ライフサイエンスコーパス: sequential activation

1 ial lipid raft localization, and may undergo sequential activation.

2 caspase-3 cleavage product (p20), suggesting sequential activation.

3 by phosphorylation events that lead to their sequential activation.

4 earer distinction between co-activations and sequential activations.

5 Thus, simultaneous input led to sequential activation across cortical retinotopy.

6 After this sequential activation, all four regions were simultaneou

7 ients had a single early site with focal and sequential activation along the tendon of Todaro.

8 ons of the mechanism are consistent with the sequential activation and 1,2-addition of hydrosilane ac

9 The sequential activation and destruction of CDK-cyclin acti

10 these data suggest a molecular basis for the sequential activation and inactivation of CaMKIV.

11 h the cell cycle is regulated in part by the sequential activation and inactivation of cyclin-depende

12 f eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-depende

13 nt of sporulating Bacillus subtilis involves sequential activation and inactivation of several transc

14 At later stages, including adulthood, sequential activation and inhibition of Wnt activity is

15 o super-resolution fluorescence imaging uses sequential activation and localization of individual flu

16 gh the germinal center (GC) is controlled by sequential activation and repression of key transcriptio

17 ession known as "switching" involve both the sequential activation and silencing of the individual gl

18 The sequential activation and summation of these units resul

19 le that of the mammalian type II enzyme with sequential activation by Galpha followed by Gbetagamma.

20 Sequential activation by way of alkylation of the imidaz

21 reaction through an iminium-enamine-iminium sequential activation initiated by a hetero-Michael addi

22 We present evidence of a sequential activation mechanism in the STIM1 cytosolic d

23 Kinetic analysis supports a sequential activation mechanism in which individual Btk

24 s two possible activation pathways (parallel-sequential activation model).

25 pled receptor signaling does not result from sequential activation of a linear pathway of proteins/en

26 ze target recognition and eradication by the sequential activation of a reconstituted immune system,

27 is is a cellular death process involving the sequential activation of a series of caspases, endonucle

28 t Rab along the pathway, can account for the sequential activation of a series of Rabs, but it does n

29 -dependent NF-kappaB activation involves the sequential activation of a serine kinase cascade involvi

30 erm-egg interaction causes egg activation by sequential activation of a Src-like kinase and phospholi

31 The sequential activation of a transient FPRL1 ligand and a

32 A) node is usually thought to arise from the sequential activation of a variety of ionic currents in

33 res the accumulation of arachidonic acid and sequential activation of acid sphingomyelinase for the g

34 ained, as in other hair-cell systems, by the sequential activation of alpha9/alpha10 and SK channels.

35 he PKA-I isozyme in primary T lymphocytes by sequential activation of an intracellular pathway compri

36 namics of Lgr5(+) stem cells and demonstrate sequential activation of an oncogene in established colo

37 Thus, a common toxicity of mutant SOD1 is a sequential activation of at least two caspases, caspase-

38 ry that orchestrates the innate response via sequential activation of both cell surface and endocytic

39 a pericentrin-dependent manner, and promotes sequential activation of both kinases via T-loop phospho

40 he conditions studied here, simultaneous and sequential activation of both the D and I pathways cause

41 me that EGF enhances expression of PAI-1 via sequential activation of c-Src, protein kinase C delta (

42 emma ("coupled" Ca(2+) sparks) revealing the sequential activation of Ca(2+) release sites of the j-S

43 iated store-operated Ca(2+) entry (SOCE) and sequential activation of Ca(2+)/calmodulin-dependent pro

44 en together, these results indicate that the sequential activation of caspase 3 and c-Jun participate

45 In this study, we investigated the sequential activation of caspase family members, to gain

46 of the death receptor family is promoted by sequential activation of caspase zymogens.

47 the IRF-1 promoter, induction of IRF-1, and sequential activation of caspase-1 and -3.

48 of transgenic mSOD1 mice is the site of the sequential activation of caspase-1 and caspase-3.

49 pase activation and kinetic studies show the sequential activation of caspase-8, caspase-9, and caspa

50 se in mitochondrial transmembrane potential, sequential activation of caspase-9 and -3, and a 90% dec

51 d that apoptosis in MCF-7 cells proceeds via sequential activation of caspases 9, 7 and 6.

52 Here we show the sequential activation of caspases and calpain during dru

53 optosis by thrombospondin-1 all required the sequential activation of CD36, p59fyn, caspase-3 like pr

54 llow stimulus-selective, temporally-extended sequential activation of cell assemblies.

55 er extravascular cells is exposed to plasma, sequential activation of coagulation proteases coordinat

56 Pharmacological studies determined that sequential activation of CXCR4, the IL-1beta receptor, a

57 m G(1) to S phase in the cell cycle requires sequential activation of cyclin-dependent kinase 4 (cdk4

58 asymmetrical strengths, which also explains sequential activation of different fates.

59 The sequential activation of distinct developmental gene net

60 From these results, we propose a sequential activation of DNA-PK and PARP-1 in cells arre

61 t greater Ca2+ influx, the delay between the sequential activation of eager sites was reduced.

