ライフサイエンスコーパス: set point

1 ve to the sRNA and mRNA concentrations ('Hfq set-point').

2 e salt concentration of previous growth (the set point).

3 ristics of the host and virus that affect VL set point.

4 vels fluctuate randomly around a homeostatic set point.

5 tabilizing long-term blood pressure around a set point.

6 adjusts its response to accommodate the new set point.

7 d acted as the primary driver of the cognate set point.

8 f 5% and 10% resulted in lowering of the off-set point.

9 ed to a discrete level, which was termed the set point.

10 w cells sense, modify and establish a volume set point.

11 levels and decline rates but not viral load set point.

12 the same images at a predetermined and fixed set point.

13 d is a key determinant of the blood pressure set point.

14 mune responsiveness and an altered endocrine set point.

15 enotype, suggesting a more anti-inflammatory set point.

16 progresses toward the lower liver:body mass set point.

17 energy intake and reprogram the body weight set point.

18 , limiting the ability to evaluate virologic set point.

19 associated with a significantly lower viral set point.

20 amatically from acute infection to the viral set point.

21 eplication or further reduction in the viral set point.

22 he subsequent 6 months does not affect HIV-1 set point.

23 ivity, operating around a higher mechanostat set point.

24 in maintaining the already established virus set point.

25 pe correlated negatively with the virus load set point.

26 re length is regulated around an equilibrium set point.

27 ovide an accurate linear read-out of whisker set point.

28 features of whisking including the phase and set point.

29 ention until the artery remodels to a normal set point.

30 s to maintain a dynamic range around a given set point.

31 approximately 46% of the variation in HIV-1 set point.

32 oll-like receptor (TLR) alleles on the HIV-1 set point.

33 of acyclovir) explained 46% of variation in set point.

34 n almost half of the variation in viral load set point.

35 ice of restoring the nonstressed homeostatic set point.

36 initial immune responses modulate the viral set point.

37 correlated with the later plasma viral load set-point.

38 ion were inversely correlated with the viral set-point.

39 s inoculation of virus isolated at the viral set-point.

40 nd behavioral variables: heating and cooling set points.

41 l plasma and establishing viremia at various set points.

42 bent and extended conformations at different set points.

43 etermining postacute-phase viral replication set points.

44 d inverted except at low amplitudes and high set points.

45 readth were associated with lower viral load set-points.

46 eak (1.9-log reduction; P < 0.03) and at the set point (2.6-log reduction; P < 0.006) than those in c

47 onses showed an influence on the early viral set point, a broader HIV-specific CD8 T cell response ta

48 n the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable

49 Set-point adaptation balances tonic activity so that rec

50 MVS set-point adaptation is a biological model with applicat

51 daptation, thus implicating them in the slow set-point adaptation of the excitatory population.

52 Set-point adaptation was elicited with magneto-hydrodyna

53 n about another essential form of learning, "set-point" adaptation.

54 her differences in the core body temperature set point affect the regulation of human body weight.

55 ent HIV acquisition and/or reduce viral load set-point after infection.

56 lls in NOD mice exhibit an altered migration set point, allowing increased occupation of the MZ, a ni

57 human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515),

58 he dominant impact of HLA-B alleles on virus set point and absolute CD4 count variation remains signi

59 between genital inflammation and viral load set point and blood CD4 cell counts 12 months after infe

60 ection was associated with higher viral load set point and CD4 depletion, which are markers of rapid

61 adth was associated with a higher viral load set point and greater HIV-1 env diversity early in infec

62 sion was used to determine associations with set point and R(2) to estimate variation explained by co

63 ntly associated with an increased viral load set point and shorter times to reaching a CD4(+) T-cell

64 response that impacts the plasma viral load set point and the rate of progression to AIDS.

65 The log(10) HIV-1 RNA load at the ATI set point and the time-averaged area under the curve ser

66 to 33 +/- 3 mmHg significantly increased the set point and threshold pressures of the CSP-SPP relatio

67 In adjusted analysis, median viral load set point and time to clinical AIDS/death did not differ

68 These data suggest that viral set points and disease progression rates at the populati

69 ive alleles in a population may affect viral set points and rates of disease progression in that popu

70 , current PCR approaches rely on temperature set points and reaction contents that are optimized and

71 ction were associated with higher viral load set points and, to a lesser extent, with CD4 depletion.

