ライフサイエンスコーパス: sequestosome

1 agy-regulatory proteins LC3 (LC3-II) and p62/Sequestosome.

2 show that deficiency of either autophagy or sequestosome 1 (p62 or SQSTM) led to inflammasome hypera

3 nscription factor resulting from accumulated sequestosome 1 (SQSTM1 or p62) in Atg7(-)/(-) macrophage

4 A subset of cDNAs, encoding sequestosome 1 (SQSTM1) and dipeptidylpeptidase 3 (DPP3)

5 ochondrial association of autophagosomal p62/sequestosome 1 (SQSTM1) and processed microtubule-associ

6 The selective autophagy receptor p62/sequestosome 1 (SQSTM1) interacts directly with LC3 and

7 anonical ubiquitin-like autophagy receptors [sequestosome 1 (SQSTM1), microtubule-associated protein

8 umorigenesis, genetic down-regulation of p62/sequestosome 1 (SQSTM1), the autophagy substrate that ac

9 The most important of these is Sequestosome 1 (SQSTM1), which is a scaffold protein in

10 Sequestosome 1 (SQSTM1)/p62 is an interacting partner of

11 Two markers of autophagy, sequestosome 1 (SQSTM1/p62) and microtubule-associated p

12 The gene encoding sequestosome 1 (SQSTM1/p62) maps to within the PDB3 crit

13 FHOD3 also prevents its interaction with p62/sequestosome 1 and its recruitment to autophagosomes.

14 er autophagy-mediated down-regulation of p62/sequestosome 1 contributes to its pro-survival role, we

15 p62/sequestosome 1 is a multifunctional protein and a signal

16 p62/Sequestosome 1 is a scaffold protein involved in the reg

17 d protein-1 light chain beta II (LC3II), and sequestosome 1(SQSTM1), in a membrane-enriched fraction,

18 Mutations in the p62 (sequestosome 1) gene occur in one-third of patients with

19 d phosphorylated the autophagic adaptor p62 (sequestosome 1) on Ser-403, a residue essential for its

20 he levels of the autophagy-cargo protein p62/sequestosome 1, and the lipidated form of microtubule-as

21 e of the autophagic degradation pathway, p62/sequestosome 1.

22 (SMIR) that we identified previously in p62/sequestosome 1.

23 ulation of the ubiquitin-binding protein p62/sequestosome 1.

24 Sequestosome 1/p62 (p62) is a scaffold/adaptor protein w

25 athways and enhances the interaction between sequestosome 1/p62 and caspase-8, which leads to the agg

26 that increased levels of the adaptor protein Sequestosome 1/p62 are observed in human breast cancers

27 hat the ubiquitin-associated (UBA) domain of sequestosome 1/p62 displays a preference for binding K63

28 tudies have shown that deletion of the mouse sequestosome 1/p62 gene results in mature-onset obesity

29 at the SH(2) domain at the amino terminus of sequestosome 1/p62 interacts with IRS-1 upon insulin sti

30 Sequestosome 1/p62 is a scaffolding protein with several

31 Sequestosome 1/p62 is involved in receptor-mediated sign

32 Autophagic adaptors referred to as SLRs (sequestosome 1/p62-like receptors) are themselves a cate

33 SQSTM1 (sequestosome 1; also known as p62) encodes a multidomain

34 The scaffold protein p62 (sequestosome 1; SQSTM1) is an emerging key molecular lin

35 Sequestosome-1 (p62), an adapter protein that has no int

36 idate mitophagy receptors optineurin (OPTN), sequestosome-1 (p62), and nuclear dot protein 52 (NDP52)

37 p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor pro

38 ress but dependent on the autophagic protein sequestosome-1 (SQSTM1), which was involved in the degra

39 with the multifunctional scaffolding protein sequestosome-1 (SQSTM1/p62) confirmed autophagy.

40 ress but dependent on the autophagic protein sequestosome-1 (SQSTM1; p62).

41 e otherwise unrelated Ub-binding protein p62/Sequestosome-1 have been shown to be sequestered into ag

42 ition, rifampicin decreased the level of p62/sequestosome-1 in the brain without affecting the increa

43 mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and ty

44 The ubiquitin-binding protein p62/sequestosome-1 promoted aggregation of CUL3-modified cas

45 the interaction surface for the adaptor p62/Sequestosome-1, which is required for IL-1 signaling to

46 ha associates with another IFN-induced gene, sequestosome-1/p62 (p62).

47 embly of polyubiquinated proteins sorting to sequestosomes and proteasomes.

48 including optineurin (OPTN) and p62 (SQSTM1/sequestosome), both of which have also been implicated i

49 such fusion proteins, SET-Nup214 and SQSTM1 (sequestosome)-Nup214, both containing C-terminal portion

50 of TRAF6 was apparently mediated by the p62 sequestosome protein, which is a factor important for se

51 ved proteins (SLiPs) into autophagosomes via sequestosome (SQSTM1, p62) mediated association of ubiqu

52 associated proteins, Map1-LC3 (LC3), and p62/sequestosome, which localize to RVs.