62 novel signal transduction pathway involving sequential activation of Epac, PLCepsilon, PKCepsilon, a

63 The sequential activation of ERK and Rsk2 by Ca2+ leads to t

64 h which receptor-activated G(q) leads to the sequential activation of ERK1/2 and IRS2 signaling, thus

65 ible renal medullary gene expression wherein sequential activation of ERKs and Elk-1 results in incre

66 Peroxynitrite caused the sequential activation of extracellular signal-regulated

67 esolution microscopy techniques based on the sequential activation of fluorophores can achieve image

68 protein-coupled receptor (PAR1) leads to the sequential activation of G alpha(q), Rac, Rho, and PIP5K

69 y G(q/13)-coupled receptors are initiated by sequential activation of Galpha(q)/alpha13, RhoGEF, and

70 initiated by G(i)-coupled receptors involve sequential activation of Gbetagamma(i), PI 3-kinase, and

71 sters from 3'to 5', which contributes to the sequential activation of gene expression.

72 a complex developmental event requiring the sequential activation of genes encoding the component pa

73 thelium during pregnancy is characterized by sequential activation of genes over several orders of ma

74 We conclude that sequential activation of Gs and Gi, mediated by cAMP-dep

75 yocardium, the heartbeat originates from the sequential activation of ionic currents in pacemaker cel

76 According to a model of sequential activation of kinases, Syk acts downstream of

77 ed that CTGF production was mediated through sequential activation of MAPkinase and Smad-dependent pa

78 The sequential activation of master regulatory basic-helix-l

79 tream of, and that ALG-3 interferes with the sequential activation of members of the ICE family prote

80 ulated maturation process characterized by a sequential activation of Merkel cell-specific genes.

81 A two-step sequential activation of MT1-MMP is likely to include th

82 wn as central pattern generators produce the sequential activation of muscles needed for locomotion.

83 c triggers microglial activation through the sequential activation of NADPH oxidase, PARP-1, and NF-k

84 The sequential activation of neurons has been observed in va

85 Sequential activation of neurons is a common feature of

86 This would allow sequential activation of neutrophil degranulation in the

87 xes are essential initiators of arthritis by sequential activation of neutrophils and mast cells to a

88 Sequential activation of NF-kappaB and an increased Gata

89 estration of an immune cascade involving the sequential activation of NK cells, cDCs, and CD8(+) T ce

90 nsient subsecond firing responses in CINs by sequential activation of NMDA, D2-type, and D1-type rece

91 and postsynaptic spikes instead requires the sequential activation of NMDARs followed by voltage-sens

92 depend on an increase in cytosolic Ca2+ and sequential activation of NOX5-S and NF-kappaB in SEG1 ce

93 Breathing, for example, involves the sequential activation of numerous muscles hypothesized t

94 type of pancreatic malignancy, involves the sequential activation of oncogenes and inactivation of t

95 an indomethacin-sensitive pathway involving sequential activation of phospholipase C, mobilization o

96 ression and cell proliferation may depend on sequential activation of PI-PLCgamma2 and ERK2 MAP kinas

97 ing from Ras to Tsp-1 repression induces the sequential activation of PI3 kinase, Rho and ROCK, leadi

98 novel platelet activation pathway involving sequential activation of PI3K, Akt, nitric-oxide synthas

99 betaPMA exerts its effects on HCN gating via sequential activation of PKC and diacylglycerol kinase (

100 ulate cPLA2-mediated AA release only through sequential activation of PKC and MAP kinase.

101 iments provided additional evidence that the sequential activation of PKCepsilon, mitogen-activated p

102 Sequential activation of place cells was not required fo

103 ts recapitulated apoptotic events, including sequential activation of procaspase-9 and procaspase-3 a

104 orage proteins in the MVBs may allow for the sequential activation of processing proteases as the MVB

105 n wavelengths (365, 405, and 760 nm) for the sequential activation of protein function in live cells.

106 nts of signal transduction cascades in which sequential activation of protein kinases culminates in t

107 ar tyrosine kinase cascade that involves the sequential activation of PYK2 and Src.

108 motes tumor metastasis in prostate cancer by sequential activation of Pyk2, FAK, MAPK, and Akt follow

109 The addition of agrin induces the sequential activation of Rac and Rho in C2 muscle cells.

110 t the CB1R, through G alpha(o), mediates the sequential activation of Rap1 to Ral to Src to Stat3 in

111 in complex including Shc, Grb2, and Sos, and sequential activation of Ras, Raf, and MEK.