72 Ps) for associations with HIV-1 acquisition, set-point and disease progression in African couples.

73 by varying fluid pumping frequencies using 4 set-points and the effect of clot formation using a chem

74 ontrolled at 124 +/- 2 mmHg, the threshold, 'set point' and saturation pressures of the PAP-SPP relat

75 rized by a stable HIV viral load (viral load set point) and evolution of antibodies with increased co

76 o warming treatments (+3.5 and +5 degrees C, set-points) and the presence and absence of the ant Form

77 point, identify a mechanism for varying the set point, and demonstrate its relevance to vessel remod

78 cell division and expansion, (2) the gravity set point angle, and (3) radial cell division or expansi

79 pment including root length, a novel gravity set point angle, differences in cortical cell layer patt

80 s reset, not to be confused with the gravity set point angle.

81 part of the organ toward a photogravitropic set-point angle.

82 ith respect to gravity, known as gravitropic set point angles (GSAs).

83 plementarily in establishing the gravitropic set-point angles of lateral roots.

84 energy stores to regulate the defense of Tc set points are distinct from those required to respond t

85 rently, it is unknown how stable homeostatic set points are within the nervous system.

86 equires an optimal mRNA concentration ('mRNA set-point') as well as an optimal Hfq concentration.

87 y virus-specific CTL responses and the viral set point, as well as the slope of CD4+ T-cell decline.

88 the establishment of infection to the viral set point at 1 year after the infection.

89 ion are sufficient to determine the glycemic set point at which DN occurs.

90 es seemed to generate a new equilibrium, or "set-point," at which self-tissue damage no longer occurr

91 y 10 weeks post-infection, a higher plateau (set-point) being achieved and maintained in study Group

92 Consistent with this, an altered set point between RNA-binding and aconitase forms was ob

93 rs viral dynamics: we found a higher rebound set point but similar peak viral loads compared to the p

94 f individual BES cells at or below a maximum set point by bypassing a portion of applied current with

95 ion of MMP promoter activation and that this set point can be adjusted up or down by a secondary biol

96 By logical extension, deviation from the set point can only be sustained if the pressure natriure

97 fter adjustment for plasma viral load, viral set point, CD4(+) T-cell count, herpes simplex virus typ

98 In 3/5 patients, this set point changed significantly over the time period stu

99 ing the gradual decrease in nystagmus as the set point changes over progressively longer time courses

100 This enables 7.1 degrees C decrease of the set-point compared to normal textile, greatly outperform

101 Moreover, the early viral set point, consequent on the first CD8(+) T cell respons

102 rate that changes in the regulatory feedback set point control of Insig1/SREBP1 represent an adaptive

103 the value of integral feedback in achieving set-point control; the usefulness of self-organizing beh

104 Large amplitudes and low set points corrected the step height inversion, but did

105 ility of homeostatic systems with adjustable set points creates vulnerability to dysregulation and di

106 short term fasting; and (iii) a shift of the set point defining the switch between hepatic glucose pr

107 ble to a rheostat: it is tuned to an optimal set point depending on the inhibitory and stimulatory in

108 he long-term survival of stem cells, and its set point determines the proliferative capacity of diffe

109 ually returned to a precise, cell-autonomous set point during periods of active wake, with lengthenin

110 lower peak viral load but an unchanged viral set point during viral rebound.

111 hat homolog pairing requirements dictate DSB set points during meiosis.

112 ese data suggest that a mechanical-molecular set point exists for the induction of MMP promoter activ

113 This large set-point expansion can save more than 35% of building h

114 and TLR7 rs179012) also were associated with set point, explaining 6% and 5% of the variation, respec

115 ryos, suggesting that FBP contributes to Myc set point fixation.

116 impermeant anions determine the homeostatic set point for [Cl(-)], and hence, neuronal volume and th

117 ding partner of cadherins and functions as a set point for cadherin expression by preventing cadherin

118 of basally released ATP in establishing the set point for fibrotic activity in adult rat CFs and ide

119 between HIF-alpha isoforms, establishes the set point for hypoxic sensing by the carotid body and ad

120 The homeostatic set point for metabolism is determined by the threshold,

121 th NHE3 apparently establishes the exchanger set point for pHi, and modification in this set point is

122 lls to an invasive phenotype by reducing the set point for stimulation by activated TGF-beta.

123 Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex

124 raphy during thymic maturation determine the set point for TCR responsiveness.

125 appears to be critical for establishing the set point for the blue-green switch in ecologically rele

126 Divergent expression profiles at set point for the immunized groups implied distinct immu

127 The establishment of set points for cellular activities is essential in regul

128 the basal forebrain, to determine threshold set points for filtering out weak olfactory inputs in th

129 e show that basal conformational equilibrium set points for integrin alpha4beta1 are cell type specif

130 tility as antiobesity agents by lowering the set-point for hunger between meals.

131 expectation, and experience could alter the set-point for valence-based behavior.

