ライフサイエンスコーパス: serum response factor

1 ly regulated by TGF-beta1/SMAD and myocardin/serum response factor.

2 iption factors such as NF-kappaB, C/EBP, and serum response factor.

3 of nuclear factors of activated T cells and serum response factor.

4 ophy, likely by its direct interactions with serum response factor.

5 ing transcription factor, NF-kappaB/Rel, and serum response factor.

6 h muscle gene expression by associating with serum response factor.

7 scle differentiation by its association with serum response factor.

8 ivation by HEB and E2-2 was synergistic with serum response factor.

9 absence of ELK1 binding partners, ERK1/2 and serum-response factor.

10 ering the displacement of myocardin from the serum-response factor.

11 We found that Tbx1 binds serum response factor, a master regulator of muscle diff

12 scle-specific transcriptional coactivator of serum response factor, a ubiquitous transcription factor

13 lial tumours, and that, in this context, Mal/serum response factor activation is rate-limiting for tu

14 ion and inhibited the wild type Trio-induced serum response factor activation.

15 pe Galpha13, Galpha13K204A induced much less serum-response factor activation when expressed in HeLa

16 anically-induced stimuli with the control of serum response factor activity and localization through

17 buted in part to inappropriate repression of serum response factor activity in stressed hearts.

18 We found that leupaxin forms a complex with serum response factor and associates with CArG-containin

19 ct as bridging molecules that associate with serum response factor and GATA proteins.

20 Conversely, the interaction between serum response factor and its co-activator myocardin was

21 The CArG box is activated by the binding of serum response factor and its coactivators, myocardin (M

22 CYA-depleted cells depended on activation of serum response factor and its cofactors, myocardial-rela

23 Serum response factor and its transcriptional cofactor M

24 rough the CArG box-binding proteins, such as serum response factor and members of the myocardin (Myoc

25 ation-associated increase in the activity of serum response factor and RhoA GTPase.

26 erentiation through the transcription factor serum response factor and the signaling effector calcine

27 sts, including that of runt-1, required SRF (serum response factor) and sos-1.

28 (cAMP response element binding factor), SRF (serum response factor), and MEF2 (myocyte enhancer facto

29 TAATC(C/T) cis-element, by interacting with serum response factor, and by increasing histone acetyla

30 ith Brg1 of the SNF/SWI complexes, recruited serum response factor, and remodeled smooth muscle targe

31 iate with the MADS box transcription factor, serum response factor, and synergistically activate tran

32 However, serum response factor appears to transiently induce cyto

33 ding sites for muscle regulatory factors and serum response factor as well as a conserved homeodomain

34 ly all smooth muscle genes are controlled by serum response factor binding sites in their promoter re

35 Both PDGF-BB and KLF4 markedly reduced serum response factor binding to CArG containing regions

36 VSMC contractile genes as well by increasing serum response factor binding to CArG-containing regions

37 d or myr-Akt expressing cells showed reduced serum response factor binding to SM-specific CArG elemen

38 nce inhibits Rho-induced gene expression via serum response factor but has no apparent effect on Rho-

39 bind them (e.g. ternary complex factor/ELK1; serum response factor, cAMP response element-binding pro

40 Nuclear accumulation of the serum response factor coactivator MAL/MKL1 is controlled

41 yocardin (Myocd), a known CArG box-dependent serum response factor coactivator, participates in Smad3

42 myocardin, revealing unique roles for these serum response factor coactivators in the development of

43 lasmic/nuclear shuttling and functions as an serum response factor cofactor in the nucleus.

44 odulation of the subcellular localization of serum response factor cofactors is 1 mechanism by which

45 ex factors (TCFs; SAP-1, Elk-1, and Net) are serum response factor cofactors that share many function

46 6 can modulate the activity of the myocardin-serum-response factor complexes.

47 CC(A/T)6GG-dependent (CArG-dependent) and serum response factor-dependent (SRF-dependent) mechanis

48 otein localized to the Z disc that activates serum response factor-dependent (SRF-dependent) transcri

49 nd limits the ability of leupaxin to enhance serum response factor-dependent gene transcription.

