ライフサイエンスコーパス: serve to

1 y memories, suggesting that the healthy mOFC serves to access outcome value information when it is no

2 Eye movements serve to accumulate information from the visual world, c

3 pha-beta double bond of the substrate, which serves to activate the substrate toward decarboxylation.

4 le solid-electrolyte interphase layers which serve to address both issues.

5 activity in vivo by high light intensity may serve to adjust anthocyanin accumulation to the duration

6 We suggest that AhR may serve to adjust liver repair and to block tumorigenesis

7 pression, called extraclassical suppression, serves to adjust the size tuning, response gain, and tem

8 Light-sheet fluorescence microscopy (LSFM) serves to advance developmental research and regenerativ

9 evere organ shortages, and these data should serve to allay the concerns of the transplant community

10 n miRNAs, such as miR-150, at late pregnancy serves to allow translation of targets crucial for lacta

11 (amino acids 380-385) on the C-terminal tail serves to alter the conformational state of PTEN from an

12 1 also sends preparatory signals to vS1 that serve to amplify and sharpen the response of neurons in

13 ating LTB4 synthesis during migration, which serves to amplify the magnitude of neutrophil recruitmen

14 have a prolonged afferent-evoked EPSC, which serves to amplify the synaptic input.

15 is a highly expressed cell membrane receptor serving to anchor lung epithelia to matrix components, a

16 Fluorescence correlation spectroscopy served to assess (i) SGLT1 abundance in both vesicles an

17 no Metropolitan Area in 2011, 2013, and 2014 served to assess the trends in immunity and program perf

18 occurs in the context of host factors, which serve to augment or dampen the physiologic response to t

19 essential for Drp1 interactions, but rather serves to augment cooperative self-assembly of Drp1 prox

20 ich the unique iron of the catalytic cluster serves to bind exogenous sulfide, thus acting as a sulfu

21 inking with a 3-kDa CD4 miniprotein mimetic, serving to block ligation of gp140 on CD4(+) T cells whi

22 ey distinctly tuned visual inputs to V1 that serve to boost V1 neurons' responses to SF.

23 o be capable of reinfection, a vaccine could serve to both prevent disease and diminish human amplifi

24 olymerisation of dopamine around the complex served to both entrap the complex, holding the aptamer i

25 Following ligand interaction with TLRs, TIR serves to both initiate intracellular signaling and faci

26 ed regulation of Nedd4/Nedd4L expression may serve to broadly modulate the trafficking or degradation

27 Importantly, our results suggest that IR serves to broadly regulate mRNA levels.

28 This information could serve to buffer the anticipated negative effects on agri

29 Such multisectoral collaboration can serve to build health systems for cancer, and more broad

30 s an integral part of human interaction that serves to build social relationships and affects attitud

31 ng site, with the high-mannose patch glycans serving to camouflage it from most antibodies.

32 plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long

33 g as the earliest regulator in this process, serving to capture and transport these lipids to promote

34 These data serve to characterize an interferon-stimulated gene with

35 ecific antibodies against particular domains served to characterize CTFs of APP in human CSF.

36 Endocardial unipolar voltage mapping serves to characterize epicardial scar in this setting.

37 used to construct a hierarchical index that serves to classify roads in terms of their importance.

38 t of ACN present at the tip of the capillary served to collapse the micelles migrating into the capil

39 These results serve to complete a highly efficient chemical cycle for

40 commercialization, the outcomes of this work serve to confirm advancements in the matrix compatibilit

41 This work serves to confirm the structure (4) originally assigned

42 ores of NU-1000, between the zirconia nodes, serving to connect these nodes along the c-direction to

43 interrupting STAT5 tetramer formation might serve to control NK leukaemia.

44 tivators of a variety of host responses that serve to control virus infections.

45 e we report that the Ras-related GTPase RIT1 serves to control the sequential proliferation and diffe

46 haviour generated by molecular clocks, which serve to coordinate internal time with the external worl

47 A methylation, suggesting that this compound serves to coordinate glycolytic flux with epigenetic mod

48 or Ifh1 and the rRNA processing factor Utp22 serves to coordinate RPG transcription with that of rRNA

49 ve changes to speech acoustical outputs that serve to correct for the perturbation.

