ライフサイエンスコーパス: serotonergic

1 subtype), noradrenergic alpha1 and alpha2 , serotonergic 5-HT1A and dopaminergic D1/5 receptors usin

2 ; noradrenergic alpha1 and alpha2 receptors; serotonergic 5-HT1A receptors; dopaminergic D1/5 recepto

3 Serotonergic (5-HT) and noradrenergic (NA) input to spin

4 anxiety, which is dependent on activation of serotonergic (5-HT) dorsal raphe nucleus (DRN) neurons t

5 As is well recognized, serotonergic (5-HT) fibers distribute widely throughout

6 1 sensitization was maintained by descending serotonergic (5-HT) input from the brainstem.

7 cognized importance of the dorsal raphe (DR) serotonergic (5-HT) nuclei in the pathophysiology of dep

8 en have abnormalities of the brainstem raphe serotonergic (5-HT) system.

9 Both the glutamatergic and serotonergic (5-HT) systems are implicated in the modula

10 explore the role of microRNAs in regulating serotonergic (5HT) neuron activity.

11 Serotonergic (5HT) neurons exert diverse and widespread

12 Serotonergic (5HT) neurons modulate diverse behaviors an

13 olated neurons, and its ability to stimulate serotonergic accumulation in cortical synaptic vesicles.

14 The link between dysregulated serotonergic activity and depression and anxiety disorde

15 Both dorsal raphe serotonergic activity during aversive reinforcement and

16 data suggest that the MCHergic modulation of serotonergic activity within the DRN is involved in the

17 amatergic drive onto these neurons, and that serotonergic afferent activation alters the responses of

18 resting and odorant-evoked responses during serotonergic afferent stimulation.

19 Current-clamp experiments demonstrate that serotonergic afferents are largely excitatory for mitral

20 Serotonergic afferents are predominately inhibitory for

21 These results suggest that serotonergic afferents from raphe dynamically modulate o

22 Finally, optogenetically stimulating raphe serotonergic afferents in the OB had heterogeneous effec

23 at mood disorders or enhance the efficacy of serotonergic agents.

24 n DRN neurons increases habituation, whereas serotonergic agonism or DRN activation with ChR2 reduces

25 absence of ligand and bound to four distinct serotonergic agonists.

26 chanisms underlying interactions between the serotonergic and cholinergic systems related to mood dis

27 pe might mediate the interaction between the serotonergic and cholinergic systems.

28 ffects were moderated by genetic variants in serotonergic and dopaminergic pathways.

29 ht significantly increased the number of DRN serotonergic and GABAergic cells expressing c-Fos.

30 sociations between retinal afferents and DRN serotonergic and GABAergic neurons were observed.

31 These results suggest that DR serotonergic and LC noradrenergic neurons play different

32 d the putative biological cross-talk between serotonergic and melatonergic systems, a series of new (

33 at ETS-5 functions in a complex network with serotonergic and neuropeptide signaling pathways to cont

34 to the lateral ventricle, is internalized in serotonergic and non-serotonergic DRN neurons in rats an

35 of spinal nociception through activation of serotonergic and noradrenergic bulbospinal circuits.

36 y relates to the cholinergic, noradrenergic, serotonergic and orexinergic systems, and the GABAergic

37 neurons relevant for the feeding effect are serotonergic and project broadly within the brain, sugge

38 drivers, we targeted different fractions of serotonergic and raphe neurons in mice for tetanus toxin

39 Thus, we characterised the serotonergic and regional brain volume correlates of tra

40 We identified cholinergic, serotonergic, and catecholaminergic ciliomotor neurons.

41 y relates to the cholinergic, noradrenergic, serotonergic, and orexinergic systems and is extended to

42 n relates to the cholinergic, noradrenergic, serotonergic, and orexinergic systems and is extended to

43 c drug coverage in Ontario, Canada, in utero serotonergic antidepressant exposure compared with no ex

44 To evaluate the association between serotonergic antidepressant exposure during pregnancy an

45 risk of child autism spectrum disorder with serotonergic antidepressant exposure during pregnancy ma

46 Serotonergic antidepressant exposure was defined as 2 or

47 oncept of metyrapone for the augmentation of serotonergic antidepressants in the clinically relevant

