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1 rocytes enhanced production and release of d-serine.
2 ric disease through abnormal production of D-serine.
3 so far, been mainly limited to cysteine and serine.
4 ding induced by the replacement of H375 by a serine.
5 n two CRF01_AE Envs (CM244 and 92TH023) by a serine.
6 which was rescued by adding extracellular D-serine.
7 that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2alpha a
8 ylation of histone H4 antagonizes histone H4 serine 1 phosphorylation (H4S1ph), and that downregulati
9 )-catalyzed phosphorylation of histone H3 at serine 10 or 28 and expression of immediate-early (IE) g
11 included previously described sites such as serine 116 and newly found sites such as serine 2652 thr
13 KII-mediated phosphorylation level of GluN2B serine 1303 (S1303) in the PVN, but not in the hippocamp
16 imerization of TRPC6 are not altered, making serine 14 phosphorylation a potential drug target to int
18 pendent kinases (CDKs) phosphorylate PAH1 at serine 162, which reduces both its activity and membrane
20 ently, additional phosphorylation of ZBP1 at serine 181 (Ser181) was described in non-neuronal cells.
22 n-regulated TMPRSS2 (transmembrane protease, serine 2) gene to the open reading frame of ERG, encodin
23 ce of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with the erythroblast transform
27 s spectrometry identified phosphorylation on Serine 269 in Su(H), potentially serving as a point of c
28 that, after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation
30 DNA replication, but specifically blocks the serine 345 phosphorylation of the DNA damage checkpoint
31 of p66Shc facilitates its phosphorylation on serine 36 and translocation to the mitochondria, where i
33 residues such as histidine or tryptophan for serine 375 (S375H/W) in the gp120 Phe 43 cavity, where P
35 phagy is inhibited, p53 is phosphorylated at serine-392 by PINK1, a kinase associated with mitophagy,
36 ro Specifically, Neto2 was phosphorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent prot
37 und CK1 catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD
44 phorylation of serine 65 in parkin's UBL and serine 65 of ubiquitin fully activate ubiquitin ligase a
46 lation of the AMPA GluA1 receptor subunit at serine 831 (S831), a CaMKII site, along with an increase
47 roliferator-activated receptor gamma through serine 84 phosphorylation and promoting activator protei
48 K1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction a
49 ically, NEM increased the phosphorylation of serine 940 (Ser-940), whereas it decreased phosphorylati
53 h 8/4 or 9/3 structures efficiently inserted serine, alanine and cysteine in response to stop and sen
54 In contrast, miropin uniquely blocked many serine and cysteine endopeptidases of disparate architec
57 ed survival following dietary restriction of serine and glycine in these models was further improved
58 nd their phages employ the 8/4 structure for serine and histidine tRNAs, while minor cysteine and sel
59 be particularly relevant in the PFC, where D-serine and its converting enzyme are highly expressed.
61 found that Alr2 could interconvert l- and d-serine and that Alr2 bound to l- and d-serine with appro
62 nserved canonical extensin repeat, Ser-Hyp4, serine and the consecutive C4-hydroxyprolines (Hyps) are
63 we report the mass spectrometry analysis of serine and threonine pyrophosphorylation, a protein modi
66 oting ER retention, while mutation of target serines and drug inhibition of GSK-3 activity coordinate
69 mary uptake pathways, glucose, glutamine and serine, are each characterized by three features: (1) me
72 sible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm
75 nal inputs and reveal a potential role for d-serine as an endogenous modulator of circuit refinement.