50 a receptor for tyramine, and suggest that it serves to curb high levels of courtship activity through

51 initiation codons in the EPRS mRNA 5'-leader serve to dampen levels of translation initiation at the

52 ogether, the data suggest that G2A signaling serves to dampen intestinal inflammation via the product

53 balance between antitumor mechanisms, which serve to decrease cancer growth, and the protumor inflam

54 eveloping hippocampus, reduced Cyfip1 levels serve to decrease paired pulse facilitation and increase

55 d for various symmetrical and skewed gambles served to define formally the direction of stochastic do

56 In essence, the very mechanism that serves to degrade an antiviral IFN-beta effector is expl

57 pull incentives and particularly those that served to delink the revenues from the volumes sold.

58 tic) studies, GRP78-targeting AAVP particles served to deliver the human Herpes simplex virus thymidi

59 derived Pi stress perception, and the phloem serves to deliver a cascade of signals to various sinks,

60 trand exchange regions of these 78 deletions served to demarcate the cores of the PRS1 and PRS2 hotsp

61 Finally, this work serves to demonstrate the potential for naphthazarin as

62 he protruding domain of the capsid protein), serves to demonstrate the reliability and versatility of

63 Here, CDOCKER and Glide served to design model inhibitors in order to characteri

64 Such clustering serves to differentiate asthma subgroups that can be use

65 nfluenza A virus (IAV) RNA packaging signals serve to direct the incorporation of IAV gene segments i

66 This tag serves to direct the lysosomal enzymes to lysosomes.

67 tures of severe asthma exacerbations and can serve to discern driving mechanisms and promote the deve

68 linear to dendritic nucleation activity may serve to distinguish the properties of actin structures

69 markers, the newly identified signature also serves to distinguish individuals at risk, predict the t

70 ergy transported by that undulation can also serve to distribute energy over a larger area of the mem

71 Moreover, recurrence serves to distribute signals throughout chaotic networks

72 Fast-evolving MHC class I polymorphism serves to diversify NK cell and CD8 T cell responses in

73 Our analysis serves to document the considerable and rapid progress w

74 ically relevant temperature of 38 degrees C, serves to drive a structural transition that yields a pa

75 g growth factor (TGF) beta signalling, which serves to drive chemotactic mesenchymal patterning when

76 Rather, we propose that Rcf1 serves to dynamically interact with complex IV during it

77 amma-band local field potentials, presumably serving to efficiently integrate olfactory sensory infor

78 by which engagement of cosignaling networks serve to either dampen or augment alloimmunity.

79 relative to those of the exciton states can serve to either inhibit or promote singlet fission.

80 still lack an essential component that would serve to elevate surface temperatures, at least locally,

81 These findings serve to elucidate the mechanisms of CMV entry, spread,

82 ting crucial cancer hallmark mechanisms that serve to enable carcinogenesis.

83 demands, yet the nature of the signals that serve to engage control remains unknown.

84 as several chemical structural features that serve to enhance antimalarial specificity.

85 r, these data suggest that dexamethasone may serve to enhance EXT by altering Fkbp5-mediated glucocor

86 The nanopores serve to enhance the dopant/organic semiconductor charge

87 nd descending influences in the thalamus may serve to enhance the salience of speech signals that are

88 initiates synthesis on naked RNA and that P serves to enhance the initiation and processivity of the

89 can be reversed, with the steroid receptors serving to enhance binding of FoxA1.

90 y arise only as post-meiotic germ cells that serve to ensure a diploid genome upon fertilization.

91 This network serves to ensure that cells have the proteins they need

92 ations suggest that polyP synthesis not only serves to establish a buffer for transient drops in cyto

93 zo[1,4]dioxin) (MFU-4l) with reactive metals serves to establish a general platform for selective ole

94 anule initiation, the N-terminal part of SS4 serves to establish the correct granule morphology by pr

95 orrespondingly the lateral openings probably served to expel water and waste material.

