ライフサイエンスコーパス: sequential

1 using differential scanning calorimetry, and sequential (2)H and (31)P solid-state nuclear magnetic r

2 ting the desaturation pathway, followed by a sequential abstraction of a hydrogen atom or proton-coup

3 We demonstrate that sequential accumulation of oncogenic mutations in Wnt, E

4 ized beta-mannanases, we propose a scheme of sequential action by the glycoside hydrolases encoded by

5 l., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-inducibl

6 inated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1

7 The sequential activation of neurons has been observed in va

8 Sequential activation of NF-kappaB and an increased Gata

9 CSN activity during performance revealed the sequential activation of topographically ordered functio

10 Over learning, the sequential activity across cortical modules became tempo

11 rance of virally infected cells requires the sequential activity of innate and adaptive immunity effe

12 We found that the sequential activity of these enzymes converts 5-ethynylc

13 he striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing t

14 ugh the action of four ASATs, which catalyze sequential addition of acyl groups to the R2, R4, R3, an

15 ral, and assembly is thought to occur by the sequential addition of capsid protein subunits to a nucl

16 ble alkylation of isopropanol is achieved by sequential addition of different alcohols.

17 structural changes on BPA oxidation rate, 12 sequential additions of 80 muM BPA are performed at pH 7

18 a Cox proportional hazards model, following sequential adjustment for covariates and testing for an

19 missed after an experimental study involving sequential administration of then-standard influenza vac

20 ified with MnO2 nanoparticles via a two-step sequential adsorption under careful temperature and pH c

21 re discrete early stages of CME and show how sequential, allosterically regulated conformational chan

22 ferent redox conditions (anaerobic, aerobic, sequential anaerobic-aerobic), and the extracellular oxi

23 Trial sequential analyses on primary and secondary outcomes su

24 We applied this approach, called sequential analysis of fractionated eluates by SRM (SAFE

25 ofluidic channels allows automation to mimic sequential analytical steps in benchtop environment.

26 AZM mediated SV docking and priming models: sequential and concurrent SV docking/priming.

27 ng sulfidation protocols (e.g., concerted or sequential) and key operational variables (e.g., S/Fe ra

28 The novel self-templated strategy, including sequential anion- and cation-exchange reactions, integra

29 Thus, in a sequential approach based on colonoscopy offered first,

30 Sequential assembly allows for initiation, signaling, an

31 role of the adaptor protein in mediating the sequential assembly of the phage tail.

32 med by a slow decrease in pH, which leads to sequential assembly.

33 ynthesis of substituted [6]carbohelicenes by sequential Au-catalyzed intramolecular hydroarylation of

34 b-type lectins are proteins consist of three sequential beta-sheet subdomains that bind to specific c

35 promotes cancer cell aggressiveness through sequential beta1 integrin stabilization, activation of a

36 from the three-state model imply asymmetric sequential binding of the terminal domains.

37 opulation was observed in 6 individuals with sequential blood samples and upon compartmental analysis

38 The reaction likely involves sequential C-N bond formation followed by C(CO)-C(alkyl)

39 It involves a sequential carbon-nitrogen/carbon-oxygen bond formations

40 A sequential-casting ternary method is developed to create

41 ch was largely inspired by early examples of sequential catalytic transformations.

42 the neural population are the key driver of sequential categorical decisions.

43 outside of the cell cycle while displaying a sequential cell order reflecting preceding cell growth a

44 (n=30) and from healthy volunteers (n=4) by sequential centrifugation.

45 n of cytokines and chemokines in response to sequential challenges with LPS and Poly I:C, a TLR3 liga

46 beta-catenin and/or PIK3CA(H1047R) to follow sequential changes in cancer-related signaling networks,

47 Antibiotic regimens often include the sequential changing of drugs to limit the development an

48 rom Skp, providing direct evidence against a sequential chaperone model.

49 stained biocidal release were prepared using sequential chemical grafting of nano-objects with differ

50 ates that inorganic nitrate (NO3(-)) through sequential chemical reduction in vivo provides a source

51 certain whether this approach is superior to sequential chemotherapy followed by postoperative radiot

52 When chemotherapy usage was incorporated, sequential chemotherapy was associated with the best sur

53 We present SplashRNA, a sequential classifier to predict potent microRNA-based s

54 cleotide-initiated events, mutations reflect sequential cleavage by the enzyme.

