ライフサイエンスコーパス: serine kinase

1 otein associates with an IFN-alpha-regulated serine kinase.

2 arly cloned one of its subunits, IKKalpha, a serine kinase.

3 st that MA is a target of the Nef-associated serine kinase.

4 ol of an interleukin-2 (IL2)-activated Stat5 serine kinase.

5 ls with IFN-alpha activates the PI 3'-kinase serine kinase.

6 K was molecularly cloned and identified as a serine kinase.

7 protein kinase, suggesting a potential novel serine kinase.

8 ly by activating a distinct IGFBP-5 receptor serine kinase.

9 d that EhC2PK is an unusual Mn(2+)-dependent serine kinase.

10 perfamily, signal via type II and I receptor serine kinases.

11 e II (ActRII/IIB) and type I (ALK4) receptor serine kinases.

12 ivation of resident nuclear proteins through serine kinases.

13 identification of the substrates of specific serine kinases.

14 nase may be related to other Golgi-localized serine kinases.

15 eromeric complexes of transmembrane receptor serine kinases (1, 2).

16 tissue of the translation initiation factor serine-kinase-6-1, which is known to mediate amino acid-

17 Two previously characterized serine kinases activated by IL-2, MAP kinase/ERK2 and p7

18 nes similar to those induced by the receptor serine kinase, activin receptor-like kinase (ALK)-2.

19 specificity enzyme possessing both lipid and serine kinase activities.

20 ivity, with a lesser amount of threonine and serine kinase activities.

21 er, these data strongly suggest that unknown serine kinase activity and Ser(789) phosphorylation of I

22 We conclude that the serine kinase activity associated with the insulin recep

23 ansmembrane receptors with intrinsic protein serine kinase activity bind ligand in the extracellular

24 ossesses intrinsic, Mn(2+)-dependent protein serine kinase activity capable of phosphorylating the 85

25 how that in addition to its previously known serine kinase activity directed toward the RsbS antagoni

26 of insulin proreceptors revealed associated serine kinase activity early in receptor synthesis.

27 he cytoplasmic domain, affinity precipitated serine kinase activity from BJAB cell extracts.

28 in-resistant rodent models, that an enhanced serine kinase activity in liver is associated with insul

29 resistant rodent models, indicating enhanced serine kinase activity in vivo.

30 It was recently reported that the serine kinase activity of Cdk9 not only targets RNA poly

31 osphorylatable and BtrW mutants defective in serine kinase activity or the ability to bind BtrV were

32 In contrast, P3 was phosphorylated by the serine kinase activity prepared from all insulin-resista

33 The current study investigated serine kinase activity toward IRS-1 in several models of

34 on, we found that ACK1 possesses significant serine kinase activity toward WASP (directed at Ser-242)

35 Elevated serine kinase activity was detected in Chinese hamster o

36 e tested the possibility that the associated serine kinase activity was intrinsic to the receptor cat

37 eviously reported the tight association of a serine kinase activity with the human insulin receptor.

38 ACK1 expressed in bacteria retained its serine kinase activity, eliminating the possibility of c

39 ure medium caused a dramatic increase in Bcr serine kinase activity, yielding predominantly phosphose

40 vitro was used as an index of the associated serine kinase activity.

41 d to be an in vitro substrate of the PIKfyve serine kinase activity.

42 f phosphorylation depending on the source of serine kinase activity.

43 Activins bind specific type II receptor serine kinases (ActRII or IIB) to promote the recruitmen

44 educed the insulin-induced activation of the serine kinase Akt by up to 49%; these activities were re

45 ly active ALK-2 but not the related receptor serine kinase, ALK-4.

46 t and phosphorylation of the type I receptor serine kinase, ALK4, which then regulates gene expressio

47 eta, or mu, or by any of several other known serine kinases, although PKC has an indirect role in pro

48 domains with putative enzymatic activities (serine kinase and serine phosphatase).

49 sm appears similar to that of the eukaryotic serine kinases and ATPases.