50 gnals to the nucleus, activating a subset of serum response factor-dependent genes promoting myogenic

51 calcification through a Runx2 and myocardin-serum response factor-dependent pathway.

52 ilent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activ

53 The serum response factor-dependent TGFbeta1 regulation was

54 rexpression of SOCS-3 specifically increased serum response factor-driven transcriptional activity bu

55 tin polymerization-controlled coactivator of serum response factor, drives myofibroblast transition f

56 , we found that larval glia are enriched for serum response factor expression, explaining the apparen

57 the SMC marker gene promoters as well as the serum-response factor, GATA, and MEF2 enhancers.

58 ey cardiac transcription factors such as the serum response factor, Gata4, and Nkx2-5.

59 d found that its ability to activate Rac1 or serum response factor in vivo was abolished.

60 ics approach to investigate the role of SRF (serum response factor) in the serum response of fibrobla

61 ted a highly conserved CArG box, which binds serum response factor, in intron 15 of mylk1.

62 es apoptotic engulfment, and determined that serum response factor is important for MFG-E8 production

63 second transcription factor that is probably serum response factor, is located within the first intro

64 ions ablated receptor-mediated activation of serum response factor luciferase, a classic measure of G

65 ctin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cyc

66 5-HT triggered Rho-dependent serum response factor-mediated reporter activation in PA

67 Co-injection of zsrf (serum response factor) mRNA rescues the cardiac phenotyp

68 itous myocardin-related transcription factor/serum response factor (MRTF-A/SRF) transcription pathway

69 t the Myocardin-related transcription factor/Serum response factor (MRTF/SRF) pathway plays a key rol

70 The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a pr

71 Because the Nox4 promoter harbors a serum response factor/MRTF cis-element (CC(A/T)6GG box),

72 nding sites for three transcription factors, serum response factor, myelin transcription factor-1, an

73 R-143 were direct transcriptional targets of serum response factor, myocardin and Nkx2-5 (NK2 transcr

74 ression and promoting the association of the serum response factor-myocardin complex with VSMC contra

75 ansactivated the Bmp10 gene via binding of a serum response factor-myocardin protein complex to a non

76 tion, through signaling events targeting the serum response factor-myocardin-related transcription fa

77 gulating myocardin expression and preventing serum response factor/myocardin from associating with SM

78 muscle differentiation regulators including serum response factor, MyoD and Mef2.

79 targets of RhoA and Rac1 signaling including serum response factor, NF-kappaB, and other transcriptio

80 nscriptional activity of Stat3, NFkappaB, or serum response factor, nor the expression of the cell di

81 or three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer facto

82 stingly, FHL2 does not affect recruitment of serum response factor or Myocd, however, it inhibits rec

83 es many transcription factors, including the serum response factor partner Elk-1.

84 -SRF (myocardin-related transcription factor-serum response factor) pathway for sustained PM blebbing

85 n/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

86 Expression of myocardin/serum response factor-regulated myofibrillar genes is ex

87 was potentiated by MSY1, but antagonized by serum response factor, reinforcing the idea that interpl

88 AR along with the transcription factor SRF (serum response factor), representing less than 6% of and

89 based assays, including Ca(2+) mobilization, serum response factor response element, stress fiber for

90 ownstream effector, the transcription factor serum response factor resulted in analogous developmenta

91 o and in transgenic mice increased myocardin/serum response factor signaling and increased expression

92 reased levels of cellular ATP, and increased serum response factor signaling in primary fibroblasts,

93 Foxf2 attenuated myocardin/serum response factor signaling in smooth muscle cells t

94 ent is critically dependent on a RAF/MEK/ERK/serum response factor signaling pathway and suggest that

95 f the myocardin-related transcription factor/serum response factor signaling pathway as a therapeutic

96 is essential for intestinal development and serum response factor signaling.

97 st of ID proteins and has been implicated in serum-response factor signaling.