55 f Alzheimer's disease (AD) and are formed by sequential cleavage of the amyloid precursor protein (AP

56 conjugates were prepared through a two-step sequential click approach with a combination of oxime li

57 ZEBOV-GP) across a 6 log10 dose range in two sequential cohorts.

58 en with bilateral PCHI were studied from two sequential cohorts.

59 e revealed after endoscopic visualization of sequential colonic segments, which were re-examined for

60 ure could be distinguished, characterized by sequential colonisation of i) intrauterine/vaginal birth

61 ultiple complications or the contribution of sequential complications to variation.

62 Sequential condensation of aryl isothiocyanates with ami

63 ur results show that ATP hydrolysis triggers sequential conformational waves." They also suggest that

64 A sequential construction of C-C, C-O, C horizontal lineN,

65 developed new algorithms that carry out the sequential construction of EICs and detection of EIC pea

66 the reuse of individual gestures in multiple sequential contexts (e.g., a single phoneme in different

67 edict with certainty the visual outcome of a sequential contralateral NAION event based on the severi

68 Through a participatory framework and sequential, cross-realm integration in spatial optimizat

69 well as a method of determining the need for sequential CT in patients with mild TBI.

70 ana In contrast, in Lycopodium clavatum, two sequential cyclases, LcLCC and LcLCD, are required to pr

71 To address that question, sequential cytoplasmic TbetaRI truncations and point mut

72 As a modeling tool, iHMMs can analyze sequential data without a priori setting a specific numb

73 Combined with ever more abundant sequential data, we anticipate that this study will be i

74 In endosomes, CD74 undergoes sequential degradation by different proteases, including

75 GC-A-10E had little effect on activity, and sequential deletion of individual glutamates in GC-A-8E

76 We then constructed sequential deletions in regions that span the 530 bps.

77 imulation of data, we demonstrate that group sequential designs have the potential to improve the eff

78 Despite the potential benefits of sequential designs, studies evaluating treatments or exp

79 ors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell su

80 ional flanking bases were required to invoke sequential dimerization of the bound protein.

81 Sequential dissemination of information from one enzyme

82 ical process by which feedback repression of sequential DNA rearrangements ensures that only one auto

83 nts assigned to lanadelumab were enrolled in sequential dose groups: total dose of 30 mg (4 patients)

84 ]pyrimidin-3(2H)-one] using simultaneous and sequential dosing schedules.

85 This molecule can be accessed by the sequential double deprotonation of a mono-nido-carborany

86 s needed to evaluate whether simultaneous or sequential drug treatment has maximal therapeutic effica

87 ing the droplet microarray platform with the sequential electrochemical read-out of individual drople

88 f ST131 in this population was not driven by sequential emergence of increasingly resistant subclades

89 s on endogenous parasite glycoproteins using sequential endoglycosidase H and peptide:N-glycosidase-F

90 is to determine the underlying mechanisms of sequential energy transfer from laser light to nanoparti

91 al microcompartments (BMCs) that encapsulate sequential enzymatic reactions of diverse metabolic path

92 IgE and IgG4 binding to sequential epitopes derived from five major CM proteins

93 Tomato ASATs catalyze the sequential esterification of acyl-coenzyme A thioesters

94 mine the best method for both individual and sequential evaluations.

95 redundantly prevent premature progression of sequential events in secondary growth.

96 The determination of the sequential events required to form this new growth axis

97 th potential implications for the outcome of sequential exposure to heterologous DENVs.

98 f survival of L. casei and release of oil in sequential exposure to simulated salivary, gastric and i

99 rally ordered, at least in part, through the sequential expression of different cyclins.

100 ial use of transcription factors enables the sequential expression of transcriptional programs for ar

101 cles and inner tissues were distinguished by sequential extraction, and the cuticle was verified to b

102 ses contacts with promoter elements in a non-sequential fashion during escape.

