ライフサイエンスコーパス: serrated

1 ghout the colon, of which more than 50% were serrated.

2 ould also harbor BRAF mutations and that non-serrated ACF would not.

3 tations would be found more often in the non-serrated ACF.

4 aditional serrated adenoma (TSA), or sessile serrated adenoma (SSA) with villous characteristics (>/=

5 as cancer or a tubular adenoma, traditional serrated adenoma (TSA), or sessile serrated adenoma (SSA

6 rsor lesion, the proximal hyperplastic polyp-serrated adenoma pathway.

7 as without dysplasia, as well as traditional serrated adenoma with dysplasia.

8 ma with low grade dysplasia, n = 27; sessile serrated adenoma, n = 4; tubulovillous adenoma with high

9 AF mutation were pathologically proven to be serrated adenoma.

10 CRC precursor lesions (including sessile serrated adenoma/polyps (SSA/P), traditional serrated ad

11 d sites was significantly higher in sporadic serrated adenomas (2.0 +/- 1.7) than in tubular adenomas

12 IMP-high) was also more frequent in sporadic serrated adenomas (68%, 15 of 22) than in tubular adenom

13 al adenomatous polyposis (n = 18) or sessile serrated adenomas (n = 15) and normal colonic tissue fro

14 redominance of HPs in the right colon and/or serrated adenomas (P = 0.0009) and were associated with

15 Sessile serrated adenomas (SSAs) and traditional serrated adenom

16 hat contribute to the development of sessile serrated adenomas (SSAs).

17 ted adenomas/polyps (SSA/Ps) and traditional serrated adenomas (TSAs) are now distinguished from hype

18 ile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) constituted 36.8% (137 of 372)

19 We therefore evaluated CIMP in 22 sporadic serrated adenomas and 6 serrated adenomas with multiple

20 CpG island methylation is common in sporadic serrated adenomas and may play an important role in thei

21 Human sessile serrated adenomas and right-sided colorectal tumors with

22 nly hyperplastic polyps but also traditional serrated adenomas and sessile serrated adenomas.

23 Serrated adenomas are characterized by a saw-toothed gro

24 In this study, SSA/Ps and traditional serrated adenomas are referred to collectively as STSAs.

25 subgroup analysis was performed for sessile serrated adenomas for 2007-2012.

26 The polyps in our patients and control serrated adenomas had a decrease or absence of endocrine

27 Patients with sporadic serrated adenomas had a higher frequency of hyperplastic

28 Sporadic serrated adenomas had significantly more frequent methyl

29 p studies, premalignant potential of sessile serrated adenomas has been described and screening utili

30 pigenetic alterations in the pathogenesis of serrated adenomas is not clear.

31 oreover, ectopic crypts found in traditional serrated adenomas show basal LGR5 mRNA, indicating that

32 ps in our patients were much more similar to serrated adenomas than to hyperplastic polyps and were c

33 Sessile serrated adenomas were uncommon (n = 417, 4.5 %), with g

34 All five serrated adenomas with admixed hyperplastic glands and a

35 CIMP in 22 sporadic serrated adenomas and 6 serrated adenomas with multiple (6 to 10) hyperplastic p

36 ons includes hyperplastic polyps and sessile serrated adenomas without dysplasia, as well as traditio

37 ific polymerase chain reaction in 102 HPs, 8 serrated adenomas, 19 tubular adenomas, and 9 adenocarci

38 resected colorectal cancer, and in 70 HPs, 4 serrated adenomas, 3 admixed hyperplastic-adenomatous po

39 f HPs (P = 0.01 versus sporadic HPs), 75% of serrated adenomas, 33% of admixed hyperplastic-adenomato

40 and molecular characteristics of 129 HPs, 6 serrated adenomas, and 3 admixed hyperplastic-adenomatou

41 of human hyperplastic polyps (HPPs), sessile serrated adenomas, and traditional serrated adenomas.

42 ing also is activated in human HPPs, sessile serrated adenomas, and traditional serrated adenomas.

43 pression of GREM1 also occurs in traditional serrated adenomas, sporadic premalignant lesions with a

44 serrated adenoma/polyps (SSA/P), traditional serrated adenomas, tubular adenomas >/=10 mm or with hig

45 , sessile serrated adenomas, and traditional serrated adenomas.