48 neurons (e.g., retrotrapezoid nucleus, RTN; serotonergic) are activated by PCO2 and stimulate breath

49 stability and enabled a clear delineation of serotonergic areas and melatonin-producing pineal gland

50 eptors as potential mechanisms for mediating serotonergic attenuation of cocaine abuse-related neuroc

51 More specifically, we found altered serotonergic axon growth resulting from increased 5-HT i

52 Moreover, optogenetic activation of serotonergic axon terminals increased excitability of fu

53 required for pathfinding by dopaminergic and serotonergic axons in the brain and by a subset of optic

54 chronically repaired cord only low levels of serotonergic axons regenerated into the graft, with no e

55 More serotonergic axons sprout and/or regenerate caudal to th

56 owth of transected corticospinal, sensory or serotonergic axons through severe spinal cord injury (SC

57 synaptic inputs from corticospinal tract or serotonergic axons, limited bouton numbers suggested tha

58 We assessed the preservation of neurons and serotonergic axons, the levels of inhibitory CSPGs and m

59 ll responses, axon sparing, and sprouting of serotonergic axons.

60 anus toxin (tox) in raphe neurons expressing serotonergic bacterial artificial chromosome drivers Pet

61 Serotonergic biosynthesis in the endocrine pancreas, of

62 pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans.

63 sive but may include transiently compromised serotonergic brain signaling.

64 The serotonergic cells are active when cilia are beating.

65 prostaglandin E2 receptor EP3 selectively on serotonergic cells or selectively in the area of the dor

66 inflammatory pain aversion, EP3 receptors on serotonergic cells were dispensable for acute nociceptiv

67 Further, we identify a candidate serotonergic cellular mechanism mediating this process.

68 cular, by investigating the dopaminergic and serotonergic changes both presynaptically and postsynapt

69 INTERPRETATION: Dopaminergic and serotonergic changes progress in a similar fashion in LR

70 ological pathways included genes involved in serotonergic, cholinergic, dopaminergic, GABAergic, and

71 nels are critical regulators of a C. elegans serotonergic circuit and demonstrate a mechanism in whic

72 s local axonal tiling and global assembly of serotonergic circuitries and results in depression-like

73 s required for axonal tiling and assembly of serotonergic circuitries.

74 life adversity may have a lasting impact on serotonergic circuits underlying executive function that

75 y linking metabolism to activity of NMDA and serotonergic circuits, which regulate a broad range of b

76 We further show that this differential serotonergic control in the adult emerges from a non-mod

77 CRF levels in the hypothalamus to DRN-driven serotonergic control of CRF levels in the amygdala may c

78 that a cocaine-induced shift from MRN-driven serotonergic control of CRF levels in the hypothalamus t

79 Thus, differential descending serotonergic control of spinal touch and pain processing

80 es that exploit descending noradrenergic and serotonergic control pathways.

81 iomarker in autopsied infants with SIDS with serotonergic defects.

82 m in individuals with Lewy body disease, and serotonergic degeneration in human ventromedial caudate

83 express a series of molecules essential for serotonergic development, including tryptophan hydroxyla

84 d mood, in part through its signaling in the serotonergic dorsal raphe (DR).

85 technology, we found that stimulation of the serotonergic dorsal raphe nucleus (DRN) afferents to the

86 in larval zebrafish, we discovered that the serotonergic dorsal raphe nucleus (DRN) mediates short-t

87 cle, is internalized in serotonergic and non-serotonergic DRN neurons in rats and cats.

88 Serotonergic DRN neurons respond phasically to swim-indu

89 ion antidepressant treatment that included a serotonergic drug.

90 ic hypertension, peripartum state, or use of serotonergic drugs with clinical worsening.

91 The amygdala is a key structure in serotonergic emotion-processing circuits.

92 Serotonergic enterochromaffin (EC) cells are proposed to

93 distinct behavioral or cognitive states, and serotonergic fibers are concentrated in the DCN.