103 The ability to learn tasks in a sequential fashion is crucial to the development of arti

104 entified two classes of markers expressed in sequential fashion when new pigment cells are generated

105 crease in the concentration of dsRNA fed and sequential feeding of two different dsRNAs increased mor

106 a pulcherrima and Torulaspora delbrueckii in sequential fermentation with Saccharomyces cerevisiae an

107 rks in vivo and in vitro In the hippocampus, sequential firing of many neurons over periods of 100-30

108 Tasks such as mixing, timing, and sequential fluid delivery have been achieved in paper an

109 Cas9 system, then barcodes those loci by DNA sequential fluorescence in situ hybridization in fixed c

110 The synthetic strategy involved sequential fluoride-catalyzed nucleophilic addition of P

111 Compared with sequential focal radiofrequency ablation in a linear pat

112 romyces cerevisiae, ECM remodeling refers to sequential formations of the primary and secondary septa

113 d = 1 and a sample size of n = 18 per group, sequential frequentist analysis consumes in the long run

114 the lactam/sultam ring and allows late stage sequential functionalization of the amine and amide nitr

115 Phagosomes mature into phagolysosomes by sequential fusion with early endosomes, late endosomes,

116 pose three parallel mechanisms involving (i) sequential G-protein interactions at the cognate site, (

117 Electrochemical dual-pulse plating with sequential galvanostatic and potentiostatic pulses has b

118 o enhancers: One enhancer is responsible for sequential gene activation, and the other is responsible

119 male gametogenesis involves orchestration of sequential gene regulation for somatic differentiation i

120 Sequential glycan KO modifications significantly reduce

121 with both three- and four-component, one-pot sequential glycosylation reactions, and in both cases, t

122 lycoside, have been achieved using a one-pot sequential glycosylation technique.

123 ntegrated and stored to elicit a delayed and sequential grooming response.

124 the exemestane group and 67% (65-69) for the sequential group (hazard ratio 0.96, 0.88-1.05; p=0.39).

125 velopment is a complex process that involves sequential growth and fusion of the facial prominences.

126 binding site (CD4bs), HCDR3-binder bnAbs via sequential HIV-1 Env vaccination.

127 is three-component reaction proceeds through sequential hydroazidation of the terminal alkyne and add

128 Pepsin-hydrolysis and sequential hydrolysis by pepsin and trypsin hydrolyzed a

129 eavy molecular weight chains of collagen but sequential hydrolysis yielded higher degree of hydrolysi

130 evaluate their impact on immune responses to sequential IAV infections, adult female mice were treate

131 Two sequential, identically designed studies were carried ou

132 Importantly, although sequential immunization with DNA and Ad5 maximized antit

133 Sequential immunization with mutationally distant varian

134 ltisite, observational study following three sequential, independent cohorts, from a single U.S. heal

135 ts, guided by model predictions, reveal that sequential inductions generate distinct cell fates by ch

136 Moreover, sequential infection of ferrets with H1N1 influenza viru

137 Furthermore, sequential infection of ferrets with viral vectors expre

138 Between-subject measures of this implicit sequential inference strategy had a neurobiological unde

139 onal contraceptives, levonorgestrel, impacts sequential influenza A virus infection by modulating ant

140 injection of a cocktail of radioligands; and sequential injection of different radioligands.

141 ologous vaccination regime was used with the sequential inoculation of three different inactivated FM

142 ficantly (p<0.05) between co-inoculation and sequential inoculation.

143 sing an efficient synthon strategy involving sequential intramolecular bisboronate homocoupling and r

144 of gap genes, resulting in the induction of sequential kinematic waves of gap gene expression.

145 One approach to realizing such films is sequential layer-by-layer assembly, whereby atomically t

146 We have identified sequential left-right asymmetries at the poles, which bi

147 the hypothesis testing, we proposed a novel sequential likelihood ratio test procedure, which iterat

148 While CRN designs for synchronous sequential logic circuits have been proposed and their i

149 n the fusion domain of gB following multiple sequential low-pH exposures or following prolonged low-p

150 or targets are differentially expressed in a sequential manner and make for 1% of the total DEGs at a

151 and subsequently bone formation markers in a sequential manner in euthyroid but not hypothyroid mice,

152 bly of the tail has been shown to occur in a sequential manner to ensure proper molecular interaction

153 tion (uncaging) and photo-cross-linking in a sequential manner, as well as a click-handle for subsequ

154 cell types (gating) involves time-consuming sequential manual steps, untenable for larger studies.