46 , sessile serrated adenomas, and traditional serrated adenomas.

47 so traditional serrated adenomas and sessile serrated adenomas.

48 hyperplastic polyps, adenomas, and solitary serrated adenomas.

49 indicate that the polyps in our patients are serrated adenomas.

50 ed adenomas/polyps (SSA/Ps), and traditional serrated adenomas.

51 Sessile serrated adenomas/polyps (SSA/Ps) and traditional serrat

52 SPs comprise hyperplastic polyps, sessile serrated adenomas/polyps (SSA/Ps), and traditional serra

53 gh protein expression, especially in sessile serrated adenomas/polyps and Lynch syndrome.

54 6.8%; relative risk = 2.1), and for sessile serrated adenomas/polyps than for conventional adenomas

55 body fat, tended to be stronger for sessile serrated adenomas/polyps than hyperplastic polyps.

56 human colorectal tissue samples--48 sessile serrated adenomas/polyps, 70 sporadic high-grade dysplas

57 Serrated adenomatous polyposis has not been described be

58 It is found that the dark side is serrated and comprised of coherent twin boundaries and s

59 rences in the stem cell dynamics between the serrated and conventional pathways of colorectal carcino

60 Although Kras/KRAS mutation promotes serrated and hyperplastic morphologic features in colon

61 plastic lesions were further classified into serrated and non-serrated histologies, there was a stron

62 tional types of dysplasia, such as foveolar, serrated, and early crypt dysplasia, which make interpre

63 gative, and KRAS mutation positive; n = 58), serrated (any MSI, CIMP high, BRAF mutation positive, an

64 ated kinases (ERK)1/2 were phosphorylated in serrated areas of human hyperplastic polyps (HPPs), sess

65 colony types: smooth (S), wrinkled (W), and serrated (C).

66 The morphologic features of serrated colorectal lesions, the molecular alterations t

67 F(V600E) mutation was identified in 10 of 16 serrated compared with 1 of 33 non-serrated lesions (P =

68 sely, KRAS mutations were present in 3 of 16 serrated compared with 14 of 33 non-serrated lesions.

69 n act as a potential tumor suppressor in the serrated CRC pathway by inhibiting Wnt/beta-catenin sign

70 colorectal cancer (CRC) associated with the serrated CRC pathway.

71 Activation of Kras led to hyperplasia and serrated crypt architecture akin to that observed in hum

72 hosphorylation of EGFR and ERK1/2 within the serrated epithelium.

73 usion of lesions that were obviously SMIC or serrated, factors associated with covert SMIC were recto

74 ncluding aberrant cotyledon vein patterning, serrated floral organs, and reduced stature, but plants

75 The statistical and dynamic analyses of the serrated-flow behavior in the nanoindentation of a high-

76 The analyses of serrated flows reveal plentiful and useful information o

77 e contact line adopts a peculiar micrometric serrated form.

78 cinogenesis (ie, traditional, alternate, and serrated) have been proposed, based on specific combinat

79 ere further classified into serrated and non-serrated histologies, there was a strong inverse relatio

80 trong association between BRAF mutations and serrated histology in hyperplastic ACF supports the idea

81 enomas, and hyperplastic polyps exhibiting a serrated histology were very likely to possess BRAF muta

82 gy was defined as an adenoma with villous or serrated histology, high-grade dysplasia, or an invasive

83 same advanced colonic lesions exhibited non-serrated histology, they were wild type for BRAF; among

84 est IRR after adjusting for size and sessile serrated histology.

85 unofluorescence microscopy showed a linear n-serrated IgG deposition pattern along the basement membr

86 The serrated leaf morphology of abh1 is similar to the serra

87 ERING LOCUS C (FLC) and which also result in serrated leaf morphology were identified in T-DNA and fa

88 independent roles in the formation of simple serrated leaves and in the suppression of bract formatio

89 opment, reduced plant growth, and virescent, serrated leaves but were viable and produced seed.

90 ruct in which the uORF was mutated exhibited serrated leaves, compact rosettes, and, most significant

91 10), exhibited developmental defects such as serrated leaves, curled stems, contorted flowers and twi

92 h abnormally shaped lateral organs including serrated leaves, narrow floral organs, and petals that c

93 and in addition showed a reduced stature and serrated leaves.

94 ures or high-grade dysplasia, any dysplastic serrated lesion, or invasive cancer.

