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1 enhanced STAT1-mediated gene expression via serine phosphorylation.
2 the addition of a negative charge mimicking serine phosphorylation.
3 tivation, which followed the onset of RhoGDI serine phosphorylation.
4 specifically localized to the ER on its own serine phosphorylation.
5 (PKA) activity and increases beta3 integrin serine phosphorylation.
6 Instead PTP1B was activated by serine phosphorylation.
7 ession, GRK-2 sequestration, and D1 receptor serine phosphorylation.
8 2) membranous translocation, and D1 receptor serine phosphorylation.
9 both direct and indirect regulation of IRS1 serine phosphorylation.
10 d in wild-type, metastatic mammary tumors by serine phosphorylation.
11 h key protein interactions are controlled by serine phosphorylation.
12 cking antibodies and involved beta1 integrin serine phosphorylation.
13 cent subunits and regulating factors such as serine phosphorylation.
14 ttle is known about the significance of Spry serine phosphorylation.
15 egulated by EGFR through modulation of STAT3 serine phosphorylation.
16 ine phosphorylation, while stimulating c-Met serine phosphorylation.
17 lipase C (PLC) activity was required for PKD serine phosphorylation.
18 ne/threonine kinase responsible for alphaPIX serine phosphorylation.
19 stimulate HBV replication by increasing core serine phosphorylation.
20 ion by ERBB4 is also mediated through STAT5A serine phosphorylation.
21 y through a detailed study of the role of MA serine phosphorylation.
22 ich key protein interactions are governed by serine phosphorylation.
23 nd NF-kappaB signaling through modulation of serine phosphorylation.
24 Exposure to E2 significantly decreased STIM1 serine phosphorylation.
25 in in a ternary complex that is regulated by serine phosphorylation.
26 dation, consistent with GRK isoform-specific serine phosphorylation.
27 ivation of Stat5b requires both tyrosine and serine phosphorylation.
28 lysine methylation, lysine acetylation, and serine phosphorylation.
29 tochemistry showed decreases in beta-catenin serine phosphorylation (33/37) and ubiquitinylation in t
31 interaction is regulated by topoisomerase I serine phosphorylation, a modification that regulates to
32 ding domain or mutating two newly discovered serine phosphorylation acceptor sites, Ser106 and Ser110
33 t posttranslational modifications, including serine phosphorylation, acetylation, methylation, and su
35 BDNF stimulated m-calpain but not mu-calpain serine phosphorylation, an effect also blocked by MAPK i
37 activates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated
39 tion of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ens
40 3-kinase (PI3K)/Akt pathway, which involves serine phosphorylation and degradation of IkappaB alpha.
41 d Ser523 as the first-described site of Jak2 serine phosphorylation and demonstrated that this site i
42 nction-blocking antibodies on beta3 integrin serine phosphorylation and EC-ralpha4LN fragment binding
43 cient mice fail to exhibit LPS-induced Stat3 serine phosphorylation and IL-10 gene expression yet sti
46 der various pathological conditions, through serine phosphorylation and inhibition of insulin recepto
48 titutively active Src expression resulted in serine phosphorylation and inhibition of WASP-associated
49 a transcription factor that is regulated by serine phosphorylation and is critical for the developme
52 e isomerisation can be inhibited by adjacent serine phosphorylation and requires a prolyl isomerise,
53 direct-detect experiments and show that both serine phosphorylation and RNA binding are necessary for
54 cer and activator of transcription 1 (Stat1) serine phosphorylation and Stat1 nuclear translocation t
55 (-/-) animals, OPN was necessary for PDLIM2 serine phosphorylation and STAT1 ubiquitination in bone
56 induces Egr-1 nuclear accumulation and CREB serine phosphorylation and that both are markedly attenu
57 glucose induces a decrease in overall PDX-1 serine phosphorylation and that overexpression of WT PAS
58 e we show that Ins(1,3,4,5,6)P5 inhibits the serine phosphorylation and the kinase activity of Akt/PK
61 etagamma subunits were required for both PKD serine phosphorylation and tyrosine phosphorylation, int
63 lated Akt phosphorylation and higher Irs-1/2 serine phosphorylation, and all of these events were dep
64 alpha, PKA, PKG, and CaMKII, which catalyzed serine phosphorylation, and ERK1, JNK, and p38, which ca
65 d partial inhibition of IkappaB and RelA/p65 serine phosphorylation, and p50 and p65 nuclear transloc