96 These findings serve to explain how GlcNAc-1-phosphotransferase recogni

97 ead direction system, they could potentially serve to explain optimal cue combination in other sensor

98 lity in realistic synthesis environments can serve to explain or predict the synthetic accessibility

99 ization of the different mulberry clones and served to explain the great intraspecific variability in

100 us on the processes that shape these systems serves to explain the relationship between them and cont

101 that increasing the amount of steric strain serves to extend the lifetime of the (5,7)MLCT from 14.0

102 We suggest that these groupings serve to facilitate inter-sexual provisioning, kin provi

103 Although Rad18 serves to facilitate replication of damaged genomes by p

104 e known activators of eIF2alpha-P and likely serves to facilitate stress adaptation in response to a

105 er, these data reveal a splicing switch that serves to fine tune the Hippo-YAP pathway.

106 ivariate statistical analysis approach which serves to first find the areas of maximum variance withi

107 ormation of trifluoromethyl aryl ethers also served to form difluoromethyl and monofluoromethyl aryl

108 They revealed that THC served to functionally isolate CA1 from CA3 by reducing

109 GTx is a useful tool and may serve to further clarify Kv2 channel functions in neuron

110 Our findings serve to further enhance the structural diversity of cya

111 ne-arene interactions are more favorable and serve to further stabilize cis-[Pd(IMes)2(eta(2)-O2)].

112 rrent exposomics research is facing and will serve to gain a deeper understanding of the impact of en

113 Our work should serve to guide future synthetic efforts toward the appli

114 on ratios from different 2A constructs could serve to guide future utilization of 2A peptides in basi

115 1 with clinical drug treatment failure could serve to guide more-effective treatment of tegumentary d

116 ded for efficient CD40-CD40L inhibition, and serve to guide the search for such immune therapeutics.

117 The data serve to highlight an early and essential role for Cyfip

118 ohn's disease from healthy samples, but also serve to identify patients who in time will progress to

119 Factors predictive of TIA could serve to identify suitable candidates for ICL placement.

120 ls such as Recon, RepeatScout or RepeatGluer serve to identify TEs purely from sequence content, but

121 th polyclonal anti-M1 antibodies, which then serve to identify the universal biomarker for the influe

122 f an ex vivo cardiovascular (CV) model which served to identify compounds that, like 2, were free of

123 In vivo (89)Zr-bevacizumab PET serves to identify heterogeneous uptake between tumor le

124 ng roles of the microbiota in carcinogenesis serve to illustrate the complex and sometimes conflicted

125 and real (near-infrared) spectral data sets serve to illustrate the proposal.

126 seemingly represent a neural mechanism that serves to implement the distinctive influence that each

127 ver sonar sound production and reception can serve to improve acoustic cues for localization tasks.

128 de an accurate measure of physician quality, serve to improve patient care, and provide useful inform

129 PGPB promote growth of microalgae which may serve to improve performance of Chlorella spp. for biote

130 ons that the six determinants of gait do not serve to improve walking economy.

131 itoring system following incorrect decisions serves to improve future task performance.

132 Convergence serves to improve sensitivity of rod vision when photons

133 nowledge representations of a mean stimulus, serving to improve performance.

134 ractions with beta- and alpha-catenin, which serve to increase adhesive strength.

135 yle behaviours, through numerous mechanisms, serve to increase brain, cerebrovascular and cognitive r

136 gating of thermoresponsive growth, which may serve to increase fitness by matching thermoresponsivene

137 Sexual displays enriched by object carrying serve to increase individual male fitness, yet are uncom

138 ptors in the same medullar column, which may serve to increase polarization contrast.

139 This putative inhibitory function could serve to increase the fidelity of vesicle docking.

140 tructure-induced transport limitations alone serve to increase the turnover frequency for CO2 activat

141 Historical trends that served to increase women's participation in elite endura

142 by multiple labs is achievable, and broadly serves to increase confidence in SWATH-mass spectrometry

143 tive response for lower-SES individuals that serves to increase control over their more threatening s

144 More specifically, resonance serves to increase the size the barrier for C-methylatio

145 The terminal polar functional group serves to increase the solubility of these analogues in

146 Hence, astrocytic GAP43 upregulation may serve to indicate beneficial astrogliosis after CNS inju

147 ctivity to natural stimuli in SC neurons and serve to inform a more general understanding of mechanis

148 where insights gained from osteocyte studies serve to inform the critical examination of cementocytes

149 late step with a large driving force, which serves to inhibit deleterious Fenton chemistry.

150 ommon feature of coronaviruses and primarily serves to inhibit the antiviral response of the host.

151 Gating by protons serves to inhibit what would otherwise be substantial no

152 ls (GIRK and TREK channels), both mechanisms serving to inhibit neurons.