94 ust sprouting of uninjured corticospinal and serotonergic fibers in a rat cervical hemisection SCI mo

95 ust sprouting of uninjured corticospinal and serotonergic fibers in a rat hemisection spinal cord inj

96 actory bulb (OB) is a prominent recipient of serotonergic fibers, particularly in the glomerular laye

97 Serotonergic fibres exert background 5-HT3R mediated fac

98 Here we present evidence that descending serotonergic fibres not only inhibit nociceptive activit

99 del investigations of depressive illness and serotonergic function, Deakin and Graeff predicted that

100 ial target for therapy is the restoration of serotonergic function, which is both deficient in behavi

101 ut microbes, colonic contractility, and host serotonergic gene expression, we evaluated mice that wer

102 SNs) showed increased expression of specific serotonergic genes that are known to be expressed in rap

103 The serotonergic HSN command neurons initiate the active sta

104 broblasts were directly converted to induced serotonergic (i5HT) neurons by the expression of Ascl1,

105 l population found in the superior raphe was serotonergic in nature.

106 ngs are discussed with respect to a critical serotonergic influence on the amygdala, particularly on

107 nally been attributed to impaired prefrontal serotonergic inhibitory control of emotional reactions t

108 The major source of forebrain serotonergic innervation is from the dorsal raphe nucleu

109 Increased serotonergic innervation might contribute to clinical di

110 Our results demonstrate that by inhibiting serotonergic innervation of the cortical-limbic neuronal

111 possibly reflecting compensatory changes in serotonergic innervation preceding the motor onset of Pa

112 this peptide over weeks restored substantial serotonergic innervation to the spinal cord below the le

113 ere improved axonal conduction and increased serotonergic innervation were also observed.

114 The raphe nuclei provide serotonergic innervation widely in the brain, thought to

115 sal raphe nucleus (DRN), the major source of serotonergic input to the forebrain, receives excitatory

116 serotonin receptor HTR7 as a key mediator of serotonergic itch.

117 ed with positron emission tomography for two serotonergic markers: serotonin transporter (SERT) and s

118 , and its specificity for key enzymes in the serotonergic metabolic pathway, was assessed in vitro (I

119 y of quantitative noninvasive imaging of the serotonergic metabolism in the pancreas using the PET tr

120 ian primary visual cortex (V1), heterogenous serotonergic modulation has been observed in anesthetize

121 These results identify a new role for serotonergic modulation in dynamically regulating the ba

122 These results identify a new role for serotonergic modulation in rapidly changing the balance

123 N channels in the AIS can be altered through serotonergic modulation of 5-hydroxytryptamine 1A (5-HT1

124 Moreover, they support a pivotal role for serotonergic modulation of anxiety-related behavior.

125 tivity ex vivo, and downstream effectors for serotonergic modulation of breathing.

126 The distinct serotonergic modulation of MCs between the MOB and AOB c

127 and enables future dissection of the role of serotonergic modulation of olfactory processing.

128 ntennal lobe, may be required for persistent serotonergic modulation of pheromone responses in the an

129 Serotonergic modulation of sensory responses among defin

130 Here we examined the serotonergic modulation of visual processing in the prim

131 Serotonergic modulation requires peptides encoded by bot

132 Elucidating how the brain's serotonergic network mediates diverse behavioral actions

133 nally, we show that activation of the entire serotonergic network, as opposed to only activation of t

134 uronal precursors, leading to altered global serotonergic neuroarchitecture and increased spontaneous

135 manic behavior may be mediated by actions on serotonergic neurocircuitry.

136 sing optogenetic tools in vivo, we show that serotonergic neuromodulation prominently inhibits the sp

137 We found three main features of serotonergic neuron activity: (1) a large fraction of se

138 to specialized neuronal subtypes within the serotonergic neuronal system, borne out in functional st

139 Induced serotonergic neurons (iSNs) showed increased expression

140 licited by direct optogenetic stimulation of serotonergic neurons activates HSF1 and upregulates mole

141 During noxious stimuli, serotonergic neurons activation was due to a suppression

142 Consequently, excitation of serotonergic neurons alone can suppress protein misfoldi

143 nduced tagged-5-HT(1A)R endocytosis in raphe serotonergic neurons and a portion of hippocampal neuron

144 TN neurons are also activated by inputs from serotonergic neurons and hypothalamic neurons.

145 oping mouse and chick neural tube, hindbrain serotonergic neurons and spinal glutamatergic V3 interne

146 tocadherin alpha (Pcdhalpha) gene cluster in serotonergic neurons disrupts local axonal tiling and gl

147 the efficient generation of functional human serotonergic neurons from human fibroblasts as a novel t

148 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts.

