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1 s partially rescued by removing the adjacent serine residue.
2 e and perturbs the position of the catalytic serine residue.
3 ch is controlled by an N-terminal regulatory serine residue.
4 s a G-to-S change at the predicted catalytic serine residue.
5 ced the highly conserved cysteine 107 with a serine residue.
6 key residue for binding is a phosphorylated serine residue.
7 from phosphorylation of the newly introduced serine residue.
8 tanoyl side group, which occurs on its third serine residue.
9 n responded to modification of even a single serine residue.
10 ted following phosphorylation at a conserved serine residue.
11 tly phosphorylates SRF on a highly conserved serine residue.
12 mapping and mutating the key O-GlcNAcylated serine residues.
13 ons, including modification of glutamine and serine residues.
14 -acetylglucosamine (O-GlcNAc) also occurs on serine residues.
15 inase 1 (Clk1) phosphorylates SPF45 on eight serine residues.
16 ymes through nonenzymatic acetylation of key serine residues.
17 rane binding and phosphorylation at specific serine residues.
18 step formal cycloaddition between two distal serine residues.
19 elium SCAR is basally phosphorylated at four serine residues.
20 effects based on phosphorylation at specific serine residues.
21 hosphorylation switch of adjacent lysine and serine residues.
22 ic peptide containing N-terminal alanine and serine residues.
23 phosphoprotein exclusively phosphorylated at serine residues.
24 e composed almost entirely of tryptophan and serine residues.
25 rylation site mutations at each of the three serine residues.
26 mediates Smad1 phosphorylation at C-terminal serine residues.
27 function of each of these two phosphorylated serine residues.
28 oteins, and (iii) phosphorylation of various serine residues.
29 ciated with dephosphorylation of the Ntcp on serine residues.
30 of three hydrophobic amino acids flanked by serine residues.
31 are within casein kinase 2 (CK2) sites, and serine residue 114, which is within a protein kinase A (
33 ion of the Na-K-2Cl cotransporter (NKCC2) at serine residue 126 (pS126 NKCC2) and of the Na-Cl cotran
34 enic-transforming activity depends on intact serine residues 127 and 381, two sites that could be pho
35 lated on three serine residues, specifically serine residues 16 and 18, which are within casein kinas
36 r sites of ICP27 that are phosphorylated are serine residues 16 and 18, within a CK2 site adjacent to
38 that constitutively active IKKbeta in which serine residues 177/181 were mutated into negatively cha
39 We discovered that dual serine (traditional serine residues 177/181) and tyrosine (188/199) phosphor
40 PKC-dependent NMDAR insertion, and identify serine residue-187 as the molecular target of PKC phosph
41 ndividually contained one of six cysteine-to-serine (residues 193, 197, 209, 211, 214, and 218) subst
44 o 2.8-fold increased phosphorylation of Cx43 serine residues 255, 262, 279/282, and 368, and appeared
45 ion with MEF2s in nuclear speckles requiring serine residues 259 and 498, whose phosphorylations cont
47 RK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is requ
48 somal neural-derived IRS-1 phosphorylated at serine residue 307 (corresponding to serine residue 312
49 ated at serine residue 307 (corresponding to serine residue 312 in humans) negatively correlated with
50 sulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in th
51 ceptor substrate 1 (IRS-1) phosphorylated at serine residue 312 was more apparent in inclusion bearin
52 cal WW domain-mediated interaction involving serine residues 324 and 325 within the carboxy-terminal
55 physiological role of AID phosphorylation at serine residue 38 (S38), and even the requirement for th
58 ABAARs is potentiated via phosphorylation of serine residues 408 and 409 (S408/9) in the beta3 subuni
59 tion, the beta3 subunit is phosphorylated on serine residues 408/409 by PKC activity, whereas the del
61 site-directed mutagenesis, which identified serine residues 421 and 423 as critical for its nuclear
68 d decreased levels of DRP1 phosphorylated at serine residue 616 (P-DRP1(S616)), a post-translational
71 hat PIM1 phosphorylates ASK1 specifically on serine residue 83 (Ser83) both in vitro and in vivo and
72 on cascade that modulates phosphorylation of serine residue 863 (S863) in the GluA1 AMPAR subunit and
73 Allodynia suppression was a consequence of serine residue 896/897 phosphorylation of NMDA receptor
74 els purified from brain is phosphorylated on serine residues 9 and 31, and that cyclin-dependent kina
75 intracellular inhibitor of PP2A (I2PP2A) on serine residues 9 and 93, resulting in enhanced binding
77 rylation of the pro-NRG1 cytoplasmic tail on serine residues adjacent to the membrane-spanning segmen