153 e synthesis of double-stranded RNAs that can serve to initiate or amplify RNA silencing.

154 ctors with stable one-electron oxidants that serve to initiate the enzyme's free-radical mechanism.

155 f protein sequence-structure mapping and may serve to inspire new protein design and protein structur

156 f inhibitory sensory relay interneurons that serve to integrate both proprioceptive and nociceptive a

157 by protein-protein interactions, which also serve to integrate external signals that stimulate and p

158 h the entire cerebral cortex, which can also serve to integrate information processing between cortic

159 A dual role for VGLUT serves to integrate neuronal activity and pH regulation

160 e novo, they also have salvage pathways that serve to interconvert the different vitamers.

161 o-electrical transducer (MET) current, which serves to keep the transduction apparatus operating with

162 occurs rapidly in wild-type macrophages and serves to kill intracellular pathogens.

163 This advisory serves to lay out a set of principles that will guide as

164 NK cell function, and suggest that NK cells serve to limit ILC2 activation and subsequent allergic a

165 of the p38alpha gene, we find that p38alpha serves to limit NF-kappaB signaling and thereby attenuat

166 n extracellular adenosine-rich milieu, which serves to limit TFH frequency and function, and also pro

167 flammation and mTORC1 signaling whereas ATF4 serves to limit the amino acid response and prevent ER s

168 o clear the bulk of circulating PMPs but may serve to locally phagocytose PMPs generated at sites of

169 The addition of an osmotic agent serves to lower the radiation dose to the bone marrow.

170 X6), and LIM domain-binding protein 1 (LDB1) serve to maintain mature adult beta cell identity, revea

171 1s under heat stress conditions, which would serve to maintain vitamin B6 homeostasis in times of nee

172 s, while increasing glycolysis, all of which served to maintain normal ATP concentrations ([ATP]) and

173 his sequential step of maturation from cMoPs serves to maintain a stable pool of BM monocytes.

174 e control and DNA repair or apoptosis, which serves to maintain genome stability.

175 othesis proposed is that an epigenetic clock serves to maintain the period of molecular rhythms via c

176 gions raises a question: can phosphorylation serve to manipulate the conformational preferences of a

177 The bead, which also serves to manipulate DNA, experiences significant drag a

178 subset of cardiac-enriched nuclear receptors serve to match mitochondrial fuel preferences and capaci

179 esion molecule (PSA-NCAM) functions broadly, serving to mediate synaptic plasticity, neurogenesis, ne

180 h, with proper policy support, recycling can serve to meet some of this growing demand.

181 hydrogenase and two terminal oxidases, which serve to metabolize formate and facilitate the use of ox

182 gether with very low axonal leak conductance serves to minimize ionic fluxes and energetic demand dur

183 sted nature of the five adjacent aryl groups serves to minimize the intermolecular interaction betwee

184 ndeans could have vascular effects and could serve to mitigate the deleterious effects of polycythemi

185 a stimulation supports the notion that IL-15 serves to mitigate inflammatory skeletal muscle loss.

186 lation is of particular relevance because it serves to modify a large number of cellular proteins.

187 teraction during UV and oxidative stress may serve to modulate active DNA repair.

188 cal connections, such a backprojection could serve to modulate information processing in hippocampal

189 This suggests that cAMP signaling may serve to modulate intrinsic MB responses toward salient

190 First, molecular structure served to modulate biodegradation in a predictable fashi

191 post-translational modification of histones, serves to modulate the chromatin environment.

192 teasome-dependent degradation of Tmc1, which serves to normalize Tmc1 protein levels after induction.

193 nishing collection of nuclear factors, which serve to not only store the nucleic acid in a stable for

194 FTIR) spectroscopy and NOx chemiluminescence serve to obtain the removal efficiency of NOx by fragmen

195 Panel on Payment and Delivery System Reform, serves to offer support and direction for further involv

196 a range of adaptive processes in plants that serve to optimize photosynthetic efficiency and promote

197 s review presents key features of uORFs that serve to optimize translational control that is essentia

198 results suggest that large opsin repertoires serve to optimize visual function under variable light e

199 ology sets the stage for these functions and serves to orient the reader.