155 r approach is based on a similar idea to the sequential Markov coalescent (SMC)-an approximation of t

156 w that c-di-GMP binds BldD using an ordered, sequential mechanism and that BldD function necessitates

157 Sequential mediation models were used to investigate ass

158 m of dual memory stem cells; the established sequential memory pathway, TSCM -->Central -->Effector m

159 Protein complexes of sequential metabolic enzymes, often termed metabolons, m

160 The observed sequential methylation/demethylation cycle suggests an i

161 , and demonstrate that it not only catalyzes sequential methylations of a methyl group to form ethyl

162 o pattern segments in either simultaneous or sequential modes, depending only on initial conditions.

163 in vivo approaches we determined the precise sequential molecular events of a new estrogen signaling

164 ified by in situ block copolymerization upon sequential monomer addition for the case of methacrylate

165 inhibitors of ERK signaling, suggesting that sequential monotherapy is ineffective and selects for a

166 e method based on FAAS was developed for the sequential multi-element determination of Cu, Zn, Mn, Mg

167 This sequential multi-target phosphorylation cascade makes th

168 assembly of an anaphase inhibitor through a sequential multi-target phosphorylation cascade.

169 ils to predict adverse outcomes arising from sequential, multi-organ metabolism of drugs and xenobiot

170 asis for choosing which ATSs to include in a sequential multiple-assignment randomized trial (or rand

171 The method can be applied to sequential multiple-assignment randomized trials to deve

172 Sequential mutagenesis identifies two evolutionarily con

173 Sequential NAION occurred in 36.8% of diabetic patients

174 The method involves sequential Norrish Type I photocleavage of a ketone (7b)

175 ryo, in which gastrulation is preceded by 13 sequential nuclear cleavages within only 2 hr of fertili

176 wo different precursor solutions to obtain a sequential nucleation and growth phase.

177 ly, bifunctional amino reagents are used for sequential nucleophilic and electrophilic C-N bond forma

178 re, and allocation was concealed with use of sequential numbered opaque envelopes.

179 rogrammed to stereoselectively produce, in a sequential one-pot operation, an excess of any one of fo

180 able LTM at a few postsynaptic MBONs through sequential ORB-regulated local protein synthesis.

181 However, the sequential order of allergen and adjuvant within a fusio

182 etwork of RNA-binding pockets based on a non-sequential-order structure alignment method for local st

183 rtality (0.66) was lower than that for quick Sequential Organ Failure Assessment (p < 0.001 for both

184 elative risk = 1.05 [1.02-1.09]; p = 0.003), Sequential Organ Failure Assessment (relative risk = 1.0

185 , the mean improvement in the cardiovascular Sequential Organ Failure Assessment (SOFA) score (scores

186 Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (SOFA) score to grad

187 with assessment of severity of illness using Sequential Organ Failure Assessment (SOFA).

188 The sensitivity of quick Sequential Organ Failure Assessment for predicting criti

189 The highest Sequential Organ Failure Assessment score from the ICU a

190 ignificantly associated with the respiratory Sequential Organ Failure Assessment score the following

191 lobin unit, the odds of worsened respiratory Sequential Organ Failure Assessment score the following

192 nonrespiratory organ failure (nonrespiratory Sequential Organ Failure Assessment score: 6 [4, 9] vs 5

193 9 [93.5%]; P = .003) and slightly lower mean Sequential Organ Failure Assessment scores (8 vs 10; P =

194 ients with suspected infection and low quick Sequential Organ Failure Assessment scores frequently re

195 ENTS/Twenty-six critically ill patients with Sequential Organ Failure Assessment scores greater than

196 with pre-extracorporeal membrane oxygenation Sequential Organ Failure Assessment scores of less than

197 mic Inflammatory Response Syndrome and quick Sequential Organ Failure Assessment scores were calculat

198 ied Acute Physiological Score II, 59 +/- 18; Sequential Organ Failure Assessment, 10 +/- 3), 229 exhi

199 01) and had slightly lower illness severity (Sequential Organ Failure Assessment, 10 vs 11; p = 0.004

200 on II, Simplified Acute Physiology Score II, Sequential Organ Failure Assessment, and Multiple Organ

201 on II, Simplified Acute Physiology Score II, Sequential Organ Failure Assessment, and Multiple Organ

202 Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, PaO2/FIO2, origin o

203 es (the 37 patients' last episodes) retained Sequential Organ-Failure Assessment score greater than 1

204 on of organ interactions via an in vivo-like sequential, organ-to-organ transfer of media.