78 er, our data suggest that phosphorylation of serine residues adjacent to the PIAS1 SUMO-interacting m
81 tly phosphorylated mTOR and RAPTOR on unique serine residues, an effect that was independent of insul
82 ate that Scute is phosphorylated by Sgg on a serine residue and that mutation of this residue results
83 diversity, consisting mostly of tyrosine and serine residues and a small but significant contribution
84 ion, we induced a mutation in the C-terminal serine residues and examined their effects on the intera
86 (AICAR) resulted in STIM1 phosphorylation on serine residues and prevented protease-activated recepto
87 structural changes due to phosphorylation of serine residues and shown a correlation between the CTD
89 erichia coli was phosphorylated by CKII on a serine residue, and its phosphorylation was dependent on
90 y, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr i
95 signature depends on phosphorylation of the serine residue at position 273 of PPARgamma, in striking
96 smic tail of rat ADAM17 contains a conserved serine residue at position 811, which resides in a canon
98 ed that the phosphate moiety attached to the serine residue at position P5 of pMART-1 is available fo
99 f-function" mutation [a leucine mutated to a serine residue at the 9' position (Leu9'Ser)] in VTA GAB
100 or tryptophan residue in Env with a natural serine residue at this position (S375H/W) increased the
102 ur findings show enhanced phosphorylation of serine residues at amino acid positions 15 and 46 in the
103 quent mutagenesis analysis demonstrated that serine residues at amino acids 225 and 232 in NS5A (geno
104 ion in cells leads to phosphorylation of two serine residues at analogous sites on both SH2 domains o
105 o restrict MLV/GaLV Env, but mutation of the serine residues at positions 52 and 56 completely allevi
106 pha-helices have an L-shape, with proline or serine residues at the kinks, which functions as a lever
109 a at serine residue 235 and Dok-7 at several serine residues but does not phosphorylate Rapsyn or Rac
111 defined, conserved N-terminal threonine and serine residues, but the kinase pathways that mediate th
114 vation, we mutated cysteine 203 of CypD to a serine residue (C203S) and determined its effect on mPTP
115 n article, we show that five, and only five, serine residues can be phosphorylated both in vitro and
116 sidue plays a role in activating an adjacent serine residue carrying out nucleophilic attack, opening
117 y ERK-mediated phosphorylation of ERG at one serine residue causes a conformational change that allow
118 as required, since mutation of the catalytic serine residue completely abolished the stimulatory acti
119 osophospecific antibody, and substitution of serine residues demonstrate phosphorylation of candidate
121 the observation that mutation of Cys475 to a serine residue eliminates the formation of the protein a
123 cytosolic S4-S5 linker of both proteins by a serine residue forces the channels into an open conforma
124 -R353A, but not FXII lacking the active site serine residue (FXII-S544A), shortened the clotting time
125 Conversely, the replacement of His 375 by a serine residue (H375S) within HIV-1 CRF01_AE decreased t
128 ough its serine-rich domain in which most of serine residues have the propensity to be phosphorylated
130 n I; group B, comprising mutations affecting serine residues important for hyperphosphorylation and a
132 sporter EAAT2, and we identified a conserved serine residue in Flot1 that is essential for transporte
134 In addition, a modification to an adjacent serine residue in Rab1 was discovered, which was indepen
136 (APC/C); while phosphorylation of a specific serine residue in the APC/C coactivator Cdc20 prevents d
140 d the consequences of changing the conserved serine residue in the P-loop to asparagine, within a chi
141 mline mutation (S631G) at a highly conserved serine residue in the uncharacterized gene VSIG10L that
142 s, BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating bind
143 he enzyme is regulated by phosphorylation of serine residues in a regulatory domain and by binding of
144 s inhibited by phosphorylation of up to four serine residues in a repeating sequence in the C-termina
145 s regulated by reversible phosphorylation of serine residues in an N-terminal regulatory domain and c
146 ly at Ser12, indicating that the pore-facing serine residues in BM2 mediate proton relay to the proto
147 t stress-induced phosphorylation of specific serine residues in domain 3 of PACT increases its affini
148 equires phosphorylation at three clusters of Serine residues in Drosophila Hedgehog (Hh) signaling.
150 entially phosphorylated at three clusters of serine residues in response to levels of Hh activity.