132 parative value, as a stage of life, and as a setting point for the life course.

133 ol system similar to controls, but that the 'set point' for mobilizing their limbic arousal system ha

134 llenge), day 14 (peak viremia), and week 12 (set point) from animals immunized with replicating adeno

135 The melting peaks and off-set points generally shifted slightly towards higher tem

136 The Hfq and mRNA set-points generate novel regulatory properties that can

137 NMJ, appropriate for a synapse at which the set point has been increased.

138 A lower core body temperature set point has been suggested to be a factor that could p

139 clinical symptoms and development of a viral set point have been associated with the emergence of HIV

140 when the tip amplitude was low or at a high set point (high force).

141 ide direct evidence for a fluid shear stress set point, identify a mechanism for varying the set poin

142 udinally from peak viremia until the viremia set point in a cohort of six subjects with acute infecti

143 ignificantly inversely correlated with viral set point in chronic HIV infection (R = -0.5; P = 0.03),

144 to determine the appropriate telomere length set point in human embryonic stem cells.

145 s about the assumption of a thermoregulatory set point in humans, and our evolutionary ability to ada

146 seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 s

147 ed host and virus factors that predict HIV-1 set point in people who recently acquired HIV-1, finding

148 dysregulation of the immuno-neuro-endocrine set point in PP, with a notable over-activation of the m

149 fficacy was limited to a modest reduction in set point in some of the groups and did not correlate wi

150 rate of HIV-1 acquisition or the viral-load set point in the population studied.

151 s HLA-B*3501 is associated with a high viral set point in two further B-clade-infected cohorts, in Ja

152 was able to significantly decrease the viral set point in vaccinated patients, with a concomitant inc

153 was associated with a decrease in viral load set points in 6 of 8 subjects (P = .08).

154 vel mechanism for establishing the requisite set points in the interferon pathway that balances the b

155 Unexpectedly, the viral set points in the treated monkeys became established at

156 ys a strategic role in determining the viral set-point in a newly HIV-1-infected patient.

157 e model and show how it encodes an "activity set point" in single neurons.

158 of telomere length and the significance of "set points" in inheritance of telomere length.

159 sted as a minor population even at the viral set point; in contrast, the majority of acute escape epi

160 rus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects revers

161 How this set point is determined remains unknown.

162 set point for pHi, and modification in this set point is effective in the hormonal stimuli-mediated

163 This set-point is mediated by an integrated neural network th

164 Intriguingly, this 'muscle-full set-point' is delayed by resistance exercise (RE) (i.e.

165 ulating hormone (TSH) production and the TSH set point later in life.

166 a peak, and then declines until it reaches a set point level.

167 ses, and the plasma viremia is reduced to a "set point" level.

168 to even slight deviations from physiological set-point levels, thereby ensuring cholesterol homeostas

169 nd virus factors interact to determine HIV-1 set point may elucidate novel mechanisms or biological p

170 decline and median regression for viral load set point (mean level 6-24 months from seroconversion).

171 h 24 (termed week 28+ infection), viral-load set point (mean plasma HIV-1 RNA level 10 to 20 weeks af

172 Both salt gradients and set point memory are encoded in ASER temporal activity p

173 gether, these findings are consistent with a set point model in which PC1 expression levels regulate

174 t models of body weight regulation, with the set-point model being most commensurate with current dat

175 n the context of static, settling point, and set-point models of body weight regulation, with the set

176 -17RA and is relevant to maintain the normal set point of blood neutrophil counts in vivo.

177 monstrate key determinants of the fibrogenic set point of cardiac fibroblasts (CFs) by focusing on th

178 nse and accurately predicted the homeostatic set point of each clone.

179 ulation using a standardized distance from a set point of entry.

180 ed dose of inducible IFN with a higher basal set point of IFN-responsive genes.

181 We defined the apoptotic set point of neuroblastomas using responses to distinct

182 osophila to investigate the stability of the set point of synaptic homeostasis across the lifespan of

183 These findings suggest that the set point of telomere lengths of offspring is determined

184 ive oxygen species essential for poising the set point of the redox proteome.

185 Thus, AgRP neurons determine the set point of the reward circuitry and associated behavio

186 h an age-dependent change to the homeostatic set point of the synapse during middle age.

187 significantly associated with the subsequent set point of viral replication.

188 /ml, whereas three noncontroller animals had set points of 2 x 10(5) to 8 x 10(5) RNA copies/ml.

189 121.2 to 29.3; P=0.44), with mean viral-load set points of 4.46 and 4.47 HIV-1 RNA log10 copies per m

190 atic immune response; developing an elevated set-point of myeloid regulatory signalling and sugar-lip

191 heir instantaneous spike rate and adjust the set-points of the stimulus-response relationships by ada

192 ent immunological status - or 'cancer-immune set point' - of an individual.