76 olecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve ke
77 gn and characterization of expanded-spectrum serine beta-lactamase inhibitors that potently inhibit c
78 c acid and avibactam are clinically deployed serine beta-lactamase inhibitors, important as a defence
79 ycolysis, the pentose phosphate pathway, and serine biosynthesis seems to be spatially regulated by t
81 ns and differs from PRDM9a by an arginine-to-serine change (R764S) in ZF9 and by replacement of ZF11
82 ly, GRIP1 is phosphorylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), whic
86 r that has properties that set it apart from serine complexes of different sizes or from complexes co
87 the four major protease mechanistic classes-serine, cysteine, aspartyl, and metallo-proteases-and de
89 of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the ne
93 arbouring a substitution of leucine 150 to a serine fully rescued pmr1 Mn-sensitivity at all concentr
95 rform significant amount of respiration, use serine-glycine cycle and produce ethanol in mitochondria
96 served that reversion of amino acid 375 to a serine (H375S) resulted in a loss of functionality of bo
98 vity-dependent proximity ligation (ADPL), to serine hydrolase and cysteine protease enzymes enables q
104 s applied to pooled plasma samples to enrich serine hydrolases using a fluorophosphonate (FP2) activi
106 etrahydrofolate dehydrogenase 1 (MTHFD1) and serine hydroxymethyltransferase (SHMT) generate 5,10-met
107 opyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to impr
110 find that HAstV-2 capsid spike containing a serine in this loop is immunogenic and elicits antibodie
111 rylatable slr1-6SA-GFP protein, in which six serines in SR/RS clusters are substituted with alanines,
114 HIV-1 particles and suggest that channeling serine into lipid biosynthesis may not be a cardinal cel
116 gulating seven of those polar metabolites (L-serine, L-leucine, glucose, fructose, myo-inositol, citr
117 diffusible molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoseri
118 n their premature responding and glycine and serine levels in vmPFC during the performance of the sta
119 injury, hippocampal neurons downregulated d-serine levels, while astrocytes enhanced production and
122 Two PSMA-I&T-derived inhibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moieti
123 hibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moieties were evaluated in para
124 e important implications for understanding D-serine-mediated N-methyl-D-aspartate receptor plasticity
126 or of l-serine over the normally preferred l-serine-O-sulfate ( approximately 1200-fold change in kca
132 it composition after activation by glycine/D-serine or glutamate and hence presents the first plate-b
133 ate can be influenced by the introduction of serine or threonine at sequence position 69 (Eos notatio
136 mination substrate specificity in favor of l-serine over the normally preferred l-serine-O-sulfate (
138 n orthologue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic
139 n, isolation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the fi
140 as evolutionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomo
142 umour cells reduces flow through the PPP and serine pathways, thereby depleting the antioxidants NADP
144 nts 912 References 912 Subtilases (SBTs) are serine peptidases that are found in all three domains of
147 analysis, Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not l
150 rowth in the presence of the chemoattractant serine, pointing to a physiological relevance of the obs
151 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) 3:1 mol/mole and at neutral pH, the peptid
155 A canonical model entails a C1r2s2 with its serine protease domains tightly packed together in the c
158 i2A) was studied in mouse TH2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 gen
159 at alpha-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT
160 otease TMPRSS2, but Zhou et al. found that a serine protease inhibitor was more protective than a cat
161 ng pathway and alpha1-antitrypsin protein (a serine protease inhibitor) expression and downregulation
162 The variant is located in the gene encoding serine protease inhibitor, low levels of which are assoc
164 pider Cupiennius salei The chymotrypsin-like serine protease is a 28-kDa heterodimer with optimum act
165 t addition of subtilisin (50 nm to 2 mum), a serine protease secreted by the non-pathogenic bacterium
166 ontrolling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles.
167 than on the cell surface acid pH-independent serine protease TMPRSS2, but Zhou et al. found that a se
168 Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in ac
170 king mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1) and MASP-3 contain zymogenic
171 ative C3 by mannan-binding lectin-associated serine protease-2 bound to LP-activation complexes captu
173 ne defenders against infection, express four serine proteases (NSPs) that play roles in the control o
182 We recently identified the StmPr1 and StmPr2 serine proteases to be the substrates of the Xps type II
183 ma kallikrein-kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (F
186 demonstrated that the type II transmembrane serine proteinase (TTSP) matriptase acts as a novel init
188 kinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-typ
190 Transforming growth factor-beta (TGF-beta), serine proteinases such as trypsin, and proteinase-activ
194 ession quantitative trait locus of the human serine racemase (SRR) gene, was associated with fear-rel
195 the astrocytic d-serine-synthesizing enzyme serine racemase after CCI injury improved synaptic plast
196 O-Lys(114) hydrogen-bonding network in human serine racemase lowers the pKa of the Ser(84)re-face bas
197 T-based FLIM approach, we demonstrate that D-serine rapidly induces a conformational change of the Gl
198 ask-related recruitment of vmPFC glycine and serine release, and the loss of an inverse relationship
201 sulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in th
202 ceptor substrate 1 (IRS-1) phosphorylated at serine residue 312 was more apparent in inclusion bearin
204 sidue plays a role in activating an adjacent serine residue carrying out nucleophilic attack, opening
205 y ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allow
206 d ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signatur
207 osphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser-883 in Xe
209 in activation, we demonstrated a key role of serine residue S1163 of the alphaE chain intracellular d
210 sphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress respo
214 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubi
216 fy HDAC1 and the phosphorylation of specific serine residues in the molecule as potential targets for
217 s studies have shown that phosphorylation of serine residues on synaptic proteins is a major regulato
218 cultured cells, phosphorylation of specific serine residues within the cluster is also required for
221 ation; each contains a transmembrane domain, serine rich region and a conserved cytoplasmic domain.