152 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubi
153 vered a new form of ADPr that is attached to serine residues in target proteins (Ser-ADPr) and showed
154 ediated interaction involving phosphorylated serine residues in the absence of any proline residues a
155 sphorylation of PKD1 at two highly conserved serine residues in the activation loop; this modificatio
156 1/2) interact directly with CIITA, targeting serine residues in the amino terminus of the protein, in
158 dy revealed extensive phosphorylation of two serine residues in the C terminus of both MKP-1 and MKP-
159 MPK-mediated inhibition of TREK involves key serine residues in the C-terminus that are also known to
160 s spectrometry analysis, we identified three serine residues in the CCE domain of CRY2 (S588, S599, a
161 we report that substitution of two conserved serine residues in the cytosolic tail of TCRalpha to ala
163 ed a mutational analysis of highly conserved serine residues in the linker region between domains I a
164 Many prior papers have pinpointed several serine residues in the low complexity sequence I region
165 fy HDAC1 and the phosphorylation of specific serine residues in the molecule as potential targets for
167 thway responsible for the phosphorylation of serine residues in the Ser-x-Glu/pSer motifs in several
169 s can form hydrogen bonds with two conserved serine residues in transmembrane helix 5 (Ser(5.42) and
171 hway, which phosphorylates Runx2 on multiple serine residues including S301 and S319 (equivalent to S
172 phosphorylation of IRS-1 by S6K1 at multiple serine residues including Ser-270, Ser-307, Ser-636, and
173 vates PDC by phosphorylating PDH at specific serine residues, including Ser-293, whereas dephosphoryl
174 t study of phosphorylated and phosphomimetic serine residues indicating lowered single motor stalling
175 f Dazl by MK2 on an evolutionarily conserved serine residue inhibits its interaction with poly(A)-bin
176 LGST motif from bacteria to humans, only the serine residue is absolutely required for Psd1p autocata
178 osphorylation of kinesin motor domain at the serine residue is implicated in Huntington's disease, wi
179 the nitrogen atom of an internal cysteine or serine residue is usually cleaved by the side chain -SH
180 n of the viral nonstructural protein NS5A at serine residues is important for the efficient assembly
181 t phosphorylation of Rex-2, predominantly on serine residues, is correlated with an altered conformat
182 ing PKCbeta phosphorylation of TFEB on three serine residues located in its last 15 amino acids.
183 d ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signatur
185 osphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser-883 in Xe
188 kt, the enzyme multi-phosphorylated a single serine residue of a diserine DCF substrate in a time-dep
189 established that transesterification of the serine residue of desmethylsalinamide E with acylated gl
190 tide synthetase machinery, to the C-terminal serine residue of microcin E492 (MccE492), an 84 aa ribo
196 b1(SSAA/SSAA)' mice, in which the IKK-target serine residues of p105 were substituted with alanine.
198 rthermore, we show that SRPK1 phosphorylates serine residues of SR/RS dipeptides in the hinge region
199 Specific phosphorylation of tyrosine and serine residues of STAT1 was observed in polyI:C-treated
200 effects of phosphorylation of the individual serine residues of stathmin on microtubule dynamic insta
202 ets RNA polymerase II but also the conserved serine residues of the polylinker region in Smad3, sugge
203 the N-terminal structure suggested that the serine residue (of CSQCH) would be anchored where the fi
206 res phosphorylation of Ser(1107), a critical serine residue on the II-III loop of the channel pore pr
211 s studies have shown that phosphorylation of serine residues on synaptic proteins is a major regulato
212 by GCK-3 kinase-mediated phosphorylation of serine residues on the cytoplasmic C-terminus linker con
213 l six cysteines were individually altered to serine residues, only C145S and C195S derivatives lost t
214 th this prediction, phosphorylation at these serine residues or mutation to aspartate inhibits bindin
216 )KVTF(901), and can dephosphorylate multiple serine residues phosphorylated by checkpoint kinases.
217 press mutant versions of hLigI in which four serine residues phosphorylated in vivo were replaced wit
218 pathway in human cells; additionally, as the serine residue promoting thermal lability is conserved a
219 erential phosphorylation of SPL tyrosine and serine residues provides a key to understanding both.
220 ing with the dockerin's critically conserved serine residues reduced the observed rupture forces.