66 r export, is associated with increased HDAC7 serine phosphorylation, and requires conserved serines i
67 we demonstrated that both Stat3 tyrosine and serine phosphorylations are required for optimal binding
70 aling promotes AQP4 expression by decreasing serine phosphorylation associated with the water channel
72 e findings suggested that the requirement of serine phosphorylation at residue 536 and the distance b
74 utational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions
76 coexpressed with ERBB4, we identified STAT5A serine phosphorylations at the previously described Ser-
77 ivities of GSK-3 are regulated negatively by serine phosphorylation but positively by tyrosine phosph
78 whose activities are negatively regulated by serine phosphorylation but positively controlled by tyro
79 rotein, reduction in efflux, and increase in serine phosphorylation by 12S-hydroxyeicosatetranoic aci
80 singly, full Paxillin activity also requires serine phosphorylation by a kinase downstream of MOS and
82 nding motif, dramatically increased endoglin serine phosphorylation by all three receptors, suggestin
83 uman PDC is subject to inactivation at E1 by serine phosphorylation by four kinases, an inactivation
91 F2 factors and that alternative splicing and serine phosphorylation converge to provide complex combi
94 including the ligand-stimulated and specific serine phosphorylation-dependent degradation of the IFNA
96 importance of threonine phosphorylation than serine phosphorylation due to larger induced structural
99 ike that of H358 cells, is largely devoid of serine phosphorylation, has low activity, and complexes
103 inhibitor, resulted in an opposite effect on serine phosphorylation in N2A cells and primary hippocam
104 r, these results highlight the importance of serine phosphorylation in regulating type II hemidesmoso
105 eins have been shown to undergo tyrosine and serine phosphorylation in response to growth factor stim
106 s expressed ubiquitously and is activated by serine phosphorylation in response to viral infection or
107 f binding to EloC is negatively regulated by serine phosphorylation in the BC-box motif of the SOCS-b
109 N2A neuroblastoma cell line along with p35, serine phosphorylation in their Cdk5 motifs was found to
110 ted erbB2/4 tryosine phosphorylation and Akt serine phosphorylation in ventricular myocytes, whereas
113 ersed inflammatory cytokine-stimulated IRS-1 serine phosphorylation, increased insulin signaling to A
115 hypothesis that PKA regulates beta3 integrin serine phosphorylation indirectly through phosphorylatio
116 at antagonism between lysine methylation and serine phosphorylation is a fundamental mechanism for co
122 ortance of sequential modification of FAK-by serine phosphorylation, isomerization, and tyrosine deph
123 phosphorylation, resulting in blocking Stat1 serine phosphorylation, its subsequent nuclear transloca
124 e 3 (GSK-3beta) association and beta-catenin serine phosphorylation levels were increased and beta-ca
125 insulin/glucose-dependent Ser/Thr-Pro motif serine phosphorylation mediated by the mTOR pathway.
126 inhibited IL-2-induced Stat5a/b tyrosine and serine phosphorylation, nuclear translocation, and DNA b
127 ore serine mutants demonstrate that multiple serine phosphorylations occur on the same core protein.
129 Treatment of myeloma cells with IL-6 induced serine phosphorylation of A1 and increased its binding t
133 actions, including erbB2/4 phosphorylation, serine phosphorylation of Akt, and negative inotropy.
135 cetylglucosamine modifications and maximized serine phosphorylation of ankyrin(G) and p85 binding to
136 to alanine abolished the insulin-stimulated serine phosphorylation of APS and prevented the localiza
138 oocyte permeability assays, we conclude that serine phosphorylation of AQP0 does not inhibit CaM bind
140 ity of GSK-3beta, which in turn affected the serine phosphorylation of beta-catenin and its proteosom
141 assic isoforms of protein kinase C mediating serine phosphorylation of beta-catenin and Src-tyrosine
143 We recently revealed that p38 MAPK-mediated serine phosphorylation of both Stat1 and Stat3 is requir
144 hat PTEN initially induces a decrease in the serine phosphorylation of Brf1, leading to a selective r
145 is accompanied by PKC-dependent increase in serine phosphorylation of c-Cbl in cells expressing elev
146 ibitors of protein kinase C activity reduced serine phosphorylation of caveolin-1 and increased stero
148 inase assays show that EGFRvIII induction of serine phosphorylation of Dock180 is PKA-dependent.