200 dium supply in the deposited electrodes that serves to passivate and dope the cadmium selenide nanocr

201 al and visual cortices in the brain that may serve to perpetuate consumption in a feed-forward manner

202 This article and summary of the literature serves to possibly deliver an improved volatile data set

203 could suppress let-7 targets, as these could serve to potentially intercede in tumors driven by loss

204 (FSL) is a fast encoding mechanism that can serve to precisely initiate startle responses when speed

205 Apcdd1 thus serves to precisely modulate Wnt/Norrin signaling activi

206 ng acts to prime vision for stimuli that may serve to predict outcome.

207 ying degrees among the deaf subjects, it may serve to predict the potential for auditory rehabilitati

208 If delivered passively, 10E8 might serve to prevent or treat HIV-1 infection.

209 od-brain barrier (BBB) and the glia limitans serve to prevent the migration of cells and other large

210 mediated by territorial cues and presumably serves to prevent misdirected care in this poison frog.

211 in developing enamel (e.g., P148) primarily serves to prevent uncontrolled mineral formation during

212 Together, these SDRs then serve to produce oryzalexins A-C from oryzalexin D, esse

213 t solely for self-preservation processes and serve to promote and support cell survival.

214 that these paralogues have on proliferation serve to promote cell competition, leading to apoptosis

215 tive positions presented in this article may serve to promote open and informed dialogue within the c

216 coordinated by Mn(4+) and Li(+) ions, which serve to promote the localization, and not the formation

217 s with mass-compatible techniques that could serve to promote their widespread utilization.

218 s the donor activating reagent; the In(OTf)3 serves to promote apparent transfer of the donor glycosy

219 el, we found, surprisingly, that neutrophils serve to protect the host from LPS-induced lethal inflam

220 pposite regulation occurring in D1-MSNs, and serves to protect against cocaine-induced addictive-like

221 These findings also serve to provide a rationale for the evolution of the BC

222 These findings may serve to provide a strategy for the safe and effective t

223 a feature of necroptotic cell death and may serve to provide an immunologically-silent window by gen

224 An expanded network would serve to provide an international rapid surveillance sys

225 ugh the findings are correlational, they may serve to raise concern about the long-term consequences

226 udy showed remarkable foresight, yet it also served to raise as many questions as it answered.

227 the dry material combined with chemometrics served to rapidly sort out samples containing >10.0% CA

228 FGGY could act as metabolite repair enzymes, serving to re-phosphorylate free d-ribulose generated by

229 signal changes in animals' circumstances and serve to reconfigure neural circuits.

230 We therefore suggest that DEN1 serves to recover diverted NEDD8 moieties from autoneddy

231 epithelial cells, a key source of CCL2 that serves to recruit monocytes and macrophages.

232 cellular trafficking by cleaving RILP, which serves to redirect Rab7-containing vesicles to a kinesin

233 ffective across socioeconomic groups and may serve to reduce observed socioeconomic inequalities in d

234 ptive perspective, cortisol coregulation may serve to reduce risk in challenging, potentially threate

235 compromised presynaptic release collectively serve to reduce synaptic strength to levels that fall be

236 MPH serves to reduce maladaptive electrophysiological precur

237 are highest in the input layer and attention serves to reduce these correlations.

238 e factor for this rice leaf streak pathogen, serving to reduce the jasmonic acid-mediated defense res

239 falciparum malaria importation to China can serve to refine malaria elimination strategies and the m

240 suggest that the domain interactions of UL16 serve to regulate not just the interaction of this tegum

241 ith FEN1 during lagging-strand synthesis may serve to regulate sequential strand displacement and fla

242 on of BamA, the central component, which may serve to regulate the BAM complex.

243 ations of SNX1 or SNX2 with SNX5 or SNX6 and serve to regulate the biogenesis of tubular endosomal so

244 stablishment of pregnancy in the pig and may serve to regulate the proinflammatory response of endome

245 red and dynamic environmental interface that serves to regulate cellular physiology and block invasio

246 and microfluidic negative-feedback loop then serves to regulate the concentration of the protein in t

247 mbrane trafficking of M2Rs, whose activation serves to regulate the postsynaptic excitatory and inhib

248 cell divisions and cell rearrangements that serve to relax tissue strain.