193 t HIV replication and is predictive of viral set point, offering the first immunologic evidence of CD

194 develop and maintain an elevated body weight set-point once they are provided with sufficient calorie

195 about what drives these species-specific DSB set points or the regulatory pathways that control them.

196 ally significant association with viral load set point (P = 5.6 x 10(-10)).

197 DS (relative hazard, 4.01; P=.03), and viral set point (P= .04).

198 ial viremia) and the established early viral set points (P < 0.0001).

199 s in acute infection resulted in lower viral set points (P = 0.002).

200 fection duration, age, race, CD4 cell count, set-point, peak viral load, or most recent viral load.

201 tive of non-AIDS morbidity and death, higher set point plasma virus load and virus acquisition; thus,

202 The decay rate in set point plasma virus recipient animals is approximatel

203 Estimated set-point plasma viral loads increased from 4.05 log10 c

204 ted with increased viremia, as both peak and set-point plasma viremias were similar between PTM and R

205 mp-up plasma virus recipient animals than in set-point plasma virus recipient animals.

206 how measurements wherein a user-programmable set-point precisely alters the protein concentration in

207 to the primary course of disease (i.e. viral set point, previously acquired adaptations of the virus)

208 ies are not present, low amplitudes and high set points produce images with proper contrast due to to

209 it was inversely associated with viral load set point (r = -0.68 and P = .002).

210 function by keeping neuronal firing within a set point range, but such firing rate homeostasis has ne

211 it function by keeping firing rates within a set-point range, but whether this process is gated by br

212 to reduced CB afferent activity and the PCO2 set-point recovery to CNS plasticity.

213 This stable HIV-1 set point represents an equilibrium between the virus an

214 which explained 13% and 10% of variation in set point, respectively.

215 velopmental period can alter the homeostatic set point, resulting in epilepsy-like activity.

216 odulated imaging mode: small amplitude small set-point (SASS), which optimises resolution for a given

217 r to challenge was inversely correlated with set point SIV plasma viral loads after challenge.

218 Env resulted in improved control of peak and set point SIV RNA levels following challenge.

219 d a approximately 1-log lower peak and early set-point SIV viral load than the unvaccinated animals,

220 (between 1:1 and 1:10) and a lower ratio in set-point-stage plasma (between 1:75 and 1:750).

221 fter inoculation) from seven macaques, and a set-point-stage plasma pool was made from plasma samples

222 Further, when the heat-inactivated set-point-stage plasma pool was mixed with ramp-up-stage

223 fected 2 of 2 rhesus macaques, while for the set-point-stage plasma, i.v. inoculation with 1,500 vRNA

224 emergence was associated to the early viral set point, suggesting an involvement in early control, i

225 ates of 1, 5 and 10 degrees C/min with final set-point temperatures and holding times could be easily

226 l temperature to within 2.3% of regeneration set-point temperatures.

227 her the mitotic spindle actively maintains a set point tension magnitude for properly attached sister

228 ociated with a 0.52 log(10) lower viral-load set point than HLA-B*42:02 (P = 0.02), which presents no

229 B*5703 is associated with a lower viral-load set point than HLA-B*5702 and HLA-B*5801 (medians, 5,980

230 B*58:02, vaccinees had a lower chronic viral set point than placebo recipients (median, 7240 vs 122 5

231 Whisking was centered on a set point that changed in concert with running so that m

232 l, represented by the EPSP, is a homeostatic set point that is precisely maintained via changes in sy

233 hy, but masticatory muscles have a different set point that mimics disuse atrophy in the appendicular

234 CD8(+) T cells can establish differentiation set points that are stably maintained in clonal progeny

235 dentified a pathway controlling a brain size set-point that involves feedback inhibition between wnt1

236 a preferred level of fluid shear stress, or 'set point', that determines remodeling.

237 Throughout acute infection up to the set-point, the infection rate is higher in ramp-up plasm

238 upon the maintenance of a highly sensitive "set point," the derangement of which may lead to the dev

239 TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acqui

240 Here we propose a set point theory that hypothesises that a given threshol

241 oventilation and increases the arterial PCO2 set-point; these effects eventually subside.

242 cells leads to the definition of homeostatic set points, thus maximizing clonal diversity.

243 returned to an intrinsic centrosome number "set point." Thus, cells with cancer-associated mutations

244 e how tonic activity is adapted toward a new set point to prevent eye drift when the head is still [3

245 chanisms, thereby resetting the hypothalamic set point to reverse obesity and metabolic syndrome.

