ライフサイエンスコーパス: set point

1 ve to the sRNA and mRNA concentrations ('Hfq set-point').

2 e salt concentration of previous growth (the set point).

3 ention until the artery remodels to a normal set point.

4 s to maintain a dynamic range around a given set point.

5 approximately 46% of the variation in HIV-1 set point.

6 oll-like receptor (TLR) alleles on the HIV-1 set point.

7 of acyclovir) explained 46% of variation in set point.

8 n almost half of the variation in viral load set point.

9 ice of restoring the nonstressed homeostatic set point.

10 initial immune responses modulate the viral set point.

11 ristics of the host and virus that affect VL set point.

12 vels fluctuate randomly around a homeostatic set point.

13 tabilizing long-term blood pressure around a set point.

14 adjusts its response to accommodate the new set point.

15 d acted as the primary driver of the cognate set point.

16 f 5% and 10% resulted in lowering of the off-set point.

17 ed to a discrete level, which was termed the set point.

18 w cells sense, modify and establish a volume set point.

19 levels and decline rates but not viral load set point.

20 the same images at a predetermined and fixed set point.

21 d is a key determinant of the blood pressure set point.

22 mune responsiveness and an altered endocrine set point.

23 y regulate firing rates around an individual set point.

24 enotype, suggesting a more anti-inflammatory set point.

25 progresses toward the lower liver:body mass set point.

26 , limiting the ability to evaluate virologic set point.

27 associated with a significantly lower viral set point.

28 amatically from acute infection to the viral set point.

29 evel, indicating a change in the firing rate set point.

30 n stem cells with an altered telomere length set point.

31 energy intake and reprogram the body weight set point.

32 re length is regulated around an equilibrium set point.

33 ovide an accurate linear read-out of whisker set point.

34 features of whisking including the phase and set point.

35 correlated with the later plasma viral load set-point.

36 ion were inversely correlated with the viral set-point.

37 s inoculation of virus isolated at the viral set-point.

38 hing or maintaining this balance at specific set points.

39 nd behavioral variables: heating and cooling set points.

40 l plasma and establishing viremia at various set points.

41 d inverted except at low amplitudes and high set points.

42 readth were associated with lower viral load set-points.

43 bient [CO(2) ] + e[CO(2) ]) is +/-20% of the set point 1-min average target.

44 perature decreases far below its homeostatic set-point(3-5).

45 onses showed an influence on the early viral set point, a broader HIV-specific CD8 T cell response ta

46 n the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable

47 Set-point adaptation balances tonic activity so that rec

48 MVS set-point adaptation is a biological model with applicat

49 daptation, thus implicating them in the slow set-point adaptation of the excitatory population.

50 Set-point adaptation was elicited with magneto-hydrodyna

51 n about another essential form of learning, "set-point" adaptation.

52 her differences in the core body temperature set point affect the regulation of human body weight.

53 ent HIV acquisition and/or reduce viral load set-point after infection.

54 lls in NOD mice exhibit an altered migration set point, allowing increased occupation of the MZ, a ni

55 between genital inflammation and viral load set point and blood CD4 cell counts 12 months after infe

56 ection was associated with higher viral load set point and CD4 depletion, which are markers of rapid

57 nfection was associated with the early viral set point and disease progression (rho = 0.47, P = 0.02,

58 sion was used to determine associations with set point and R(2) to estimate variation explained by co

59 ntly associated with an increased viral load set point and shorter times to reaching a CD4(+) T-cell

60 response that impacts the plasma viral load set point and the rate of progression to AIDS.

61 to 33 +/- 3 mmHg significantly increased the set point and threshold pressures of the CSP-SPP relatio

62 In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ

63 , demonstrate the differential regulation of set points and compensatory mechanisms, and propose a ne

64 These data suggest that viral set points and disease progression rates at the populati

65 ive alleles in a population may affect viral set points and rates of disease progression in that popu

66 , current PCR approaches rely on temperature set points and reaction contents that are optimized and

67 ction were associated with higher viral load set points and, to a lesser extent, with CD4 depletion.

68 Ps) for associations with HIV-1 acquisition, set-point and disease progression in African couples.

69 by varying fluid pumping frequencies using 4 set-points and the effect of clot formation using a chem

70 ontrolled at 124 +/- 2 mmHg, the threshold, 'set point' and saturation pressures of the PAP-SPP relat

71 rized by a stable HIV viral load (viral load set point) and evolution of antibodies with increased co

72 o warming treatments (+3.5 and +5 degrees C, set-points) and the presence and absence of the ant Form

73 point, identify a mechanism for varying the set point, and demonstrate its relevance to vessel remod

74 ubstantially reduced retroviral replication, set point, and pathogenesis.IMPORTANCE Immune control of

75 he result of a changed retinal slip velocity set point, and thus, a sensorimotor memory.

