ライフサイエンスコーパス: serum uric acid

1 asminogen activator inhibitor-1 antigen, and serum uric acid.

2 9 (SLC2A9), polymorphisms with variation in serum uric acid.

3 ut not meat had the lowest concentrations of serum uric acid.

4 d as the covariate responsible for rendering serum uric acid a statistically nonsignificant predictor

5 found positive genetic correlations between serum uric acid and BMI z score (rhoG = 0.45, P = 0.002)

6 nd specific association between the level of serum uric acid and cardiovascular morbidity and mortali

7 Quantitative traits, including serum uric acid and creatinine, also showed a moderate l

8 enous blood was taken for the measurement of serum uric acid and glycosylated haemoglobin (HbA1C).

9 In addition, genetic correlations between serum uric acid and other cardiovascular risk factors, s

10 mechanism for SLC2A9-mediated modulation of serum uric acid, and detail a bioinformatic approach for

11 ne of serum urea nitrogen, serum creatinine, serum uric acid, and serum phosphorus; and faster rate o

12 Elevated concentrations of serum uric acid are associated with increased risk of go

13 Levels of serum uric acid are known to be highly heritable, and mu

14 model experiments demonstrate that increased serum uric acid causes increased BP that initially is re

15 Human serum uric acid concentration (SUA) is a complex trait.

16 ent an opinion on the nature of link between serum uric acid concentration and the risk for cardiovas

17 of causality arguments, one can start using serum uric acid concentration as an inexpensive cardiova

18 to test our hypothesis that the reduction in serum uric acid concentration induced by sevelamer would

19 lopurinol intolerance or refractoriness, and serum uric acid concentration of 8.0 mg/dL or greater.

20 c uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared

21 this study was to investigate differences in serum uric acid concentrations between meat eaters, fish

22 In both men and women, serum uric acid concentrations differed significantly by

23 In women, serum uric acid concentrations were slightly higher in v

24 netic variation in SLC2A9 is associated with serum uric acid concentrations, an important biomarker o

25 A9, that explain 1.7-5.3% of the variance in serum uric acid concentrations, following a genome-wide

26 nsporters and their strong associations with serum uric acid concentrations, GLUT9 and ABCG2 appeared

27 s associated with a significant reduction in serum uric acid concentrations.

28 the effects of vitamin C supplementation on serum uric acid concentrations.

29 ut and primates have uniquely high levels of serum uric acid due to missense mutations in the uricase

30 xcessive dietary sodium intake and increased serum uric acid during follow-up despite pharmacological

31 xcretion, the relationship between change in serum uric acid during follow-up, final left ventricular

32 systolic blood pressure, sodium intake, and serum uric acid emerged as independent and significant d

33 f single nucleotide polymorphisms (SNPs) and serum uric acid explain a small fraction of the heritabi

34 The mean level of serum uric acid for both the groups was within normal ra

35 tion between RNFL and macular thickness with serum uric acid in both the groups.

36 A5 rs5438 was associated with an increase in serum uric acid in European American males.

37 Our results show that variation in serum uric acid in Hispanic children is under considerab

38 oring quantitative trait loci that influence serum uric acid in Mexican Americans using data from 644

39 er showed significantly higher level of mean serum uric acid in no diabetic retinopathy group (p = 0.

40 ith the exception of a transient increase in serum uric acid in the acadesine group.

41 ibre layer (RNFL) and macular thickness with serum uric acid in type 2 diabetic patients.

42 lowup provide evidence that higher levels of serum uric acid increase the risk of gout in a graded ma

43 ial hypertension, the prevalence of elevated serum uric acid is >90%, and preliminary clinical trial

44 nderance of data support the hypothesis that serum uric acid is a cause or exacerbating factor of hyp

45 Increased serum uric acid is associated with increased risk for fu

46 An elevated serum uric acid is associated with the development of hy

47 Serum uric acid is determined by production and the net

48 aim was to investigate whether variation in serum uric acid is under genetic influence and whether t

49 Whether vitamin C reduces serum uric acid is unknown.

50 atios for incident hyperuricemia (defined as serum uric acid level >/=7.0 mg/dL) according to prespec