98 We also show that Barx2, MyoD, and serum response factor simultaneously occupy the SMA prom

99 P-response element binding protein CREB, the serum response factor SRF, and the nuclear factor of act

100 orylation of a cluster of amino acids in the serum response factor (SRF) "MADS box" alphaI coil DNA b

101 Serum response factor (SRF) activates genes involved in

102 ber et al. identify actin polymerization and serum response factor (SRF) activation as key steps link

103 Actin signaling controls serum response factor (SRF) activity via SRF interaction

104 -mediated processes, including regulation of serum response factor (SRF) activity.

105 ly identified that the transcription factor, serum response factor (SRF) and a number of its target g

106 ntractility and motility by associating with serum response factor (SRF) and activating genes involve

107 factor-responsive transcription cofactors of serum response factor (SRF) and are activated by MAP kin

108 at Tip60alpha, Tip60beta, and Tip55 can bind serum response factor (SRF) and by transient transfectio

109 The interactions between serum response factor (SRF) and CArG elements are critic

110 ein-2 (FHL2) and FHL2-mediated inhibition of serum response factor (SRF) and extracellular signal-reg

111 ction, because it acted synergistically with serum response factor (SRF) and GATA6 to activate the SM

112 Actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator megakary

113 Serum response factor (SRF) and its coactivator, myocard

114 ecent studies have shown that interaction of serum response factor (SRF) and its numerous accessory c

115 CBF regulation, express in AD high levels of serum response factor (SRF) and myocardin (MYOCD), two i

116 required for SMC differentiation, including serum response factor (SRF) and myocardin family members

117 Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transc

118 stigated the combinatorial role of myocardin/serum response factor (SRF) and Notch signaling in the t

119 actor myocardin functionally synergizes with serum response factor (SRF) and plays an important role

120 oLSD1 can interact with transcription factor serum response factor (SRF) and set the chromatin state

121 -related transcription factor A (MRTF-A) and serum response factor (SRF) and the other using the tran

122 Elk-1 and the serum response factor (SRF) are downstream transcription

123 n promoter and Elk-1 binding is dependent on serum response factor (SRF) binding to a nearby CArG box

124 romatin immunoprecipitation assays confirmed serum response factor (SRF) binding to both CArG element

125 Serum response factor (SRF) binds a 1216-fold degenerate

126 The serum response factor (SRF) binds to coactivators, such

127 or transcriptional synergy between GATA4 and serum response factor (SRF) but not other cardiac cofact

128 Myocardin is a serum response factor (SRF) co-activator that regulates

129 cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic

130 The Serum Response Factor (SRF) coactivator myocardin stimul

131 Myocardin (Myocd) is a serum response factor (SRF) coactivator that promotes SM

132 We previously reported the importance of the serum response factor (SRF) cofactor myocardin in contro

133 proteins (myocardin, MRTF-A, and MRTF-B) are serum response factor (SRF) cofactors and potent transcr

134 in-related transcription factors (MRTFs) are serum response factor (SRF) cofactors that promote a smo

135 Serum response factor (SRF) controls multiple genes gove

136 Serum response factor (SRF) controls SMC gene transcript

137 Serum response factor (SRF) controls the transcription o

138 Serum response factor (SRF) directs programs of gene exp

139 in part from TGFbeta-induced enhancement of serum response factor (SRF) DNA binding and transcriptio

140 n factors megakaryoblastic leukemia-1 (MKL1)/serum response factor (SRF) during myofibroblast differe

141 e extreme thrombocytopenia than mice lacking serum response factor (SRF) expression in the megakaryoc

142 We tested the idea that T-box factors direct serum response factor (SRF) gene activity early in devel

143 Serum response factor (SRF) homozygous-null embryos from

144 y inhibiting the transcriptional activity of serum response factor (SRF) in cardiomyocytes.

145 Knockdown of serum response factor (SRF) in SMCs significantly reduce

146 Here, we show that deletion of serum response factor (SRF) in specific neuronal populat

147 s, we found a potential binding site for the serum response factor (SRF) in the promoter of the ubiqu

148 tain two or more essential binding sites for serum response factor (SRF) in their control regions.