76 n after HTLV-1 proviral load has reached its set point, and we estimate that between 100 and 200 new

77 cell division and expansion, (2) the gravity set point angle, and (3) radial cell division or expansi

78 pment including root length, a novel gravity set point angle, differences in cortical cell layer patt

79 iented lateral roots and altered gravitropic set point angle, while loss of all three DRO family memb

80 s reset, not to be confused with the gravity set point angle.

81 TOR signalling controls RSA, the gravitropic set-point angle (GSA) of lateral roots (LRs), auxin leve

82 part of the organ toward a photogravitropic set-point angle.

83 ith respect to gravity, known as gravitropic set point angles (GSAs).

84 plementarily in establishing the gravitropic set-point angles of lateral roots.

85 energy stores to regulate the defense of Tc set points are distinct from those required to respond t

86 However, whether and how activity set points are regulated remains unknown.

87 rently, it is unknown how stable homeostatic set points are within the nervous system.

88 N(2)O production pathways, circumneutral pH set-points are suggested to minimize overall N(2)O emiss

89 equires an optimal mRNA concentration ('mRNA set-point') as well as an optimal Hfq concentration.

90 the establishment of infection to the viral set point at 1 year after the infection.

91 ion are sufficient to determine the glycemic set point at which DN occurs.

92 y 10 weeks post-infection, a higher plateau (set-point) being achieved and maintained in study Group

93 rs viral dynamics: we found a higher rebound set point but similar peak viral loads compared to the p

94 cle from its corresponding local homeostatic set point, but with different sensitivities.

95 f individual BES cells at or below a maximum set point by bypassing a portion of applied current with

96 By logical extension, deviation from the set point can only be sustained if the pressure natriure

97 lease across all inputs around a homeostatic set point, caused a compensatory decrease in synaptic dr

98 fter adjustment for plasma viral load, viral set point, CD4(+) T-cell count, herpes simplex virus typ

99 In 3/5 patients, this set point changed significantly over the time period stu

100 ing the gradual decrease in nystagmus as the set point changes over progressively longer time courses

101 d represents the first example in Pd-AAA for setting point chirality on a nucleophile simultaneous to

102 This enables 7.1 degrees C decrease of the set-point compared to normal textile, greatly outperform

103 rate that changes in the regulatory feedback set point control of Insig1/SREBP1 represent an adaptive

104 the value of integral feedback in achieving set-point control; the usefulness of self-organizing beh

105 Large amplitudes and low set points corrected the step height inversion, but did

106 ility of homeostatic systems with adjustable set points creates vulnerability to dysregulation and di

107 short term fasting; and (iii) a shift of the set point defining the switch between hepatic glucose pr

108 mitochondria as a key regulator of activity set points, demonstrate the differential regulation of s

109 he long-term survival of stem cells, and its set point determines the proliferative capacity of diffe

110 tent stem cells, while their telomere length set point determines the proliferative capacity of their

111 ually returned to a precise, cell-autonomous set point during periods of active wake, with lengthenin

112 lower peak viral load but an unchanged viral set point during viral rebound.

113 hat homolog pairing requirements dictate DSB set points during meiosis.

114 - 21 umol/mol (mean +/- SD) or 98 +/- 14% of set point enrichment target.

115 Furthermore, it is possible that IOP-based set points exist within RGCs to impact the direction of

116 This large set-point expansion can save more than 35% of building h

117 and TLR7 rs179012) also were associated with set point, explaining 6% and 5% of the variation, respec

118 ryos, suggesting that FBP contributes to Myc set point fixation.

119 impermeant anions determine the homeostatic set point for [Cl(-)], and hence, neuronal volume and th

120 of basally released ATP in establishing the set point for fibrotic activity in adult rat CFs and ide

121 between HIF-alpha isoforms, establishes the set point for hypoxic sensing by the carotid body and ad

122 The homeostatic set point for metabolism is determined by the threshold,

123 th NHE3 apparently establishes the exchanger set point for pHi, and modification in this set point is

124 lls to an invasive phenotype by reducing the set point for stimulation by activated TGF-beta.

125 Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex

126 raphy during thymic maturation determine the set point for TCR responsiveness.