51 was associated with a 0.24-mg/dL increase in serum uric acid level (P = 1.37 x 10(-80)) and a 1.75-fo

52 her the mechanism of association of elevated serum uric acid level (SUA) with cardiovascular disease

53 Current evidence supports use of serum uric acid level as a biomarker for diagnosis of es

54 ol fractions, and plasma glucose levels, the serum uric acid level continued to predict the risk of d

55 l protein intake was not associated with the serum uric acid level in multivariate analyses (P = 0.74

56 The serum uric acid level increased with increasing total me

57 ney function and cohort; therefore, elevated serum uric acid level is a modest, independent risk fact

58 Elevated serum uric acid level is associated with obesity, insuli

59 ubjects who were aged 25 to 74 years and had serum uric acid level measurements at baseline.

60 rt at least once every other day had a lower serum uric acid level than did those who did not consume

61 med milk 1 or more times per day had a lower serum uric acid level than did those who did not drink m

62 in children, presenting the possibility for serum uric acid level to serve as a biomarker for diagno

63 nce was 1664+/-81 dyne x s x cm(-5), average serum uric acid level was 7.5+/-0.35 mg/dL, and average

64 In men, after adjustment for age, elevated serum uric acid level was not associated with increased

65 Among patients with chronic gout, elevated serum uric acid level, and allopurinol intolerance or re

66 orter height, family history of ESRD, higher serum uric acid level, and lower measured GFR.

67 ds have long been suspected of affecting the serum uric acid level, but few data are available to sup

68 For each 1-mg/dl increase in the serum uric acid level, there was a 39% increase in the r

69 onsumption was inversely associated with the serum uric acid level.

70 r-treated stage 1 essential hypertension and serum uric acid levels > or = 6 mg/dL.

71 me of interest was hyperuricemia, defined as serum uric acid levels >/=6 mg/dL.

72 ft ventricular ejection fraction </=40%, and serum uric acid levels >/=9.5 mg/dL to receive allopurin

73 In a multivariable analysis, serum uric acid levels (all P<0.005) and diastolic blood

74 Rs2231142 was significantly associated with serum uric acid levels (P = 2.37 x 10(-67), P = 3.98 x 1

75 cebo and the allopurinol groups had baseline serum uric acid levels (SDs) of 8.7 (1.6) mg/dl and 8.3

76 (ABCG2) has been shown to be associated with serum uric acid levels and gout in Asians, Europeans, an

77 e shed new light on the genes which regulate serum uric acid levels and susceptibility to gout.

78 ent data on lifestyle factors that influence serum uric acid levels and the risk of gout and attempts

79 sweetened soda and orange juice can increase serum uric acid levels and, thus, the risk of gout, but

80 ogical studies have suggested that increased serum uric acid levels are a risk factor for cardiovascu

81 Serum uric acid levels are an independent predictor of d

82 Reductions in serum uric acid levels are clinically relevant.

83 Epidemiologic studies suggest that serum uric acid levels are heritable.

84 Our data suggest that increased serum uric acid levels are independently and significant

85 After adjusting for age, the difference in serum uric acid levels as compared with no intake increa

86 Increased serum uric acid levels had a positive relationship to ca

87 Serum uric acid levels have been linked to many ageing i

88 tudy was to evaluate the prognostic value of serum uric acid levels in a large cohort of men and wome

89 the relationship between dietary factors and serum uric acid levels in a nationally representative sa

90 , allopurinol effectively and safely lowered serum uric acid levels in adults with stage 3 CKD and as

91 stroke incidences or mortalities related to serum uric acid levels in adults.

92 systolic blood pressure, triglycerides, and serum uric acid levels in the CsA reduction group.

93 n mice and non-human primates and normalized serum uric acid levels in uricase-deficient mice.

94 Serum uric acid levels increased with increasing beer or

95 or women per 1,000 person-years according to serum uric acid levels of <5.0, 5.0-5.9, 6.0-6.9, 7.0-7.

