コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 ic activity of this unique membrane-anchored serine protease.
2 subunit of ClpP, an evolutionarily conserved serine protease.
3 otease 4 (HAT-L4) is a type II transmembrane serine protease.
4 ivary gland with the primary proteases being serine proteases.
5 m because it is actually a poor inhibitor of serine proteases.
6 n, a protease homologous to other allosteric serine proteases.
7 haracterizing the P2' specificity of various serine proteases.
8 emase (KPC), with no inhibition of mammalian serine proteases.
9 from the destructive activity of neutrophil serine proteases.
10 ates the activity of endogenous T. forsythia serine proteases.
11 oteolytic cleavage at their amino termini by serine proteases.
12 lectin complement pathway through associated serine proteases.
13 rolonged liquefaction due to the activity of serine proteases.
14 lly important property specific to leukocyte serine proteases.
15 kDa precursor though proteolytic cleavage by serine proteases.
16 nown to mostly act on potassium channels and serine proteases.
17 for generating target-tailored inhibitors of serine proteases.
18 , which regulate the proteolytic activity of serine proteases.
19 ants specifically inhibit different types of serine proteases.
20 atC without affecting those of elastase-like serine proteases.
21 ing lectin, mannan-binding lectin-associated serine proteases 1 and 2, and C4d in the lectin pathway.
22 king mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1) and MASP-3 contain zymogenic
24 ative C3 by mannan-binding lectin-associated serine protease-2 bound to LP-activation complexes captu
25 ctor enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in a
27 amma catalytic subunit (POLG1), due to HTRA3 serine protease accumulation in CS, but not in UV(s)S or
28 ing lectin, together with mannose-associated serine proteases, activates the lectin pathway of the co
29 rotease-like beta-barrel uses the degenerate serine protease active site to recognize blades 2, 3, an
31 les, and syncytium formation, and endogenous serine protease activity did not contribute greatly to i
34 er common aeroallergens, possessed intrinsic serine protease activity that elicited the rapid release
35 challenged with Alternaria (with or without serine protease activity), and inflammation, remodeling,
36 hat a major Af allergen, Asp f13, which is a serine protease, alkaline protease 1 (Alp 1), promotes a
38 is proteolytically-activated by bloodstream serine proteases also involved in the formation of blood
39 se myeloid cell proteases, but not digestive serine proteases, also bind DNA strongly and localize to
40 d a murine model of occupational asthma to a serine protease and characterized the main molecular pat
41 owing the death of an insect host, while two serine protease and two metalloprotease genes had their
43 tions sensitized viruses to entry-activating serine proteases and conferred more rapid entry kinetics
46 n-proteolytic functions of membrane-anchored serine proteases and provides unexpected new data on the
47 ase family, whose members are tetradecameric serine proteases and serve as regulators of several cell
48 gulation factor VIIa (FVIIa), a trypsin-like serine protease, and membrane-bound tissue factor (TF) i
49 -1, ficolin-2, and ficolin-3, the associated serine proteases, and complement activation products to
50 scle progenitor cell niche, which identified serine proteases, and especially neutrophil elastase, as
51 cellent selectivity against a panel of seven serine proteases, and FVII-deficient prothrombin time EC
52 The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were com
53 marrow, biosynthesis of CTSC and neutrophil serine proteases appeared normal along with initial proc
55 ure immune cells and suggest that neutrophil serine proteases are dispensable for human immunoprotect
62 se (uPA, urinary plasminogen activator) is a serine protease belonging to the peptidase S1 family.
63 KT1) exhibited no inhibitory activity toward serine proteases but was a potent inhibitor of the major
64 onoclonal antibody targeting the CP-specific serine protease C1s, on CP activity induced by cold aggl
66 Minutes before egress, an essential parasite serine protease called SUB1 is discharged into the paras
67 me natural mutation in homologous pancreatic serine proteases can evolve a new physiological role or
68 rate-binding domain (N-betaGRP) and triggers serine protease cascades for the activation of prophenol
72 , and ELISA experiments revealed that myelin serine proteases cleave C3 to generate active fragments.
73 sin, a glycosylphosphatidylinositol-anchored serine protease, cleaved human PCI and mouse PCI (mPCI)
74 ctionated salivary gland extracts identified serine protease CLIPA3 as a putative cofactor, and short
76 epsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial
78 ein components of NETs, such as histones and serine proteases, contributes to coagulation and platele
79 osin, CAP, Profilin, Lipocalin, Trypsin-like serine protease, Cupin, BetV1, Expansin and Prolamin).