149 transcription factors (MRTFs) co-activating serum response factor (SRF) in this process is largely u

150 The transcription factor serum response factor (SRF) interacts with its cofactor,

151 Serum response factor (SRF) is a key regulator of smooth

152 Serum response factor (Srf) is a MADS-box transcription

153 Serum response factor (SRF) is a major transcription fac

154 Serum response factor (SRF) is a phosphoprotein that reg

155 Serum response factor (SRF) is a prototypic transcriptio

156 Serum response factor (SRF) is a transcription factor im

157 Serum response factor (SRF) is a transcription factor re

158 Serum response factor (SRF) is a transcription factor th

159 Serum response factor (SRF) is a transcription factor th

160 The serum response factor (SRF) is a transcriptional regulat

161 Serum response factor (SRF) is a ubiquitously expressed

162 Serum response factor (SRF) is a ubiquitously expressed

163 Serum response factor (SRF) is a ubiquitously expressed

164 Serum response factor (SRF) is a widely expressed transc

165 Serum response factor (SRF) is activated by contractile

166 Serum response factor (SRF) is an essential regulator of

167 uitously expressed transcriptional regulator serum response factor (SRF) is controlled by both Ras/MA

168 The serum response factor (SRF) is essential for embryonic d

169 element (SRE)-mediated gene expression, and serum response factor (SRF) is indispensable for SRE-med

170 We demonstrate that serum response factor (SRF) is induced by both platelet-

171 Serum response factor (SRF) is known to be important for

172 Here, we show that serum response factor (Srf) is needed for optimal SC-med

173 Serum response factor (SRF) is required for the expressi

174 Our conditional serum response factor (SRF) knockout, Srf (Cko), in the

175 ER alpha binding sites, constitutively bound serum response factor (SRF) mediates estrogen stimulatio

176 Network analysis revealed that the serum response factor (SRF) network is highly affected.

177 tion of the FHL2 gene, mediated by action of serum response factor (SRF) on its proximal promoter.

178 Several genes encoding proteins of the serum response factor (SRF) pathway are located on 5q.

179 in-related cotranscription factor-A (MRTF-A)/serum response factor (SRF) pathway.

180 ly among actomyosin genes, especially in the serum response factor (SRF) pathway.

181 Serum response factor (SRF) plays a central role in regu

182 n in vascular smooth muscle cells (VSMCs) by serum response factor (SRF) plays a crucial role in vasc

183 The transcription factor serum response factor (SRF) plays an important role in t

184 Serum response factor (SRF) recruits members of two fami

185 genomic approaches, we provide evidence that serum response factor (SRF) regulates both general and c

186 Serum response factor (SRF) regulates genes involved in

187 Serum response factor (SRF) regulates transcription of i

188 yocardin-related transcription factor (MRTF)-serum response factor (SRF) regulatory axis within stria

189 Using a serum response factor (SRF) response element reporter-dr

190 have shown that neuron-specific deletion of serum response factor (SRF) results in deficits in tange

191 p38 mitogen-activated protein kinase (MAPK) serum response factor (SRF) signaling via the TRPC6 prom

192 ith multiple actin regulators and to promote serum response factor (SRF) signalling has raised the qu

193 n is an extraordinarily powerful cofactor of serum response factor (SRF) that stimulates expression o

194 og, NKX2.5, NKX3.1 acts synergistically with serum response factor (SRF) to activate expression from

195 ors (TCFs) act with the transcription factor serum response factor (SRF) to activate mitogen-induced

196 of TNF-alpha-induced NF-kappaB and myocardin/serum response factor (SRF) to convey hypertrophy signal

197 e to actin polymerization and cooperate with serum response factor (Srf) to regulate the expression o

198 n state dictates the interaction between the serum response factor (SRF) transcription factor and one

199 1) is a myocardin-related coactivator of the serum response factor (SRF) transcription factor, which

200 aryoblast leukemia 1 (MKL1), an activator of serum response factor (SRF) transcriptional activity, pr

201 Serum response factor (SRF) was recently shown to bind a

202 We postulated that serum response factor (SRF), a central cardiac transcrip

203 In this study, we have shown that serum response factor (SRF), a common transcriptional fa

204 in embryos with cardiac-specific ablation of serum response factor (SRF), a direct transcriptional re