222 Replacement of the Asp f3 cysteines with serine residues retained its dimeric structure, but dimi
224 , we found that PKG can phosphorylate Sp1 on serine residue(s) and this resulted in transcriptional a
225 in activation, we demonstrated a key role of serine residue S1163 of the alphaE chain intracellular d
227 his study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A v
228 ere we show that phosphorylation of a single serine residue (S2844) in the sarcoplasmic reticulum (SR
233 wever, RelA phosphorylation, particularly at serine residues S536 and S276, is critical for RelA func
234 ing that phosphorylation of GluA1 C-terminal serine residues S831 and S845 is not required for CaN in
235 n addition, APE2 associates with Chk1, and a serine residue (S86) in the Chk1-binding motif of APE2 i
236 tor domain by the kinase JNK3 at a conserved serine residue (Ser-175 in the B isoform and Ser-176 in
237 ntaining an aspartic acid substitution for a serine residue (Ser-189) that in GRASP65 is phosphorylat
238 hosphatase-1-mediated dephosphorylation of a serine residue (Ser-9) preceding the GIRK2 Val-13/Leu-14
239 ation of stathmin on one or more of its four serine residues (Ser(16), Ser(25), Ser(38), and Ser(63))
240 ction, MAPK phosphorylation of the preceding serine residues (Ser(P)(279)and Ser(P)(282)) increases t
241 rylation, the phosphorylation of a conserved serine residue, Ser(779), can quantitatively control Ras
242 terized several mutants of the corresponding serine residue, Ser-364, of human glutamate transporter
247 imuli promote Hsp27 phosphorylation on three serine residues--Ser(15), Ser(78), and Ser(82)-by a numb
249 s containing HSP27 mutated at three critical serine residues (Ser15, Ser78, and Ser82) to either alan
250 we investigated the roles of three conserved serine residues [Ser198(5.42), Ser199(5.43), and Ser202(
251 ing distance of the side chain hydroxyl of a serine residue (Ser201) that is conserved in both HMS an
252 s from the hearts of mice in which the three serine residues (Ser273, Ser282, and Ser302) that are ph
253 implicate the phosphorylation of a specific serine residue (Ser322) on the synaptic protein UNC-18 a
254 bits increased phosphorylation of a critical serine residue (Ser354) and higher protein expression as
255 CD4 (programmed cell death protein 4) on two serine residues (Ser76 and Ser457) that regulate its sub
256 ependent phosphorylation of Hof1 at a single serine residue (serine 313) in this region diminishes th
258 has been shown to be phosphorylated on three serine residues, specifically serine residues 16 and 18,
260 as been measured biochemically at C-terminal serine residues, suggesting that these residues are crit
261 tamine followed by a stretch of threonine or serine residues, suggesting the presence of structural r
262 t inhibition of p65 phosphorylation on these serine residues targets NF-kappaB activity to distinctiv
263 contains the C-terminal ITIM tyrosine and a serine residue that undergo activation-dependent phospho
265 egion on which lie two functionally critical serine residues that are phosphorylated during infection
267 issociation is prevented by mutation of four serine residues that are potential sites of phosphorylat
268 on of the B55alpha subunit itself on several serine residues that drastically increases the affinity
270 ter mutation of the putative phosphoacceptor serine residues, the localization of the E2 protein was
271 nes through phosphorylation of different p65 serine residues, thus shedding light on novel mechanisms
272 of RdmB and show that insertion of a single serine residue to DnrK is sufficient for introduction of
273 sphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress respo
274 he transcription factor Gata6 on a conserved serine residue to promote neural crest migration and pro
275 ally phosphorylated on specific tyrosine and serine residues to acquire full transcriptional activity
276 ammatory cytokines that target COOH-terminal serine residues to activate ubiquitination and protein d
277 rom homology modeling, mutation of three TM5 serine residues to alanine (S5.42A, S5.43A, S5.46A) had
279 ctivation, acting through N-terminal phospho-serine residues to regulate GR recruitment to its target
280 sphate precipitate core of LCP, two phosphor-serine residues were added to the N-terminal of the pept
281 enotype 1b Con1 NS5A, we found that specific serine residues were important for efficient hyperphosph
282 s known to phosphorylate PDX-1 on C-terminal serine residues, which triggers PDX-1 proteasomal degrad
283 C-terminal domain of p53 through two unique serine residues, which were acquired during recent verte
284 e specifically phosphorylates the C-terminal serine residue while ignoring those located elsewhere.
287 a PXXYHXXHXP motif, and a uniquely conserved serine residue within a GS(S/T) motif, suggesting that P
288 , by phosphorylating a specific threonine or serine residue within the activation loop which is criti
290 region (S4-S6) of TRPC4 predicts a conserved serine residue within the C-terminal sequence of the pre
291 nase A-dependent phosphorylation of a single serine residue within the core of the polybasic domain,
294 In both cases, in vitro phosphorylation of serine residues within the acidic tail stabilizes the as
296 forming a complex that dephosphorylates two serine residues within the catalytic domains of IkappaB
297 cultured cells, phosphorylation of specific serine residues within the cluster is also required for
299 at GSK-3beta phosphorylated two stretches of serine residues within the nuclear export signal and the
300 basal conditions, whereas phosphorylation of serine residues within three amino-terminal protein kina
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