150 SK1 phosphorylation at Serine-966, decreased serine phosphorylation of FAK, and decreased association
151 on of 18 kDa subunit of complex I, decreased serine phosphorylation of FeS protein in complex III, in
153 d treatment with lithium and VPA potentiated serine phosphorylation of GSK-3 alpha and beta isoforms
154 otein kinase IV (CaMKIV), through inhibitory serine phosphorylation of GSK-3beta and inhibition of FB
156 Similarly, whereas CaMKIV(+/+) Mphi showed serine phosphorylation of HMGB1 in response to LPS, this
161 tutive activation of NF-kappaB signalling by serine phosphorylation of IkappaBalpha and constitutive
163 mammalian target of rapamycin (mTOR)-induced serine phosphorylation of insulin receptor substrate (IR
165 nied by increased phosphorylation of JNK and serine phosphorylation of insulin receptor substrate 1 (
167 kt and insulin receptor was reduced, whereas serine phosphorylation of insulin receptor substrate 1 w
169 c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate-1 (
170 Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 a
171 togen-activated protein kinase, enhances the serine phosphorylation of insulin receptor substrate-1,
172 ns-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1.
178 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, o
179 creased expression of p85alpha and increased serine phosphorylation of IRS-1 is needed to induce clin
181 n of the PI3K/Akt pathway via the inhibitory serine phosphorylation of IRS-1, notably on serine 1101
187 n by activating protein kinases that enhance serine phosphorylation of IRS1 and have been thus associ
188 lin-induced akt phosphorylation by increased serine phosphorylation of IRS1 and increased expression
189 uced (siRNA or a pharmacological inhibitor), serine phosphorylation of IRS1 is reduced, and insulin-i
190 cells resulted in a significant induction of serine phosphorylation of JAK3 and STAT5, and serine/thr
191 that Fsk-treated cells resulted in elevated serine phosphorylation of Jak3 but not Stat5, suggesting
194 Specifically, AMPA stimulation triggered serine phosphorylation of KLC2 and, subsequently, the di
195 s attain additional negative charges through serine phosphorylation of Lys-Ser-Pro (KSP) repeat motif
197 ng [(3)H]tetraphenylphosphonium), as well as serine phosphorylation of NOS-3 (by Western blotting and
200 neutrophil NADPH oxidase involves extensive serine phosphorylation of p47(phox), the role of tyrosin
203 resent study, we show that palmitate-induced serine phosphorylation of phosphoinositide-dependent pro
204 -linking of VCAM-1 stimulated an increase in serine phosphorylation of PTP1B, the active form of PTP1
206 respectively, leading to enhanced inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) a
207 anding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) b
208 otensin II or 1 microm serotonin resulted in serine phosphorylation of Rb that was equal in magnitude
209 r 15 min of ligand stimulation, but only the serine phosphorylation of signal transducer and activato
210 tide agonist suppressed the TGF-beta-induced serine phosphorylation of Smad2, a critical mediator of
212 LC-MS/MS analysis further revealed that serine phosphorylation of Sort1 protein was required for
214 n of MAPK activity blocked IFN-gamma-induced serine phosphorylation of STAT1alpha; but its tyrosine p
215 As well, OSM and IL-6/R induce tyrosine and serine phosphorylation of STAT3 in primary cortical neur
216 es such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activati
217 e kinase responsible for LMP1-CTAR1-mediated serine phosphorylation of STAT3 was identified to be PKC
221 m DARPP-32-depleted mice, basal tyrosine and serine phosphorylation of striatal NMDA receptor subunit
223 one (PTH) inhibits Na+-K+-ATPase activity by serine phosphorylation of the alpha1 subunit through pro
224 d adhesion via a protein kinase A-dependent, serine phosphorylation of the alpha4 cytoplasmic domain.
225 ome disassembly by a mechanism that involves serine phosphorylation of the beta 4 integrin subunit.