205 Here we report that murine serum response factor (SRF), a gene regulator linked to

206 of MRTFs to the nucleus where they activate serum response factor (SRF), a regulator of actin and ot

207 These changes are largely controlled by the serum response factor (SRF), a transcription factor that

208 d lamellipodin share the ability to activate serum response factor (SRF), a transcription factor that

209 tal actin signals physically associates with serum response factor (SRF), activating a subset of SRF-

210 distintegrin and metalloprotease family 10), serum response factor (SRF), and insulin-like growth fac

211 r-related, locus 5 (NKX2-5), T-box 5 (TBX5), serum response factor (SRF), and myocyte-enhancer factor

212 the c-fos cellular oncogene is regulated by serum response factor (SRF), and Tax is known to induce

213 iscernible CArG motifs, the binding site for serum response factor (SRF), and we show that the enhanc

214 the activity-dependent transcription factor, serum response factor (SRF), as a novel upstream mediato

215 ether myocardin, a SMC-selective cofactor of serum response factor (SRF), contributed to Ang II-induc

216 response element binding protein (CREB) and serum response factor (SRF), in mediating this induction

217 the stimulus-dependent transcription factor, serum response factor (SRF), in neural precursor cells (

218 ile gene transcription factors myocardin and serum response factor (SRF), independent of mammalian ta

219 diated by the MADS-box transcription factor, serum response factor (SRF), its actin-binding myocardin

220 Ablation of KLF3, known to interact with serum response factor (SRF), or SRF itself, results in f

221 the stimulus-dependent transcription factor, serum response factor (SRF), plays a critical role in re

222 TEAD1 competes with myocardin for binding to serum response factor (SRF), resulting in disruption of

223 ecific depletion of the transcription factor Serum Response Factor (SRF), suffer from loss of BBB int

224 cription factor-A (MRTF-A), a coactivator of serum response factor (SRF), we discovered a muscle-enri

225 ripts is the nodal transcriptional regulator serum response factor (SRF), whereas another is calcineu

226 ir differentiation state can be regulated by serum response factor (SRF), which activates genes invol

227 n factor that functions as a coactivator for serum response factor (SRF), which controls genes involv

228 of smooth muscle (SM) cells is controlled by serum response factor (SRF), which drives the expression

229 ocardin is a transcriptional co-activator of serum response factor (Srf), which is a key regulator of

230 fferentiation is mediated by the activity of serum response factor (SRF), which is tightly controlled

231 RTFs) MRTF-A and MRTF-B are coactivators for serum response factor (SRF), which regulates genes invol

232 (SMCs) is regulated, in part, by an intronic serum response factor (SRF)-binding CArG element.

233 Myocardin, a serum response factor (SRF)-dependent cofactor, is a pot

234 transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program requi

235 l activation in response to mitogens through serum response factor (SRF)-dependent recruitment of Elk

236 Forskolin also significantly inhibited serum response factor (SRF)-dependent reporter gene (SRE

237 Overexpression of MKL1 transactivates serum response factor (SRF)-dependent SMC-restricted tra

238 Here we report that Galphaz signals inhibit serum response factor (SRF)-dependent transcription.

239 e second is a cryptic degron adjacent to the serum response factor (SRF)-interaction domain that mark

240 cription factors (MRTFs) are coactivators of serum response factor (SRF)-mediated gene expression.

241 ellular F-actin/G-actin levels also regulate serum response factor (SRF)-mediated gene regulation, su

242 induce activation of Rho GTPase, leading to serum response factor (SRF)-mediated gene transcription

243 Serum response factor (SRF)-mediated transcription contr

244 uced nuclear actin polymerization results in serum response factor (SRF)-mediated transcription throu

245 tiation, we screened for TGF-beta1 and MYOCD/serum response factor (SRF)-regulated TSPANs in VSMC by

246 identified PTPLa as a new target gene of the serum response factor (SRF).

247 tain a CArG box, which is a binding site for serum response factor (SRF).

248 Fos-dependent activator protein-1 (AP-1) via serum response factor (SRF).

249 vel synergistic interaction between KLF3 and serum response factor (SRF).