205 To complete this methodological study, a "sequential" oxidation/SNAr procedure was performed to ac

206 urden, and co-occurring somatic mutations in sequential patient samples from the clinical trial and c

207 Twenty-four sequential patients admitted after cardiac surgery.

208 of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these s

209 This synthetic protocol consists of sequential Pd-catalyzed carbon-nitrogen bond formation f

210 ssion between the movements determines their sequential performance.

211 We conducted a multicenter, sequential period analysis of 528,108 patients without E

212 All patients underwent sequential pharmacokinetic evaluations of their prestudy

213 PY system exerts differential effects on the sequential phases of non-social and social memory.

214 de attempt or ideation and was composed of 3 sequential phases: (1) a treatment as usual (TAU) phase

215 Sequential phosphorylations of Eco1 by CDK, DDK, and Mck

216 8-week prerandomization period that included sequential placebo and tolvaptan run-in phases, during w

217 n a patient with advanced metastatic PCa via sequential planar whole-body SPECT imaging at 1, 3, 5, a

218 Metabolites were quantified in sequential plasma samples taken over a 25 h period using

219 The COFs were subjected to sequential postsynthetic modifications to yield function

220 In contrast, conditions of sequential presentation have been assumed to be free fro

221 precision, and challenge the assumption that sequential presentation removes competition.

222 ssion that Doc2B plays distinct roles in two sequential priming steps in mouse adrenal chromaffin cel

223 This method, called RNA sequential probing of targets (SPOTs), provides an accur

224 y, IFE target fabrication process, employing sequential processing operations within a continuous enc

225 cond hydrogen atom transfer (HAT) and second sequential proton loss electron transfer (SPLET) mechani

226 RT is facilitated by sequential proton-coupled electron transfer (PCET) steps

227 acy of Clarithromycin and Levofloxacin-based sequential quadruple therapies as first-line treatment o

228 nary reactions provide a platform from which sequential quaternary, one-pot quaternary, and sequentia

229 omly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adju

230 In contrast, a trial with sequential randomization to more intensive therapy achie

231 thiophene-2-carboxylates through the one-pot sequential reaction of alpha-lithiated alkoxyallenes wit

232 , confirming that light absorption induces a sequential reaction path in which a Z-E photoisomerizati

233 se, a substrate for fucosylglycans, requires sequential reactions mediated by GDP-mannose 4,6-dehydra

234 Because PutAs catalyze sequential reactions, they are good systems for studying

235 Flowing fluorinated amines through sequential reactor coils mediates diazoalkane formation

236 reveals a structural role for a coactivator sequential recruitment and biochemical process in ER-med

237 Using this model, we observed the sequential recruitment of early and late endolysosomal m

238 Sequential reduction of busulfan dose was successfully a

239 The screening examination uses a sequential referral approach and assesses presenting vis

240 n to a DNMTi, thus devising a new, low-dose, sequential regimen that imparts a robust anti-tumor effe

241 expectation maximization and Q.Clear (block-sequential regularized expectation maximization with poi

242 Patterns of epitope abundance and the sequential release of cell wall polymers with specific c

243 Specifically, mnemonic binding across sequential representations is more challenging at contex

244 g to the developmental events and leading to sequential reprogramming of metabolic and developmental

245 but that they also learn an accurately timed sequential response pattern.

246 ocesses with expression patterns that showed sequential reversal following N resupply and uncovered a

247 confluence at 2 and 3 wk, followed by three sequential rounds of confluence in 2% CS for 2 wk.

