ライフサイエンスコーパス: serve @2 role

1 Therefore, spike 2158-2159 might serve a similar role.

2 actions, individual active site residues may serve multiple roles.

3 ator of oxidative stress genes whereas SpxA2 served a backup role.

4 rough a variety of mechanisms, with proteins serving pivotal roles.

5 ts that are rarely co-opted by the genome to serve a beneficial role.

6 nality during viral LRI, with PD-1 and LAG-3 serving prominent roles.

7 een the two steps of splicing, with eta-eta' serving an ancillary role.

8 se sensitive, consistent with hepoxilin A(3) serving a chemotactic role.

9 that of a load-shifting process transiently serving a compensatory role.

10 me, it is plausible that some of these genes serve critical cellular roles.

11 As (ssRNAs) are ubiquitous RNA elements that serve diverse functional roles.

12 are targeted to various locations where they serve distinct functional roles.

13 d doubly, palmitoylated states that may also serve distinct functional roles.

14 of the MAPK terminal effectors, potentially serving a cardioprotective role.

15 These bacterial chips serve dual roles: (1) They can be applied as MALDI-MS ta

16 tamination--and for the past 60 years it has served a role analogous to that of a model organism.

17 JAM-A serves many roles and contributes to barrier function an

18 obial competition; however, which components serve purely structural roles, and which serve as toxic

19 n source of Wnt ligands in the thymus, which serves a nonredundant role, and lack of TEC-provided Wnt

20 The nanonets serve a dual role as a structural support and an efficie

21 if disulfide bonds are present, they do not serve a functional role as measured via NLC.

22 RGS7 must also serve a role as changes in RGS7(Delta/Delta)/RGS11(-/-)

23 crete the putative glucanase Exg8, which may serve a similar role as Eng1 in removing exposed beta-gl

24 Natural products (NPs) serve important roles as drug candidates and as tools fo

25 ds constitute a diverse group of lipids that serve important roles as structural entities of biologic

26 ince its discovery in 1989, the receptor has served a pivotal role as the prototype cytokine receptor

27 ne sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number o

28 ATF6 serves an important role as a previously unappreciated l

29 em includes a nanostructured Au surface that serves dual roles as the electrochemical working electro

30 s are consistent with the new copper complex serving its intended role as a photoredox catalyst, work

31 Golgi cells (GoCs) serve these roles at the input layer of the cerebellar c

32 ROS serve a dual role; at high concentrations they act as mi

33 sible after acute resuscitative efforts, may serve therapeutic roles beyond providing calories and pr

34 ual function of the phenylsilyl group, which serves a crucial role both in the synthesis of a novel a

35 opulation of resident brain macrophages that serves key homeostatic roles but also has the potential

36 of highly homologous cohesin domains, which serve a dual role by coordinating a multiplicity of enzy

37 inalis (BST) are highly similar regions that serve complimentary roles by integrating fear- and anxie

38 hia coli DNA polymerases (Pol) II, IV, and V serve dual roles by facilitating efficient translesion D

39 port a mechanism in which the ClBcat reagent serves a bifunctional role by sequentially activating th

40 entiated neuroblastoma cells, and that CRLF1 serves its protective role by a cell autonomous mechanis

41 A strategic nitrogen atom chiral auxiliary serves three critical roles, by (1) enabling in situ ass

42 Although it serves an important role, careful consideration of VUS r

43 utation in an inedible ancestral strain that served a protective role converted it to a "domesticated

44 s exposure, which suggests that AGRP neurons serve a dedicated role coordinating this complex behavio

45 e that dorsomedial and dorsolateral striatum serve fundamentally different roles during place learnin

46 that the regulative functions of the MSC may serve quality control roles during larval development, i

47 igin binding domain (OBD) of SV40 large T-ag serves a critical role during initiation of DNA replicat

48 tes within ticks from mammalian antibody and serves an additional role during tick colonization.

49 g interaction between Arg254 and Asp256 that serves an important role during DNA synthesis reactions.