246 eport, we describe how four independent data sets point to the differential expression across ACOO of

247 by CA-074 was maintained in a late treatment setting, pointing to a role in metastatic outgrowth.

248 e changes in the DA system, which lowers the set point toward neuronal dysfunction and degeneration.

249 r, that is, by maintaining a redox potential set-point value, appeared to be ineffective in the prese

250 ak VLs ranged from 10(7) to 10(8) copies/ml; set-point values were 10(4) to 10(5) SIV RNA copies/ml.

251 t not viral infectivity, correlates with the set point viral load (Spearman r = 0.346; P = 0.045) and

252 ce as a strictly evolutionary process, using set point viral load (SPVL) as a proxy, to make inferenc

253 evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human gene

254 r immune responses correlated inversely with set point viral loads and correlated directly with time

255 with pIL-12 compared to the median peak and set point viral loads in mock-immunized controls (P < 0.

256 .4 log reductions of the median SIV peak and set point viral loads in rhesus macaques (RMs) that rece

257 istically significant reductions in peak and set point viral loads were observed in the immunized ani

258 he cloned viruses revealed typical acute and set point viral-load dynamics with pathological immune a

259 In HIV patients, the set-point viral load (SPVL) is the most widely used pred

260 w model can explain the large differences in set-point viral load (SPVL) observed between patients an

261 e in Ugandans was correlated positively with set-point viral load and negatively with duration of vir

262 d Kingdom) and estimated the heritability of set-point viral load at 31% (CI 15%-43%).

263 her geography nor heterogeneity in the HIV-1 set-point viral load could account for the roughly 10-fo

264 icantly and independently contributed to the set-point viral load in the newly infected partner, acco

265 In HIV-1 infection, the early set-point viral load strongly predicts both viral transm

266 Accordingly, set-point viral load, the most common measure of virulen

267 lation, we must quantify the heritability of set-point viral load, which is the fraction of variation

268 HIV-1 set-point viral load-the approximately stable value of v

269 l depletion, elite controlling macaques with set-point viral loads < or = 500 viral RNA copies/mL mou

270 factors responsible for the wide spectrum of set-point viral loads are complex and likely reflect an

271 icited by that vaccine lowered both peak and set-point viral loads in macaques that became infected d

272 In multivariable models, early set-point viral loads in seroconverting partners were a

273 ly approximately 2% of the variance in early set-point viral loads of seroconverters (P = 0.046 by un

274 Reduction of set-point viral loads should have resulted in a 20% redu

275 fficacy was limited to a modest reduction in set point viremia after challenge with SIVmac239.

276 The peak and set point viremia correlated directly with colorectal vi

277 The peak and set point viremia was 150- and 17-fold lower, respective

278 se in viremia were inversely correlated with set point viremia.

279 ion of endogenous NAbs correlated with lower set-point viremia and 100% survival of infected animals.

280 esult in an approximately 1.6-log decline in set-point viremia.

281 acute-phase (peak) and early chronic-phase (set-point) viremias.

282 B*81 showed little deviation from the normal set point VL (P > 0.18) while maintaining high CD4 count

283 ted polymorphisms showed opposing effects on set-point VL and the balance between the two was signifi

284 with Ki67+CCR5+CD4+ T cell frequency, while set-point VL was associated with expansion of a myeloid

285 two was significantly associated with higher set-point VLs in a multivariable model including other r

286 highly favorable (P </= 0.03) in analyses of set-point VLs.

287 A viral set point was established by day 42 p.i. at 10(3) to 10(

288 The mean VL at set-point was 4.5 log(10) copies/mL (95% CI, 3.9-5.1 log

289 me-averaged area under the curve and the ATI set point were 0.24 (P=.04, unadjusted) and 0.26 (P=.07,

290 on statistical deviations from a homeostatic set point were examined.

291 The strongest predictors of set point were HLA alleles (B*53:01, B*14:01, and B*27:0

292 cortex to answer two questions: for a given set-point, what is range of contrasts represented within

293 ing a glass-polymer coupling point, an early setting point, where decreasing toughness unexpectedly r

294 V-encoded TLR ligands and influenza virus at set point, whereas animals that progressed rapidly to AI

295 ese neuronal processes is referred to as the set point, which is the value that the homeostatic syste

296 have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay diseas

297 o the establishment and maintenance of viral set-point, which is a strong predictor of progression to

298 e that regulates HIV-1 replication and viral set point while governing susceptibility to opportunisti

299 Exercising at levels below the set point will result in ageing being contaminated by th

300 h levels of viremia that decrease to a viral set point with the first emergence of virus-specific CD8