50 uanylate kinase calcium/calmodulin-dependent serine kinase, and to Hrs, an endosomal ATPase that regu

51 ne phosphorylation, activation of downstream serine kinases, and glucose uptake.

52 e serine phosphatase domain, BtrW contains a serine kinase/anti-sigma factor motif, and BtrV includes

53 HDACs in B lymphocytes and suggest that PKD serine kinases are a critical link between the BCR and e

54 gulated protein kinase (ERK1/2), and protein-serine kinase B alpha (Akt), at early times after WNV in

55 ositol 3-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subseq

56 cella-zoster virus (VZV) codes for a protein serine kinase called ORF47; the herpes simplex virus (HS

57 ein kinase (PKA), but not a variety of other serine kinases, can specifically phosphorylate LPL and L

58 and may involve fat-induced activation of a serine kinase cascade involving IKK-beta.

59 tion involves the sequential activation of a serine kinase cascade involving phosphatidylinositol 3-k

60 re with insulin signaling by activation of a serine kinase cascade involving PKCtheta in skeletal mus

61 olites inside skeletal muscle may activate a serine kinase cascade involving protein kinase C-theta (

62 ipid accumulation, which in turn activates a serine kinase cascade that leads to defects in insulin s

63 Here we describe a serine kinase, casein kinase I (CKI), which was isolated

64 th ARF can be restored by treatment with the serine kinase, casein kinase II.

65 ntibodies to Lck and to the cyclin-dependent serine kinase, Cdc2, as well as the cyclin-dependent kin

66 , were identified as closely related protein serine kinases containing leucine zipper and helix-loop-

67 eporter gene in COS-7 cells, suggesting that serine kinase control of Stat5 activity differs from tha

68 this viral protein interacts with a cellular serine kinase, designated Nef-associated kinase.

69 ceiver (REC) domain flanked by an N-terminal serine kinase domain and a C-terminal serine phosphatase

70 S6K1 (p70S6K) is a serine kinase downstream from Akt in the insulin signali

71 lation of the extracellular-signal-regulated serine kinase ERK, which was restored following expressi

72 ATA also mimicked PRL activation of serine kinases ERK1 and ERK2.

73 line, causing rapid hyperphosphorylation of serine kinases ERK1/2 and AKT and enhanced cytolysis of

74 mber of the phospholipid-dependent threonine/serine kinase family, is an endogenous photosensitizer,

75 dings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the

76 Degenerate oligonucleotides to consensus serine kinase functional domains previously identified a

77 No recombinant alphaherpesvirus serine kinase has been biologically active in vitro.

78 The RsbT serine kinase has two known functions in the signal tran

79 r associated factors, two recently described serine kinases, I kappa B kinase (IKK) alpha and IKK bet

80 The core IKK consists of two catalytic serine kinases, IKKalpha and IKKbeta, and a noncatalytic

81 cated fatty acid-dependent activation of the serine kinase IKKbeta, which plays a key role in tissue

82 ystal form of Sky1p, a constitutively active serine kinase implicated in yeast RNA processing, each i

83 The STAT serine kinase in CLL cells has not been identified, and

84 ities of GTP hydrolase and protein threonine/serine kinase in separate domains.

85 if for AMP-activated protein kinase, but the serine kinase in the insulin-resistant animals was shown

86 stimulates RsbS phosphorylation by the RsbT serine kinase in vitro.

87 criptional activity of STAT5 is regulated by serine kinases in T lymphocytes.