50 ve candidate enzymes have been considered to serve this role: fatty acid amide hydrolase (FAAH), cycl

51 mammalian cells; such mismethionylation may serve a beneficial role for cells to protect their own p

52 ssential protein for virus viability but can serve a stimulatory role for replication in some culture

53 g levels of Na(+) and K(+) , ions assumed to serve important roles for the human pathogen, Plasmodium

54 ent eukaryotic assemblies that have probably served cellular housekeeping roles for at least one bill

55 conserved motif corresponding to mutant A49 serves an important role for establishing a physical con

56 These findings may serve a benchmark role in evaluating the efficacy of nov

57 naling pathway and its effector beta-cat/TCF serve a beneficial role in suppressing hepatic gluconeog

58 rated oxidation products of cholesterol that serve a central role in mediating cholesterol homeostasi

59 8S/2S RNA components of the ribosomes and so serve a central role in protein synthesis.

60 We propose that LINC complexes serve a conserved role in DNA repair through both the in

61 activity of inflammatory cytokines, PHD3 may serve a critical role in degenerative disc disease.

62 utamate transporters on oligodendrocytes may serve a critical role in maintaining glutamate homeostas

63 Mitochondria serve a critical role in physiology and disease.

64 n the upper and lower respiratory tracts may serve a critical role in preventing pneumonia due to Str

65 aride locus bpsABCD has been demonstrated to serve a critical role in the development of mature biofi

66 excitatory and inhibitory synapses, and they serve a critical role in the spatiotemporal regulation o

67 ding the opioids, oxytocin, and vasopressin, serve a crucial role in the regulation of affiliative be

68 a feature of physiologic hypertrophy and may serve a cytoprotective role in lipid overload states.

69 discuss whether exome sequencing can come to serve a dual role in diagnosis and discovery.

70 ies, suggesting that ER-associated ribosomes serve a global role in mRNA translation.

71 Thus, miR-515-5p may serve a key role in human trophoblast differentiation; i

72 Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating vi

73 results demonstrate that vibrational signals serve a key role in the biology of one well-known arbore

74 n intermediate stage in visual hierarchy and serve a key role in the increasing functional specializa

75 mature biofilms and the bpsABCD locus would serve a key role in this process.

76 These proteins serve a limited role in hemostasis, suggesting that anti

77 This study shows that LV serve a novel role in the tumor microenvironment apart f

78 new evidence in rat pups that 5-HT neurones serve a physiological role in autoresuscitation.

79 This pathway may serve a physiological role in the maintenance of mitocho

80 ADF element in association with PARP-1, may serve a platform role in stabilizing the activating comp

81 the associated auditory signals, they likely serve a predictive role in facilitating auditory process

82 rocess, and although T lymphocytes appear to serve a prominent role in the interorgan effects of AKI,

83 a are not required for axon degeneration and serve a protective role in C. elegans axons.

84 to regulate oral bioavailability as well as serve a protective role in the blood-brain barrier, the

85 ggest that the histone chaperone OsNAPL6 may serve a regulatory role in abiotic stress physiology pos

86 ysine residues in histones has been known to serve a regulatory role in gene expression.

87 dian nature of adrenal Icer expression could serve a role in a time-dependent gating mechanism.

88 ulators, suggesting that isomerization could serve a role in assembling regulatory complexes in vivo.

89 K. brevis and hypothesized that brevetoxins serve a role in osmoregulation.

90 The advanced imaging methods also serve a role in selecting appropriate patients for radio

91 Therefore, although O antigen may serve a role in swarming by promoting wettability, the l

92 This input may serve a role in the maturation of the ascending (afferen

93 As (miRNAs) and histone deacetylases (HDACs) serve a significant role in the pathogenesis of a variet

94 tein from the flagellum, suggesting it might serve a similar role in Tol-Pal.

95 Noncriminal DNA databases may serve a societal role in identifying victims of crime an

96 ates immune surveillance and allows HLA-C to serve a specialized role in macrophages.

