ライフサイエンスコーパス: serum iron

1 ice also have elevated Zn protoporphyrin and serum iron.

2 acts and hyperferritinemia without increased serum iron.

3 Additionally, bdh2 null mice exhibit reduced serum iron.

4 transferrin saturation, serum ferritin, and serum iron.

5 mbined risk ratio, 1.0; 95% CI, 0.7 to 1.5), serum iron (0.8; 95% CI, 0.7 to 1.0), and total dietary

6 al chow, carbonyl iron-fed rats had elevated serum iron (42 vs. 21 muM; P=0.007) and TGs (190 vs. 115

7 Homozygous b/b rats had greater serum iron (68 vs. 28 muM; P=0.0004) and TG levels (180

8 Serum iron, a potential pro-oxidant, also decreased by 4

9 or health (including chronic conditions, low serum iron and albumin levels) and exclusion of 44 death

10 vation in acute-phase reactants, and fall in serum iron and albumin.

11 There was no association between serum iron and colorectal cancer risk in women.

12 iron-chelation therapy for FRDA, we measured serum iron and ferritin concentrations in 10 FRDA patien

13 Serum iron and ferritin levels declined rapidly on MG2 a

14 Serum iron and ferritin levels were markedly elevated (P

15 n, with a subsequent decrease in circulating serum iron and hemoglobin levels and a concomitant incre

16 Adults aged 30 or more years at baseline had serum iron and high density lipoprotein cholesterol (HDL

17 erved differences in the association between serum iron and nonskin cancer risk is unclear.

18 Serum iron and TIBC fell significantly over time [P < 0.

19 GSTT1-0 (n = 37), was associated with higher serum iron and total and LDL-cholesterol concentrations

20 On the contrary, serum iron and transferrin levels were decreased in ICU

21 12 hours, coinciding with a 50% reduction in serum iron and transferrin saturation over the 24-hour p

22 with reduced intestinal (59)Fe uptake, lower serum iron and transferrin saturation, but no change in

23 We compared serum iron and triglycerides (TGs) in Belgrade rats, a g

24 from depleted iron stores (decreased liver, serum iron, and ferritin), reduced erythropoiesis, and s

25 g tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mic

26 s BMP6 improved hepcidin deficiency, reduced serum iron, and redistributed tissue iron to appropriate

27 dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance o

28 Both tissue iron overloading and elevated serum iron are also found in hea and fsn neonates.

29 These findings identify serum iron as a critical protective factor in renal allo

30 cularly transferrin saturation, that reflect serum iron availability, are strong outcome predictors i

31 Transferrin saturation (serum iron concentration divided by total iron binding c

32 igher hepcidin levels and consequently lower serum iron concentration on days 14 and 21, and manifest

33 morphism most strongly associated with lower serum iron concentration was rs4820268 (P = 5.12 x 10(-9

34 macrophage iron retention, resulting in low serum iron concentrations (hyposideremia).

35 Seventy-two hours later, serum iron concentrations and hepatic levels of STAT3 ph

36 Serum iron concentrations and serum ferritin concentrati

37 or menopausal status (breast cancer), higher serum iron concentrations and transferrin saturation wer

38 The mean serum iron concentrations and transferrin-saturation val

39 hepcidin messenger RNA levels and decreased serum iron concentrations in Alk2- but not Alk3-deficien

40 hepatic hepcidin gene expression and reduce serum iron concentrations is dependent on the BMP type I

41 Most AN patients had normal serum iron concentrations on admission.

42 Conversely, in men, higher serum iron concentrations were associated with decreased

43 Higher transferrin saturation or serum iron concentrations were associated with increased

44 plenic macrophage iron content and increased serum iron content.

45 values correlated with ferritin levels, and serum iron correlated strongly with transferrin saturati

46 receptor (sTfR) increased (P < 0.0001), and serum iron decreased from 2M to 5M (P < 0.01).

47 e evolved effective mechanisms to circumvent serum iron deprivation.

48 as up-regulated with concomitant lowering of serum iron during acute murine Influenza A/PR/8/34 virus

49 ligoribonucleotide, prevents the decrease in serum iron during experimental human endotoxemia.

50 ne increased hepcidin expression and reduced serum iron, effects that were inhibited by LDN-193189 or

51 luble transferrin receptor (sTfR), hepcidin, serum iron, erythropoietin, serum folate, vitamin B-12,

52 Serum iron, ferritin, transferrin, interleukin (IL)-6, a

53 Moreover, the increase in serum iron following induction of erythropoiesis was ent

54 lasts, a cell type that consumes most of the serum iron for use in hemoglobin synthesis.

55 e (indicated by increased haemoglobin level, serum iron, FPN expression and decreased ferritin level)

56 At T = 9 hours, serum iron had increased by 15.9 +/- 9.8 micromol/L from

57 ratio 0.92; 95% CI, 0.89-0.95; P < .001) and serum iron (hazard ratio 0.98; 95% CI, 0.97-0.99; P = .0

58 injection of hepcidin caused a rapid fall of serum iron in a dose-dependent manner, with a 50-microg

59 Lowering serum iron in Belgrade rats reduced TG levels (274 to 67

60 use model of AI and demonstrated to modulate serum iron in cynomolgus monkeys.

61 cantly lower, with a concomitant increase in serum iron in Hri-/- mice upon LPS treatment.