149 The dorsal raphe (DR) serotonergic neurons have long been implicated in the pr

150 te to the dysregulation of noradrenergic and serotonergic neurons implicated in the pathogenesis of M

151 directs a subset of these cells to generate serotonergic neurons in a particular location is unresol

152 eurons during development and maintenance of serotonergic neurons in adults.

153 as been observing the activity of identified serotonergic neurons in animals engaged in behavioral ta

154 f the two molecules was confirmed in primary serotonergic neurons in culture.

155 itch sensation, whereas mice lacking 5-HT or serotonergic neurons in the brainstem exhibit markedly r

156 Serotonergic neurons in the brainstem raphe nuclei dense

157 There are approximately 100 serotonergic neurons in the Drosophila nervous system, a

158 glutamatergic neurons in the spinal cord and serotonergic neurons in the RVM.

159 d a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN).

160 both short- and long-term activation of DRN serotonergic neurons induce antidepressant-like behavior

161 erm activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust behavioral responses

162 expression and regulation of these genes in serotonergic neurons invites speculation that they may m

163 gic neuron activity: (1) a large fraction of serotonergic neurons modulated their tonic firing rates

164 Serotonergic neurons of the DRN are involved in the cont

165 gered internalization of tagged 5-HT(1A)R in serotonergic neurons only.

166 We propose that DR serotonergic neurons preempt reward delays at the decisi

167 Serotonergic neurons project their axons pervasively thr

168 -like episodes correlated with the number of serotonergic neurons restored with orexin receptor expre

169 Electrophysiologically, female serotonergic neurons showed blunted membrane excitabilit

170 These results suggest that serotonergic neurons signal information about reward and

171 -Fos expression was greatly increased in DRN serotonergic neurons suggesting that OFF DRN-projecting

172 Its differential occurrence in serotonergic neurons supports the idea that 5-HT(1A)R in

173 pical plate and pharyngeal endoderm, and 4-6 serotonergic neurons that are confined to the apical pla

174 However, it remains unknown how serotonergic neurons that innervate the first olfactory

175 We examined the sole pair of serotonergic neurons that innervates the Drosophila ante

176 These SONs activate serotonergic neurons to inhibit nociceptor-to-SON transm

177 ession of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible tran

178 in 1 receptor-positive neurons or descending serotonergic neurons were ablated before hyperalgesic pr

179 F DRN-projecting RGCs predominately activate serotonergic neurons whereas ON DRN-projecting RGCs main

180 We 'tagged' serotonergic neurons with the light-sensitive protein ch

181 In this study, we use a pair of identified serotonergic neurons within the Drosophila olfactory sys

182 1B heteroreceptors (receptors located on non-serotonergic neurons).

183 c excision of KOR from dopaminergic, but not serotonergic neurons, also blocked KOR-mediated disrupti

184 he i5HT neurons expressed markers for mature serotonergic neurons, had Ca(2+)-dependent 5HT release a

185 provide a comprehensive map of the inputs to serotonergic neurons, highlighting the complexity and di

186 the larva forms an anterior concentration of serotonergic neurons, or apical organ.

187 chniques and a novel lentiviral reporter for serotonergic neurons, we identified and overexpressed ke

188 l role of GLUA1-containing AMPA receptors in serotonergic neurons, we used the Cre-ERT2/loxP-system f

189 lls also activate dorsal raphe nucleus (DRN) serotonergic neurons, which project to the vicinity of t

190 Pet1 neurons may act downstream of Egr2-Pet1 serotonergic neurons, which were previously established

191 ntly augmented or reduced the activity of DR serotonergic neurons, while mice decided between differe

192 a branch specific for the differentiation of serotonergic neurons.

193 h is the only Pcdhalpha isoform expressed in serotonergic neurons.

194 crossed with Tph2-Cre mice expressing Cre in serotonergic neurons.

195 ption factors to successfully generate human serotonergic neurons.

196 partial agonist displayed an effect only in serotonergic neurons.

197 ned place aversion to pain via inhibition of serotonergic neurons.