97 We propose that early cortical cells serve a synchronizing role in the initiation and propaga

98 We conclude that the VOF is likely to serve a unique role in the communication of signals betw

99 ck, PHYLIP, FASTA, NeXML, etc.), allow it to serve a useful role in various phyloinformatics and phyl

100 Stem cells serve a vital role in multicellular organisms by constan

101 olved in DNA metabolism in all organisms and serve a vital role in replication, recombination and rep

102 ropose that decapping and lncRNA degradation serve a vital role in transcriptional regulation specifi

103 Empirical models can therefore serve an important role in advancing the understanding o

104 These findings suggest that FRZB may serve an important role in determining hip shape and may

105 within the cellular cytoplasm and, as such, serve an important role in epithelial cell protection fr

106 Spo0A* and AbrB concentrations, which might serve an important role in generating cell variability.

107 tical source of type 2 cytokines in vivo and serve an important role in orchestrating the type 2 resp

108 nts a rough mineralized interface that might serve an important role in stress transfer between tendo

109 the NTD-CTD interface and has been shown to serve an important role in the assembly of infectious vi

110 These hormones may serve an integral role in protecting nonadipose tissues

111 distinct metabolic pathways but nevertheless serve complementary roles in mediating plant interaction

112 that muscarinic and nicotinic receptors may serve complementary roles in regulating coherence and sp

113 GCN2 and ATF4 serve complementary roles in the hepatic response to asp

114 idues conserved among all alphaherpesviruses serve critical roles in cytoplasmic virion envelopment a

115 protein family (EHD1, EHD2, EHD3, EHD4) that serve critical roles in endosome-based membrane protein

116 or emerge among a variety of animals and may serve critical roles in fitness [1, 2].

117 amolecular disulfide bonds of GP64 appear to serve critical roles in membrane fusion, the unusual int

118 n in the design of powerful reporters, which serve critical roles in modern cell biology and assay de

119 GS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling an

120 e gyrus of hippocampus, a region believed to serve critical roles in seizure generation and learning

121 We hypothesized that both FHA and PRN would serve critical roles in the adhesion process and be nece

122 l elements of mechanosignal transduction and serve critical roles in tissue repair.

123 scovery of an array of immune-mediators that serve crucial roles in HSC regulation and function.

124 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal tra

125 Accordingly, the two pathways are likely to serve different functional roles in the transmission of

126 We demonstrate that these domains serve different roles in regulating the kinetics of LPL

127 our GABAergic subtypes that almost certainly serve different roles in the processing of auditory stim

128 es for the cooccurring protein families that serve different roles in the same biological system.

129 NOD2 may serve differential roles in the eye to promote inflammat

130 eins regulate various cellular functions and serve distinct roles in normal development throughout li

131 ther our findings suggest that SIN3 isoforms serve distinct roles in transcriptional regulation by pa

132 the model that Spt5p and related homologues serve diverse critical roles in the control of transcrip

133 ly to metabolize progesterone and thereby to serve diverse roles in the physiology of pregnancy in ma

134 n immunodeficiency virus type 1 (HIV-1) RNAs serve dual roles in the cytoplasm as mRNAs encoding the

135 Carbohydrates and natural products serve essential roles in nature, and also provide core s

136 In photosynthetic organisms, carotenoids serve essential roles in photosynthesis and photoprotect

137 Lipoproteins serve essential roles in the bacterial cell envelope.

138 sitol and inositol-containing molecules that serve important roles in both eukaryotes and prokaryotes

139 ar that exosomes (endosome derived vesicles) serve important roles in cellular communication both loc

140 , RO, and R2N) in mammalian plasma and cells serve important roles in nitric oxide (NO) dependent as

141 nnels are ATP-activated cation channels that serve important roles in sensory signaling and inflammat

142 egative feedback loop regulated by TGF-beta, serve important roles in the developmental regulation of

143 t the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/

144 We find that different arrest mechanisms serve indispensable roles in the proper cellular respons

145 ine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection.

146 ostsynaptic membrane microdomains, which may serve key roles in the function of the neuronal synapse.

147 Cellular microRNAs serve key roles in the post-transcriptional regulation o

148 The Gag:vRNA interaction appears to serve multiple critical roles in assembly: specific sele

149 y evolved from ancestral plant-like genes to serve paralog-specific roles in gametogenesis.

