sequence variability in the species.

83 nfectious clones of noroviruses and the high sequence variability in their capsids, it has not been p

84 ved between species despite a high degree of sequence variability in their guanine nucleotide dissoci

85 lusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domain

86 Sequence variability in V3 among the subtype C viruses w

87 Using DNA shuffling to introduce functional sequence variability into a protein of interest, we scre

88 an immunodeficiency virus (HIV)'s tremendous sequence variability is a major obstacle for the develop

89 contrast to that for subtype B HIV-1, where sequence variability is associated with such substitutio

90 Sequence variability is high in all three satellite fami

91 IV-1 isolates in sub-Saharan Africa and that sequence variability is not a feature of the V3 region o

92 Interspecies sequence variability is observed in all functional class

93 e beta-arrestins throughout their N termini, sequence variability is present at a small number of res

94 ful to date, due in part to the virus's high sequence variability leading to immune escape.

95 The sequence variability map of the hu4D5 binding site is co

96 We hypothesized that regions of amino acid sequence variability may contain signal motifs that dire

97 Such subtype sequence variability must be accounted for when generati

98 hese species have 11 to 14 rRNA operons, and sequence variability occurs among the multiple 16S rRNA

99 Recently, it has been discovered that sequence variability occurs in BoNTs produced by serotyp

100 has proved challenging due to high levels of sequence variability of non-canonical targeting signals,

101 C virus (HCV) persistence is related to the sequence variability of putative envelope genes.

102 As expected, sequence variability of the antigen-binding site is over

103 Here we analyzed the sequence variability of the assay target region from >2,

104 Here, we analyzed the sequence variability of the assay target regions from 1,

105 cal isolates, but nothing is known about the sequence variability of the gL and gO genes.

106 (emm typing) is effective for surveying the sequence variability of the M virulence protein, and com

107 In contrast to the sequence variability of the second SH3bm, tyrosine 89, w

108 The overall sequence variability of the subtype C V3 region was no g

109 We analysed the sequence variability of the third gene (MG192 or mgpC) o

110 s, along with the unexpectedly high level of sequence variability of the UL144 ORF, suggests that the

111 The extreme sequence variability of the virus resulting from error-p

112 eer and camel was carried out to investigate sequence variability of these genes among ruminants.

113 polymerases has been hampered by the extreme sequence variability of these sequences.

114 To examine the sequence variability of this nonanucleotide promoter mot

115 Recent findings of low sequence variability of Y chromosome genes has led to su

116 Furthermore, sequence variability predicted from TERM data agrees clo

117 in genomic efforts to define and analyze the sequence variability present among individuals within a

118 dynamic and interactive viral ecosystem with sequence variability ranging over 2 orders of magnitude

119 he tolerance of this metal-free fold towards sequence variability, six additional peptides resulting

120 cular stability and lineage sharing of mtDNA sequence variability suggest that mutations arise in the

121 n is old, it will have an island of enhanced sequence variability surrounding it, which represents a

122 ients confirmed that there was extremely low sequence variability surrounding the PePHD.

123 sed vaccine strategies because it shows less sequence variability than other HIV-1 proteins.

124 osed modified classifiers are more robust to sequence variability than standard SVM classifiers, impr

125 ated class 5 pilins show much higher genetic sequence variability than the remainder of the pilin pro

126 -subunit rRNA genes demonstrate much greater sequence variability than the small-subunit rRNA sequenc

127 of beta-tubulin isotypes are regions of high sequence variability that bind to microtubule-associated

128 Despite extensive sequence variability, the two major domains of sigma(E)

129 es must take into account the extensive BoNT sequence variability; the seven BoNT serotypes differ by

130 Some species exhibit very high levels of DNA sequence variability; there is also evidence for the exi

131 ctural probing methods, we show that despite sequence variability they contain a common three-dimensi

132 This limited sequence variability was also a feature of subtype B V3

133 Sequence variability was assessed by direct sequence ana

134 No sequence variability was detected in the distal portion

135 virus (HCV) envelope proteins, and envelope sequence variability was examined in chimpanzees.

136 nce at the four repeats, but some nucleotide sequence variability was observed at AUGC(865-868) if th

137 CDR (CDR-H3) presents significant length and sequence variability, we find a substantial contribution

138 By incorporating E2 sequence variability, we found a number of E2 polymorphi

139 was highly polymorphic and 22 "hot spots" of sequence variability were noted.

140 ositive clinical specimens and evaluated for sequence variability, which demonstrated transmission of

141 This pocket demonstrates considerable sequence variability, which has allowed species-specific

142 resent at this locus, there is unusually low sequence variability, with the mean number of nucleotide

143 onserved core domain mediates catalysis, and sequence variability within a structurally related N- an

144 Extensive sequence variability within and between RSV group A and

145 Against the background of ovulin's high sequence variability within and between species, we have

146 This contrasts markedly with the observed sequence variability within each serotype, which is conf

147 B molecules have significant strain-specific sequence variability within surface-exposed regions (loo

148 ndividuals, it was possible to quantify gene sequence variability within the population.

149 mRNA start sequence can tolerate significant sequence variability without affecting G protein product