249 lyst and a weak phosphate base cooperatively serve to remove both a proton and an electron from an am

250 apoptosis is a form of rapid cell death that serves to remove damaged progenitors and promote qNSC ac

251 the majority of Lgr5-positive cell divisions serve to renew epithelial cells and only few result in t

252 We hypothesised that this behaviour serves to repel ectoparasites and tested the repellency

253 Transplantation and gene therapy may serve to replace or resurrect dead or injured retinal ne

254 within the basal layer of the epidermis and serve to replenish the loss of differentiated cells beca

255 id cycle, whereas increased glutamine uptake serves to replenish the TCA cycle.

256 The current study serves to resolve the long-standing controversy about th

257 e possibility that short circuiting also may serve to restrict the function of host E3s in cells.

258 he exact local expression cues, tomo-seq can serve to reveal novel genes and key transcription factor

259 similar Mg uptake and metabolic pathways and serves to reveal Mg cycling in ecosystems.

260 A model-based sensitivity analysis serves to reveal the most crucial experimental parameter

261 Attention is critical to perception, serving to select behaviorally relevant information for

262 has challenged our understanding of how they serve to selectively facilitate translocation of nuclear

263 BSA (forming the whole biorecognition layer) served to selectively capture the procalcitonin target a

264 generally, our data suggest that adaptation serves to selectively enhance processing of the stimuli

265 d on elucidating the signaling pathways that serve to sense and respond to oxidative redox stress wit

266 ogether, these data indicate that HS binding serves to sequester AAV capsids from the vitreous to the

267 sence of one nuclear spin-free ligand, which served to shield the vanadium centers against solvent nu

268 This review thus serves to showcase the potential of organic synthesis fo

269 gulatory nodes is notable in dendritic cells serving to simultaneously shut down multiple pathways of

270 It proposes that dACC serves to specify the currently optimal allocation of co

271 lier simulations suggested that calcium ions serve to stabilize key substrate-binding extracellular l

272 range hydrophobic interactions follow, which serve to stabilize the complex.

273 e active form of its ligand, GAS6, that also served to stabilize the AXL protein.

274 he previously held notion that calcification serves to stabilize the atherosclerotic plaque.

275 ackbone structure, the protonated N-terminus serves to stabilize the beta-hairpin by positioning itse

276 data suggest that the receptor binding head serves to stabilize the stalk to regulate fusion.

277 uggests that the N-H bond is not cleaved but serves to stabilize the turnover-determining transition

278 ysis and that a hard, O-based anionic ligand serves to stabilize this state in a switchable fashion.

279 ApcC is shifted within the cylinder cavity, serving to stabilize the interaction between the OCP and

280 that specific sequences within the CHOP uORF serve to stall elongating ribosomes and prevent ribosome

281 ition, biochemical analysis reveals that RPA serves to stimulate the primase activity of PrimPol.

282 NA might either play no significant role or serve to strengthen memories that are degraded by EMs.

283 ecialised nodal regions of peripheral nerves serves to strengthen the links between their unique micr

284 hether oscillatory activity in the beta band serves to support this theory within the cortical motor

285 lts suggest the interpretation that the I dc serves to suppress scattering between states near the Fe

286 on and dephosphorylation in the cytosol also serves to suppress the pathway in down-gradient regions

287 In parallel, molecular statics calculations serve to test the validity of two interatomic potentials

288 merase II was trapped in these factories and served to transcribe viral genomes, which coincided with

289 , the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrP(Sc), t

290 This spectral synthesis also serves to transform distinct types of spectra into a com

291 ollectively support a mechanism wherein CTCF serves to translate alphaKG-sensitive metabolic changes

292 The FGs serve to transmit the target magnetic flux to the OPM th

293 In general, SLC26 solute carriers serve to transport a variety of anions across biological

294 override selfish impulses: Deliberation only serves to undermine cooperation with strangers.

295 identification of suitable inhibitors could serve to understand the emerging biology of these metabo

296 t progress in perceptual decision-making has served to unite decision accuracy, speed, and confidence

297 ut the wealth of experimental data on Cu can serve to validate any proposed mechanisms.

298 h influence binding of affinity reagents and serve to validate the target specificity of affinity ass

299 wn mediators of castration resistance, which served to validate the screen, we identified a mitotic-r

300 ol volumes within 5 mL for all device types, serving to validate the device.