198 The serotonin transporter (SERT) terminates serotonergic neurotransmission by performing reuptake of

199 While in the past our understanding of serotonergic neurotransmission has come mainly from mous

200 broblasts as a novel tool for studying human serotonergic neurotransmission in health and disease.

201 Here, it was investigated whether serotonergic neurotransmission in obesity is a stable tr

202 Serotonergic neurotransmission is modulated by the membr

203 Serotonergic neurotransmission is terminated by reuptake

204 ssociated with social anxiety phenotypes and serotonergic neurotransmission, may be a biomarker of th

205 l-limbic brain activity and dysregulation of serotonergic neurotransmission.

206 ntia can be partially restored by increasing serotonergic neurotransmission.

207 s important in GABAergic, glutamatergic, and serotonergic neurotransmission.

208 ctional utility of i5HT neurons for studying serotonergic neurotransmission.

209 The serotonergic neurotransmitter system has been widely imp

210 with ttx-3 to determine the identity of the serotonergic NSM neurons.

211 cially consistent abnormality, and brainstem serotonergic nuclei merit further study in depressive il

212 ed and provided evidence for the key role of serotonergic pathology in patients with Parkinson's dise

213 One study identified a serotonergic pathway in which multiple SNPs influenced r

214 l, and enhanced the plasticity of descending serotonergic pathways and corticospinal tract axonal reg

215 OP-sensitive mu-opioid receptors, descending serotonergic pathways, and activation of spinal glial ce

216 pression and anxiety, and alterations in the serotonergic phenotype of raphe neurons have dramatic ef

217 Here, we identified a symmetrical pair of serotonergic PLP neurons that are necessary for the prop

218 ersely, we identified a subset of inhibitory serotonergic projection neurons in the dorsal raphe that

219 Our results highlight a differential role of serotonergic projections arising from the MRN and DRN in

220 nucleus (MRN) and dorsal raphe nucleus (DRN) serotonergic projections differentially mediate these ph

221 We demonstrate that serotonergic projections from raphe neurons regulate pat

222 We find that serotonergic projections from the raphe nuclei to the ol

223 Here, we show that the raphe nucleus and its serotonergic projections regulate pathfinding of commiss

224 KEY POINTS: There are serotonergic projections to both the main (MOB) and the

225 In addition, we proposed that changes in serotonergic projections to the forebrain also contribut

226 ffects were observed when we manipulated the serotonergic projections to the nucleus accumbens (NAc).

227 l cortex (PFC), as a downstream target of DR serotonergic projections, was also infused.

228 tem to selectively suppress 5-HT1A levels in serotonergic raphe neurons from post-natal days (P) 14 t

229 The serotonergic raphe nuclei are involved in regulating bra

230 However, the level of involvement of the serotonergic raphe nuclei in early Parkinson's disease i

231 The serotonergic raphe nuclei of the midbrain are principal

232 However, it is unclear which specific serotonergic receptors are involved in the effects.

233 The serotonergic regulation of excitability is G-protein-dep

234 blished integrity of submidbrain circuits of serotonergic reticulospinal innervation at lumbar levels

235 While selective serotonergic reuptake inhibitors are often effective in

236 U87 glioblastoma cells and 47.8-fold in rat serotonergic RN46A-B14 cells.

237 hreats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate

238 Our data imply both serotonergic signaling and estradiol in the mechanisms b

239 sustained inhibition of SERT activity alters serotonergic signaling and influences platelet activatio

240 cross talk between brain innate immunity and serotonergic signaling as a key player in mood alteratio

241 ctly, but appears to enhance SER-4-dependent serotonergic signaling by increasing endogenous 5-HT.

242 ter that shapes peripheral taste signals via serotonergic signaling during processing gustatory infor

243 y-related behavior and altered GABAergic and serotonergic signaling in the brain.

244 atterns of sleep and wakefulness by blunting serotonergic signaling in the lateral hypothalamus.

245 toward midline-crossing axons and that when serotonergic signaling is blocked by pharmacological inh

246 nB2a mutant can rescue midline crossing when serotonergic signaling is blocked.