127 appears to be critical for establishing the set point for the blue-green switch in ecologically rele

128 criticality is consistent with a homeostatic set point for visual cortical dynamics and suggest a key

129 ing goals, onscreen positions that served as set points for a control model that produced observed jo

130 The establishment of set points for cellular activities is essential in regul

131 the basal forebrain, to determine threshold set points for filtering out weak olfactory inputs in th

132 e show that basal conformational equilibrium set points for integrin alpha4beta1 are cell type specif

133 tility as antiobesity agents by lowering the set-point for hunger between meals.

134 expectation, and experience could alter the set-point for valence-based behavior.

135 parative value, as a stage of life, and as a setting point for the life course.

136 ol system similar to controls, but that the 'set point' for mobilizing their limbic arousal system ha

137 The melting peaks and off-set points generally shifted slightly towards higher tem

138 The Hfq and mRNA set-points generate novel regulatory properties that can

139 NMJ, appropriate for a synapse at which the set point has been increased.

140 A lower core body temperature set point has been suggested to be a factor that could p

141 clinical symptoms and development of a viral set point have been associated with the emergence of HIV

142 when the tip amplitude was low or at a high set point (high force).

143 ide direct evidence for a fluid shear stress set point, identify a mechanism for varying the set poin

144 udinally from peak viremia until the viremia set point in a cohort of six subjects with acute infecti

145 o identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping

146 ignificantly inversely correlated with viral set point in chronic HIV infection (R = -0.5; P = 0.03),

147 to determine the appropriate telomere length set point in human embryonic stem cells.

148 s about the assumption of a thermoregulatory set point in humans, and our evolutionary ability to ada

149 seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 s

150 ed host and virus factors that predict HIV-1 set point in people who recently acquired HIV-1, finding

151 dysregulation of the immuno-neuro-endocrine set point in PP, with a notable over-activation of the m

152 fficacy was limited to a modest reduction in set point in some of the groups and did not correlate wi

153 rate of HIV-1 acquisition or the viral-load set point in the population studied.

154 s HLA-B*3501 is associated with a high viral set point in two further B-clade-infected cohorts, in Ja

155 was able to significantly decrease the viral set point in vaccinated patients, with a concomitant inc

156 was associated with a decrease in viral load set points in 6 of 8 subjects (P = .08).

157 drogenase (DHODH) as a regulator of activity set points in hippocampal networks.

158 vel mechanism for establishing the requisite set points in the interferon pathway that balances the b

159 ied the efficacy of reduced dissolved oxygen set-point in reducing N(2)O emission by 60%, but also co

160 The device reaches the target temperature set-point in under 1 h.

161 e model and show how it encodes an "activity set point" in single neurons.

162 sted as a minor population even at the viral set point; in contrast, the majority of acute escape epi

163 rus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects revers

164 neuronal firing rates from a locally defined set-point, independent of global sleep-wake state.

165 Local homeostatic set point is determined from a simulation with normal ac

166 How this set point is determined remains unknown.

167 set point for pHi, and modification in this set point is effective in the hormonal stimuli-mediated

168 This set-point is mediated by an integrated neural network th

169 Intriguingly, this 'muscle-full set-point' is delayed by resistance exercise (RE) (i.e.

170 ulating hormone (TSH) production and the TSH set point later in life.

171 a peak, and then declines until it reaches a set point level.

172 tion as viral replication is controlled to a set-point level, and later by their functional decline a

173 nd virus factors interact to determine HIV-1 set point may elucidate novel mechanisms or biological p

174 Such altered set points may relate to differential vulnerability to s

175 decline and median regression for viral load set point (mean level 6-24 months from seroconversion).

176 h 24 (termed week 28+ infection), viral-load set point (mean plasma HIV-1 RNA level 10 to 20 weeks af

177 Both salt gradients and set point memory are encoded in ASER temporal activity p

178 gether, these findings are consistent with a set point model in which PC1 expression levels regulate

179 t models of body weight regulation, with the set-point model being most commensurate with current dat

180 n the context of static, settling point, and set-point models of body weight regulation, with the set

181 monstrate key determinants of the fibrogenic set point of cardiac fibroblasts (CFs) by focusing on th

182 nse and accurately predicted the homeostatic set point of each clone.

183 ulation using a standardized distance from a set point of entry.

184 st that early exposure to GCs can change the set point of future transcriptional responses to stress

185 ed dose of inducible IFN with a higher basal set point of IFN-responsive genes.

186 We defined the apoptotic set point of neuroblastomas using responses to distinct

187 osophila to investigate the stability of the set point of synaptic homeostasis across the lifespan of

188 ive oxygen species essential for poising the set point of the redox proteome.