95 Results Nondiminutive serrated lesions (>/=6 mm) were seen at CT colonography-

96 10 of 16 serrated compared with 1 of 33 non-serrated lesions (P = 0.001); conversely, KRAS mutations

97 evaluated for the presence of nondiminutive serrated lesions and advanced adenomas.

98 Conclusion Serrated lesions are seen at CT colonography-based scree

99 In contrast, serrated lesions display basal localization of LGR5, and

100 We excluded serrated lesions from the analysis of covert SMIC due to

101 In contrast, 55% of serrated lesions harbored mutant BRAF, 26% were CIMP-hig

102 ggest that SSPs and other large, right-sided serrated lesions have a unique molecular profile that is

103 Risk factors for CIMP-high-serrated lesions included Caucasian race, current smokin

104 The family of serrated lesions includes hyperplastic polyps and sessil

105 There were 580 conventional adenomas and 419 serrated lesions successfully assayed.

106 The presence of high-grade dysplasia in serrated lesions was uncommon when compared with advance

107 Large right-sided serrated lesions were confirmed in 20 individuals (1.4%)

108 tics that may contribute to visualization of serrated lesions were investigated, including polyp size

109 status, and a history of polyps, whereas for serrated lesions with mutant BRAF, the significant risk

110 mately resected were neoplastic (adenomas or serrated lesions), of which 43% (nine of 21) were charac

111 d 36.8% (137 of 372) and 4.3% (16 of 372) of serrated lesions, respectively; hyperplastic polyps (HPs

112 3 of 16 serrated compared with 14 of 33 non-serrated lesions.

113 up CT colonography, many of which were flat, serrated lesions.

114 Fx-/- mice developed colitis and serrated-like lesions.

115 oss of JAGGED function causes organs to have serrated margins.

116 rectal cancer by means of a new pathway: the serrated neoplasia pathway.

117 Progression to serrated neoplasia requires cells to escape OIS via inac

118 contained the terms risk or risk factor, and serrated or hyperplastic, and polyps or adenomas, and co

119 of SP development and indicate that risk of serrated pathway colorectal neoplasms could be reduced w

120 gnificant proportion of which arise from the serrated pathway of carcinogenesis.

121 6Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development.

122 Microsimulation using the ASCCA (Adenoma and Serrated pathway to Colorectal CAncer) model.

123 nel, or a potentially initiating step on the serrated pathway to colorectal carcinoma.

124 sociated with the traditional, alternate, or serrated pathways, but was associated with a subset of p

125 rous lesion found in the colon, exhibiting a serrated phenotype would also harbor BRAF mutations and

126 nd 2007 and comprised 628 adenoma cases, 594 serrated polyp cases, 247 cases with both types of polyp

127 contrast material tagging markedly improved serrated polyp detection with an odds ratio of 40.4 (95%

128 ing at least 1 hamartomatous or hyperplastic/serrated polyp.

129 The SIR for CRC in patients with serrated polyposis (0.51; 95% CI, 0.01-2.82) did not dif

130 ta from 53 patients who met the criteria for serrated polyposis and 145 patients who did not meet the

131 was similar between patients with confirmed serrated polyposis and multiple serrated polyps (odds ra

132 Patients with serrated polyposis syndrome (SPS) are advised to undergo

133 g the World Health Organization criteria for serrated polyposis syndrome, and their relatives have si

134 ated polyps who do not meet the criteria for serrated polyposis, and in their first-degree relatives,

135 s similar to that of patients diagnosed with serrated polyposis.

136 orectal cancer (CRC) as those diagnosed with serrated polyposis.

137 cts with multiple SSAs; most had features of serrated polyposis.

138 ween first-degree relatives of these groups (serrated polyposis: 3.28, 95% CI, 2.16-4.77; multiple se

139 , and 15.6% had conventional adenomas and/or serrated polyps >/=6 mm.

140 om the SIR for CRC in patients with multiple serrated polyps (0.74; 95% CI, 0.20-1.90; P = .70).

141 vs 8.2%; P = .73) or clinically significant serrated polyps (10.0% vs 10.3%; P = .82) at the follow-

142 whether detection of proximal nondysplastic serrated polyps (ND-SP) at screening and surveillance co

143 th confirmed serrated polyposis and multiple serrated polyps (odds ratio, 1.35; 95% confidence interv

144 ing that it is also associated with multiple serrated polyps (odds ratio, 460; 95% confidence interva

145 h sessile serrated polyps but not with other serrated polyps (P = 0.02).