224 tants by mutating known conserved regulatory serine (S) residues 255, 279/282, 365, 368, and 373 loca
226 naling cascade leading to phosphorylation of serine S845 on GluA1 AMPA receptors and their traffickin
228 ect on hD4R levels is noted when cytoplasmic serine (Ser) and threonine (Thr) residues are mutated.
229 -2 reactions is necessary and sufficient for serine-specific ADPr of histones and PARP-1 itself.
230 eration in exon 3, which causes a leucine to serine substitution at codon 102 (Human Genome Variation
231 F-1 also mediates increased flux through the serine synthesis pathway and mitochondrial one-carbon (f
233 While some cancer cells upregulate de novo serine synthesis, many others rely on exogenous serine f
234 yte-specific elimination of the astrocytic d-serine-synthesizing enzyme serine racemase after CCI inj
237 lar kinases that phosphorylate extracellular serine, threonine, and tyrosine residues of numerous pro
238 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all fou
239 n of each individual complex, stabilizes the serine-threonine protein kinase PINK1 on the mitochondri
240 n using a few representative cancer-relevant serine/threonine and tyrosine kinases and their interpla
241 gene transcription are profoundly shaped by serine/threonine and tyrosine signaling kinases and comp
242 recruitment of ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where
243 ate-activated protein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as
245 vitro and in vivo by microtubule-associated serine/threonine kinase 3 (MAST3 kinase), an enzyme of p
248 expression of general control nonrepressed 2 serine/threonine kinase and increased expression of mamm
249 Expression of general control nonrepressed 2 serine/threonine kinase and mammalian target of rapamyci
251 tral element within the RAS/ERK pathway, the serine/threonine kinase BRAF plays a key role in develop
256 acting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development an
257 protein of the MTOR complex 1 (RAPTOR), the serine/threonine kinase V-Akt murine thymoma viral oncog
258 teracting protein kinase (HIPK) 2, a nuclear serine/threonine kinase, activates CREB through Ser271 p
260 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in proliferating myoblasts.
262 extracellular penicillin-binding-protein and serine/threonine kinase-associated (PASTA) domains which
263 of bacterial Penicillin-binding-protein And Serine/Threonine kinase-Associated (PASTA) kinases is of
265 mprise an evolutionarily conserved family of serine/threonine kinases involved in mitosis and meiosis
267 e (smMLCK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal assoc
268 L-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in ini
272 Surprisingly, this structure revealed a serine/threonine phosphatase fold that unexpectedly targ
273 Protein phosphatase-2A (PP2A) is an abundant serine/threonine phosphatase with anti-inflammatory acti
274 nd phosphatases modulate GPCR signaling, how serine/threonine phosphatases integrate with G protein s
276 ound that knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1) increased both
279 ological inhibition of either IKKbeta or the serine/threonine protein kinase TAK1 in monocytes blocke
281 e PKM isoforms in A549 cells lacking LKB1, a serine/threonine protein kinase upstream of AMPK, failed
282 thioredoxin-fold-containing eukaryotic-like serine/threonine protein kinase, is a virulence factor i
283 rectly with the scaffolding A subunit of the serine/threonine protein phosphatase, PP2A, and that pho
284 report that a poxvirus kinase phosphorylates serine/threonine residues in the human small ribosomal s
285 the O-linkage of beta-N-acetylglucosamine to serine/threonine residues of membrane, cytosolic, and nu
287 f PTPN12 by CDK2 impaired recruitment of the serine/threonine-protein kinase 1 (PAK1) to HER2, result
288 daptor proteins such as receptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-inte
289 otein kinase 1 (RIPK1), receptor-interacting serine/threonine-protein kinase 3 (RIPK3), TIR-domain-co
290 estigated the functions of the Hippo pathway serine/threonine-protein kinases Lats1 and Lats2, which
292 e in a loop within the PL-2 epitope due to a serine-to-proline mutation, locking the loop in a confor
293 ephalopathy and that their potentiation by D-serine treatment may underlie the associated clinical im
294 Notably, the naturally occurring coagonist D-serine was able to attenuate hypofunction of GluN2B(p.P5
297 ation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the neuron
298 and d-serine and that Alr2 bound to l- and d-serine with approximately 2-fold weaker affinity to that
299 s, mutation of four previously characterized serines within the Kv3.4 N-terminal inactivation domain
300 through a conserved four amino acid motif, (serine-X-isoleucine-proline) which exists within an intr
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