112 vior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian stero

113 actin cytoskeleton are closely linked to the sequential activation of Rho GTPases through PI 3-kinase

114 This analysis reveals how sequential activation of sets of transcription factors s

115 Inflammation involves the sequential activation of signaling pathways leading to t

116 programmed cell death in many cells involves sequential activation of specific caspases, we tested th

117 Skeletal development is programmed by the sequential activation of specific genetic pathways that

118 king of GPVI mediates activation through the sequential activation of Src and Syk family kinases and

119 at platelet spreading on fibrinogen requires sequential activation of Src and Syk in proximity to alp

120 n matrix assembly through the uPAR-dependent sequential activation of Src kinase, EGFR, and beta1 int

121 Sequential activation of Src, mitogen-activated protein

122 ditional inhibitor studies revealed that the sequential activation of Src, p38 MAPK, EGFR, and p38 MA

123 esults in JNK activation, which requires the sequential activation of Src, Rac1, and JNK.

124 Therefore, nonoverlapping, sequential activation of STAT3 and STAT5, achievable by

125 osensory evoked potential primarily reflects sequential activation of supragranular and infragranular

126 e for discrete medullary pathways subserving sequential activation of swallowing reflexes.

127 Thus, sequential activation of synaptic then extrasynaptic NMD

128 oth muscle following vagotomy is mediated by sequential activation of tachykinin-containing spinal af

129 Cortical current densities revealed the sequential activation of temporal regions, from the occi

130 The salient feature of the strategy involves sequential activation of terminal and internal alkynes l

131 GF in the parietal cells are mediated by the sequential activation of the Akt and the Shh signal tran

132 case of the soft selenium Lewis acid PhSeCl, sequential activation of the alkyne bonds leads initiall

133 itor MAD2L2 also contributes to ensuring the sequential activation of the APC/C by CDC20 and CDH1.

134 We have previously demonstrated that sequential activation of the bacterial ilvIH-leuO-leuABC

135 These signals cause the selective, sequential activation of the calcium-dependent, proline-

136 , interestingly, dependent on the apparently sequential activation of the dantrolene-sensitive, nonre

137 pe 1 TNF-alpha receptor tail, leading to the sequential activation of the downstream NF-kappaB-induci

138 beta-cell proliferation and survival through sequential activation of the epidermal growth factor rec

139 Activation of Ras, in turn, leads to sequential activation of the following three serine-thre

140 on of the catalytic domain of the kinase and sequential activation of the MAPK-activated protein kina

141 We found that interfering with the sequential activation of the microtubule assembly pathwa

142 Both ATM and DNA-PK promote sequential activation of the mitogen-activated protein k

143 own to be activated by mIgM, consists of the sequential activation of the mitogen-activated protein k

144 h human H2009 lung cancer cells demonstrated sequential activation of the nanoparticles inside endocy

145 etion of ATP by infected macrophages and the sequential activation of the P2X7 purinergic receptor an

146 hat cadmium induces ho-1 gene expression via sequential activation of the p38 kinase pathway and Nrf2

147 GF-1, can regulate RUNX2 DNA binding through sequential activation of the PI3K/Pak1 and ERK1/2 signal

148 This rapid sequential activation of the relevant and irrelevant fea

149 nd this process required an MT1-MMP-mediated sequential activation of the Src and JAK/STAT pathways.

150 antigen receptor (TCR) engagement results in sequential activation of the Src protein tyrosine kinase

151 we show that sonic hedgehog (SHH)-dependent sequential activation of the transcription factors OLIG2

152 l of Fc epsilon RI engagement leading to the sequential activation of the tyrosine kinases Lyn and th

153 port the hypothesis that there is three-step sequential activation of the vir regulon.

154 g of intracellular calcium dynamics revealed sequential activation of these ensembles after ETH actio

155 The sequential activation of these global regulators is also

156 To test whether the sequential activation of these microtubule assembly path

157 se activation was dependent on Syk, and that sequential activation of these molecules was required fo

158 Taken together, these data suggest that the sequential activation of these two quorum-sensing system

159 Such a 'switchable' GEF could ensure sequential activation of these Ypts, thereby coordinatin

160 We propose a model where the sequential activation of TLRs tailors the immune respons

161 generated in macrophages as a consequence of sequential activation of toll-like receptor 4 (TLR4), a

162 CSN activity during performance revealed the sequential activation of topographically ordered functio

163 these studies provide an example of how the sequential activation of transcription factors can deter

164 N-type ICa,V by bradykinin (BK) requires the sequential activation of two G-proteins, heterotrimeric

165 tion of foreign targets by antibodies drives sequential activation of two serine proteases, C1r and C

166 It signals through the sequential activation of two serine/threonine kinase rec

167 irus (EBV) infection of B cells leads to the sequential activation of two viral promoters, Wp and Cp,

168 nsforming infection are characterized by the sequential activation of two viral promoters, Wp and Cp,

169 Most action potentials are produced by the sequential activation of voltage-gated sodium (Nav) and

170 synergies could be readily reconstructed as sequential activations of spatial synergies (a subset of

171 aling involves PIP(3) generation through the sequential activations of the p110 PI3-kinases and IPMK.

172 mation, such as object distance, it is their sequential activation over longer timescales that track

173 Skeletal myogenesis involves sequential activation, proliferation, self-renewal/diffe

174 Sequential activation with the cytokines IFN-gamma and e