150 e mammalian ATM and ATR genes, respectively) serve partially redundant roles in the detection of DNA

151 c pathways, as depicted in this study, could serve pivotal roles in the control of intracellular poly

152 Secreted proteins serve pivotal roles in the development of multicellular

153 r data demonstrate that nesprin 1 and desmin serve redundant roles in nuclear anchorage and that the

154 idence supports the notion that gangliosides serve regulatory roles in neurogenesis; little is known,

155 endent phosphorylation, which is believed to serve regulatory roles in the function of CRY2.

156 ) facilitate intercellular communication and serve several roles in regulation of tissue function and

157 ammalian and insect homologues of pqn-47 may serve similar roles in regulated secretion.

158 F-class state, substituting for miRNAs that serve such roles in iPSCs.

159 Our data suggest that dopamine and GABA serve temporally distinct roles in these dual transmitte

160 lators of G-protein signaling (RGS) proteins serve this role in platelets, using mice with a G184S su

161 roup" on the S-aryl moiety of the thio ether served a critical role in facilitating the oxidative add

162 operant in the kidney during endotoxemia and served a cytoprotective role in mitigating acute kidney

163 Autophagy/mitophagy served a protective role in limiting cell death, and ove

164 es of exposure to TLR agonists and that this served an essential role in supporting the de novo synth

165 Feasts likely served important roles in the negotiation and solidifica

166 These results indicate that MMP10 serves a beneficial role in response to acute infection

167 ication within and between brain regions and serves a central role in establishing complex and adapti

168 The Wnt signaling pathway serves a central role in specifying posterior cell fates

169 Ceramide, which serves a central role in sphingolipid metabolism, is gen

170 the leaderless cytokine IL-1beta and thereby serves a central role in the inflammatory response and i

171 eplacement studies showed that the TM domain serves a critical role in GP64 function.

172 naptic function in glutamatergic neurons and serves a critical role in learning and memory.

173 mber of neurological disease states and that serves a critical role in normal cell function.

174 Formation of heterochromatin serves a critical role in organizing the genome and regu

175 is highly induced upon B cell activation and serves a critical role in regulating activation-induced

176 zes microtubule minus ends, an activity that serves a critical role in the organization of the microt

177 Thus, MMP-1 serves a critical role in the repair of damaged human sk

178 on of host lipid synthesis and sequestration serves a critical role in this transition.

179 Solvent polarity serves a crucial role in changing the regioselectivity,

180 Autophagy serves a dichotomous role in cancer and recent advances

181 Each member of the PLA2 family of enzymes serves a distinct role in generating active lipid metabo

182 s Kir6.2 C-terminal AnkB-binding motif (ABM) serves a dual role in K(ATP) channel trafficking and mem

183 thanolamine (pEtN) transferase (Cj0256) that serves a dual role in modifying not only the lipooligosa

184 pEtN) transferase Cj0256, renamed EptC, that serves a dual role in modifying the flagellar rod protei

185 s is a novel function and indicates that VSG serves a dual role in trypanosome biology-that of facili

186 utoimmune diseases, it is unclear whether it serves a functional role in autoimmune responses.

187 toxicity due to nitrite accumulation, HcpR1 serves a global role in regulating the response to nitra

188 findings suggest that while TSLPR signaling serves a key role in allergen-driven Th2 responses, it e

189 ot fully understood, although the centrosome serves a key role in determining when and how much repli

190 nsensus is that the autonomic nervous system serves a key role in emotional processes, by providing p

191 resses Pink1-dependent mitophagy and thereby serves a key role in hematopoietic homeostasis.

192 RAD51, RAD51AP1 (RAD51-associated protein 1) serves a key role in homologous recombination-mediated c

193 a receptor SUR1 and potassium channel Kir6.2 serves a key role in insulin secretion regulation by lin

194 IKKalpha therefore serves a key role in the negative feedback of NF-kappaB

195 at entrainment of low-frequency oscillations serves a mechanistic role in enhancing perceptual sensit

196 The results suggest that PpeGID1c serves a primary role in vegetative growth and elongatio

197 nosine is produced in response to injury and serves a protective role in early stages of injury and i

198 In conclusion, IL-13Ralpha2 serves a protective role in the pathogenesis of allergic

199 n the axial and axial oblique planes, and it serves a restrictive role in internal rotation; the pubo