189 Thus, AgRP neurons determine the set point of the reward circuitry and associated behavio

190 h an age-dependent change to the homeostatic set point of the synapse during middle age.

191 121.2 to 29.3; P=0.44), with mean viral-load set points of 4.46 and 4.47 HIV-1 RNA log10 copies per m

192 ting homeostatic regulation towards a common set-point of Ca(2+) influx.

193 SPAN-7 as a key regulator in determining the set-point of glucose-stimulated Ca(2+) influx and insuli

194 glucose-stimulated Ca(2+) entry and thus the set-point of GSIS.

195 atic immune response; developing an elevated set-point of myeloid regulatory signalling and sugar-lip

196 heir instantaneous spike rate and adjust the set-points of the stimulus-response relationships by ada

197 ent immunological status - or 'cancer-immune set point' - of an individual.

198 t HIV replication and is predictive of viral set point, offering the first immunologic evidence of CD

199 t the spatial covariance (SCV) tolerance and set-points on an amino acid residue-by-residue basis in

200 develop and maintain an elevated body weight set-point once they are provided with sufficient calorie

201 about what drives these species-specific DSB set points or the regulatory pathways that control them.

202 ial viremia) and the established early viral set points (P < 0.0001).

203 s in acute infection resulted in lower viral set points (P = 0.002).

204 tive of non-AIDS morbidity and death, higher set point plasma virus load and virus acquisition; thus,

205 The decay rate in set point plasma virus recipient animals is approximatel

206 Estimated set-point plasma viral loads increased from 4.05 log10 c

207 ted with increased viremia, as both peak and set-point plasma viremias were similar between PTM and R

208 mp-up plasma virus recipient animals than in set-point plasma virus recipient animals.

209 how measurements wherein a user-programmable set-point precisely alters the protein concentration in

210 to the primary course of disease (i.e. viral set point, previously acquired adaptations of the virus)

211 ies are not present, low amplitudes and high set points produce images with proper contrast due to to

212 it was inversely associated with viral load set point (r = -0.68 and P = .002).

213 function by keeping neuronal firing within a set point range, but such firing rate homeostasis has ne

214 Maintaining average activity within a set-point range constitutes a fundamental property of ce

215 it function by keeping firing rates within a set-point range, but whether this process is gated by br

216 to reduced CB afferent activity and the PCO2 set-point recovery to CNS plasticity.

217 t its role in establishing a telomere length set point remains elusive.

218 This stable HIV-1 set point represents an equilibrium between the virus an

219 which explained 13% and 10% of variation in set point, respectively.

220 velopmental period can alter the homeostatic set point, resulting in epilepsy-like activity.

221 odulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given

222 r to challenge was inversely correlated with set point SIV plasma viral loads after challenge.

223 emergence was associated to the early viral set point, suggesting an involvement in early control, i

224 ates of 1, 5 and 10 degrees C/min with final set-point temperatures and holding times could be easily

225 l temperature to within 2.3% of regeneration set-point temperatures.

226 her the mitotic spindle actively maintains a set point tension magnitude for properly attached sister

227 ociated with a 0.52 log(10) lower viral-load set point than HLA-B*42:02 (P = 0.02), which presents no

228 B*5703 is associated with a lower viral-load set point than HLA-B*5702 and HLA-B*5801 (medians, 5,980

229 B*58:02, vaccinees had a lower chronic viral set point than placebo recipients (median, 7240 vs 122 5

230 nd RPL5B establish a shorter telomere length set point than wild type.

231 Whisking was centered on a set point that changed in concert with running so that m

232 l, represented by the EPSP, is a homeostatic set point that is precisely maintained via changes in sy

233 hy, but masticatory muscles have a different set point that mimics disuse atrophy in the appendicular

234 CD8(+) T cells can establish differentiation set points that are stably maintained in clonal progeny

235 n type properties are tuned to circuit-level set points that vary within and between animals.

236 ear the mean odor concentration, an adaptive set-point that has been observed in the olfactory system

237 dentified a pathway controlling a brain size set-point that involves feedback inhibition between wnt1

238 a preferred level of fluid shear stress, or 'set point', that determines remodeling.

239 Throughout acute infection up to the set-point, the infection rate is higher in ramp-up plasm

240 upon the maintenance of a highly sensitive "set point," the derangement of which may lead to the dev

241 TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acqui

242 Here we propose a set point theory that hypothesises that a given threshol

243 oventilation and increases the arterial PCO2 set-point; these effects eventually subside.

244 cells leads to the definition of homeostatic set points, thus maximizing clonal diversity.