146 GROUND & AIMS: Certain subsets of colorectal serrated polyps (SP) have malignant potential.

147 Certain subsets of colorectal serrated polyps (SP) have malignant potential.

148 CKGROUND & AIMS: Surveillance guidelines for serrated polyps (SPs) are based on limited data on longi

149 tial localization of some neoplasms, such as serrated polyps (SPs), in specific areas of the intestin

150 highest prevalence of markers was in sessile-serrated polyps (SSP) of >/=10 mm that were in the right

151 CRC, advanced adenomas, or large (>/=10 mm) serrated polyps after 3 surveillance colonoscopies were

152 6.7 % with high-grade dysplasia (HGD), 9.6 % serrated polyps and 11.2 % adenocarcinomas.

153 Human intestinal serrated polyps are a heterogeneous group of benign lesi

154 gher proportion of subjects with significant serrated polyps as well as a higher total number of sign

155 enoma, 1.47; 95% CI, 1.27-1.71), more than 3 serrated polyps at the index examination (RR=2.16, 95% C

156 ry of colorectal cancer and detection of 1-2 serrated polyps at the index examination.

157 Detection rates of significant serrated polyps between both arms were compared using th

158 ation was positively correlated with sessile serrated polyps but not with other serrated polyps (P =

159 of EGFR protein and phosphorylation in human serrated polyps by immunohistochemical and immunoblot an

160 well as a higher total number of significant serrated polyps compared to standard colonoscopy (12.8%

161 report the prevalence and characteristics of serrated polyps identified in a large, average-risk popu

162 These serrated polyps include not only hyperplastic polyps but

163 cerous lesions (advanced adenomas or sessile serrated polyps measuring >/=1 cm in the greatest dimens

164 For nonadvanced adenomas and for serrated polyps overall, only rs961253 was statistically

165 und in the distal colon, while 80.5 % of all serrated polyps were detected in the proximal colon.

166 on varied significantly between adenomas and serrated polyps were sex (P < 0.001), use of estrogen-on

167 ffers a higher detection rate of significant serrated polyps when compared to standard colonoscopy.

168 The risk of CRC in patients with multiple serrated polyps who do not meet the criteria for serrate

169 definition white light colonoscopy regarding serrated polyps' detection.

170 (P = 0.05 among adenomas and P < 0.001 among serrated polyps), postmenopausal estrogen-only therapy (

171 among adenomas), and obesity (P = 0.01 among serrated polyps).

172 rols, 489 cases with adenoma, 401 cases with serrated polyps, and 188 cases with both polyp types.

173 of colorectal polyps, including adenomas and serrated polyps, and single-nucleotide polymorphisms (SN

174 The importance of serrated polyps, as well as their surveillance intervals

175 investigated whether patients with multiple serrated polyps, but not meeting the World Health Organi

176 67 was significantly associated with sessile serrated polyps, but this association was opposite of th

177 the membrane) rapidly developed large cecal serrated polyps.

178 he intestine of mice promotes development of serrated polyps.

179 of mice promoted development of small cecal serrated polyps.

180 ve 1 or more adenomas, advanced adenomas, or serrated polyps.

181 We studied CRC risks associated with serrated polyps.

182 these lesions using current terminology for serrated polyps.

183 polyposis: 3.28, 95% CI, 2.16-4.77; multiple serrated polyps: 2.79, 95% CI, 2.10-3.63; P = .50).

184 variety of intriguing phenotypes, including serrated rosette leaves, irregular flowers, floral organ

185 ith FIT (P=0.004); the rates of detection of serrated sessile polyps measuring 1 cm or more were 42.4

186 kades with unique and easily distinguishable serrated shape electrical signals.

187 The key enabling feature is the serrated teeth along the edges across an inclined gap as

188 To investigate the effectiveness of serrated teeth on the formation of multiple fiber bundle

189 The sharp points on the serrated teeth provide favorable charge dissipation poin

190 ing the antorbital and mandibular fenestrae, serrated teeth, and closed lower temporal bar.

191 s, KRAS mutations were found mainly in a non-serrated variant.