248 Prime-boost vaccination via sequential s.c. and i.m. administration yielded greater

249 We used sequential sampling to recruit individuals.

250 We propose a sequential-sampling model of epiphany learning (EL) and

251 t peak-switching, dual-source, split-filter, sequential-scanning, and dual-layer detector systems.

252 comitant DDP/PTX treatments, suggesting that sequential schedules could improve antitumor efficacy.

253 Patients with sequential second Ahmed valves implanted in the same eye

254 regardless of the seed ranking method used, sequential seeding strategies deliver better coverage th

255 Here, we demonstrate programmed sequential self-assembly of DNA functionalized emulsions

256 quential quaternary, one-pot quaternary, and sequential senary thiol-Michael reactions were designed

257 f the proposed flowchart including the quick Sequential (Sepsis-related) Organ Failure Assessment (qS

258 value of a change of 2 or more points in the Sequential [Sepsis-related] Organ Failure Assessment (SO

259 step involving both TAA(+) units rather than sequential single electron transfer events.

260 can benefit from much greater exploration of sequential social interactions.

261 ved propargyl alcohol, which is submitted to sequential Sonogashira/Suzuki or Sonagashira/Stille coup

262 d to the conventional tracer [(123)I]iodide (sequential SPECT/CT).

263 ncing ( 1000-fold genome-wide coverage) with sequential sputum sampling, we were able to detect trans

264 We also characterized sequential stages of TLS maturation in LSCC culminating

265 We found that there were two sequential steps during the association of BoNT/A with n

266 The underlying molecular sequential steps that likely take place during hopping a

267 gging-strand synthesis may serve to regulate sequential strand displacement and flap cleavage at othe

268 A sequential strategy was developed to discriminate among

269 ined with UV-visible spectroscopy, to reveal sequential structural evolution of CNCbl in the excited

270 atients and Methods Patients accrued to four sequential studies of ibrutinib were included in these a

271 cells give rise to IgE(+) PCs by direct and sequential switching, whereas the isolated GC B-cell fra

272 ource of IgE(+) PCs, generates IgE(+) PCs by sequential switching.

273 We incorporated biological detail using sequential synaptic input onto spines in morphologically

274 However, sequential tests of typical foods, including egg, milk,

275 We demonstrate a sequential therapeutic process comprising genotyping and

276 Standard sequential therapy showed significantly better results i

277 -like heterostructures were then obtained by sequential TiO2 coating, during which the magnetic dipol

278 of trials, participants indicate whether two sequential tones share the same pitch or location depend

279 liative Care (DePAC) project was a two-phase sequential transformative mixed methods design with know

280 ical monocytes is consistent with a model of sequential transition.

281 The reaction proceeds by sequential transnitrilation and SNAr reactions.

282 Finally, using sequential transplantation experiments, we show that the

283 horts in oncology and other fields requiring sequential treatment decisions.

284 with PEGylated IFN-alpha, and patients with sequential treatment of Entecavior and PEGylated IFN-alp

285 In contrast, sequential treatment was antagonistic and had a minimal

286 trial confirm that both exemestane alone and sequential treatment with tamoxifen followed by exemesta

287 c-MPL signaling also enables sequential tumor cell killing, enhances the formation of

288 From the studies, we uncover a sequential, two-step mechanism of cellular reprogramming

289 ne 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic c

290 ity of soy protein hydrolysates (SPH) during sequential ultrafiltration (UF) and nanofiltration (NF)

291 vic acid (PLFA) isolates are fractionated by sequential ultrafiltration, and the resultant fractions

292 This approach utilizes sequential unmasking of cysteine residues with orthogona

293 r pre-primitive-streak competent epiblast by sequential upregulation of SOX17 and BLIMP1 in response

294 high levels by 500 generations, 56% favoured sequential use and 44% favoured mixtures.

295 tion by investigating the relative merits of sequential use of insecticides versus their deployment a

296 Modeling the sequential use of these two orthogonal markers for liver

297 Thus, sequential utilization of different carbon pools induced

298 ow during the temperature-swing stage in the sequential vapor deposition growth process allowed us to

299 Patients were excluded if their sequential visual fields showed an improvement in MD or

300 a-dependent and data-independent (via SWATH, Sequential Windowed Acquisition of All Theoretical Fragm