82 present study demonstrates that two cellular serine proteases, DESC1 and MSPL, activate influenza vir
83 estigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human ca
85 ational analysis defines a chymotrypsin-like serine protease domain that mediates SltB autoproteolysi
87 A canonical model entails a C1r2s2 with its serine protease domains tightly packed together in the c
88 e to azurophil granules, including the major serine proteases, elastase, cathepsin G, and proteinase
91 -specific serine protease (TSSP), a putative serine protease expressed by cortical thymic epithelial
95 blood coagulation as the pro-cofactor to the serine-protease Factor IXa (FIXa) in the FVIIIa-FIXa com
99 to define the importance of these neutrophil serine proteases for antibacterial protection, granuloma
100 pecifically inhibits granzyme B, a cytotoxic serine protease found in the cytosolic granules of cytot
101 Together, these data indicate CTSC protects serine proteases from degradation in mature immune cells
102 h Temperature Requirement A (HtrA) family of serine proteases function in the periplasm to degrade da
104 e that LOXL2 is processed extracellularly by serine proteases, generating a 65-kDa form lacking the f
105 s also revealed, including the repression of serine-protease genes and the induction of protease-inhi
107 8(+) T lymphocytes and can be cleaved by the serine protease granzyme B, one of the main components o
110 mice, we demonstrate that the membrane-bound serine protease hepsin is the enzyme responsible for the
112 these conditions the activity of neutrophil serine proteases, however, was not abolished in precurso
114 nspeptidase (ggt), collagenase, the secreted serine protease htrA, and components of a type VI secret
116 llikrein-related peptidase 2 (KLK2) is a key serine protease in semen liquefaction and prostate cance
117 timulation and that this MBP cleaves L1 as a serine protease in the L1 extracellular domain at Arg(68
118 riptionally upregulated TFPI2, a Kunitz-type serine protease in the tissue factor pathway that inhibi
124 deficient mosquitoes showed a persistence of serine proteases in the midgut at 48 h after blood feedi
127 d their potency against related trypsin-like serine proteases including trypsin itself could be furth
128 ansmembrane protein and inhibitor of several serine proteases, including hepatocyte growth factor act
129 ted via proteolytic cleavage by trypsin-like serine proteases, including kallikrein-5 (KLK5), or by t
130 nder conditions where CDCP1 was processed by serine proteases, indicating that FAK/PI3K/Akt pathway o
132 ontaining protein-1 (CDCP1), by plasmin-like serine proteases induces outside-in signal transduction
134 ta uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accu
136 at secreted proteins Fibronectin 1 (FN1) and serine protease inhibitor (serpin) family E member 2 (SE
138 ajority of patients harbor a mutation in the serine protease inhibitor 1A (SERPINA1) gene leading to
140 -c) and IgE-tp interact with polymers of the serine protease inhibitor alpha-1-antitrypsin (A1AT).
141 caused by the Z mutation (Glu342Lys) in the serine protease inhibitor alpha1-antitrypsin (alpha1AT),
142 i2A) was studied in mouse TH2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 gen
146 eased the selectivity of ShPI-1, a versatile serine protease inhibitor from the sea anemone Stichodac
147 static associations between filaggrin (FLG), serine protease inhibitor Kazal-type 5 (SPINK5), and thy
149 e inhibition of protease activity by using a serine protease inhibitor leupeptin or two structurally
150 eatments of C57/BL6J-betaENaC-Tg mice with a serine protease inhibitor ONO-3403, a derivative of camo
153 , we observed a compensatory increase in the serine protease inhibitor Serpina3n in mouse models of M
154 at alpha-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT
155 otease TMPRSS2, but Zhou et al. found that a serine protease inhibitor was more protective than a cat
156 ng pathway and alpha1-antitrypsin protein (a serine protease inhibitor) expression and downregulation
157 carbamoyl triazole TCMDC-134379 (1), a known serine protease inhibitor, as an excellent starting poin
161 The variant is located in the gene encoding serine protease inhibitor, low levels of which are assoc
162 translational processing is inhibited by the serine protease inhibitor, phenylmethylsulfonyl fluoride
165 c alpha-amylase inhibitor CM2 (Tri a 29.02), serine protease inhibitor-like allergen (Tri a 39), and
168 odulating, and tissue-protective circulating serine-protease inhibitor, with levels that increase dur
170 in inhibition, which is in contrast to other serine protease inhibitors (camostat mesylate and aproti
172 f the MBP cleavage site within L1 as well as serine protease inhibitors and an L1 peptide containing
173 essing resistance to inhibition by canonical serine protease inhibitors and in cleaving these inhibit
174 ultiple human and murine cell lines and that serine protease inhibitors block Xps-mediated rounding a
175 modulators of tumorigenesis/metastasis from serine protease inhibitors but also strengthens the func
176 nents of the Toll and JAK/STAT pathways, and serine protease inhibitors in both social and solitary b
179 on in the absence of the cognate Kunitz-type serine protease inhibitors, hepatocyte growth factor act
186 t protein A1 (HtrA1) is a primarily secreted serine protease involved in a variety of cellular proces
188 pider Cupiennius salei The chymotrypsin-like serine protease is a 28-kDa heterodimer with optimum act
189 The elevated level of chymases and other serine proteases is closely related to inflammatory and