200 To more precisely determine whether LuxS serves a role in mammalian infection, mice were simultan

201 Thus, CD16 serves a role in NK cell-mediated spontaneous cytotoxici

202 expressed in most human adenocarcinomas and serves a role in promoting growth and the transformed ph

203 induced repression of flavonoid accumulation serves a role in removing the inherent inhibitory action

204 Previous studies suggest that TRPML2 serves a role in the immune system; however, the evidenc

205 ult splicing transitions in muscle and MBNL2 serves a similar role in the brain, the function of MBNL

206 our results suggest that ATP binding to JH2 serves a structural role in JAKs, which is required for

207 d to function as a noncatalytic subunit that serves a structural role in the complexation of the oxyg

208 s a prominent example of such regulation and serves a ubiquitous role in segregating the synthesis of

209 etabolomic analyses indicate that Kras(G12D) serves a vital role in controlling tumor metabolism thro

210 ine kinase that functions in development and serves a vital role in many human cancers.

211 Whether clathrin serves additional roles in receptor recycling, degradati

212 Studies suggest that glucose serves an additional role in the regulation of cellular

213 Our results demonstrate that NPC1 serves an atheroprotective role in mice through regulati

214 ch demonstrates that the protein matrix also serves an entatic role in keeping the Met bound to the a

215 These data suggest that PTK7 serves an essential role in Flt-1-mediated angiogenesis.

216 TERT serves an essential role in formation of the anterior-po

217 Although quiescence serves an essential role in preserving stem cell functio

218 that the Wiskott-Aldrich gene product (WASP) serves an essential role in T regulatory cells to contai

219 Whether IL-9 serves an essential role in the initiation of host-prote

220 (VDAC) in the outer membrane of mitochondria serves an essential role in the transport of metabolites

221 ised of LIN9, LIN37, LIN52, LIN54, and RBBP4-serves an essential role in three distinct transcription

222 s showed that the enoyl CoA-hydratase MAOC-1 serves an important role in ascaroside biosynthesis and

223 argest subunit of RNA polymerase II (Pol II) serves an important role in coordinating stage-specific

224 s overexpressing oncogenes, suggesting MRE11 serves an important role in countering oncogene-induced

225 atory mediators in vitro, suggesting that it serves an important role in directing the progression an

226 uggest that the TH9 subset of helper T cells serves an important role in driving ulcerative colitis b

227 Thus, quantification of D-dimer levels serves an important role in guiding therapy.

228 These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombina

229 vely, these data demonstrate that cytoglobin serves an important role in muscle repair and regenerati

230 This demonstrates that DC-SCRIPT serves an important role in regulating GR function in DC

231 stabilizes the P1 and P3 helices, magnesium serves an important role in stabilizing a pseudoknot int

232 ABSTRACT: The median preoptic nucleus (MnPO) serves an important role in the integration of water/ele

233 Glutamate activation of intracellular mGluR5 serves an important role in the regulation of nuclear Ca

234 Furthermore, YBX1 serves an important role in the secretion of miRNAs in e

235 migration used only by Treg in tissues that serves an important role in their suppressive function a

236 These results suggest that EF-Ts serves an unanticipated role in the cell of actively reg

237 Here we show that Akt1 serves an unexpected role in the regulation of energy me

238 G protein signaling (RGS) family of proteins serves critical roles in G protein-coupled receptor (GPC

239 previously that the UL20/gK protein complex serves crucial roles in cytoplasmic virion envelopment a

240 stribution of PIST suggests that the protein serves distinctive roles in specific neuronal population

241 he mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP produ

242 Myelin serves essential roles in the functioning of the nervous

243 Ventral pallidum (VP) serves important roles in reward and motivation and is a

244 role in CCM, the E1 component of Mtb's KDHC serves key roles in situational defense that contribute

245 Homologous recombination serves multiple roles in DNA repair that are essential f

246 Corelease thus serves multiple roles in synaptic transmission.

247 us chitin in vertebrates and suggest that it serves multiple roles in vertebrate biology.

248 w study suggests instead that pha-1 actually serves no role in development and instead is a component

249 icate that aberrant expression of SEC61gamma serves significant roles in glioblastoma multiforme cell

250 y to expectation, gamma-5 acts as a TARP and serves this role in Bergmann glia.