96 n Survey suggested that these factors affect serum uric acid levels parallel to the direction of risk

97 effect of individual alcoholic beverages on serum uric acid levels varies substantially: beer confer

98 ention to minidose aspirin and its effect on serum uric acid levels was addressed.

99 ation of stroke incidence and mortality with serum uric acid levels were calculated.

100 Serum uric acid levels were determined in all patients s

101 disease in both men and women increased when serum uric acid levels were in the highest quartile comp

102 ight heart catheterization was performed and serum uric acid levels were measured in all patients.

103 At the end of the study period, serum uric acid levels were significantly reduced in the

104 We evaluated whether lowering serum uric acid levels with allopurinol improves endothe

105 umans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crys

106 athologies, including myocardial infarction, serum uric acid levels, mean platelet volume, aortic roo

107 etween intakes of beer, liquor, and wine and serum uric acid levels.

108 eas moderate wine drinking does not increase serum uric acid levels.

109 ity and therefore may promote a reduction in serum uric acid levels.

110 y in metabolic phenotypes, such as increased serum uric acid levels.

111 lood cell count, blood glucose, D-dimer, and serum uric acid levels; and were more likely to have met

112 ral lines of evidence suggest that increased serum uric acid may be a significant modifiable risk fac

113 ial evidence suggests that agents that lower serum uric acid may lower BP in this select population.

114 Serum uric acid may serve as a valuable biomarker to tar

115 From episodic, longitudinal sequences of serum uric acid measurements in 4368 individuals we prod

116 e lowest to the highest quartile of baseline serum uric acid, net mean changes (95% confidence interv

117 -6.15, p < 0.001), hyperuricemia (per 1mg/dl serum uric acid; OR = 1.35, 95% CI = 1.12-1.62, p < 0.01

118 In multivariate analysis, serum uric acid (P = 0.001), estimated glomerular filtra

119 s negatively related to blood urea nitrogen, serum uric acid, proteinuria, and supernatant IL-4; wher

120 pharmacologic and nonpharmacologic means of serum uric acid reduction prior to clinical use as a the

121 gh the investigations are still preliminary, serum uric acid represents a possible new and intriguing

122 moking status, body mass index, haemoglobin, serum uric acid, serum albumin, albuminuria, and C react

123 Serum uric acid showed a poor correlation with RNFL and

124 Compared with placebo, allopurinol lowered serum uric acid significantly but did not improve endoth

125 ers of endothelial dysfunction, specifically serum uric acid (SUA) and urine albumin excretion (UAE),

126 Oxypurinol reduced serum uric acid (SUA) by approximately 2 mg/dl (p < 0.00

127 s of SLC2A9/GLUT9 were associated with lower serum uric acid (SUA) levels and the effects were strong

128 atients initiating treatment for an elevated serum uric acid (SUA), the SUA normalized or improved in

129 500 mg/day of vitamin C for 2 months reduces serum uric acid, suggesting that vitamin C might be bene

130 s with MS have significantly lower levels of serum uric acid than controls.

131 We found serum uric acid to be significantly heritable [h(2) +/-

132 The relationship between serum uric acid (UA) and outcomes after acute ischemic s

133 Serum uric acid (UA) could be a valid prognostic marker

134 In 10 CHF patients with normal serum uric acid (UA) levels (315+/-42 micromol/L) and 9

135 Elevated serum uric acid (UA) levels strongly reflect and may eve

136 tative trait loci with measurable effects on serum uric acid variability.

137 Mean baseline serum uric acid was 5.9 +/- 1.5 mg/dl, mean baseline ser

138 Serum uric acid was first noted to be associated with in

139 Serum uric acid was found to exhibit significant heritab

140 Serum uric acid was measured in 3315 patients of the Lud

141 Serum uric acid was measured in 7,968 men at the baselin

142 The mean serum uric acid was significantly higher in patient with

143 The association between rs2231142 and serum uric acid was significantly stronger in men, postm

144 , it is not known whether the association of serum uric acid with SLC2A9 polymorphisms manifests in c

145 t mean changes (95% confidence intervals) in serum uric acid with vitamin C supplementation were -0.4