190 protease-like activity factor), a Chlamydia serine protease, is activated via proximity-induced inte
191 was dependent on coagulation factor XIIa, a serine protease known to induce cleavage of high-molecul
192 focuses on human KLK1 and KLK5, 2 of the 15 serine proteases known as the kallikrein-related peptida
193 accharide hydrolysis by 18B7, and a putative serine protease-like active site was identified in the l
199 s implicated the involvement of two putative serine proteases, MamE and MamO, during the early stages
202 e serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and
203 recognition receptor complex, MBL-associated serine protease (MASP)-3/collectin-L1/K1 hetero-oligomer
204 d ficolins complexed with the MBL-associated serine proteases (MASP)-1 and MASP-2 cleave C4 and C2 to
205 with the MBL/ficolin/collectin-11-associated serine proteases (MASPs) in binding to MBL and the ficol
208 e autoactivation of the type 2 transmembrane serine protease matriptase and subsequent activation of
209 d that the membrane-anchored epithelial cell serine protease matriptase is critical in maintaining th
210 n IECs, and HAI-2 regulates the cell surface serine protease matriptase, a known modifier of intestin
211 he recently described hepcidin repressor-the serine protease matriptase-2 (encoded by Tmprss6)-is res
214 ed mannose-binding lectin-mannose-associated serine protease (MBL-MASP) functional activity in Crohn'
215 olymers in plasma protects the antibody from serine protease-mediated degradation, without affecting
217 lot, we discovered that granzyme A (GrmA), a serine protease not previously identified in human plate
222 ne defenders against infection, express four serine proteases (NSPs) that play roles in the control o
225 potently inhibits the activity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), prote
226 monstrate that EatA, an immunogenic secreted serine protease of ETEC, contributes to virulence by deg
229 s sufficient for the selective inhibition of serine proteases or whether other regions of a canonical
230 in hyperactivation, thereby leading to skin serine protease overexpression and disruption of skin ba
232 (MAp)44, in regulating the composition of a serine protease-pattern recognition receptor complex, MB
233 e plasma by the liver, the proteinase K-like serine protease PCSK9 binds the low-density lipoprotein
234 od involves activation of plasminogen to the serine protease plasmin and facilitated cleavage of two
235 ssing FnBPB could be activated to the potent serine protease plasmin by staphylokinase and tissue pla
237 Endogenous inhibitors of human neutrophil serine proteases preferentially inhibit HNE and to a les
238 ma kallikrein-kinin system (KKS) consists of serine proteases, prekallikrein (pKal) and factor XII (F
239 d prostate cancer, and proteinase 3 (PR3), a serine protease present in inflammatory neutrophils and
241 glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-factor for matr
243 nstead, caspase-3 activation was mediated by serine protease proteinase 3 (PR3), which is present in
246 Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPI
253 t addition of subtilisin (50 nm to 2 mum), a serine protease secreted by the non-pathogenic bacterium
255 ing genetic analysis, we determined that the serine proteases StmPr1 and StmPr2, which were confirmed
257 ontrolling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles.
261 of oxidants and granule proteins, including serine proteases, support the microbial killing in phago
264 e is an epithelia-specific membrane-anchored serine protease that has received considerable attention
265 t, Mycoplasma Ig protease (MIP), is a 97-kDa serine protease that is able to cleave off the VH domain
266 atriptase-2 (MT2) is a type II transmembrane serine protease that is predominantly expressed in hepat
269 hat the L. pneumophila effector Lpg1137 is a serine protease that targets the mitochondria and their
270 ent protease A (HtrA) represents a family of serine proteases that play important roles in microbial
272 e of activated platelets are degraded by the serine protease thrombin and release the urokinase plasm
274 ity with respect to the related trypsin-like serine proteases (thrombin, tPA, FXa, plasmin, plasma ka
275 led receptors that are activated by multiple serine proteases through specific N-terminal proteolytic
276 at our approach may also be applied to other serine proteases, thus opening new avenues for a systema
277 his study, we show how the membrane-anchored serine protease TMPRSS2 stimulates a proteolytic cascade
278 than on the cell surface acid pH-independent serine protease TMPRSS2, but Zhou et al. found that a se
279 We recently identified the StmPr1 and StmPr2 serine proteases to be the substrates of the Xps type II
286 vious studies suggested that thymus-specific serine protease (TSSP), a putative serine protease expre
289 n protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients wi
292 subsequently, upon nuclease activity, active serine proteases, which proteolytically degrade NET-asso
293 ying special attention to neutrophil-derived serine proteases, which subsequently induce inflammation
294 Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in ac
295 ein-related peptidases (KLKs) are a group of serine proteases widely expressed in various tissues and
297 tivated protein C (APC) is a multifunctional serine protease with anticoagulant, cytoprotective, and
298 nan-binding protein 2) is a Ca(2+)-dependent serine protease with putative roles in blood coagulation
300 tion of proteolytic activity of plasmin-like serine proteases with aprotinin prevented beta1 integrin
WebLSDに未収録の専門用語(用法)は "新規対訳" から投稿できます。