88 Furthermore, other serine kinases including Akt, extracellular regulated ki

89 beta (IKKbeta), but the activities of other serine kinases including p38, ERK2, and JNK1 are not aff

90 1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Rib

91 serum, and the stabilizing effect of general serine kinase inhibition implied that ER mannosidase I i

92 The serine kinase inhibitor H7 augmented the increase of STA

93 tor of p38 activation, whereas the MAPKAPK-2 serine kinase is a downstream effector for the RA-activa

94 , these data establish that the PI 3'-kinase serine kinase is activated by IFN-alpha and may play an

95 established that the IL2-activated Stat5a/b serine kinase is insensitive to several selective inhibi

96 tral resistin promotes the activation of the serine kinases Jun NH(2)-terminal kinase and p38 mitogen

97 n suggested to trigger activation of several serine kinases, leading to a serine phosphorylation of I

98 activation and that this is regulated by the serine kinase LIM kinase (LIMK) and the novel phosphatas

99 ase D (PKD) is an antigen receptor-activated serine kinase localized at either the plasma membrane or

100 thus suggesting that a yet-to-be-identified serine kinase mediates Stat5a/b activation.

101 nstrated that Nef associates with a cellular serine kinase (NAK) activity.

102 is associated with activation of diverse AGC serine kinases (named after family members protein kinas

103 t with a regulatory role of the PI 3'-kinase serine kinase on the phosphorylation of the protein.

104 ML-specific BCR-ABL oncogene, but not by the serine kinase oncogene v-MOS.

105 , proteasomal degradation, and potentially a serine kinase other than glycogen synthase kinase-3beta

106 aracterization of antigen receptor-activated serine kinase pathways in lymphocytes.

107 yase (phosphorylating), EC 4.1.1.31] protein-serine kinase (PEPC-PK) phosphorylates serine-15 of its

108 es the links between the GTPase RhoA and the serine kinase protein kinase D (PKD) during thymocyte de

109 The serine kinase protein kinase D (PKD) has a cysteine-rich

110 rted association of Nef with an unidentified serine kinase provides a clue as to how Nef might exert

111 unique concept that 5-HT transactivates the serine kinase receptor, BMPR 1A, to activate Smads 1/5/8

112 erized its ability to transduce signals from serine kinase receptors.

113 late the P3 peptide, suggesting that another serine kinase regulates this modification of IRS-1 in in

114 The enhanced serine kinase specifically phosphorylates the conserved

115 circuit involving the anti-sigma factor and serine kinase SpoIIAB, and the anti-anti-sigma SpoIIAA.

116 onist protein (S or V), and a switch protein/serine kinase (T or W).

117 SDK1 is clearly distinct from other types of serine kinases tested, including casein kinase II, the a

118 Thus, HipA is a serine kinase that is at least partially phosphorylated

119 Protein kinase D (PKD) is a protein serine kinase that is directly stimulated in vitro by ph

120 substrate, we identified a cytosolic protein-serine kinase that is rapidly and transiently stimulated

121 TGF-beta signals through a receptor serine kinase that phosphorylates and activates the tran

122 nd negatively regulates sigmaF, as well as a serine kinase that phosphorylates and inactivates the an

123 It activates a receptor threonine/serine kinase that phosphorylates the transcription fact

124 ptional activity, but the IFNalpha-dependent serine kinase that regulates such phosphorylation remain

125 t purified recombinant TAFII250 is a protein serine kinase that selectively phosphotylates RAP74 but

126 ransduction pathway and establishes PKD as a serine kinase that temporally and spatially disseminates

127 A number of serine kinases that phosphorylate serine residues of IRS

128 ta signals through its cell surface receptor serine kinases that phosphorylate Smad2 or Smad3 protein

129 xpression, and p38 mitogen-activated protein serine kinase was necessary for LTA-induced NO productio

130 n, paxillin and protein kinase C (PKC) mu, a serine kinase, were co-immunoprecipitated as a complex f

131 togenic GPCR agonists and positions PKD as a serine kinase whose kinase activity and intracellular lo

132 Protein kinase D (PKD) is a serine kinase whose myocardial substrates are unknown.

133 SDK1 is a serine kinase with molecular mass 50-60 kDa that is stro

134 ical manifestations, including activation of serine kinases with proteolytic activity for parotid sec

135 tains the genes encoding CSBP, p21, HSU09564 serine kinase, ZNF76, TCP-11, RPS10, HMGI(Y), BAK, and t