62 P6 increases hepcidin expression and reduces serum iron in mice.

63 Here, we investigated the role of serum iron in the sterile inflammation that follows kidn

64 f the proteins that help hepcidin to monitor serum iron, including HFE and, in rarer instances, trans

65 more, since patients with elevated available serum iron, including those with diabetic ketoacidosis (

66 is condition and pre-dispose to increases in serum iron indices, are over-represented in diabetic pop

67 Serum iron is bound to transferrin and enters erythroid

68 shown to be due to an increase in available serum iron leading to enhanced red cell hemoglobinizatio

69 gue-Dawley rats resulted in no change in the serum iron level, a marked increase in the urinary excre

70 rpuscular volume, mean corpuscular Hb level, serum iron level, and Tfsat, and increased red blood cel

71 independently associated with elevations in serum iron level, serum transferrin-iron saturation, ser

72 els of serum cholesterols and persistent low serum iron level.

73 Deferoxamine infusion decreased serum iron levels (P<0.001).

74 ions and inflammation, causing a decrease in serum iron levels and contributing to the development of

75 ive iron overload in the liver and increased serum iron levels and iron deposition in several organs

76 le T cells resulted in a significant rise in serum iron levels and liver iron content.

77 itionally, the Btbd9 mutant mice had altered serum iron levels and monoamine neurotransmitter systems

78 and 1200 ng/ml (reference 100 to 199 ng/ml), serum iron levels between 60 and 120 microg/ml (referenc

79 hich is secreted by the liver, and decreases serum iron levels by causing the down-regulation of the

80 decreased hepcidin expression and increased serum iron levels by mobilizing iron from splenic stores

81 Hepcidin reduces serum iron levels by promoting degradation of the iron e

82 eral or oral administration to mice, lowered serum iron levels comparably to those after parenteral n

83 The results suggest that elevated serum iron levels coupled with either high VLDL-C or low

84 nistic support for interventions that reduce serum iron levels in individuals at risk for hypertrigly

85 els of bioactive hepcidin and its effects on serum iron levels in mice infected with Borrelia burgdor

86 dietary iron caused significant elevation of serum iron levels in p53(-/-) mice.

87 Increasing serum iron levels in patients may thus improve prognosis

88 mobilizes splenic iron stores, and increases serum iron levels in vivo.

89 increases hepcidin expression and decreases serum iron levels in vivo.

90 Serum iron levels were decreased with DFO treatment afte

91 However, serum iron levels were reduced to a significantly greate

92 LFKO(-/-) mice on either diet, although the serum iron levels were slightly elevated in LFKO-/- mice

93 Iron loading was confirmed by increases in serum iron levels, percentages of transferrin saturation

94 ped an anemia associated with abnormally low serum iron levels, yet accumulated hepatic and renal iro

95 erroportin downregulation and a reduction of serum iron levels.

96 e induces hepcidin and diminishes tissue and serum iron levels.

97 lted in reduced liver hepcidin and increased serum iron levels.

98 hepcidin production and increased tissue and serum iron levels.

99 2 in Hfe-null mice had no effect on liver or serum iron levels.

100 ducibly antagonize the effect of hepcidin on serum iron, likely because of its rapid conversion to in

101 mary viremic phases of HCV or HBV infection; serum iron marginally increased during acute HBV infecti

102 We analyzed the associations of serum iron measures and antioxidant concentrations with

103 Serum iron measures were also collected.

104 ary hemochromatosis in persons with elevated serum iron measures, but even this use is limited by unc

105 sfusion was followed by increases in AUC for serum iron (P < 0.01), transferrin saturation (P < 0.001

106 Serum iron parameters at admission were correlated with

107 rate that the presence of elevated available serum iron predisposes the host to mucormycosis.

108 cate that the presence of elevated available serum iron predisposes the host to mucormycosis.

109 on:transferrin ratio in lactating mice whose serum iron ranged from 8 to 66 microM.

110 L-6)-induced hypoferremia, NOX-H94 inhibited serum iron reduction completely.

111 Serum iron remained suppressed for more than 48 hours af

112 Iron parameters (serum iron, serum ferritin, total iron-binding capacity

113 dmixture-mapping and association studies for serum iron, serum ferritin, transferrin saturation (SAT)

114 Serum iron, serum hepcidin, and hepatic iron concentrati

115 th hemochromatosis diagnosed on the basis of serum iron studies and liver biopsy findings, 60 (91%) w

116 Serum iron studies, quantitative hepatic iron concentrat

117 mochromatosis is traditionally done by using serum iron studies.

118 using HFE gene testing were less costly than serum iron studies.

119 tical model of the relation between milk and serum iron suggests that the affinity of apotransferrin

120 dren with T1D and CD had significantly lower serum iron than children with T1D alone (8.5 mugm/L Vs 1

121 d the first genome-wide association study of serum iron, total iron binding capacity (TIBC), transfer

122 romatosis (Hfe(-/-)) significantly decreased serum iron, transferrin saturation and liver iron accumu

123 We measured serum iron, transferrin saturation, and ferritin in all

124 Plasma TAS, serum ferritin, serum iron, transferrin saturation, and hemoglobin were

125 llected clinical data, including hemoglobin, serum iron, transferrin saturation, and serum ferritin c

126 Milk iron was linearly related to the serum iron:transferrin ratio in lactating mice whose ser

127 alter the relation between milk iron and the serum iron:transferrin ratio.

128 The serum iron transport protein human transferrin (hTf) is

129 ric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE

130 nsects have evolved distinctive forms of the serum iron transport protein, transferrin, and the stora

131 In the absence of serum, iron treatment was associated with a reduction of

132 Many patients with HH have abnormal serum iron values before the development of any signific

133 from observational studies that have linked serum iron variables and cancer outcomes has been incons

134 Serum iron was also significantly higher in the Fe than

135 rin receptor, transferrin receptor index, or serum iron-was related to APP concentrations, but poor p

136 in, haemoglobin with erythrocyte indices and serum iron were recorded for all patients.

137 6 inhibits hepcidin expression and increases serum iron, whereas DRAGON.Fc has no effect.

138 d CRP remained significantly associated with serum iron, with no evidence that such a relationship wa