コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 pe that was corrected by transformation with serine palmitoyltransferase.
2 hesis of complex sphingolipids downstream of serine palmitoyltransferase.
3 imiting enzyme in sphingolipid biosynthesis, serine palmitoyltransferase.
4 but unlike myriocin FTY720 does not inhibit serine palmitoyltransferase.
5 the activities of both ceramide synthase and serine palmitoyltransferase.
6 s and knockdowns affecting either subunit of serine palmitoyltransferase, a key enzyme in ceramide an
8 ntial substrate specificity of virus-encoded serine palmitoyltransferase, a key enzyme of sphingolipi
9 sphingolipids, apparently via modulation of serine palmitoyltransferase, a rate-limiting enzyme in d
10 were protected from diet-induced increase in serine palmitoyltransferase, acid sphingomyelinase, and
11 tion that associates with increased monocyte serine palmitoyltransferase activity and chemotaxis towa
12 These mutations are dominant and decrease serine palmitoyltransferase activity by 50% when the wil
20 n, isolation, and analyses of the Toxoplasma serine palmitoyltransferase, an enzyme catalyzing the fi
22 ion of [(3)H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into
23 ation of [3H]palmitate, a substrate for both serine palmitoyltransferase and ceramide synthase, into
24 isin B1, specific inhibitors of key enzymes (serine palmitoyltransferase and dihydroceramide synthase
25 thase activity (over 2-fold, p = 0.01); both serine palmitoyltransferase and glucosylceramide synthas
26 hytosphingosine bypasses the requirement for serine palmitoyltransferase and restores proteolysis.
27 generation through the de novo pathway (e.g. serine palmitoyltransferase) and via the hydrolysis of s
28 hingolipid biosynthetic pathway (mediated by serine palmitoyltransferase), and at least regulated, de
30 zymes known as the alpha-oxoamine synthases, serine palmitoyltransferase catalyzes the committed step
32 cycloserine, and 4-HPR transiently activated serine palmitoyltransferase, demonstrating that 4-HPR in
33 is work demonstrates that one subunit of the serine palmitoyltransferase enzyme, SPTLC1, but not subu
35 ace of L-serine, the mutant HSAN1-associated serine palmitoyltransferase generates deoxysphingolipids
36 While the putative homologues of giardial serine palmitoyltransferase (gSPT) subunit genes (gspt-1
37 two isoforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the
38 as evolutionarily related to the prokaryotic serine palmitoyltransferase, identified in the Sphingomo
39 A-stimulated RAW264.7 cells (and mutation of serine palmitoyltransferase in CHO-LYB cells); furthermo
40 e for de novo sphingoid base biosynthesis by serine palmitoyltransferase in the transient G0/G1 arres
41 we1 kinase renders mutant cells sensitive to serine palmitoyltransferase inhibition due to impaired s
42 esis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show st
45 oamine synthases are soluble homodimers, but serine palmitoyltransferase is a membrane-associated enz
48 ort here that the gene encoding a subunit of serine palmitoyltransferase is located within the HSN1 l
49 This result suggests that the activation of serine palmitoyltransferase is the event responsible for
50 1-100, which harbors a temperature-sensitive serine palmitoyltransferase, lacked increased de novo ge
51 n orthologue to be a functional, homodimeric serine palmitoyltransferase localized to the endoplasmic
52 f ceramide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is req
53 onstrated that the ER-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1), which
54 itary neuropathies are dominant mutations in serine palmitoyltransferase, long chain base subunit 1 (
55 the gene was identified as SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1.
57 ysical interaction between Orm1 and Orm2 and serine palmitoyltransferase, responsible for the first c
58 ynthase, and ISP-1, myriocin an inhibitor of serine palmitoyltransferase, significantly attenuated th
72 volved, we utilized two models: heterozygous serine palmitoyltransferase (SPT) subunit 2 (Sptlc2) gen
73 yridoxal-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising t
74 ndensation of alanine with palmitoyl-CoA via serine palmitoyltransferase (SPT), as indicated by incor
75 n SPTLC1 gene, encoding the Lcb1p subunit of serine palmitoyltransferase (SPT), cause hereditary sens
77 s with either L-cycloserine, an inhibitor of serine palmitoyltransferase (SPT), or fumonisin B(1), an
78 ere labeled with [14C]serine, a substrate of serine palmitoyltransferase (SPT), the enzyme catalyzing
79 -chain base 1 (LCB1), one of two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing
80 not directly alter the in vitro activity of serine palmitoyltransferase (SPT), the enzyme responsibl
81 apid decrease in LCB levels, indicating that serine palmitoyltransferase (SPT), the first and rate-li
82 nesis, the ehv050 gene predicted to encode a serine palmitoyltransferase (SPT), the first and rate-li
83 ot associated with changes in mRNA levels of serine palmitoyltransferase (SPT), the rate-limiting enz
85 osynthesis in Leishmania, we have focused on serine palmitoyltransferase (SPT), which catalyses the f
95 ion is catalysed by the PLP-dependent enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which is
96 of the Lcb1p subunit of yeast and mammalian serine palmitoyltransferases (SPT) were investigated.
98 trypanosomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2-) and SLs grow well, a
100 th myriocin (50 nm), a specific inhibitor of serine palmitoyltransferase (the first step in de novo s
101 n of Sptlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enzyme responsible for
102 synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting
103 is, increase the activity and mRNA levels of serine palmitoyltransferase, the first committed step in
104 rtially reduced by myriocin, an inhibitor of serine palmitoyltransferase, the first committed step in
106 treated with myriocin, a potent inhibitor of serine palmitoyltransferase, the rate-limiting enzyme in
107 investigation using a labeled substrate for serine palmitoyltransferase, the rate-limiting enzyme in
109 synthase, but not by ISP-1, an inhibitor of serine palmitoyltransferase, the rate-limiting step in t
110 xysphingolipids are produced when the enzyme serine palmitoyltransferase uses l-alanine instead of l-
111 cted a deletion mutant of BF2461, a putative serine palmitoyltransferase whose yeast homolog catalyze
113 t lack Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates end
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。