251 ate that the p38MAPK pathway activated by pX serves this role in p53 apoptosis.

252 ents indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: red

253 ings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation vi

254 in pancreatic ductal adenocarcinoma (PDAC), serving a critical role in tumor initiation.

255 r support the concept of interdomain linkers serving a dual role in substrate binding by appropriatel

256 ng recent work that recasts these regions as serving a key role in on-task control processes.

257 nnate immune system identified in animals as serving an essential role in antiviral immunity.

258 completed research and are now recognized as serving an important role in determining what future res

259 d maintenance of the peptidoglycan cell wall serving essential roles in survival in the host environm

260 crophages are now increasingly recognized as serving many roles in tissue development, homeostasis an

261 amplify type 2 immune responses, but do not serve a protective role, in chronic infection of mice wi

262 plasma membrane receptor termed STRA6, which serves a dual role: it mediates transport of retinol fro

263 zed by STRA6, a plasma membrane protein that serves a dual role: it mediates uptake of retinol from e

264 zed by STRA6, a plasma membrane protein that serves a dual role: it transports retinol from extracell

265 ngiogenic differentiation, transplanted CDCs serve as "role models," recruiting endogenous regenerati

266 ributions to research and teaching, and they serve as positive role models to others aspiring to such

267 minority scientists as support groups and to serve as role models within our institutions is stressed

268 TMEG can serve dual role of extracting the waste heat and convert

269 amps are loaded onto DNA by clamp loaders to serve the critical role of coordinating various enzymes

270 During the halogenation, CuX2 served the dual role of a halogen source as well as a co

271 ts on choroid plexus pericytes, and together serves the important role of coordinating the developmen

272 nctional receptor-receptor coupling seems to serve a modulatory role on both channels, this might not

273 other components of microfibrils; these may serve structural roles, providing stability to ducts and

274 esis that cerebellar Purkinje neuron atrophy serves an adaptive role rather than being simply a nonsp

275 rent physiological processes and potentially serve different functional roles remains unclear.

276 stem/progenitor cells, yet how this pathway serves these dichotomous roles remains enigmatic.

277 To serve numerous functional roles, RNA must fold into spec

278 EHD4 serves a role similar to that of EHD1 in TRE vesiculatio

279 However, these receptors serve complementary roles, such that double-knockout MIG

280 They have been reported to serve several physiological roles, such as in defense ag

281 re negative clock element FREQUENCY (BcFRQ1) serves additional roles, suggesting extracircadian funct

282 However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-depe

283 ce of sufficient levels of alpha2(V) chains, serve functional roles that partially compensate for los

284 ny cases, the long noncoding RNAs themselves serve key regulatory roles that were assumed previously

285 n a mouse model for early-stage AD appear to serve a neuroprotective role through maintenance of the

286 These modifications may serve a feedback role to maintain leptin concentrations

287 Among these, memory T cells serve a sentinel role to protect against pathogens, and

288 The two parameters may serve a similar role to Vmax, KM, and kcat in classical

289 We conclude that HXA3 and LTB4 serve independent roles to collectively coordinate an ef

290 g evidence that N-fixing trees do not always serve the facilitative role to neighboring trees during

291 PNs) are a largely transient population that serves a critical role to establish functional cortical

292 Thus, recruitment of NO is serving a compensatory role to boost synaptic transmissi

293 rRNA control ribosome assembly and could be serving a regulatory role to couple ribosome assembly to

294 ing Center (DRSC) at Harvard Medical School, serves a dual role, tracking both production of reagents

295 tion, we present a model whereby Glu-333 can serve a dual role via similar mechanisms in the recruitm

296 However, GLH-4 serves redundant roles with GLH-1: loss of both genes' f

297 uggesting that the eIF4A binding domains may serve a regulatory role, with the C-terminal binding sit

298 es, which together suggests that SPARC might serve a specific role within muscle cells.

299 es, in addition to a crystallographic water, serve critical roles within the enzymatic mechanism.

300 op, and polyproline type II (PPII)] that may serve several functional roles within the enamel matrix.