227 ide additional support for the idea that the serine phosphorylation of the C-terminal domain (CTD) se
230 a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at th
232 ds to a significant decrease in the level of serine phosphorylation of the insulin receptor substrate
233 ha inhibitory peptide blocked PTH-stimulated serine phosphorylation of the Na+-K+-ATPase alpha1 subun
234 sphoinositide 3-kinase and PKB/Akt-dependent serine phosphorylation of the precursor SREBP-1c protein
235 of gene expression by Sall1 is modulated by serine phosphorylation of the Sall1 repression motif.
236 2A and NR2B was drastically reduced, whereas serine phosphorylation of these NMDA subunits was unchan
238 Lipopolysaccharide (LPS) treatment induced serine phosphorylation of USP14 as well as further reduc
240 Src diminished the SGK1-mediated increase in serine phosphorylation of WNK4, suggesting that c-Src en
241 KNgamma in turn increases threonine (but not serine) phosphorylation of phospholipase C (PLC) gamma1
242 de (AICAR) and used to assess the following: serine-phosphorylation of Akt (P-Akt), immunoreactivity
244 us of FX mice displayed decreased inhibitory serine-phosphorylation of GSK3beta compared with wild-ty
246 orylation on residue Y705 but have increased serine phosphorylation on residue S727, consistent with
247 l peptides were synthesized with and without serine phosphorylation on S231 and S235, and the ability
248 ased STAT1 tyrosine phosphorylation, whereas serine phosphorylation on the protein was unchanged.
251 ynamic remodeling of the CTD, especially its serine phosphorylation pattern, conveys informational cu
252 hat PKD plays a key role in copper-dependent serine phosphorylation, permitting high levels of ATP7B
254 oprecipitate with IGF-1R and increase IGF-1R serine phosphorylation, promoting beta-arrestin1 associa
257 uced rapid, sustained, and site-specific k-8 serine phosphorylation (pSer73) dependent on signaling b
259 b have been extensively studied, the role of serine phosphorylation remains to be fully elucidated.
260 ct tyrosine kinase activity to regulate GAT1 serine phosphorylation requires a change in its tyrosine
261 fails to share a positionally conserved Stat serine phosphorylation sequence; however, known phosphoa
262 etween tyrosine phosphorylation (Tyr(P)) and serine phosphorylation (Ser(P)) of IRS-2 after IL-4 stim
263 To investigate these issues, we mutated a serine phosphorylation site (S408) in the cytoplasmic ta
264 analysis, Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not l
265 to acquire full transcriptional activity, no serine phosphorylation site in STAT2 has been reported.
266 ence of c-Src, and by mutation of a putative serine phosphorylation site in the actin-binding domain
269 ectrometry analyses of DP revealed six novel serine phosphorylation sites dependent on GSK3 signaling
270 f 14-3-3 required 2 previously unappreciated serine phosphorylation sites in LNK, and we found that t
271 binding focal adhesion protein with several serine phosphorylation sites in the amino terminus that
273 dentified serines 1248 and 1291 as the major serine phosphorylation sites of the IGF-1R, and subseque
275 the alpha-parvin N-terminal proline-directed serine phosphorylation sites reduced its complex formati
276 YK phoshorylates Ikaros at unique C-terminal serine phosphorylation sites S358 and S361, thereby augm
279 arkedly increased upon mutation of two GSK-3 serine phosphorylation sites within the carboxyl-termina
283 orylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an
285 ted threonine phosphorylation required prior serine phosphorylation, suggesting a sequential mechanis
286 ot all, MAPK agonists induced the regulatory serine phosphorylation, suggesting an involvement of dif
287 Tyr(641) was dispensable for IL4-mediated serine phosphorylation, suggesting that dimerization is
288 duced ABCA1 protein levels and increased its serine phosphorylation, suggesting that PLD2-generated d
289 l growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmi
295 axillin and significantly increased paxillin serine phosphorylation, whereas Nek3 siRNA-transfected c
296 is also inhibited, thereby preventing Stats serine phosphorylation, which is essential for downstrea
300 owed that Grb10 underwent insulin-stimulated serine phosphorylation, yet the kinase(s) responsible fo
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