245 returned to an intrinsic centrosome number "set point." Thus, cells with cancer-associated mutations

246 y regulate neuronal activity around a stable set point to compensate for learning-related plasticity,

247 e how tonic activity is adapted toward a new set point to prevent eye drift when the head is still [3

248 by CA-074 was maintained in a late treatment setting, pointing to a role in metastatic outgrowth.

249 e changes in the DA system, which lowers the set point toward neuronal dysfunction and degeneration.

250 r, that is, by maintaining a redox potential set-point value, appeared to be ineffective in the prese

251 scales to maintain network activity around a set-point value.

252 t not viral infectivity, correlates with the set point viral load (Spearman r = 0.346; P = 0.045) and

253 ce as a strictly evolutionary process, using set point viral load (SPVL) as a proxy, to make inferenc

254 To detect differences in the HIV set point viral load (SPVL), linear regression was used;

255 ting for up to 12% of the variation in HIV-1 set point viral load (spVL).

256 evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human gene

257 r immune responses correlated inversely with set point viral loads and correlated directly with time

258 with pIL-12 compared to the median peak and set point viral loads in mock-immunized controls (P < 0.

259 .4 log reductions of the median SIV peak and set point viral loads in rhesus macaques (RMs) that rece

260 he cloned viruses revealed typical acute and set point viral-load dynamics with pathological immune a

261 In HIV patients, the set-point viral load (SPVL) is the most widely used pred

262 w model can explain the large differences in set-point viral load (SPVL) observed between patients an

263 e in Ugandans was correlated positively with set-point viral load and negatively with duration of vir

264 d Kingdom) and estimated the heritability of set-point viral load at 31% (CI 15%-43%).

265 her geography nor heterogeneity in the HIV-1 set-point viral load could account for the roughly 10-fo

266 icantly and independently contributed to the set-point viral load in the newly infected partner, acco

267 In HIV-1 infection, the early set-point viral load strongly predicts both viral transm

268 Accordingly, set-point viral load, the most common measure of virulen

269 lation, we must quantify the heritability of set-point viral load, which is the fraction of variation

270 HIV-1 set-point viral load-the approximately stable value of v

271 factors responsible for the wide spectrum of set-point viral loads are complex and likely reflect an

272 icited by that vaccine lowered both peak and set-point viral loads in macaques that became infected d

273 In multivariable models, early set-point viral loads in seroconverting partners were a

274 ly approximately 2% of the variance in early set-point viral loads of seroconverters (P = 0.046 by un

275 Reduction of set-point viral loads should have resulted in a 20% redu

276 fficacy was limited to a modest reduction in set point viremia after challenge with SIVmac239.

277 The peak and set point viremia correlated directly with colorectal vi

278 nd viral rebound with return to pretreatment set point viremia following treatment interruption.

279 We demonstrate consistent early peak and set point viremia, rapid declines in viremia to undetect

280 se in viremia were inversely correlated with set point viremia.

281 ion of endogenous NAbs correlated with lower set-point viremia and 100% survival of infected animals.

282 esult in an approximately 1.6-log decline in set-point viremia.

283 acute-phase (peak) and early chronic-phase (set-point) viremias.

284 The association of LTBI with a reduced HIV set point virus load and fewer unrelated infections in H

285 B*81 showed little deviation from the normal set point VL (P > 0.18) while maintaining high CD4 count

286 ted polymorphisms showed opposing effects on set-point VL and the balance between the two was signifi

287 nfection was associated with lower early and set-point VL in women.

288 with Ki67+CCR5+CD4+ T cell frequency, while set-point VL was associated with expansion of a myeloid

289 two was significantly associated with higher set-point VLs in a multivariable model including other r

290 highly favorable (P </= 0.03) in analyses of set-point VLs.

291 The mean VL at set-point was 4.5 log(10) copies/mL (95% CI, 3.9-5.1 log

292 on statistical deviations from a homeostatic set point were examined.

293 The strongest predictors of set point were HLA alleles (B*53:01, B*14:01, and B*27:0

294 cortex to answer two questions: for a given set-point, what is range of contrasts represented within

295 ing a glass-polymer coupling point, an early setting point, where decreasing toughness unexpectedly r

296 V-encoded TLR ligands and influenza virus at set point, whereas animals that progressed rapidly to AI

297 ese neuronal processes is referred to as the set point, which is the value that the homeostatic syste

298 have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay diseas

299 o the establishment and maintenance of viral set-point, which is a strong predictor of progression to

300 Exercising at levels below the set point will result in ageing being contaminated by th