250 ponse element binding protein (CREB) and the serum response factor (SRF).

251 enes (IEG) involves the transcription factor serum response factor (SRF).

252 romotes muscle differentiation by activating serum response factor (SRF).

253 L, a coactivator of the transcription factor serum response factor (SRF).

254 roteins are transcriptional coactivators for serum response factor (SRF).

255 igration, and myogenesis by associating with serum response factor (SRF).

256 ac and smooth muscle-specific coactivator of serum response factor (SRF).

257 wound healing/angiogenesis--is regulated by serum response factor (Srf).

258 muscle-specific transcriptional cofactor for serum response factor (SRF).

259 nteract with class I bHLH factors as well as serum response factor (SRF).

260 holipase Cbeta2 by Rac3 and signaling to the serum response factor (SRF).

261 rG boxes, which represent a binding site for serum response factor (SRF).

262 ctor for the ubiquitous transcription factor serum response factor (SRF).

263 nhances myoblast proliferation by repressing serum response factor (SRF).

264 array of muscle-specific genes controlled by serum response factor (SRF).

265 is regulated by RhoA-dependent activation of serum response factor (SRF).

266 n promoter required co-expressed full-length serum response factor (SRF).

267 mplexes with the human counterpart of Mcm1p, serum response factor (SRF).

268 tor (MRTF), a transcriptional coactivator of serum response factor (SRF).

269 riptional level via the transcription factor serum response factor (SRF).

270 marker expression and promoter activity in a serum response factor (SRF)/CArG box-dependent manner.

271 ll-restricted genes governed directly by the serum response factor (SRF)/myocardin (MYOCD) transcript

272 The serum response factor (SRF)/myocardin complex binds to C

273 ptional control by the transcription factor, serum response factor (SRF); however, the mechanisms dyn

274 SMA) is mediated by the transcription factor serum-response factor (SRF) along with its co-activator,

275 Serum-response factor (SRF) is an obligatory transcripti

276 (MRTFs), through their interaction with the serum-response factor (SRF) on CArG box regulatory eleme

277 hypertrophy via activation of Rho-dependent serum-response factor (SRF) signaling.

278 ion corresponded with elevated expression of serum-response factor (SRF), a master regulator of mitog

279 In addition, PKN increased the activities of serum-response factor (SRF), GATA, and MEF2-dependent en

280 A/MAL/MKL1/BSAC) regulates the expression of serum-response factor (SRF)-dependent target genes in re

281 ), which directly binds actin and stimulates serum-response factor (SRF)-dependent transcription.

282 Megakaryoblastic leukemia (MKL)/serum-response factor (SRF)-mediated gene transcription

283 tion with myocyte-enhancing factor (MEF2) or serum-response factor (SRF).

284 genes are enriched for binding sites of the serum-response factor (SRF).

285 GATA-6 did not interfere with the serum-response factor-stimulated promoter activity but b

286 mechanism for fine tuning the expression of serum response factor target genes in a gene-specific ma

287 Thus, Arc is the first target of serum response factor that functions at synapses to medi

288 nteracts with Pico, and, Mal, a cofactor for serum response factor that responds to changes in G:F ac

289 transcriptional coactivators cooperate with serum response factor to activate smooth muscle gene exp

290 binding of the sequence-specific factor Srf (serum response factor) to Egr1 regulatory sites is depen

291 in the context of cardiac hypertrophy, where serum response factor transactivation is a key event nec

292 of dilated cardiomyopathy (DCM) triggered by Serum Response Factor transcription factor depletion in

293 ers cofilin phosphorylation, F-actin levels, serum response factor transcriptional activity and colla

294 Serum response factor transcriptional activity is contro

295 143/145 was dependent upon the myocardin and serum response factor transcriptional switch as well as

296 ular smooth muscle phenotype is regulated by serum response factor, which is itself regulated in part

297 This element binds serum response factor, which is recruited by synaptic ac

298 tors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiov

299 ption factor A (MRTF-A), is a coactivator of serum response factor, which regulates transcription of

300 ced stress fiber formation and activation of serum response factor without affecting Smad signaling.