247 imply that thermosensory activity coupled to serotonergic signaling is sufficient to activate the pro

248 d aggressive behaviors are both modulated by serotonergic signaling, specifically through the seroton

249 responsible for the termination of synaptic serotonergic signaling.

250 ction among cannabinoid, octopaminergic, and serotonergic signaling.

251 Here we provide evidence that activation of serotonergic signalling is beneficial in animal models o

252 d in the 24-month colon, affecting TRPV1 and serotonergic signalling pathways.

253 ts suggest that small molecule modulation of serotonergic signalling represents a promising therapeut

254 The serotonin transporter (SERT) terminates serotonergic signalling through the sodium- and chloride

255 Serotonergic signalling was attenuated at 24 months, but

256 e show that extending lifespan by inhibiting serotonergic signals by the antidepressant mianserin att

257 tion of 5-HT2c-Rs and their influence on the serotonergic signals mediating mood disorders remain unc

258 nsistent with a model in which inhibition of serotonergic signals slows age-dependent physiological d

259 serotonergic system by actively suppressing serotonergic specification in the spinal cord.

260 al variant frontotemporal dementia including serotonergic strategies to improve disinhibition.media-1

261 The serotonergic synapse is dynamically regulated by seroton

262 s elucidate that the Merkel disc is a unique serotonergic synapse located in the epidermis and plays

263 The epidermal serotonergic synapse may have important clinical implica

264 (false discovery rate (FDR)=0.0097) and the serotonergic system (FDR=0.0213).

265 romiscuous pharmacological influences on the serotonergic system and demonstrate the utility of molec

266 g3 establishes the posterior boundary of the serotonergic system by actively suppressing serotonergic

267 he findings suggest that modification of the serotonergic system by early exposures may contribute to

268 The brain's serotonergic system centrally regulates several physiolo

269 nteraction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely t

270 may be that reported sex differences in the serotonergic system confound the comparison between diag

271 The wide range of drugs targeting the serotonergic system could be useful to treat spasticity

272 Serotonergic system dysfunction has been associated with

273 bjective was to analyze 17 other variants in serotonergic system genes (HTR1A, HTR2A, HTR1B, HTR2C, T

274 Dysfunction of the serotonergic system gives rise to a variety of mental il

275 ides preliminary evidence of the role of the serotonergic system in compensatory mechanisms.

276 through modulation of estrogen action on the serotonergic system in the DRN.

277 can be used for quantitative imaging of the serotonergic system in the endocrine pancreas.

278 This study investigates how the serotonergic system modulates the initial processing of

279 em and neuroimaging studies suggest that the serotonergic system, which originates from the brainstem

280 lding block for the broader functions of the serotonergic system.

281 nstream effects, and to abnormalities in the serotonergic system.

282 therapy, suggesting treatment effects on the serotonergic system.

283 traditionally linked to deficiencies in the serotonergic system.

284 tudinal changes of both the dopaminergic and serotonergic systems in seven asymptomatic 1-methyl-4-ph

285 from genetic differences in neurotrophic and serotonergic systems to sleep quality and omega-3 fatty

286 ative value' signals to the dopaminergic and serotonergic systems.

287 iginate from predominantly noradrenergic and serotonergic systems.

288 buspirone pretreatment had higher levels of serotonergic terminal functional integrity.

289 These findings indicate that striatal serotonergic terminals contribute to LIDs pathophysiolog

290 In advanced stages of Parkinson's disease, serotonergic terminals take up L-DOPA and convert it to

291 ts with LIDs showed relative preservation of serotonergic terminals throughout their disease.

292 Neurog3 switches ventral progenitors from a serotonergic to V3 differentiation program by repressing

293 These findings indicate that diminished serotonergic tone in the OFC may be an endophenotype tha

294 Here we report that enhancing serotonergic tone via administration of 5-HT potentiates

295 n of the brain innate immunity and decreased serotonergic tonus in the brain are key players in Abeta

296 ype identified by expression of Tac1 and the serotonergic transcription factor gene Pet1, referred to

297 Sex hormones modulating serotonergic transmission are proposed to partly underli

298 ow that prostaglandin-mediated modulation of serotonergic transmission controls the affective compone

299 patient stratification in clinical trials of serotonergic treatments in Parkinson's disease.

300 rgeted different portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (Tph2)(+) neurons